BacMap

Definition	Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome.
Accession	NC_012731
Length	5,248,520

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The map label for this gene is hpaE [H]

Identifier: 238892918

GI number: 238892918

Start: 728142

End: 729608

Strand: Reverse

Name: hpaE [H]

Synonym: KP1_0741

Alternate gene names: 238892918

Gene position: 729608-728142 (Counterclockwise)

Preceding gene: 238892919

Following gene: 238892917

Centisome position: 13.9

GC content: 62.17

Gene sequence:

>1467_bases
ATGAAAAAGATTAACCATTGGATCAACGGTAAAAACGTTGCCGGCGCAGACTATTTTCATACCACCAACCCGGCCACCGG
CGAGGTACTGGCGGAAGTCGCCTCCGGCGGTGAAGCCGAAATAAACCAGGCGGTGGCGGCGGCGAAAGAGGCCTTCCCGA
AGTGGGCTAACCTGCCGATGAAAGAGCGCGCGCGCCTGATGCGCCGCCTGGGGGATCTGATCGATCAGAACGTCCCGGAG
ATCGCGGCGATGGAAACCGCCGATACCGGCCTGCCGATCCACCAGACCAAAAACGTGTTGATCCCGCGCGCCTCACACAA
TTTCGAATTTTTCGCCGAAGTATGCCAGCAGATGAACGGCAAGACCTATCCGGTCGACGACAAGATGCTGAACTACACCC
TCGTGCAGCCGGTTGGCGTCTGCGCGCTGGTGTCGCCGTGGAACGTGCCGTTTATGACCGCCACCTGGAAGGTGGCGCCG
TGCCTGGCGCTGGGGAATACCGCGGTGCTGAAAATGTCCGAACTGTCGCCGCTGACCGCCGATCGTCTGGGCGAGCTGGC
GCTGGAAGCCGGGATCCCGGCTGGCGTACTCAATGTGGTGCAGGGCTACGGCGCCACCGCCGGCGACGCGCTGGTGCGCC
ATCATGATGTGCGCGCCGTCTCCTTCACCGGCGGCACCGCCACCGGCCGCAACATCATGAAAAACGCCGGTCTGAAAAAG
TACTCCATGGAGCTGGGCGGAAAATCGCCGGTGCTGATTTTTGAAGATGCCGATATCGAGCGCGCGCTTGACGCCGCGCT
GTTCACCATCTTCTCGATCAACGGCGAACGCTGCACCGCCGGCTCGCGCATCTTTATTCAGCAGAGTATCTACCCCGAGT
TCGTTAAACGCTTCGCCGAGCGCGCCAATCGCCTGCGCGTAGGCGATCCGACCGATCCGAACACCCAGATCGGCGCGCTG
ATTAGCCAGCAGCACTGGGAGAAAGTGTCCGGCTACATTCGCCTCGGCATCGAAGAGGGGGCCACCCTGCTGGCCGGCGG
CGCGGATAAACCGTCCGACCTGCCGGCGCATCTGAAAGCCGGCAACTTCCTGCGCCCGACGGTGCTGGCGGATGTCGACA
ACCGTATGCGCGTCGCCCAGGAAGAGATTTTTGGCCCGGTCGCCTGCCTGCTGCCGTTCAAAGACGAAGCGGAAGGGCTG
CGCCTGGCGAACGATGTGGAATACGGCCTGGCGTCGTATATCTGGACCCAGGACGTCAGCAAAGTGCTGCGCCTGGCGCG
CGGTATTGAAGCCGGGATGGTGTTCGTCAACACCCAGAACGTGCGCGACCTGCGTCAGCCGTTCGGCGGCGTGAAGGCCT
CCGGCACCGGCCGCGAAGGCGGCGAGTACAGCTTTGAAGTGTTCGCCGAAATGAAAAACGTCTGCATCTCGATGGGCGAC
CATCCGATCCCGAAATGGGGAGTCTGA

Upstream 100 bases:

>100_bases
CCGACGTGGTACCGGGCGACGAGGTGATCGTTGAAGTCGAGGGCGTGGGCCGCCTGGTCAACCATATCATCAGCCAGCAA
GCGTATGAGGAGACACTGTC

Downstream 100 bases:

>100_bases
TATGGGTAAATTAGCGTTAGCAGCAAAAATCACTCACGTGCCGTCGATGTATCTGTCTGAGCTGCCGGGGAAAAACCACG
GCTGCCGTCAGGGCGCGATC

Product: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase

Products: 5-carboxymethyl-2-hydroxymuconate; NADH; H+

Alternate protein names: CHMS dehydrogenase [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MKKINHWINGKNVAGADYFHTTNPATGEVLAEVASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPTDPNTQIGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGADKPSDLPAHLKAGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV

Sequences:

