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The map label for this gene is ilvD [H]

Identifier: 238025301

GI number: 238025301

Start: 2454689

End: 2456530

Strand: Reverse

Name: ilvD [H]

Synonym: bglu_2g19750

Alternate gene names: 238025301

Gene position: 2456530-2454689 (Counterclockwise)

Preceding gene: 238025302

Following gene: 238025300

Centisome position: 86.89

GC content: 69.06

Gene sequence:

>1842_bases
ATGCCCATCTATCGTTCACGCACTTCCACCCACGGCCGCAACATGGCCGGCGCGCGCAGCCTGTGGCGCGCCACCGGGAT
GACCGACGCCGATTTCGACAAGCCGATCATCGCGGTGGTCAATTCCTTCACGCAGTTCGTGCCCGGGCACGTGCACCTGA
AGGATCTCGGCCAGCTGGTCGCCCGCGAGATCGAAGCGGCCGGCGCGGTCGCCAAGGAGTTCAACACGATCGCGATCGAC
GACGGCATCGCGATGGGCCACGACGGGATGCTGTACAGCCTGCCGTCGCGCGAGCTGATCGCCGACAGCGTCGAATACAT
GGTCAACGCGCACTGCGCGGACGCGATGGTCTGCATTTCGAATTGCGACAAGATCACGCCGGGGATGCTGATGGCCGCGA
TGCGCCTGAACATTCCGGTGATCTTCGTGTCGGGCGGGCCGATGGAGTCCGGCAAGCTGACGTTTCGCGGCAAGCGGCGC
GCGTTCGATCTGATCGACGCGATGGTGGTGGCCGCCGACTCGCAGGTGACGGACGACGAGGTGCGCGCGGTCGAGAACGT
CGCCTGCCCGACCTGCGGCTCGTGCTCCGGGATGTTTACCGCGAACTCGATGAACTGCCTTGCCGAAGCGCTCGGCCTCG
CGCTGCCGGGAAACGGCTCGGTGCTGGCGACGCATGCCGAGCGCAGGCGCCTGTTCCTCGAGGCCGGGCGAGTGATCGTC
GAGCTCGCGCGTCGCTACTACGAGCAGGACGATGCGAGCGTGCTGCCGCGTTCGATCGCGTCGCGCGAGGCATTCGAGAA
CGCGATGACCCTCGACATCGCGATGGGCGGATCGACCAACACGGTGCTGCACCTGCTGGCCGCCGCCCACGAGGGCGAAG
TGCCGTTCACGATGGCCGACATCGACCGGCTGTCGCGCCGCGTGCCGGTGCTGTGCAAGGTCGCGCCGTCCGTGCAGGAC
GTGCACATGGAGGACGTGCACCGTGCCGGCGGCGTGATCGGGATCATGGGCGAGCTCGATCGCGCGGGGCTGCTGAACAC
GACGCTGCCGACCGTCCACGCGCCGAGCGTCGCCGACGTGCTCGCGCGCTGGGACGTGATGCGCAATCGCGTCGATTCGG
TGTCGCGCTTCTATCGCGCGGCACCGGGCGGCGTGCGCTCGCACGTTGCGTTCAGCCAGGACAACCGCTACGACGAGCTC
GATCTCGACCGCCGGACCGGCTGCATCCGCGATGCCGAACACGCGTTCTCGCGCGACGGCGGGCTCGCGGTGCTGTTCGG
CAACATCGCGCGCGACGGCTGCATCGTGAAGACCGCGGGCGTCGACGGCGGCATGCTGAGGTTCACCGGCACCGCGCGCG
TGTTCGAGGGGCAGGAGGAGGCCGTCGAAGGCATTCTCGGCGGCGCCGTCGGCCCGGGCGACATCGTGATCGTGCGCTAC
GAAGGACCGCGCGGCGGGCCGGGCATGCAGGAGATGCTCTATCCGACCAGCTACCTGAAATCGAAGGGGCTCGCGAAGCA
GTGCGCGCTGATCACCGACGGCCGCTTCTCCGGCGGCTCGTCGGGGCTGTCGATCGGGCACGTGTCTCCCGAAGCGGCGG
AGGGCGGCGAGATCGGGCTGATCGAGAGCGGCGACGCGATCGAGATCGACATTCCGAACCGCTCGATCAACCTGCTGGTG
CCGGACGAGGAACTGCAGCGCCGCCGCGCGGCGATGGAGGCGCGCGGCAAGCTCGCCTGGCAGCCGGAGAAGCGGCAGCG
CCGCGTGTCGGGCGCGCTGCGCGCCTACGCGGCGATGACCACGAGCGCGGCGCGCGGTGCCGTGCGCATCGTCAAGGGCT
GA

