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The map label for this gene is prlC [H]

Identifier: 238921585

GI number: 238921585

Start: 3623122

End: 3625164

Strand: Reverse

Name: prlC [H]

Synonym: NT01EI_3738

Alternate gene names: 238921585

Gene position: 3625164-3623122 (Counterclockwise)

Preceding gene: 238921586

Following gene: 238921584

Centisome position: 95.09

GC content: 61.87

Gene sequence:

>2043_bases
ATGACCAATCCTTTGCTGACTCCCTTTGTATTCCCGCCCTTCTCCCGTATTACGCCACCGGATGTGGTACCGGCGGTGAG
CGCGGCGCTGGCCGACTGCCGTGTCGTGGTGGAACGAGTGGTGGCGCAGACCGGCCCCTTTACCTGGGAGAATCTGGTAC
AACCGCTGGCTGAGGCCGACGATCGTTTGGGGCGTATTTTTTCGCCGGTCAGCCACCTCAATGCAGTGCAGAACAGCCCG
GAGCTGAGGGCGGCCTATGAACAGTGCCTGCCGCTGCTGTCGGAGTACGGTACCTGGGTTGGCCAGCATCAGGGGCTGTA
TCAGGCCTACCGTCAGCTGAAGGCGGGAGAGGGCTACATGGCGCTGGACAAGGCCCAGAAGCGGGCGGTGGATAATGCGC
TGCGTGACTTTGAGCTGTCCGGTATCGGCCTGCCGCCGGAGGCGCAGAAGCGCTACGGCGAAATCGTCATGCGTCTGTCC
GAGCTGGGCTCCGCCTTCAGCAACAATGTGCTGGATGCGACCATGGGCTGGAGCAAGCTGATGACGGAGAAGGCATCGCT
GGCCGGCCTGCCGGAGAGTGCACTGGCGGCGGCTTATGAGCTGGCGTCGTCACGTGGCCAGCAGGGGTGGCTGCTGACGC
TGGATATGCCGAGTTACCTGCCGGTGATGACCTATGCAGACAACCGCGAACTGCGCTATGAGATGTACCGCGCCTTTACC
ACGCGAGCCTCCGATCAGGGGCCGAACGCAGGCGAATGGGACAACGGCGCCATCATGAACGAGACGCTGGCGCTGCGTCA
TGAGCTGGCCCAGCTGCTGGGCTTTGCCAGCTACGCCGACAAGTCGCTGGCGACCAAGATGGCTGAAAATCCGCAGCAGG
TGTTGGGGTTCCTCAACGATCTGGCGCAGCGTGCCCATAAACAGGGGACAGCGGAGCTGGAGCAGCTCAGCGCCTTCGCC
CTGCGCCATTATGGCGTCAGCGAGCTGGCGCCTTGGGACATCACCTACTACAGCGAGAAACAGAAGCAGCATCTCTACGC
CATCAGTGACGAGGAGCTGCGTCCCTATTTCCCCGAGCCGACGGTGCTGAGCGGGCTGTTTGAGGTGGTGCATCGCATCT
ATGGCATCACGGCCAAAGAGCGTCACGACGTGGATGTCTGGCATCCAGAGGTACGTTTCTTTGAGCTGTACGGCAGCGAT
GGTGAGTTGTGCGGCAGCTTCTACCTGGATCTGTACGCGCGCGAACACAAGCGCGGTGGCGCCTGGATGGATGACTGCGC
CGGGCGTCTGCGTCGCGCCGACGGCACGCTACAGAAGCCGGTGGCCTACCTGACCTGCAACTTTAACCGCCCGTTGGGCG
ATCAGCCGGCGCTGTTCACCCATAATGAAGTCACCACGCTGTTCCACGAGTTTGGCCACGGTCTGCACCATATGTTGACC
CGTATCGAAACCCCGGGGGTTTCCGGTATTAACGGGGTGCCGTGGGATGCGGTCGAGTTGCCGAGCCAGTTTATGGAAAA
CTGGTGCTGGGAGCCGGAGGCGCTGGCCTTTATCTCCGGCCACTATCAGAGCGGCGAGCCGTTGCCACAGGCGATGCTGG
AGCGGATGCTGGCGGCCAAGAACTATCAGTCCGCGCTGTTTATCCTGCGCCAGCTGGAGTTCGGGCTGTTTGACTTCCGT
CTGCACACCGAATTCGACCCGTCGCAGGGCGCTCAGATCATGGAGACCCTGCGTCAGGTCAAGGCGCTGGTGGCAGTGGT
GCCGTCGCCGGAGTGGGGGCGTTTCCCACACGCGTTCAGCCACATCTTTGCCGGTGGCTATGCGGCCGGTTACTACAGCT
ATCTGTGGGCTGAGCTGCTGTCGGCGGATGCCTTCTCCCGCTTTGAGGAGGAGGGGATCTTTAACGTTGATACCGGGCGT
GCCTTCTTGGATAACGTGCTGTCGCAGGGGGGCTCCGATGAGCCGATGACCCTGTTTAAAGCGTTCCGCGGGCGTGAGCC
ACAGATCGATGCCATGCTGCGTCATTACGGGATCAAGGGCTGA

