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The map label for this gene is cadA [H]

Identifier: 238893512

GI number: 238893512

Start: 1356320

End: 1358473

Strand: Direct

Name: cadA [H]

Synonym: KP1_1410

Alternate gene names: 238893512

Gene position: 1356320-1358473 (Clockwise)

Preceding gene: 238893511

Following gene: 238893513

Centisome position: 25.84

GC content: 53.11

Gene sequence:

>2154_bases
TTGACTATGAACGTTATTGCAATCATGAATCACATGGGGGTTTACTTCAAAGAAGAACCCATCCGTGAACTGCATCGTGC
TCTCGAACGCCTGGACTTCCGTATTGTCTACCCGAACGACCGTGACGACTTATTAAAACTTATTGAAAACAACTCTCGTC
TGTGCGGCGTGATCTTCGACTGGGATAAATACAATCTCGAACTGTGCGAAGAAATCAGCAAAATGAACGAGTACATGCCG
CTGTATGCGTTCGCTAACACCTACTCCACTCTGGACGTTAGCCTGAACGATCTGCGCATGCAGGTTCGCTTCTTCGAATA
TGCGCTGGGCGCTGCGGAAGATATCGCGAACAAAATCAAACAGAACACTGACGAATACATCGACACCATTCTGCCGCCGC
TGACCAAAGCGCTGTTCAAATATGTCCGTGAAGGTAAATATACCTTCTGTACCCCGGGCCACATGGGCGGTACCGCGTTC
CAGAAAAGCCCGGTAGGCAGCATCTTCTATGATTTCTTTGGCTCCAACACCATGAAATCCGATATCTCCATTTCGGTTTC
TGAACTGGGTTCCCTGCTGGACCACAGCGGCCCGCACAAAGAAGCGGAAGAGTATATCGCTCGCGTGTTTAACGCAGAAC
GCAGCTACATGGTGACCAACGGTACTTCTACCGCTAACAAAATCGTCGGCATGTACTCCGCGCCGGCCGGCAGCACCGTG
CTGATTGACCGTAACTGCCACAAATCGCTGACTCACCTGATGATGATGAGCGACATTACGCCGATCTACTTCCGTCCGAC
CCGTAACGCCTACGGTATCCTCGGCGGTATTCCGCAGAGCGAATTCCAGCACGCGACTATCGCCAAGCGTGTGAAAGAGA
CGCCGAATGCGACCTGGCCGGTACACGCGGTGATCACCAACTCGACTTACGATGGTCTGCTGTATAACACCGACTTCATC
AAGAAAACCCTGGATGTGAAATCCATCCACTTTGACTCCGCATGGGTCCCTTACACCAACTTCTCGCCGATCTATGAAGG
CAAATGCGGGATGAGCGGCGGCCGCGTTGAAGGGAAAGTGATTTATGAAACCCAGTCCACGCACAAACTGCTGGCGGCGT
TCTCCCAGGCGTCGATGATCCACGTGAAAGGCGACGTAAACGAAGAGACCTTCAACGAAGCCTACATGATGCACACCACC
ACCTCTCCACACTACGGGATCGTGGCCTCCACCGAAACCGCGGCGGCGATGATGAAGGGGAACGCTGGTAAGCGTCTGAT
CGACGGCTCTATTGAACGTTCCATCAAGTTCCGTAAAGAGATCAAACGTCTGAAAGGCGAGTCTGACGGCTGGTTCTTCG
ACGTCTGGCAGCCGGAGCATATCGATGGTCCTGAATGCTGGCCGCTGCGTTCCGACAGCGCATGGCACGGTTTCAAAAAC
ATCGATAACGAACACATGTACCTCGACCCGATCAAAGTCACGCTGCTGACTCCGGGGATGAAGAAAGACGGCACCATGGA
TGACTTCGGTATTCCGGCAAGCATCGTGGCGAAATACCTCGACGAACACGGCATCGTGGTAGAGAAAACCGGTCCGTACA
ACCTGCTGTTCCTGTTCAGTATCGGTATCGATAAGACTAAAGCGCTGAGCCTGCTGCGTGCGCTGACCGACTTCAAACGC
GCGTTCGACCTGAACCTGCGGGTGAAAAACATGCTGCCGTCGCTGTACCGTGAAGATCCTGAATTCTATGAAAACATGCG
TATTCAGGACCTCGCGCAGAACATTCACAAACTGATTGAGCATCACAACCTGCCGGATCTGATGTTCCGCGCGTTTGAAG
TGCTGCCATCGATGGTGATGACCCCGTATGCCGCGTTCCAGAAAGAGCTGCACGGTCAGACGGAAGAAGTGTATCTCGAA
GAGATGGTCGGCCGCGTCAACGCCAACATGATCCTGCCGTATCCTCCGGGAGTGCCGCTGGTGATGCCGGGTGAGATGAT
CACCGAAGAGAGCCGTCCGGTGCTGGAGTTCCTGCAGATGCTGTGCGAAATCGGCGCCCACTATCCAGGCTTCGAAACCG
ATATCCACGGCGCCTATCGTCAGGCGGATGGTCGTTACACCGTTAAAGTGCTGAAAGAAGAGAATAACAAGTAA