>Translated_488_residues
MKKINHWINGKNVAGADYFHTTNPATGEVLAEVASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPTDPNTQIGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGADKPSDLPAHLKAGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV
>Mature_488_residues
MKKINHWINGKNVAGADYFHTTNPATGEVLAEVASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPTDPNTQIGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGADKPSDLPAHLKAGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV

Specific function: Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM) [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI12007648, Length=477, Percent_Identity=42.5576519916143, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI25777730, Length=480, Percent_Identity=41.4583333333333, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI25777732, Length=469, Percent_Identity=42.2174840085288, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI153266822, Length=482, Percent_Identity=39.6265560165975, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI25777724, Length=480, Percent_Identity=40, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI115387104, Length=459, Percent_Identity=39.8692810457516, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI238814322, Length=483, Percent_Identity=39.5445134575569, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI21361176, Length=480, Percent_Identity=38.5416666666667, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI21614513, Length=474, Percent_Identity=39.873417721519, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI25777728, Length=420, Percent_Identity=40.7142857142857, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI25952152, Length=477, Percent_Identity=36.4779874213836, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI25777726, Length=477, Percent_Identity=36.6876310272537, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI301500698, Length=482, Percent_Identity=36.3070539419087, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI4507229, Length=481, Percent_Identity=35.966735966736, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI25777721, Length=494, Percent_Identity=34.8178137651822, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI310128093, Length=477, Percent_Identity=27.6729559748428, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI188035924, Length=495, Percent_Identity=27.0707070707071, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI310128103, Length=477, Percent_Identity=27.4633123689727, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI11095441, Length=482, Percent_Identity=29.4605809128631, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI310128091, Length=470, Percent_Identity=27.4468085106383, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI223972651, Length=464, Percent_Identity=28.0172413793103, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI310128089, Length=331, Percent_Identity=31.4199395770393, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI238859541, Length=485, Percent_Identity=25.7731958762887, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI25777736, Length=485, Percent_Identity=25.7731958762887, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI25777734, Length=485, Percent_Identity=25.7731958762887, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI310128097, Length=263, Percent_Identity=32.6996197718631, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI206597441, Length=450, Percent_Identity=26.4444444444444, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI206597439, Length=450, Percent_Identity=26.4444444444444, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI22907049, Length=450, Percent_Identity=26.4444444444444, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI310128095, Length=318, Percent_Identity=29.874213836478, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557303, Length=345, Percent_Identity=28.695652173913, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI73466520, Length=345, Percent_Identity=28.695652173913, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI223972653, Length=462, Percent_Identity=25.1082251082251, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI73695881, Length=347, Percent_Identity=26.2247838616715, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI73695879, Length=347, Percent_Identity=26.2247838616715, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI71773324, Length=342, Percent_Identity=27.1929824561404, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4502043, Length=342, Percent_Identity=27.1929824561404, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI238814371, Length=342, Percent_Identity=27.1929824561404, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI310128087, Length=294, Percent_Identity=23.8095238095238, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI310128101, Length=236, Percent_Identity=22.0338983050847, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI310128099, Length=236, Percent_Identity=22.0338983050847, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1787558, Length=480, Percent_Identity=39.375, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1789015, Length=478, Percent_Identity=38.2845188284519, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI87082295, Length=492, Percent_Identity=38.6178861788618, Blast_Score=335, Evalue=6e-93,
Organism=Escherichia coli, GI1786504, Length=463, Percent_Identity=39.0928725701944, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI87081896, Length=464, Percent_Identity=37.9310344827586, Blast_Score=311, Evalue=8e-86,
Organism=Escherichia coli, GI1787715, Length=475, Percent_Identity=37.0526315789474, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1787684, Length=476, Percent_Identity=31.3025210084034, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87081926, Length=461, Percent_Identity=30.58568329718, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1788042, Length=474, Percent_Identity=30.168776371308, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1787250, Length=466, Percent_Identity=26.3948497854077, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1787653, Length=301, Percent_Identity=26.578073089701, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25144435, Length=466, Percent_Identity=41.2017167381974, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562198, Length=480, Percent_Identity=40, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133930964, Length=485, Percent_Identity=38.1443298969072, Blast_Score=343, Evalue=8e-95,
Organism=Caenorhabditis elegans, GI32564736, Length=420, Percent_Identity=40.9523809523809, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI25143876, Length=486, Percent_Identity=36.8312757201646, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI25143874, Length=486, Percent_Identity=36.8312757201646, Blast_Score=328, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17551164, Length=466, Percent_Identity=38.6266094420601, Blast_Score=325, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71995606, Length=485, Percent_Identity=33.4020618556701, Blast_Score=291, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI71995613, Length=421, Percent_Identity=33.4916864608076, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17534119, Length=473, Percent_Identity=32.3467230443975, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI71986308, Length=442, Percent_Identity=31.9004524886878, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI115534176, Length=488, Percent_Identity=26.0245901639344, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32566756, Length=443, Percent_Identity=28.2167042889391, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25146391, Length=444, Percent_Identity=28.1531531531532, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25146394, Length=444, Percent_Identity=28.1531531531532, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534447, Length=485, Percent_Identity=26.3917525773196, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17564084, Length=357, Percent_Identity=30.5322128851541, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI32564151, Length=445, Percent_Identity=26.7415730337079, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI115532534, Length=341, Percent_Identity=27.2727272727273, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71990744, Length=325, Percent_Identity=25.8461538461538, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320917, Length=484, Percent_Identity=38.4297520661157, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6324950, Length=460, Percent_Identity=38.4782608695652, Blast_Score=336, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6325196, Length=481, Percent_Identity=37.6299376299376, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6323822, Length=468, Percent_Identity=36.965811965812, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6323821, Length=483, Percent_Identity=35.4037267080745, Blast_Score=306, Evalue=7e-84,
Organism=Saccharomyces cerevisiae, GI6319478, Length=482, Percent_Identity=35.0622406639004, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6321828, Length=484, Percent_Identity=27.0661157024793, Blast_Score=161, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321826, Length=505, Percent_Identity=25.9405940594059, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323757, Length=359, Percent_Identity=27.2980501392758, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20129399, Length=480, Percent_Identity=43.75, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24585660, Length=482, Percent_Identity=37.9668049792531, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24650465, Length=471, Percent_Identity=39.9150743099788, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI281362580, Length=476, Percent_Identity=36.5546218487395, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI62472918, Length=476, Percent_Identity=36.5546218487395, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI62472926, Length=476, Percent_Identity=36.5546218487395, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI62472936, Length=476, Percent_Identity=36.5546218487395, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI21356737, Length=476, Percent_Identity=36.5546218487395, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI24666674, Length=474, Percent_Identity=26.5822784810127, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24638876, Length=439, Percent_Identity=31.2072892938497, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24638878, Length=442, Percent_Identity=30.7692307692308, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24668425, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24668417, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24668413, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI281360301, Length=355, Percent_Identity=26.4788732394366, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281360299, Length=355, Percent_Identity=26.4788732394366, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281360297, Length=355, Percent_Identity=26.4788732394366, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281360295, Length=355, Percent_Identity=26.4788732394366, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24586250, Length=355, Percent_Identity=26.4788732394366, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281360303, Length=356, Percent_Identity=25.8426966292135, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45552499, Length=356, Percent_Identity=25.8426966292135, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574525, Length=466, Percent_Identity=22.7467811158798, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571802, Length=347, Percent_Identity=23.6311239193084, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571800, Length=347, Percent_Identity=23.6311239193084, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571806, Length=347, Percent_Identity=23.6311239193084, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28571798, Length=347, Percent_Identity=23.6311239193084, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28571796, Length=347, Percent_Identity=23.6311239193084, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28571794, Length=347, Percent_Identity=23.6311239193084, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR011985 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: 1.2.1.60

