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The map label for this gene is lexA [H]

Identifier: 239616430

GI number: 239616430

Start: 28473

End: 29099

Strand: Direct

Name: lexA [H]

Synonym: Kole_0019

Alternate gene names: 239616430

Gene position: 28473-29099 (Clockwise)

Preceding gene: 239616429

Following gene: 239616431

Centisome position: 1.24

GC content: 47.21

Gene sequence:

>627_bases
GTGAACCTGACAGAACGCCAGAGGGAAATTCTGGAATACATAGAAAAGTTCATAAAACTCAATGGTTATCCGCCAAGCAT
CAGGGATATATGCAGAGATTTCAATATCTCATCTCCCCGAGGAGCTGCGAAGCACCTGGAAGCCCTGGAAAAGAAGGGCT
ATATTGAAAGAACGGGTGTTTCCCGGGGAATTCGTGTGATTCGTGATGCGTCTGGAGGTTCGGTAACCCTTGAAAACGAT
GTGGTCATGTTACCGGTAGTTGGGGTCATCGCAGCAGGCGAGGCTATTCGTGCTATCGAGAATCGCGATGAAAGCATTCC
GGTTCCCATGTGGATGGTAAGACGTGGATTCGAATACTACGTTCTTAAAGTTACCGGAAACAGCATGATCGAATCCCATA
TACTCAACGGGGACTACGTTGTTATCAGGAAGCAGGAATGGGCAAACAATGGAGACATTGTCGTTGCTCTTATTGACGGT
GAGAATGCTACTTTGAAACGCTTTGAACACGAAGGGCCGAAGGTTCGCCTTGTTCCTTCGAACCCCGAAATGCTTCCCAT
TGTTCTGGAAGCTGACAGGGTAAAAATCCAGGGGAAGCTGGTTGGACTATTGAGATGGTATAAATAG

Upstream 100 bases:

>100_bases
AAGGGAGTTAAGGTTGTGGAGCTTCGTGATGACGATACGGTGGCGAGTCTCGCCGTTGTTGTTGACCAGGCGGAAGTATA
GTTCAGGAGGTGGGTTATCC

Downstream 100 bases:

>100_bases
ATTAGGATTTCGAGGTGATGATTGTGAAGGTGGCTATTGCTTCAGATCACGCGGGATTCGCTATGAAAAAAGAACTCATA
GATTTTTTAAGCTCAGCAGG

Product: SOS-response transcriptional repressor, LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNLTERQREILEYIEKFIKLNGYPPSIRDICRDFNISSPRGAAKHLEALEKKGYIERTGVSRGIRVIRDASGGSVTLEND
VVMLPVVGVIAAGEAIRAIENRDESIPVPMWMVRRGFEYYVLKVTGNSMIESHILNGDYVVIRKQEWANNGDIVVALIDG
ENATLKRFEHEGPKVRLVPSNPEMLPIVLEADRVKIQGKLVGLLRWYK

Sequences:

>Translated_208_residues
MNLTERQREILEYIEKFIKLNGYPPSIRDICRDFNISSPRGAAKHLEALEKKGYIERTGVSRGIRVIRDASGGSVTLEND
VVMLPVVGVIAAGEAIRAIENRDESIPVPMWMVRRGFEYYVLKVTGNSMIESHILNGDYVVIRKQEWANNGDIVVALIDG
ENATLKRFEHEGPKVRLVPSNPEMLPIVLEADRVKIQGKLVGLLRWYK
>Mature_208_residues
MNLTERQREILEYIEKFIKLNGYPPSIRDICRDFNISSPRGAAKHLEALEKKGYIERTGVSRGIRVIRDASGGSVTLEND
VVMLPVVGVIAAGEAIRAIENRDESIPVPMWMVRRGFEYYVLKVTGNSMIESHILNGDYVVIRKQEWANNGDIVVALIDG
ENATLKRFEHEGPKVRLVPSNPEMLPIVLEADRVKIQGKLVGLLRWYK

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=206, Percent_Identity=36.4077669902913, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23527; Mature: 23527

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTERQREILEYIEKFIKLNGYPPSIRDICRDFNISSPRGAAKHLEALEKKGYIERTGV
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEECCH
SRGIRVIRDASGGSVTLENDVVMLPVVGVIAAGEAIRAIENRDESIPVPMWMVRRGFEYY
HHCEEEEEECCCCEEEECCCEEEEEHHHHHHCCHHHHHHHCCCCCCCCCHHHHHCCCEEE
VLKVTGNSMIESHILNGDYVVIRKQEWANNGDIVVALIDGENATLKRFEHEGPKVRLVPS
EEEEECCCHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCCEEEEEEC
NPEMLPIVLEADRVKIQGKLVGLLRWYK
CCCEEEEEEECCEEEEEHEEEEEEECCC
>Mature Secondary Structure
MNLTERQREILEYIEKFIKLNGYPPSIRDICRDFNISSPRGAAKHLEALEKKGYIERTGV
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEECCH
SRGIRVIRDASGGSVTLENDVVMLPVVGVIAAGEAIRAIENRDESIPVPMWMVRRGFEYY
HHCEEEEEECCCCEEEECCCEEEEEHHHHHHCCHHHHHHHCCCCCCCCCHHHHHCCCEEE
VLKVTGNSMIESHILNGDYVVIRKQEWANNGDIVVALIDGENATLKRFEHEGPKVRLVPS
EEEEECCCHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCCEEEEEEC
NPEMLPIVLEADRVKIQGKLVGLLRWYK
CCCEEEEEEECCEEEEEHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA