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The map label for this gene is hemB [H]

Identifier: 229918360

GI number: 229918360

Start: 2611437

End: 2612417

Strand: Direct

Name: hemB [H]

Synonym: EAT1b_2645

Alternate gene names: 229918360

Gene position: 2611437-2612417 (Clockwise)

Preceding gene: 229918359

Following gene: 229918361

Centisome position: 87.05

GC content: 53.01

Gene sequence:

>981_bases
ATGAACCAGTTTGACCGTCACCGTCGTCTTCGCTCATCGAAGTCGATGCGTGCCCTCGTACGTGAAAATCATGTTCGAAA
AGAAGATTTGATTTACCCGCTCTTCATCATTGAAGGGACTAACATTAAACGTGAAGTCAGCTCGATGCCTGGCGTCTTCA
ATTATTCACTTGACCGACTCGAAGAAGAGATCAAAGAAATCGTCGACCTCGGTCTCCAATCTGTGCTCTTGTTCGGCGTG
CCGGAACATAAAGACCCAGAAGGTAGTGAAGCGTATCATGACCACGGTATCGTCCAAGAGGCGATCCGTAAAGTGAAGGA
GTGGGCACCACAGCTAACGGTCATCGCCGATACGTGCCTCTGTGAATACACGTCGACAGGTCACTGTGGTCTCGTGAAGG
ATGGGGACGTCGATAACGACGCATCGCTACCTCTTCACGTCCAGACGGCGATCACGCAAGCACAGGCGGGTGCCGATATC
ATCGCACCGAGCTCGATGATGGACGGATTCGTCGCAGCTATCCGCGAAGGTCTCGACCAGAACGGATTTAGCCACATTCC
AATCATGAGCTACGGCGTCAAATATGCATCAGCCTATTACGGACCGTTTCGTGACGCAGCCCAATCAGCTCCTGGAGAAG
GCGACCGTAAAGGGTATCAGATGGACCCGGCGAACCGTCGCGAGGCGTTCCGCGAGTCACAATCGGATGTGGAACAAGGT
GCCGACTTCATGATCGTCAAACCGGCTCTCGCGTTCATGGATATCATCCGTGACATGCGCGACTCACTCGATATGCCGAT
CGTGGCGTATAACGTGAGCGGAGAGTATGCGATGATCAAAGCCGCGTCACTCAACGACTGGGTCGACGAAGAACGCATCG
TCATGGAGACGATGGTCGGATTCAAACGTGCCGGTGCCGATCTCATCGTCACGTATTTCGCAAAAGACGTCTGTCGCTAT
TTGGAAGGAGACTACGCATGA

Upstream 100 bases:

>100_bases
TGACCGAACGCGCCGTCCGACAAGTGTCGACGTTACCGATACGAGTGCCAGAATGTTATACTATGGATGCATTAATACAG
TGTGTAGGGGAGGATTTTTC

Downstream 100 bases:

>100_bases
CATATAACCAAACACGCTCACAAGAAGCGTTCGAACAAGCCCGCCCGCTCATGCCAGGCGGTGTCAACAGTCCGGTCCGT
GCCTACAAATCGGTCGGCAT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNQFDRHRRLRSSKSMRALVRENHVRKEDLIYPLFIIEGTNIKREVSSMPGVFNYSLDRLEEEIKEIVDLGLQSVLLFGV
PEHKDPEGSEAYHDHGIVQEAIRKVKEWAPQLTVIADTCLCEYTSTGHCGLVKDGDVDNDASLPLHVQTAITQAQAGADI
IAPSSMMDGFVAAIREGLDQNGFSHIPIMSYGVKYASAYYGPFRDAAQSAPGEGDRKGYQMDPANRREAFRESQSDVEQG
ADFMIVKPALAFMDIIRDMRDSLDMPIVAYNVSGEYAMIKAASLNDWVDEERIVMETMVGFKRAGADLIVTYFAKDVCRY
LEGDYA

Sequences:

>Translated_326_residues
MNQFDRHRRLRSSKSMRALVRENHVRKEDLIYPLFIIEGTNIKREVSSMPGVFNYSLDRLEEEIKEIVDLGLQSVLLFGV
PEHKDPEGSEAYHDHGIVQEAIRKVKEWAPQLTVIADTCLCEYTSTGHCGLVKDGDVDNDASLPLHVQTAITQAQAGADI
IAPSSMMDGFVAAIREGLDQNGFSHIPIMSYGVKYASAYYGPFRDAAQSAPGEGDRKGYQMDPANRREAFRESQSDVEQG
ADFMIVKPALAFMDIIRDMRDSLDMPIVAYNVSGEYAMIKAASLNDWVDEERIVMETMVGFKRAGADLIVTYFAKDVCRY
LEGDYA
>Mature_326_residues
MNQFDRHRRLRSSKSMRALVRENHVRKEDLIYPLFIIEGTNIKREVSSMPGVFNYSLDRLEEEIKEIVDLGLQSVLLFGV
PEHKDPEGSEAYHDHGIVQEAIRKVKEWAPQLTVIADTCLCEYTSTGHCGLVKDGDVDNDASLPLHVQTAITQAQAGADI
IAPSSMMDGFVAAIREGLDQNGFSHIPIMSYGVKYASAYYGPFRDAAQSAPGEGDRKGYQMDPANRREAFRESQSDVEQG
ADFMIVKPALAFMDIIRDMRDSLDMPIVAYNVSGEYAMIKAASLNDWVDEERIVMETMVGFKRAGADLIVTYFAKDVCRY
LEGDYA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=299, Percent_Identity=41.8060200668896, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI87081728, Length=312, Percent_Identity=50, Blast_Score=304, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6321398, Length=313, Percent_Identity=43.1309904153355, Blast_Score=249, Evalue=6e-67,
Organism=Drosophila melanogaster, GI21358291, Length=292, Percent_Identity=41.4383561643836, Blast_Score=244, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36510; Mature: 36510

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQFDRHRRLRSSKSMRALVRENHVRKEDLIYPLFIIEGTNIKREVSSMPGVFNYSLDRL
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEEEECCCHHHHHHHCCCHHHHHHHHH
EEEIKEIVDLGLQSVLLFGVPEHKDPEGSEAYHDHGIVQEAIRKVKEWAPQLTVIADTCL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHH
CEYTSTGHCGLVKDGDVDNDASLPLHVQTAITQAQAGADIIAPSSMMDGFVAAIREGLDQ
HHCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
NGFSHIPIMSYGVKYASAYYGPFRDAAQSAPGEGDRKGYQMDPANRREAFRESQSDVEQG
CCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
ADFMIVKPALAFMDIIRDMRDSLDMPIVAYNVSGEYAMIKAASLNDWVDEERIVMETMVG
CCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHH
FKRAGADLIVTYFAKDVCRYLEGDYA
HHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNQFDRHRRLRSSKSMRALVRENHVRKEDLIYPLFIIEGTNIKREVSSMPGVFNYSLDRL
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEEEEECCCHHHHHHHCCCHHHHHHHHH
EEEIKEIVDLGLQSVLLFGVPEHKDPEGSEAYHDHGIVQEAIRKVKEWAPQLTVIADTCL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHH
CEYTSTGHCGLVKDGDVDNDASLPLHVQTAITQAQAGADIIAPSSMMDGFVAAIREGLDQ
HHCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
NGFSHIPIMSYGVKYASAYYGPFRDAAQSAPGEGDRKGYQMDPANRREAFRESQSDVEQG
CCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
ADFMIVKPALAFMDIIRDMRDSLDMPIVAYNVSGEYAMIKAASLNDWVDEERIVMETMVG
CCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHH
FKRAGADLIVTYFAKDVCRYLEGDYA
HHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9358061 [H]