Molecular weight: Translated: 53011; Mature: 53011

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKINHWINGKNVAGADYFHTTNPATGEVLAEVASGGEAEINQAVAAAKEAFPKWANLPM
CCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHCCCCH
KERARLMRRLGDLIDQNVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNG
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSELSPLTA
CCCCCCCHHHCEEEECCCCEEEEECCCCCCEEEECCCHHHHHEECCCEEEEECCCCCCCH
DRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCCE
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAE
EHHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCEEEEEHHHHHHHHHHHHH
RANRLRVGDPTDPNTQIGALISQQHWEKVSGYIRLGIEEGATLLAGGADKPSDLPAHLKA
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCCHHCC
GNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGLRLANDVEYGLASYIWTQDVS
CCCCCCHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHH
KVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
HPIPKWGV
CCCCCCCC
>Mature Secondary Structure
MKKINHWINGKNVAGADYFHTTNPATGEVLAEVASGGEAEINQAVAAAKEAFPKWANLPM
CCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHCCCCH
KERARLMRRLGDLIDQNVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNG
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSELSPLTA
CCCCCCCHHHCEEEECCCCEEEEECCCCCCEEEECCCHHHHHEECCCEEEEECCCCCCCH
DRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCCE
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAE
EHHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCEEEEEHHHHHHHHHHHHH
RANRLRVGDPTDPNTQIGALISQQHWEKVSGYIRLGIEEGATLLAGGADKPSDLPAHLKA
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCCHHCC
GNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGLRLANDVEYGLASYIWTQDVS
CCCCCCHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHH
KVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
HPIPKWGV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-carboxymethyl-2-hydroxymuconate semialdehyde; H2O; NAD+

Specific reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737515 [H]