Upstream 100 bases:

>100_bases
CTAGGTTCATTACGCCTTATTTTATCCGCGGCGTCACGCGGCGGATAACCCGAATTCCGGGGCTGCCGTGTCAGCCCCGC
CGACTATAGGACACGTGCAG

Downstream 100 bases:

>100_bases
TGGCGGCGGTTCAGCTGCTGGCGGAGGAGGGTGCCGATGCGGCGGCGCTGAGCGCGCTGGCGCAGCGCTGGGGGCTGTGT
CATGACGCCGACGCTGTATT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFVFPPFSRITPPDVVPAVSAALADCRVVVERVVAQTGPFTWENLVQPLAEADDRLGRIFSPVSHLNAVQNSP
ELRAAYEQCLPLLSEYGTWVGQHQGLYQAYRQLKAGEGYMALDKAQKRAVDNALRDFELSGIGLPPEAQKRYGEIVMRLS
ELGSAFSNNVLDATMGWSKLMTEKASLAGLPESALAAAYELASSRGQQGWLLTLDMPSYLPVMTYADNRELRYEMYRAFT
TRASDQGPNAGEWDNGAIMNETLALRHELAQLLGFASYADKSLATKMAENPQQVLGFLNDLAQRAHKQGTAELEQLSAFA
LRHYGVSELAPWDITYYSEKQKQHLYAISDEELRPYFPEPTVLSGLFEVVHRIYGITAKERHDVDVWHPEVRFFELYGSD
GELCGSFYLDLYAREHKRGGAWMDDCAGRLRRADGTLQKPVAYLTCNFNRPLGDQPALFTHNEVTTLFHEFGHGLHHMLT
RIETPGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPQAMLERMLAAKNYQSALFILRQLEFGLFDFR
LHTEFDPSQGAQIMETLRQVKALVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAELLSADAFSRFEEEGIFNVDTGR
AFLDNVLSQGGSDEPMTLFKAFRGREPQIDAMLRHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFVFPPFSRITPPDVVPAVSAALADCRVVVERVVAQTGPFTWENLVQPLAEADDRLGRIFSPVSHLNAVQNSP
ELRAAYEQCLPLLSEYGTWVGQHQGLYQAYRQLKAGEGYMALDKAQKRAVDNALRDFELSGIGLPPEAQKRYGEIVMRLS
ELGSAFSNNVLDATMGWSKLMTEKASLAGLPESALAAAYELASSRGQQGWLLTLDMPSYLPVMTYADNRELRYEMYRAFT
TRASDQGPNAGEWDNGAIMNETLALRHELAQLLGFASYADKSLATKMAENPQQVLGFLNDLAQRAHKQGTAELEQLSAFA
LRHYGVSELAPWDITYYSEKQKQHLYAISDEELRPYFPEPTVLSGLFEVVHRIYGITAKERHDVDVWHPEVRFFELYGSD
GELCGSFYLDLYAREHKRGGAWMDDCAGRLRRADGTLQKPVAYLTCNFNRPLGDQPALFTHNEVTTLFHEFGHGLHHMLT
RIETPGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPQAMLERMLAAKNYQSALFILRQLEFGLFDFR
LHTEFDPSQGAQIMETLRQVKALVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAELLSADAFSRFEEEGIFNVDTGR
AFLDNVLSQGGSDEPMTLFKAFRGREPQIDAMLRHYGIKG
>Mature_679_residues
TNPLLTPFVFPPFSRITPPDVVPAVSAALADCRVVVERVVAQTGPFTWENLVQPLAEADDRLGRIFSPVSHLNAVQNSPE
LRAAYEQCLPLLSEYGTWVGQHQGLYQAYRQLKAGEGYMALDKAQKRAVDNALRDFELSGIGLPPEAQKRYGEIVMRLSE
LGSAFSNNVLDATMGWSKLMTEKASLAGLPESALAAAYELASSRGQQGWLLTLDMPSYLPVMTYADNRELRYEMYRAFTT
RASDQGPNAGEWDNGAIMNETLALRHELAQLLGFASYADKSLATKMAENPQQVLGFLNDLAQRAHKQGTAELEQLSAFAL
RHYGVSELAPWDITYYSEKQKQHLYAISDEELRPYFPEPTVLSGLFEVVHRIYGITAKERHDVDVWHPEVRFFELYGSDG
ELCGSFYLDLYAREHKRGGAWMDDCAGRLRRADGTLQKPVAYLTCNFNRPLGDQPALFTHNEVTTLFHEFGHGLHHMLTR
IETPGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPQAMLERMLAAKNYQSALFILRQLEFGLFDFRL
HTEFDPSQGAQIMETLRQVKALVAVVPSPEWGRFPHAFSHIFAGGYAAGYYSYLWAELLSADAFSRFEEEGIFNVDTGRA
FLDNVLSQGGSDEPMTLFKAFRGREPQIDAMLRHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=656, Percent_Identity=30.1829268292683, Blast_Score=301, Evalue=2e-81,
Organism=Homo sapiens, GI14149738, Length=639, Percent_Identity=30.0469483568075, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI156105687, Length=658, Percent_Identity=26.5957446808511, Blast_Score=192, Evalue=1e-48,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=77.7941176470588, Blast_Score=1112, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=688, Percent_Identity=30.2325581395349, Blast_Score=295, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI71999758, Length=576, Percent_Identity=25.3472222222222, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32565901, Length=628, Percent_Identity=23.2484076433121, Blast_Score=113, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319793, Length=692, Percent_Identity=28.9017341040462, Blast_Score=303, Evalue=8e-83,
Organism=Saccharomyces cerevisiae, GI6322715, Length=659, Percent_Identity=23.9757207890744, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21356111, Length=587, Percent_Identity=28.4497444633731, Blast_Score=246, Evalue=5e-65,
Organism=Drosophila melanogaster, GI20129717, Length=686, Percent_Identity=24.198250728863, Blast_Score=173, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76330; Mature: 76199

