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The map label for this gene is cadB [H]

Identifier: 238893511

GI number: 238893511

Start: 1354909

End: 1356243

Strand: Direct

Name: cadB [H]

Synonym: KP1_1409

Alternate gene names: 238893511

Gene position: 1354909-1356243 (Clockwise)

Preceding gene: 238893510

Following gene: 238893512

Centisome position: 25.82

GC content: 54.38

Gene sequence:

>1335_bases
ATGAGTTCTGCCAAGAAGATCGGGCTATTTGCCTGTACCGGTGTCGTCGCCGGTAATATGATGGGGAGCGGGATTGCATT
ATTACCTGCGAACCTGGCCAGCATCGGTGGTATTGCCATTTGGGGCTGGGTGATTTCAATTATTGGTGCGATGTCTCTGG
CTTATGTTTATGCCCGACTGGCCACTAAAAACCCGCAGCAGGGCGGTCCTATTGCCTACGCTGGCGAAATATCTCCGGCA
TTCGGTTTCCAGACCGGTGTCCTTTATTATCATGCAAACTGGATTGGTAACCTGGCCATCGGGATTACCGCAGTTTCTTA
TCTCTCTACGTTCTTCCCAATTTTAAATAACCCGGTGCCAGCAGGTATTGCCTGTATTGCCATCGTGTGGATCTTTACTT
TCGTTAATATGCTCGGCGGGACCTGGGTCAGCCGTCTGACCACTATTGGTCTGGTACTGGTGCTTATTCCGGTAGTCATG
ACCGCGGTCGTCGGCTGGCACTGGTTTGATGTCGCTACCTATCAGGCGAACTGGAATACCTCCAGCACCACCGATAGCCA
CGCGGTTATTAAAAGTATCCTGCTCTGCCTGTGGGCCTTCGTTGGCGTAGAATCCGCCGCCGTGAGTACCGGGATGGTGA
AAAACCCGAAACGTACCGTGCCGCTGGCTACCATGCTGGGCACTGCGATGGCCGGTATCGTCTACATCGCCGCGACTCAG
GTTATCGCCGGTATGTATCCTGCTTCTCAGATGGCCGCGTCCGGTGCGCCGTTCGCAATTAGCGCCTCTACCATCCTCGG
CGGCTGGGCTGCACCGATGGTATCCGCTTTCACCGCCTTTGCCTGCCTGACTTCTCTGGGCTCGTGGATGATGCTGGTTG
GCCAGGCCGGTGTACGTGCCGCCAACGACGGTAACTTCCCGAAAGTGTATGGCGAAGTTGATAACAACGGTATTCCGAAA
AAAGGCCTGCTGCTGGCCGCAGTGAAAATGACCGCGCTGATGGTGCTGATTACCCTGATGAACTCCGCCGGTGGTAAAGC
CTCTGACCTGTTCGGCGAACTGACCGGTATCGCGGTACTGCTGACCATGCTGCCTTACTTCTACTCCTGTGTTGACCTGA
TTCGTTTCGAAGGCATCAACATCCGTAACTTCGTTAGCCTGATTTGTTCGGTACTGGGTTGCGTGTTCTGCTTCATCGCG
CTGATGGGCGCAAGCTCCTTCGAACTGGCCGGCACCTTCATCGTTAGCCTGATTATCCTGATGTTCTACGGTCGCAAAAT
GCACCAGCGCCAGAACAACGCATCGGATAACAACACCACCGCTAACGCGCACTAA

Upstream 100 bases:

>100_bases
TCTCGTACAAATCAGTAATCTTGTTGGCAGTTGGTCGGGTCAATTAATGGTTCTGTATCATGATCTGTACCTCCCAAATA
AACTTAGGAGAAAAACAACC

Downstream 100 bases:

