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The map label for this gene is metC [H]

Identifier: 238025300

GI number: 238025300

Start: 2453496

End: 2454686

Strand: Reverse

Name: metC [H]

Synonym: bglu_2g19740

Alternate gene names: 238025300

Gene position: 2454686-2453496 (Counterclockwise)

Preceding gene: 238025301

Following gene: 238025299

Centisome position: 86.82

GC content: 72.63

Gene sequence:

>1191_bases
ATGCGGCCCGCCCCGAAGCGTCCGTCGGCCGACCCGCAGGTCGACACCGTGCTCGTCACGAGCGGCCGCGCGCCGGCCGC
GCATCATGGCTTCGTCAATCCGCCGGTGTACCGGGGCTCGACGGTGCTCGCGCCGAGCGTGGCCGACCTGCTCGGCTACA
CGCAGCCCTACGTGTACGGCCGGCGGGGCTCGCCGACCACCGTCGCGCTGCAGGACGCGGTGCGCGCGCTCGATCATGGC
GCGGGCGTCGTGCTGTGCCCGTCGGGTCTCGCGGCGATCACGACCGCGCTGTCGTCGTGCCTCGCGGCCGGCGACCATCT
GCTGATGACGGATGCGGTGTACAAGCCCGCGCGGCAGCTGTGCGACGGCGTGCTGCGGCGCGCGGGCATCGAGACGACCT
ACTTCGCGCCGTGCGCCTCGGTCGACGCGCTCGCCGCGCTGATCCGGCCGAACACGCGCGCGCTGTATCTCGAGGCGCCC
GCCTCGCAGAGCATGGAGATCTGCGACGTGCCGGCGCTTGCCGCGCTCGCGCGCGACCGCGGGCTGACGGTGCTGTTCGA
CAACACCTGGGCGACGCCGCTGTTCTTCGACGCGTTCGCGCACGGCGTCGATCTCGTGATCCAGGCCGGCACCAAGTATC
TGGCCGGCCATGCGGACTTGATGATCGGGATGGTGTCGGCCTCCGCGCGCGCGCTGCCGGCGCTCGAACAGTATCAGCGC
GACACCGGGCAATGCGTGAGCCCCGACGATGCGTTTCTCGCGCTGCGCGGCCTGCGCACGCTCGGCGTGCGGCTTCGCCA
GCACCAGGCCAACGCGCTGCAGGTGGCGCGCTGGCTCGCCGCGCGCCCGGAAGTGCAGCGCGTGTGCTATCCGGCGCTGG
AGCACGATGCCGGCCACGCGCTATGGGCGCGCGACTTCCGCGGCGCGACGGGGCTCTTCTCCGTCGTGCTGCGCCCGGCG
CCGCCGCAGGCGGTGGCCGCCCTGCTCGAAGGGCTCGCGTATTTCGGGCTCGGCTATTCGTGGGGCGGCTACGAAAGCCT
CGCGATGCCGTTCGACTGTACCGCCTACCGCACCGCCTCGCACTGGGACCCGGGCGGCCCGTGCGTGCGCTTTCACATCG
GCCTGGAGAACGCCGACGACCTGATCGGCGACCTCGACGCGGGCTTCGCCCGCTTCAACGACGCGTGCTGA

Upstream 100 bases:

>100_bases
CGGAGAAGCGGCAGCGCCGCGTGTCGGGCGCGCTGCGCGCCTACGCGGCGATGACCACGAGCGCGGCGCGCGGTGCCGTG
CGCATCGTCAAGGGCTGACC

Downstream 100 bases:

>100_bases
CGGGGCCGCCCGATTCCGGACGCACACATGATGCAGCTTTCCAATCACGAGGAGCCCGTATGACGAAGCAACTCTGCCTG
GGTGGATTCATGCGCCCCAT

Product: Cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MRPAPKRPSADPQVDTVLVTSGRAPAAHHGFVNPPVYRGSTVLAPSVADLLGYTQPYVYGRRGSPTTVALQDAVRALDHG
AGVVLCPSGLAAITTALSSCLAAGDHLLMTDAVYKPARQLCDGVLRRAGIETTYFAPCASVDALAALIRPNTRALYLEAP
ASQSMEICDVPALAALARDRGLTVLFDNTWATPLFFDAFAHGVDLVIQAGTKYLAGHADLMIGMVSASARALPALEQYQR
DTGQCVSPDDAFLALRGLRTLGVRLRQHQANALQVARWLAARPEVQRVCYPALEHDAGHALWARDFRGATGLFSVVLRPA
PPQAVAALLEGLAYFGLGYSWGGYESLAMPFDCTAYRTASHWDPGGPCVRFHIGLENADDLIGDLDAGFARFNDAC

Sequences:

