BacMap

Definition	Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome.
Accession	NC_012731
Length	5,248,520

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The map label for this gene is yhaU [H]

Identifier: 238896638

GI number: 238896638

Start: 4616287

End: 4617618

Strand: Reverse

Name: yhaU [H]

Synonym: KP1_4842

Alternate gene names: 238896638

Gene position: 4617618-4616287 (Counterclockwise)

Preceding gene: 238896640

Following gene: 238896637

Centisome position: 87.98

GC content: 53.6

Gene sequence:

>1332_bases
ATGATTTTGGATTCTACATTAGATGAAAAAAAAGGAATACCGACCCGCTATTTAATTCTGTTGATGATATTTGTGGTGAC
GGCAGTGAACTATGGCGACCGCGCGACCTTGTCTATCGCCGGTACTGAAGTCGCGAAAGAGCTGGGGCTCAGCGCGGTGT
CGATGGGATACATTTTTTCCGCCTTCGGCTGGGCTTATCTGCTGATGCAGATCCCTGGCGGCTGGCTGCTGGATAAATTT
GGCTCGAAAAAGGTTTATTCATACAGTCTGTTTTTCTGGTCACTGTTTACCTTCCTGCAAGGCTTTATTGATGTGTTCCC
GCTCGCCTGGGCCGGGGTCTCCATGTTCTTTATGCGTTTTATGCTGGGCTTTTCCGAAGCGCCCTCGTTTCCCGCCAACG
CCCGCATTGTGGCGGCCTGGTTTCCGGCCAAAGAGCGGGGTACGGCTTCAGCTATCTTTAATGCCGCTCAGTACTTCTCG
CTGGCTCTGTTCTCGCCGCTGCTCGGCTGGCTGACCTTCGCGCTGGGCTGGGAACATGTCTTTACCGTGATGGGGATAAT
AGGGTTTGTGCTCACCATCATCTGGGTGAAGTTTGTGCATAACCCCACCGATCATCCGCGAATGTCGGCCGTGGAGCTGA
AATATATCTCAGAAGGCGGCGCAGTGGTCGATATGGACCATAAAAAAGAGGCCACCCCGGCGGCCGGGCCGAAGATGGAC
TATATCCGCCAGCTGCTGACTAACCGAATGATGTTAGGCGTATTTTTCGGTCAGTATTTCCTGAATACCATTACATGGTT
CTTCCTGACGTGGTTTCCGATCTACCTCGTGCAGGACAAGGGAATGTCGATTCTGAAAGTGGGGTTTGTGGCTTCGATTC
CGGCGCTGTTTGGCTTTGCTGGCGGCGTACTGGGCGGGCTGTTTTCGGATTATCTGATTGGCCGCGGCTGCACGCTGACT
TTTGCGCGTAAGCTGCCCATTGTGCTGGGAATGCTGCTGGCGTCGTCCATCATCCTGTGTAACTACACGGCCAGCACGCC
GCTGGTCATTACGCTGATGGCGCTGGCGTTCTTTGGCAAAGGCTTTGGCGCGCTGGGCTGGCCGGTTATCTCGGATGTCG
CGCCGAAGGAGATTGTTGGCCTGTGCGGCGGGGTATTCAACGTCTTTGGCAATGTGGCCTCGATCGCCACGCCGCTGGTT
ATTGGCTATATCGTGAGCGAACTGCACTCATTTAATGGCGCACTGATTTTTGTTGGCGGCTCCGCGCTGATGATGATGGT
CTGCTACCTGTTTGTGGTTGGCGATATCAAACGTATGGAATTGCAGAAGTAA

Upstream 100 bases:

>100_bases
GATCGATATGCGAATAGACAGTTTCAATATCGTCTTTTAAATAAATCAGAAACCACTTAAAACAATTATAAAAGGTGTTC
TGTGCCCGAGGAATGTCTAA

Downstream 100 bases:

>100_bases
GCAACGATTAACGCAAGGTAAAAATCATGGATAACGCAATTTTTCCGAACAAATTTAAGGCCGCGCTGGCGGCGCATCAG
GTGCAGATTGGCTGCTGGTG

Product: putative transport protein

Products: NA

Alternate protein names: D-galactarate permease [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MILDSTLDEKKGIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKF
GSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFS
LALFSPLLGWLTFALGWEHVFTVMGIIGFVLTIIWVKFVHNPTDHPRMSAVELKYISEGGAVVDMDHKKEATPAAGPKMD
YIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLT
FARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLV
IGYIVSELHSFNGALIFVGGSALMMMVCYLFVVGDIKRMELQK

Sequences:

>Translated_443_residues
MILDSTLDEKKGIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKF
GSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFS
LALFSPLLGWLTFALGWEHVFTVMGIIGFVLTIIWVKFVHNPTDHPRMSAVELKYISEGGAVVDMDHKKEATPAAGPKMD
YIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLT
FARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLV
IGYIVSELHSFNGALIFVGGSALMMMVCYLFVVGDIKRMELQK
>Mature_443_residues
MILDSTLDEKKGIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKF
GSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFS
LALFSPLLGWLTFALGWEHVFTVMGIIGFVLTIIWVKFVHNPTDHPRMSAVELKYISEGGAVVDMDHKKEATPAAGPKMD
YIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLT
FARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLV
IGYIVSELHSFNGALIFVGGSALMMMVCYLFVVGDIKRMELQK