Upstream 100 bases:

>100_bases
AACACCACCGCTAACGCGCACTAATCAGCAACCCGTTTTCCTGAGGCTCCTTCCATCACCTGTCATCACGCGACGGGAGG
GGCTTTCTACATCTGGAGAT

Downstream 100 bases:

>100_bases
TAGACGCACACCAGGGAAGTGGCTTGCCACTTCCCTTTTTCACGCTGCAAGGAGAACACATGAAAACACCCTCACAGCCG
CGCGCGATTTACTACATCGT

Product: lysine decarboxylase 1

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 717; Mature: 716

Protein sequence:

>717_residues
MTMNVIAIMNHMGVYFKEEPIRELHRALERLDFRIVYPNDRDDLLKLIENNSRLCGVIFDWDKYNLELCEEISKMNEYMP
LYAFANTYSTLDVSLNDLRMQVRFFEYALGAAEDIANKIKQNTDEYIDTILPPLTKALFKYVREGKYTFCTPGHMGGTAF
QKSPVGSIFYDFFGSNTMKSDISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTV
LIDRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFI
KKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTT
TSPHYGIVASTETAAAMMKGNAGKRLIDGSIERSIKFRKEIKRLKGESDGWFFDVWQPEHIDGPECWPLRSDSAWHGFKN
IDNEHMYLDPIKVTLLTPGMKKDGTMDDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKR
AFDLNLRVKNMLPSLYREDPEFYENMRIQDLAQNIHKLIEHHNLPDLMFRAFEVLPSMVMTPYAAFQKELHGQTEEVYLE
EMVGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENNK

Sequences:

>Translated_717_residues
MTMNVIAIMNHMGVYFKEEPIRELHRALERLDFRIVYPNDRDDLLKLIENNSRLCGVIFDWDKYNLELCEEISKMNEYMP
LYAFANTYSTLDVSLNDLRMQVRFFEYALGAAEDIANKIKQNTDEYIDTILPPLTKALFKYVREGKYTFCTPGHMGGTAF
QKSPVGSIFYDFFGSNTMKSDISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTV
LIDRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFI
KKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTT
TSPHYGIVASTETAAAMMKGNAGKRLIDGSIERSIKFRKEIKRLKGESDGWFFDVWQPEHIDGPECWPLRSDSAWHGFKN
IDNEHMYLDPIKVTLLTPGMKKDGTMDDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKR
AFDLNLRVKNMLPSLYREDPEFYENMRIQDLAQNIHKLIEHHNLPDLMFRAFEVLPSMVMTPYAAFQKELHGQTEEVYLE
EMVGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENNK
>Mature_716_residues
TMNVIAIMNHMGVYFKEEPIRELHRALERLDFRIVYPNDRDDLLKLIENNSRLCGVIFDWDKYNLELCEEISKMNEYMPL
YAFANTYSTLDVSLNDLRMQVRFFEYALGAAEDIANKIKQNTDEYIDTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQ
KSPVGSIFYDFFGSNTMKSDISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVL
IDRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIK
KTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTT
SPHYGIVASTETAAAMMKGNAGKRLIDGSIERSIKFRKEIKRLKGESDGWFFDVWQPEHIDGPECWPLRSDSAWHGFKNI
DNEHMYLDPIKVTLLTPGMKKDGTMDDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRA
FDLNLRVKNMLPSLYREDPEFYENMRIQDLAQNIHKLIEHHNLPDLMFRAFEVLPSMVMTPYAAFQKELHGQTEEVYLEE
MVGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENNK

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=715, Percent_Identity=94.965034965035, Blast_Score=1438, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=69.5774647887324, Blast_Score=1093, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=740, Percent_Identity=35.6756756756757, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI87082193, Length=617, Percent_Identity=34.6839546191248, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1786909, Length=642, Percent_Identity=33.4890965732087, Blast_Score=308, Evalue=9e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 81619; Mature: 81488

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMNVIAIMNHMGVYFKEEPIRELHRALERLDFRIVYPNDRDDLLKLIENNSRLCGVIFD
CCEEHEEHHHHCCCEECCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCCEEEEEEE
WDKYNLELCEEISKMNEYMPLYAFANTYSTLDVSLNDLRMQVRFFEYALGAAEDIANKIK
CCCCCHHHHHHHHHHHHCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHH
QNTDEYIDTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSIFYDFFGSNTMKS
HCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
DISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTV
CCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEE
LIDRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWP
EEECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCC
VHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKV
EEEEEECCCCCCEEEEHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEE
IYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKG
EEECCHHHHHHHHHHCCCEEEEECCCCCHHHCCEEEEEECCCCCCEEEECCHHHHHHHCC
NAGKRLIDGSIERSIKFRKEIKRLKGESDGWFFDVWQPEHIDGPECWPLRSDSAWHGFKN
CCCCEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
IDNEHMYLDPIKVTLLTPGMKKDGTMDDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFS
CCCCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCEEEEEEE
IGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQDLAQNIHKLIE
ECCCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHH
HHNLPDLMFRAFEVLPSMVMTPYAAFQKELHGQTEEVYLEEMVGRVNANMILPYPPGVPL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCE
VMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENNK
EECCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
TMNVIAIMNHMGVYFKEEPIRELHRALERLDFRIVYPNDRDDLLKLIENNSRLCGVIFD
CEEHEEHHHHCCCEECCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCCEEEEEEE
WDKYNLELCEEISKMNEYMPLYAFANTYSTLDVSLNDLRMQVRFFEYALGAAEDIANKIK
CCCCCHHHHHHHHHHHHCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHH
QNTDEYIDTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSIFYDFFGSNTMKS
HCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
DISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTV
CCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEE
LIDRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWP
EEECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCC
VHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKV
EEEEEECCCCCCEEEEHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEE
IYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKG
EEECCHHHHHHHHHHCCCEEEEECCCCCHHHCCEEEEEECCCCCCEEEECCHHHHHHHCC
NAGKRLIDGSIERSIKFRKEIKRLKGESDGWFFDVWQPEHIDGPECWPLRSDSAWHGFKN
CCCCEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
IDNEHMYLDPIKVTLLTPGMKKDGTMDDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFS
CCCCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCEEEEEEE
IGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQDLAQNIHKLIE
ECCCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHH
HHNLPDLMFRAFEVLPSMVMTPYAAFQKELHGQTEEVYLEEMVGRVNANMILPYPPGVPL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCE
VMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKEENNK
EECCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]