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The map label for this gene is rsmA [H]

Identifier: 239616459

GI number: 239616459

Start: 57103

End: 57921

Strand: Direct

Name: rsmA [H]

Synonym: Kole_0048

Alternate gene names: 239616459

Gene position: 57103-57921 (Clockwise)

Preceding gene: 239616456

Following gene: 239616460

Centisome position: 2.48

GC content: 41.15

Gene sequence:

>819_bases
ATGAATATCACCGATATTCTGAGAAAATATGGAATACACCTAAAAGACTCGCTGGGTCAGAATTTCATCAAAGATGAGAG
AATCCTTTCGAGAATCGTAAAAGATTCTGGAATAACTGACGAGGCAACGGTTATAGAAATCGGGATCGGACTCGGTACCC
TGACGCTGAAACTCGCCAAAAAAGCGAAAAAAGTAATTGGCTTTGAGATCGACAAACGCTTTGAACAGATTCACAAAGAA
CTATTAAGCGATAAGAACATCCAGATCATTTACGAGGATTTTCTCAAAGCAGATCTTAAAGACTATGATTCCCGGCCGCT
TTTTTACGTCGCCAACATTCCTTATTACATAACCTCGCCTATTCTGGAAAAAATTCTATTCGAAGGGCCGGCCTTTGAAG
CCGCCATACTGATGGTTCAAAAAGAATATGCTGAGCGTTTGCTTGCAAAACCGTCGTCCAAATCCTACGGGGCACTTACG
GTTACAATAGGGGCTTTTACGATGGTTAGAAGGTTGTTCAACGTTTCCAGGAAAGCTTTTATCCCTGCTCCCGCAGTTGA
CTCCAGCGTGGTAAAGTTAATAATGAGGGAACAAACCCTTGTACCTTTAAATGAAAAAAGAAGGTTCAGGAACTTTGTAA
AGCTTGCTTTCTCACACAGACGAAAAAAACTAAAGAACAATTTGAAACCCATCATAGATAATCCGGAGGAATTTCTAAGA
TCGCTGGGTTTTTCTGTCAACGTGAGGGCGGAGGAATTGACCATCGAAAGCTTTGTGAAACTCTATGAAGCTTCGAAAAG
GTGGAATAAGAATGAGTGA

Upstream 100 bases:

>100_bases
GGAGAGCGTGTGACGGGCACAACCCGTCCGTGGGTTCAAATCCCACTCTCTCCGCCAGGAACGGGGTAGAAATACCCCGC
TTTTTTCTGTTGGAGGAGAT

Downstream 100 bases:

>100_bases
AAAACTTCTTGAAACCATTGTTAACGCCTTGATAGAAGCCGTAATAGTTATAGACGATTCAGAGAAAATAATCCTCATTA
ACAACGAAGCGTGCAACATT

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MNITDILRKYGIHLKDSLGQNFIKDERILSRIVKDSGITDEATVIEIGIGLGTLTLKLAKKAKKVIGFEIDKRFEQIHKE
LLSDKNIQIIYEDFLKADLKDYDSRPLFYVANIPYYITSPILEKILFEGPAFEAAILMVQKEYAERLLAKPSSKSYGALT
VTIGAFTMVRRLFNVSRKAFIPAPAVDSSVVKLIMREQTLVPLNEKRRFRNFVKLAFSHRRKKLKNNLKPIIDNPEEFLR
SLGFSVNVRAEELTIESFVKLYEASKRWNKNE

Sequences:

>Translated_272_residues
MNITDILRKYGIHLKDSLGQNFIKDERILSRIVKDSGITDEATVIEIGIGLGTLTLKLAKKAKKVIGFEIDKRFEQIHKE
LLSDKNIQIIYEDFLKADLKDYDSRPLFYVANIPYYITSPILEKILFEGPAFEAAILMVQKEYAERLLAKPSSKSYGALT
VTIGAFTMVRRLFNVSRKAFIPAPAVDSSVVKLIMREQTLVPLNEKRRFRNFVKLAFSHRRKKLKNNLKPIIDNPEEFLR
SLGFSVNVRAEELTIESFVKLYEASKRWNKNE
>Mature_272_residues
MNITDILRKYGIHLKDSLGQNFIKDERILSRIVKDSGITDEATVIEIGIGLGTLTLKLAKKAKKVIGFEIDKRFEQIHKE
LLSDKNIQIIYEDFLKADLKDYDSRPLFYVANIPYYITSPILEKILFEGPAFEAAILMVQKEYAERLLAKPSSKSYGALT
VTIGAFTMVRRLFNVSRKAFIPAPAVDSSVVKLIMREQTLVPLNEKRRFRNFVKLAFSHRRKKLKNNLKPIIDNPEEFLR
SLGFSVNVRAEELTIESFVKLYEASKRWNKNE

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=285, Percent_Identity=31.2280701754386, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI156415992, Length=304, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1786236, Length=261, Percent_Identity=28.3524904214559, Blast_Score=111, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25146882, Length=210, Percent_Identity=34.7619047619048, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25141369, Length=296, Percent_Identity=24.6621621621622, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324989, Length=180, Percent_Identity=32.7777777777778, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358017, Length=196, Percent_Identity=36.2244897959184, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI21357273, Length=288, Percent_Identity=30.2083333333333, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 31331; Mature: 31331

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITDILRKYGIHLKDSLGQNFIKDERILSRIVKDSGITDEATVIEIGIGLGTLTLKLAK
CCHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
KAKKVIGFEIDKRFEQIHKELLSDKNIQIIYEDFLKADLKDYDSRPLFYVANIPYYITSP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
ILEKILFEGPAFEAAILMVQKEYAERLLAKPSSKSYGALTVTIGAFTMVRRLFNVSRKAF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHC
IPAPAVDSSVVKLIMREQTLVPLNEKRRFRNFVKLAFSHRRKKLKNNLKPIIDNPEEFLR
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
SLGFSVNVRAEELTIESFVKLYEASKRWNKNE
HCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNITDILRKYGIHLKDSLGQNFIKDERILSRIVKDSGITDEATVIEIGIGLGTLTLKLAK
CCHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
KAKKVIGFEIDKRFEQIHKELLSDKNIQIIYEDFLKADLKDYDSRPLFYVANIPYYITSP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
ILEKILFEGPAFEAAILMVQKEYAERLLAKPSSKSYGALTVTIGAFTMVRRLFNVSRKAF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHC
IPAPAVDSSVVKLIMREQTLVPLNEKRRFRNFVKLAFSHRRKKLKNNLKPIIDNPEEFLR
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
SLGFSVNVRAEELTIESFVKLYEASKRWNKNE
HCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]