Upstream 100 bases:

>100_bases
GCCGACGCTTGCCAAGAACGACAACAACTGGGGCGCAGCCGGACAGCCGCACTGACGGCAGCCCGCCCGTTTTTCCGAAC
CGAATCTATCGAGAGCCAAG

Downstream 100 bases:

>100_bases
CCATGCGGCCCGCCCCGAAGCGTCCGTCGGCCGACCCGCAGGTCGACACCGTGCTCGTCACGAGCGGCCGCGCGCCGGCC
GCGCATCATGGCTTCGTCAA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MPIYRSRTSTHGRNMAGARSLWRATGMTDADFDKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGAVAKEFNTIAID
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMESGKLTFRGKRR
AFDLIDAMVVAADSQVTDDEVRAVENVACPTCGSCSGMFTANSMNCLAEALGLALPGNGSVLATHAERRRLFLEAGRVIV
ELARRYYEQDDASVLPRSIASREAFENAMTLDIAMGGSTNTVLHLLAAAHEGEVPFTMADIDRLSRRVPVLCKVAPSVQD
VHMEDVHRAGGVIGIMGELDRAGLLNTTLPTVHAPSVADVLARWDVMRNRVDSVSRFYRAAPGGVRSHVAFSQDNRYDEL
DLDRRTGCIRDAEHAFSRDGGLAVLFGNIARDGCIVKTAGVDGGMLRFTGTARVFEGQEEAVEGILGGAVGPGDIVIVRY
EGPRGGPGMQEMLYPTSYLKSKGLAKQCALITDGRFSGGSSGLSIGHVSPEAAEGGEIGLIESGDAIEIDIPNRSINLLV
PDEELQRRRAAMEARGKLAWQPEKRQRRVSGALRAYAAMTTSAARGAVRIVKG

Sequences:

>Translated_613_residues
MPIYRSRTSTHGRNMAGARSLWRATGMTDADFDKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGAVAKEFNTIAID
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMESGKLTFRGKRR
AFDLIDAMVVAADSQVTDDEVRAVENVACPTCGSCSGMFTANSMNCLAEALGLALPGNGSVLATHAERRRLFLEAGRVIV
ELARRYYEQDDASVLPRSIASREAFENAMTLDIAMGGSTNTVLHLLAAAHEGEVPFTMADIDRLSRRVPVLCKVAPSVQD
VHMEDVHRAGGVIGIMGELDRAGLLNTTLPTVHAPSVADVLARWDVMRNRVDSVSRFYRAAPGGVRSHVAFSQDNRYDEL
DLDRRTGCIRDAEHAFSRDGGLAVLFGNIARDGCIVKTAGVDGGMLRFTGTARVFEGQEEAVEGILGGAVGPGDIVIVRY
EGPRGGPGMQEMLYPTSYLKSKGLAKQCALITDGRFSGGSSGLSIGHVSPEAAEGGEIGLIESGDAIEIDIPNRSINLLV
PDEELQRRRAAMEARGKLAWQPEKRQRRVSGALRAYAAMTTSAARGAVRIVKG
>Mature_612_residues
PIYRSRTSTHGRNMAGARSLWRATGMTDADFDKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGAVAKEFNTIAIDD
GIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMESGKLTFRGKRRA
FDLIDAMVVAADSQVTDDEVRAVENVACPTCGSCSGMFTANSMNCLAEALGLALPGNGSVLATHAERRRLFLEAGRVIVE
LARRYYEQDDASVLPRSIASREAFENAMTLDIAMGGSTNTVLHLLAAAHEGEVPFTMADIDRLSRRVPVLCKVAPSVQDV
HMEDVHRAGGVIGIMGELDRAGLLNTTLPTVHAPSVADVLARWDVMRNRVDSVSRFYRAAPGGVRSHVAFSQDNRYDELD
LDRRTGCIRDAEHAFSRDGGLAVLFGNIARDGCIVKTAGVDGGMLRFTGTARVFEGQEEAVEGILGGAVGPGDIVIVRYE
GPRGGPGMQEMLYPTSYLKSKGLAKQCALITDGRFSGGSSGLSIGHVSPEAAEGGEIGLIESGDAIEIDIPNRSINLLVP
DEELQRRRAAMEARGKLAWQPEKRQRRVSGALRAYAAMTTSAARGAVRIVKG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=609, Percent_Identity=72.9064039408867, Blast_Score=930, Evalue=0.0,
Organism=Escherichia coli, GI1786464, Length=559, Percent_Identity=32.0214669051878, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI2367371, Length=534, Percent_Identity=29.7752808988764, Blast_Score=177, Evalue=3e-45,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=28.7569573283859, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=606, Percent_Identity=37.2937293729373, Blast_Score=348, Evalue=2e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65715; Mature: 65584