>Translated_396_residues
MRPAPKRPSADPQVDTVLVTSGRAPAAHHGFVNPPVYRGSTVLAPSVADLLGYTQPYVYGRRGSPTTVALQDAVRALDHG
AGVVLCPSGLAAITTALSSCLAAGDHLLMTDAVYKPARQLCDGVLRRAGIETTYFAPCASVDALAALIRPNTRALYLEAP
ASQSMEICDVPALAALARDRGLTVLFDNTWATPLFFDAFAHGVDLVIQAGTKYLAGHADLMIGMVSASARALPALEQYQR
DTGQCVSPDDAFLALRGLRTLGVRLRQHQANALQVARWLAARPEVQRVCYPALEHDAGHALWARDFRGATGLFSVVLRPA
PPQAVAALLEGLAYFGLGYSWGGYESLAMPFDCTAYRTASHWDPGGPCVRFHIGLENADDLIGDLDAGFARFNDAC
>Mature_396_residues
MRPAPKRPSADPQVDTVLVTSGRAPAAHHGFVNPPVYRGSTVLAPSVADLLGYTQPYVYGRRGSPTTVALQDAVRALDHG
AGVVLCPSGLAAITTALSSCLAAGDHLLMTDAVYKPARQLCDGVLRRAGIETTYFAPCASVDALAALIRPNTRALYLEAP
ASQSMEICDVPALAALARDRGLTVLFDNTWATPLFFDAFAHGVDLVIQAGTKYLAGHADLMIGMVSASARALPALEQYQR
DTGQCVSPDDAFLALRGLRTLGVRLRQHQANALQVARWLAARPEVQRVCYPALEHDAGHALWARDFRGATGLFSVVLRPA
PPQAVAALLEGLAYFGLGYSWGGYESLAMPFDCTAYRTASHWDPGGPCVRFHIGLENADDLIGDLDAGFARFNDAC

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=294, Percent_Identity=33.6734693877551, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI299473759, Length=294, Percent_Identity=30.2721088435374, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI25453487, Length=298, Percent_Identity=30.8724832214765, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1789383, Length=394, Percent_Identity=43.1472081218274, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1790375, Length=386, Percent_Identity=31.0880829015544, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71980708, Length=392, Percent_Identity=29.3367346938776, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=342, Percent_Identity=32.4561403508772, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=321, Percent_Identity=32.7102803738318, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=331, Percent_Identity=45.9214501510574, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6319307, Length=378, Percent_Identity=28.8359788359788, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321904, Length=347, Percent_Identity=26.2247838616715, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323333, Length=393, Percent_Identity=24.6819338422392, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=286, Percent_Identity=29.7202797202797, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922554, Length=380, Percent_Identity=32.6315789473684, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42197; Mature: 42197

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAPKRPSADPQVDTVLVTSGRAPAAHHGFVNPPVYRGSTVLAPSVADLLGYTQPYVYG
CCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHCCCCCEEEC
RRGSPTTVALQDAVRALDHGAGVVLCPSGLAAITTALSSCLAAGDHLLMTDAVYKPARQL
CCCCCCEEHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
CDGVLRRAGIETTYFAPCASVDALAALIRPNTRALYLEAPASQSMEICDVPALAALARDR
HHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCC
GLTVLFDNTWATPLFFDAFAHGVDLVIQAGTKYLAGHADLMIGMVSASARALPALEQYQR
CCEEEECCCCCCHHHHHHHHHHHHEEEECCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHH
DTGQCVSPDDAFLALRGLRTLGVRLRQHQANALQVARWLAARPEVQRVCYPALEHDAGHA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCE
LWARDFRGATGLFSVVLRPAPPQAVAALLEGLAYFGLGYSWGGYESLAMPFDCTAYRTAS
EHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCC
HWDPGGPCVRFHIGLENADDLIGDLDAGFARFNDAC
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRPAPKRPSADPQVDTVLVTSGRAPAAHHGFVNPPVYRGSTVLAPSVADLLGYTQPYVYG
CCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHCCCCCEEEC
RRGSPTTVALQDAVRALDHGAGVVLCPSGLAAITTALSSCLAAGDHLLMTDAVYKPARQL
CCCCCCEEHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
CDGVLRRAGIETTYFAPCASVDALAALIRPNTRALYLEAPASQSMEICDVPALAALARDR
HHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCC
GLTVLFDNTWATPLFFDAFAHGVDLVIQAGTKYLAGHADLMIGMVSASARALPALEQYQR
CCEEEECCCCCCHHHHHHHHHHHHEEEECCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHH
DTGQCVSPDDAFLALRGLRTLGVRLRQHQANALQVARWLAARPEVQRVCYPALEHDAGHA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCE
LWARDFRGATGLFSVVLRPAPPQAVAALLEGLAYFGLGYSWGGYESLAMPFDCTAYRTAS
EHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCC
HWDPGGPCVRFHIGLENADDLIGDLDAGFARFNDAC
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]