>100_bases
TCAGCAACCCGTTTTCCTGAGGCTCCTTCCATCACCTGTCATCACGCGACGGGAGGGGCTTTCTACATCTGGAGATTTGA
CTATGAACGTTATTGCAATC

Product: lysine/cadaverine antiporter

Products: cadaverine [Cytoplasm]; L-lysine [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPILNNPVPAGIACIAIVWIFTFVNMLGGTWVSRLTTIGLVLVLIPVVM
TAVVGWHWFDVATYQANWNTSSTTDSHAVIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTAMAGIVYIAATQ
VIAGMYPASQMAASGAPFAISASTILGGWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDNNGIPK
KGLLLAAVKMTALMVLITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGINIRNFVSLICSVLGCVFCFIA
LMGASSFELAGTFIVSLIILMFYGRKMHQRQNNASDNNTTANAH

Sequences:

>Translated_444_residues
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPILNNPVPAGIACIAIVWIFTFVNMLGGTWVSRLTTIGLVLVLIPVVM
TAVVGWHWFDVATYQANWNTSSTTDSHAVIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTAMAGIVYIAATQ
VIAGMYPASQMAASGAPFAISASTILGGWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDNNGIPK
KGLLLAAVKMTALMVLITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGINIRNFVSLICSVLGCVFCFIA
LMGASSFELAGTFIVSLIILMFYGRKMHQRQNNASDNNTTANAH
>Mature_443_residues
SSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPAF
GFQTGVLYYHANWIGNLAIGITAVSYLSTFFPILNNPVPAGIACIAIVWIFTFVNMLGGTWVSRLTTIGLVLVLIPVVMT
AVVGWHWFDVATYQANWNTSSTTDSHAVIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTAMAGIVYIAATQV
IAGMYPASQMAASGAPFAISASTILGGWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDNNGIPKK
GLLLAAVKMTALMVLITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGINIRNFVSLICSVLGCVFCFIAL
MGASSFELAGTFIVSLIILMFYGRKMHQRQNNASDNNTTANAH

Specific function: Probable cadaverine/lysine antiporter or part of it [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790575, Length=444, Percent_Identity=93.018018018018, Blast_Score=815, Evalue=0.0,
Organism=Escherichia coli, GI2367353, Length=435, Percent_Identity=39.5402298850575, Blast_Score=317, Evalue=9e-88,
Organism=Escherichia coli, GI1786908, Length=440, Percent_Identity=32.0454545454545, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1787890, Length=442, Percent_Identity=24.4343891402715, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082250, Length=322, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71982612, Length=332, Percent_Identity=25.6024096385542, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71982608, Length=332, Percent_Identity=25.6024096385542, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321492, Length=325, Percent_Identity=20.9230769230769, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221331183, Length=296, Percent_Identity=25.3378378378378, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647653, Length=296, Percent_Identity=25.3378378378378, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664379, Length=296, Percent_Identity=25.3378378378378, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46691; Mature: 46559

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARL
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPILNNPVP
HCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGIACIAIVWIFTFVNMLGGTWVSRLTTIGLVLVLIPVVMTAVVGWHWFDVATYQANWNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
SSTTDSHAVIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTAMAGIVYIAATQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VIAGMYPASQMAASGAPFAISASTILGGWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRA
HHHHCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ANDGNFPKVYGEVDNNGIPKKGLLLAAVKMTALMVLITLMNSAGGKASDLFGELTGIAVL
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LTMLPYFYSCVDLIRFEGINIRNFVSLICSVLGCVFCFIALMGASSFELAGTFIVSLIIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MFYGRKMHQRQNNASDNNTTANAH
HHHCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARL
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPILNNPVP
HCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGIACIAIVWIFTFVNMLGGTWVSRLTTIGLVLVLIPVVMTAVVGWHWFDVATYQANWNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
SSTTDSHAVIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTAMAGIVYIAATQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VIAGMYPASQMAASGAPFAISASTILGGWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRA
HHHHCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ANDGNFPKVYGEVDNNGIPKKGLLLAAVKMTALMVLITLMNSAGGKASDLFGELTGIAVL
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LTMLPYFYSCVDLIRFEGINIRNFVSLICSVLGCVFCFIALMGASSFELAGTFIVSLIIL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MFYGRKMHQRQNNASDNNTTANAH
HHHCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cadaverine [Cytoplasm]; Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: cadaverine [Cytoplasm] + Proton [Periplasm] + L-lysine [Periplasm] = cadaverine [Cytoplasm] + L-lysine [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]