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFVFPPFSRITPPDVVPAVSAALADCRVVVERVVAQTGPFTWENLVQPLAEAD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DRLGRIFSPVSHLNAVQNSPELRAAYEQCLPLLSEYGTWVGQHQGLYQAYRQLKAGEGYM
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
ALDKAQKRAVDNALRDFELSGIGLPPEAQKRYGEIVMRLSELGSAFSNNVLDATMGWSKL
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
MTEKASLAGLPESALAAAYELASSRGQQGWLLTLDMPSYLPVMTYADNRELRYEMYRAFT
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHH
TRASDQGPNAGEWDNGAIMNETLALRHELAQLLGFASYADKSLATKMAENPQQVLGFLND
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LAQRAHKQGTAELEQLSAFALRHYGVSELAPWDITYYSEKQKQHLYAISDEELRPYFPEP
HHHHHHHCCHHHHHHHHHHHHHHCCHHHCCCCCEEECCCHHHHHEEEECCCCCCCCCCCH
TVLSGLFEVVHRIYGITAKERHDVDVWHPEVRFFELYGSDGELCGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
AWMDDCAGRLRRADGTLQKPVAYLTCNFNRPLGDQPALFTHNEVTTLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
RIETPGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPQAMLERMLAAK
HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHC
NYQSALFILRQLEFGLFDFRLHTEFDPSQGAQIMETLRQVKALVAVVPSPEWGRFPHAFS
CHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWAELLSADAFSRFEEEGIFNVDTGRAFLDNVLSQGGSDEPMTLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCCCCHHHHHH
AFRGREPQIDAMLRHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFVFPPFSRITPPDVVPAVSAALADCRVVVERVVAQTGPFTWENLVQPLAEAD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DRLGRIFSPVSHLNAVQNSPELRAAYEQCLPLLSEYGTWVGQHQGLYQAYRQLKAGEGYM
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
ALDKAQKRAVDNALRDFELSGIGLPPEAQKRYGEIVMRLSELGSAFSNNVLDATMGWSKL
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
MTEKASLAGLPESALAAAYELASSRGQQGWLLTLDMPSYLPVMTYADNRELRYEMYRAFT
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHH
TRASDQGPNAGEWDNGAIMNETLALRHELAQLLGFASYADKSLATKMAENPQQVLGFLND
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LAQRAHKQGTAELEQLSAFALRHYGVSELAPWDITYYSEKQKQHLYAISDEELRPYFPEP
HHHHHHHCCHHHHHHHHHHHHHHCCHHHCCCCCEEECCCHHHHHEEEECCCCCCCCCCCH
TVLSGLFEVVHRIYGITAKERHDVDVWHPEVRFFELYGSDGELCGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
AWMDDCAGRLRRADGTLQKPVAYLTCNFNRPLGDQPALFTHNEVTTLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
RIETPGVSGINGVPWDAVELPSQFMENWCWEPEALAFISGHYQSGEPLPQAMLERMLAAK
HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHC
NYQSALFILRQLEFGLFDFRLHTEFDPSQGAQIMETLRQVKALVAVVPSPEWGRFPHAFS
CHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWAELLSADAFSRFEEEGIFNVDTGRAFLDNVLSQGGSDEPMTLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCCCCHHHHHH
AFRGREPQIDAMLRHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]