Specific function: Uptake of D-galactarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI21322234, Length=414, Percent_Identity=25.1207729468599, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI9945322, Length=413, Percent_Identity=25.6658595641646, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI9966811, Length=416, Percent_Identity=25, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI148743791, Length=370, Percent_Identity=26.2162162162162, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI6912666, Length=378, Percent_Identity=23.2804232804233, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4885441, Length=381, Percent_Identity=26.509186351706, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI5031955, Length=337, Percent_Identity=26.7062314540059, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI223718438, Length=235, Percent_Identity=26.8085106382979, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI148728191, Length=314, Percent_Identity=25.796178343949, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI154350196, Length=423, Percent_Identity=23.8770685579196, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI154800443, Length=330, Percent_Identity=25.7575757575758, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789515, Length=444, Percent_Identity=86.9369369369369, Blast_Score=789, Evalue=0.0,
Organism=Escherichia coli, GI1789152, Length=434, Percent_Identity=57.8341013824885, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI87082320, Length=439, Percent_Identity=41.4578587699317, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI2367379, Length=416, Percent_Identity=31.0096153846154, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI2367193, Length=325, Percent_Identity=26.4615384615385, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788573, Length=433, Percent_Identity=22.4018475750577, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533554, Length=431, Percent_Identity=27.6102088167053, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115533556, Length=432, Percent_Identity=27.7777777777778, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17535049, Length=411, Percent_Identity=25.0608272506083, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17552542, Length=314, Percent_Identity=24.5222929936306, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193205400, Length=300, Percent_Identity=24.6666666666667, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25141316, Length=348, Percent_Identity=22.9885057471264, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25141318, Length=348, Percent_Identity=22.9885057471264, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560030, Length=399, Percent_Identity=23.5588972431078, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17570335, Length=246, Percent_Identity=27.6422764227642, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25141341, Length=344, Percent_Identity=22.3837209302326, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86561091, Length=258, Percent_Identity=24.8062015503876, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17563054, Length=338, Percent_Identity=28.4023668639053, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25151055, Length=246, Percent_Identity=26.0162601626016, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17569727, Length=289, Percent_Identity=24.2214532871972, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71997452, Length=407, Percent_Identity=22.3587223587224, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562692, Length=322, Percent_Identity=25.1552795031056, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32565916, Length=288, Percent_Identity=21.875, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI32565914, Length=266, Percent_Identity=21.4285714285714, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554148, Length=405, Percent_Identity=23.9506172839506, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71991448, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71991453, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536335, Length=311, Percent_Identity=24.1157556270096, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71983953, Length=247, Percent_Identity=27.5303643724696, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45550460, Length=414, Percent_Identity=28.2608695652174, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654215, Length=450, Percent_Identity=24.8888888888889, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI19922400, Length=439, Percent_Identity=25.7403189066059, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648416, Length=453, Percent_Identity=25.1655629139073, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356189, Length=453, Percent_Identity=25.1655629139073, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28573708, Length=467, Percent_Identity=24.8394004282655, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573707, Length=467, Percent_Identity=24.8394004282655, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24655255, Length=374, Percent_Identity=28.6096256684492, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24655271, Length=422, Percent_Identity=25.8293838862559, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24639764, Length=419, Percent_Identity=23.3890214797136, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20130135, Length=426, Percent_Identity=25.3521126760563, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24641682, Length=395, Percent_Identity=23.7974683544304, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI62484226, Length=443, Percent_Identity=23.7020316027088, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583789, Length=288, Percent_Identity=27.7777777777778, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24584153, Length=381, Percent_Identity=25.4593175853018, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130167, Length=457, Percent_Identity=24.0700218818381, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24653727, Length=369, Percent_Identity=24.390243902439, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI20129235, Length=393, Percent_Identity=25.1908396946565, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573299, Length=434, Percent_Identity=25.8064516129032, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24580790, Length=359, Percent_Identity=24.5125348189415, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550364, Length=429, Percent_Identity=26.3403263403263, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24658658, Length=424, Percent_Identity=24.0566037735849, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920686, Length=414, Percent_Identity=21.9806763285024, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48663; Mature: 48663

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDSTLDEKKGIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFS
CCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHH
AFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVSMFFMRF
HHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHV
HHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTVMGIIGFVLTIIWVKFVHNPTDHPRMSAVELKYISEGGAVVDMDHKKEATPAAGPKMD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCCEEECCCCCCCCCCCCCCHH
YIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHH
GGVLGGLFSDYLIGRGCTLTFARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCC
GFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGALIFVGG
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
SALMMMVCYLFVVGDIKRMELQK
HHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MILDSTLDEKKGIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFS
CCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHH
AFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVSMFFMRF
HHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHV
HHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTVMGIIGFVLTIIWVKFVHNPTDHPRMSAVELKYISEGGAVVDMDHKKEATPAAGPKMD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCCEEECCCCCCCCCCCCCCHH
YIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHH
GGVLGGLFSDYLIGRGCTLTFARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCC
GFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGALIFVGG
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
SALMMMVCYLFVVGDIKRMELQK
HHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]