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIYRSRTSTHGRNMAGARSLWRATGMTDADFDKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGAVAKEFNTIAIDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHHHHHHCCCEEEEECCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMESGKLTFRGKRRAFDLIDAMVVAADSQVTDDE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHH
VRAVENVACPTCGSCSGMFTANSMNCLAEALGLALPGNGSVLATHAERRRLFLEAGRVIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECHHHHHHHHHHHHHHH
ELARRYYEQDDASVLPRSIASREAFENAMTLDIAMGGSTNTVLHLLAAAHEGEVPFTMAD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEHHH
IDRLSRRVPVLCKVAPSVQDVHMEDVHRAGGVIGIMGELDRAGLLNTTLPTVHAPSVADV
HHHHHCCCCEEEEECCCHHHCCHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHH
LARWDVMRNRVDSVSRFYRAAPGGVRSHVAFSQDNRYDELDLDRRTGCIRDAEHAFSRDG
HHHHHHHHHHHHHHHHHHHCCCCCHHHCEEECCCCCCCCCCCHHHCCCHHHHHHHHCCCC
GLAVLFGNIARDGCIVKTAGVDGGMLRFTGTARVFEGQEEAVEGILGGAVGPGDIVIVRY
CEEEEEECCCCCCEEEEECCCCCCEEEEECCHHEECCHHHHHHHHHCCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLAKQCALITDGRFSGGSSGLSIGHVSPEAAEGGEIGL
CCCCCCCCHHHHHCCHHHHHHCCCHHHHEEEECCCCCCCCCCCEEECCCCCCCCCCCEEE
IESGDAIEIDIPNRSINLLVPDEELQRRRAAMEARGKLAWQPEKRQRRVSGALRAYAAMT
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
TSAARGAVRIVKG
HHHCCCEEEEECC
>Mature Secondary Structure 
PIYRSRTSTHGRNMAGARSLWRATGMTDADFDKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGAVAKEFNTIAIDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHHHHHHCCCEEEEECCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMESGKLTFRGKRRAFDLIDAMVVAADSQVTDDE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHH
VRAVENVACPTCGSCSGMFTANSMNCLAEALGLALPGNGSVLATHAERRRLFLEAGRVIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECHHHHHHHHHHHHHHH
ELARRYYEQDDASVLPRSIASREAFENAMTLDIAMGGSTNTVLHLLAAAHEGEVPFTMAD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEHHH
IDRLSRRVPVLCKVAPSVQDVHMEDVHRAGGVIGIMGELDRAGLLNTTLPTVHAPSVADV
HHHHHCCCCEEEEECCCHHHCCHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHH
LARWDVMRNRVDSVSRFYRAAPGGVRSHVAFSQDNRYDELDLDRRTGCIRDAEHAFSRDG
HHHHHHHHHHHHHHHHHHHCCCCCHHHCEEECCCCCCCCCCCHHHCCCHHHHHHHHCCCC
GLAVLFGNIARDGCIVKTAGVDGGMLRFTGTARVFEGQEEAVEGILGGAVGPGDIVIVRY
CEEEEEECCCCCCEEEEECCCCCCEEEEECCHHEECCHHHHHHHHHCCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLAKQCALITDGRFSGGSSGLSIGHVSPEAAEGGEIGL
CCCCCCCCHHHHHCCHHHHHHCCCHHHHEEEECCCCCCCCCCCEEECCCCCCCCCCCEEE
IESGDAIEIDIPNRSINLLVPDEELQRRRAAMEARGKLAWQPEKRQRRVSGALRAYAAMT
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
TSAARGAVRIVKG
HHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA