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The map label for this gene is neuA [H]

Identifier: 238925592

GI number: 238925592

Start: 3086617

End: 3087333

Strand: Reverse

Name: neuA [H]

Synonym: EUBREC_3248

Alternate gene names: 238925592

Gene position: 3087333-3086617 (Counterclockwise)

Preceding gene: 238925593

Following gene: 238925591

Centisome position: 89.5

GC content: 34.03

Gene sequence:

>717_bases
ATGAGTAATATGAGTAATATTGCAATTATAACAGCTAGAGGTGGTTCAAAACGAATCCCTAAAAAAAATATAAAAGAATT
TTGTGGTAGACCAATTATTGCATATAGTATTGAGGCTGCTTTGAAGAGCAAATGTTTTGATGAAGTGATGGTGTCAACAG
ACAGTGAAGAGATAGCAGAGATAGCCAAAAAATATGGAGCAAAAGTACCGTTTTTGCGTAGTGCTGAAACATCAAATGAT
TTTGCAACTACAAGAGATGTGTTGTTAGAAGTGTTATCCGAATATAATAAGATGGGTAAGTGTTTCGATAATATGGTGTG
CCTATATCCAACAGCTCCATTTATTACGGCTGAAAAATTGAGAAGGGTATTGGTATCAATGAAGAAGAAACATGCATCCT
TAGTTATACCAGTCGTGAGATTTTCGTATCCTCCGCAAAGGGCTTATGTTCTAAAGGATGGTTTTATGAAATTTAAATGG
GAAGAATATAGAAATTCTAGATCCCAGGATTTAGAACCCTTTTTTCATGATGCTGGTCAGTTTTATTGTTATAACATAAA
GGATTATTTGGCTTGTAATGGAGTGATTACTGATAAAATTGTGCCGATTGAATTACCTGAATTAGAGGTTCAGGATATTG
ATAATGAGCAAGACTGGATTATAGCGGAAATGAAGTATAAGCTCATGAAAGGGGAAACAAAATGTCAAAATATATAG

Upstream 100 bases:

>100_bases
AATTTTATTTTAACCAATTTTTTATGGACTGAAATGATAAGGCGGGAATTCCATAATCAGATAAATATGTCTCCATGTCA
GCAATAACGGAGGGAGTAGT

Downstream 100 bases:

>100_bases
AGGTAAATGGGAGAAGGATAGGTGAGGGGTATCCCGCCTATATTATTGCTGAGATGTCTGCAAATCATTTACAGGATTAT
GAAAGAGCTAAGAAAATTAT

Product: CMP-N-acetylneuraminic acid synthetase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSNMSNIAIITARGGSKRIPKKNIKEFCGRPIIAYSIEAALKSKCFDEVMVSTDSEEIAEIAKKYGAKVPFLRSAETSND
FATTRDVLLEVLSEYNKMGKCFDNMVCLYPTAPFITAEKLRRVLVSMKKKHASLVIPVVRFSYPPQRAYVLKDGFMKFKW
EEYRNSRSQDLEPFFHDAGQFYCYNIKDYLACNGVITDKIVPIELPELEVQDIDNEQDWIIAEMKYKLMKGETKCQNI

Sequences:

>Translated_238_residues
MSNMSNIAIITARGGSKRIPKKNIKEFCGRPIIAYSIEAALKSKCFDEVMVSTDSEEIAEIAKKYGAKVPFLRSAETSND
FATTRDVLLEVLSEYNKMGKCFDNMVCLYPTAPFITAEKLRRVLVSMKKKHASLVIPVVRFSYPPQRAYVLKDGFMKFKW
EEYRNSRSQDLEPFFHDAGQFYCYNIKDYLACNGVITDKIVPIELPELEVQDIDNEQDWIIAEMKYKLMKGETKCQNI
>Mature_237_residues
SNMSNIAIITARGGSKRIPKKNIKEFCGRPIIAYSIEAALKSKCFDEVMVSTDSEEIAEIAKKYGAKVPFLRSAETSNDF
ATTRDVLLEVLSEYNKMGKCFDNMVCLYPTAPFITAEKLRRVLVSMKKKHASLVIPVVRFSYPPQRAYVLKDGFMKFKWE
EYRNSRSQDLEPFFHDAGQFYCYNIKDYLACNGVITDKIVPIELPELEVQDIDNEQDWIIAEMKYKLMKGETKCQNI

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=234, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 27350; Mature: 27219

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMSNIAIITARGGSKRIPKKNIKEFCGRPIIAYSIEAALKSKCFDEVMVSTDSEEIAE
CCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHH
IAKKYGAKVPFLRSAETSNDFATTRDVLLEVLSEYNKMGKCFDNMVCLYPTAPFITAEKL
HHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHH
RRVLVSMKKKHASLVIPVVRFSYPPQRAYVLKDGFMKFKWEEYRNSRSQDLEPFFHDAGQ
HHHHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCEEEHHHHCCCCCCCCCHHHHCCCC
FYCYNIKDYLACNGVITDKIVPIELPELEVQDIDNEQDWIIAEMKYKLMKGETKCQNI
EEEEECHHHHHCCCEEECCEEEEECCCCHHCCCCCCCCEEHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
SNMSNIAIITARGGSKRIPKKNIKEFCGRPIIAYSIEAALKSKCFDEVMVSTDSEEIAE
CCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHH
IAKKYGAKVPFLRSAETSNDFATTRDVLLEVLSEYNKMGKCFDNMVCLYPTAPFITAEKL
HHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHH
RRVLVSMKKKHASLVIPVVRFSYPPQRAYVLKDGFMKFKWEEYRNSRSQDLEPFFHDAGQ
HHHHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCEEEHHHHCCCCCCCCCHHHHCCCC
FYCYNIKDYLACNGVITDKIVPIELPELEVQDIDNEQDWIIAEMKYKLMKGETKCQNI
EEEEECHHHHHCCCEEECCEEEEECCCCHHCCCCCCCCEEHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1398032; 7830552; 8113198; 8045888; 10710307 [H]