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The map label for this gene is cdd [H]

Identifier: 239618084

GI number: 239618084

Start: 1845621

End: 1846019

Strand: Reverse

Name: cdd [H]

Synonym: Kole_1716

Alternate gene names: 239618084

Gene position: 1846019-1845621 (Counterclockwise)

Preceding gene: 239618085

Following gene: 239618083

Centisome position: 80.19

GC content: 45.36

Gene sequence:

>399_bases
ATGTTGCAGAAAGACCTGGAGAAAAAACTGATAGAAATGGCAACAAAGGCTAAAGAAAGGTCCTATTCTCCTTATTCCAA
CTTTGCCGTTGGAGCAGCACTGCTGACAGAAGATGGCGAGATATTTCTCGGAACAAACATCGAGAATTCTTCTTTCGGCC
TGACGATCTGCGCTGAACGTTCCGCGATCTTCTCGGCTGTTTCTTCCGGGAAACGGAAATTCAAAGCCATCGCGATAATA
GGTTCACAGGATGACCCCACGCCACCCTGCGGGGCTTGCAGACAGGTTATGGCAGAGTTCGGAGATTTCGATGTAATTCT
TGTGGGAAAAGAGAAAATCATCAGAACATCTGTTTCAGAATTGCTACCTTTACAATTCAAACTGAATGAGGATGAGTGA

Upstream 100 bases:

>100_bases
GGCGAACGTATTGTGGTCGGAGATTTCATTTTTGAAATCCTTGCCGCAGGAAAAAAGAAGATCGAAAAAATCAGACTAAT
AGTAGATCGGGGGAAGAAAA

Downstream 100 bases:

>100_bases
TATCTATGGAAAAATCTCTGGGTTTTAAAACATATTTCGAAGGAAAAGTGGTAAAACTCGAAAAACACGAGGTAGAGTTA
GAGAATGGTTCAAAAAGCTT

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MLQKDLEKKLIEMATKAKERSYSPYSNFAVGAALLTEDGEIFLGTNIENSSFGLTICAERSAIFSAVSSGKRKFKAIAII
GSQDDPTPPCGACRQVMAEFGDFDVILVGKEKIIRTSVSELLPLQFKLNEDE

Sequences:

>Translated_132_residues
MLQKDLEKKLIEMATKAKERSYSPYSNFAVGAALLTEDGEIFLGTNIENSSFGLTICAERSAIFSAVSSGKRKFKAIAII
GSQDDPTPPCGACRQVMAEFGDFDVILVGKEKIIRTSVSELLPLQFKLNEDE
>Mature_132_residues
MLQKDLEKKLIEMATKAKERSYSPYSNFAVGAALLTEDGEIFLGTNIENSSFGLTICAERSAIFSAVSSGKRKFKAIAII
GSQDDPTPPCGACRQVMAEFGDFDVILVGKEKIIRTSVSELLPLQFKLNEDE

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=128, Percent_Identity=50, Blast_Score=118, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17551074, Length=124, Percent_Identity=51.6129032258064, Blast_Score=135, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17540514, Length=120, Percent_Identity=53.3333333333333, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323274, Length=121, Percent_Identity=42.9752066115703, Blast_Score=97, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24582741, Length=129, Percent_Identity=45.7364341085271, Blast_Score=112, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19920920, Length=139, Percent_Identity=36.6906474820144, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24582744, Length=137, Percent_Identity=36.4963503649635, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 14441; Mature: 14441

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQKDLEKKLIEMATKAKERSYSPYSNFAVGAALLTEDGEIFLGTNIENSSFGLTICAER
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEECCCCEEEECCCCCCCCCEEEEECH
SAIFSAVSSGKRKFKAIAIIGSQDDPTPPCGACRQVMAEFGDFDVILVGKEKIIRTSVSE
HHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHH
LLPLQFKLNEDE
HCCEEEEECCCC
>Mature Secondary Structure
MLQKDLEKKLIEMATKAKERSYSPYSNFAVGAALLTEDGEIFLGTNIENSSFGLTICAER
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEECCCCEEEECCCCCCCCCEEEEECH
SAIFSAVSSGKRKFKAIAIIGSQDDPTPPCGACRQVMAEFGDFDVILVGKEKIIRTSVSE
HHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHH
LLPLQFKLNEDE
HCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11739901 [H]