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The map label for this gene is murP [H]

Identifier: 227080428

GI number: 227080428

Start: 200434

End: 201882

Strand: Direct

Name: murP [H]

Synonym: VCM66_0195

Alternate gene names: 227080428

Gene position: 200434-201882 (Clockwise)

Preceding gene: 227080427

Following gene: 227080431

Centisome position: 6.93

GC content: 52.24

Gene sequence:

>1449_bases
ATGATGGCCAAAATAACCCAAACCATGATGGCACAAGTGCTGTCTCTGGTGGGCGGCAGTGGTAACGTCGCCAAATGTGG
CAACTGCATGACTCGCTTGCGTTTAACGCTGAATAATTCTGCGCTCGCCGATCATGCGGCATTGAAAAAAATTTCTGGAG
TGATGGGCGTGGTTGAAAGTGACGCACAACTGCAGATCATCCTCGGTCCCGGTAAAGCACAAACGGCCGCGGATATGATG
AATGCCTTGATTGAATCGGGCGACAACGTGGCACCTGCAGTGAGCGAGGCGGATCTCTCCACGATTGCCGCGCAGCAGAA
AAAGCAGATGAAGAGCAAGCAAACCAGTGCGGTACAACGCTTTTTGAGCAAGTTTGCCACCATTTTTACCCCGCTGATCC
CCGGATTTATTGCCGCAGGCTTGCTGCTGGGCATTGCGACTCTGCTTGAGCAAATCTACGTGGTGGGTCAAACCCCGAGC
GAGTTTATGCTCGATCTGGTGACTTATCTCAAAGTGTTTGGCAAAGGGCTGTTTGCGTTTCTCAGCATCTTGATTGGCTA
TAACGCGCAGCAGGCATTTGGCGGCTCTGGCGTGAACGGGGCGATTCTGGCTTCGCTGTTTGTACTCGGTTATGACCCAG
AAGCGACCAAAGGTATTTACTCGGGGATGAGTGAGTTCTTCGGCTTTGCGATTGACCCGCGCGGCAACATCATCGGGGTA
TTACTGGCGGCAATTTTAGGCGCGCAAGTGGAACGTAAAGTGCGTGAATACATGCCGGATGATTTGGATATGATCCTGAC
TTCGGTGGTGACTTTGCTGATCATGGGCGCGGTGACTTTCCTTATCATCATGCCTATCGGCGGTGAGCTGTTTAAAGGCA
TGTCATGGCTGTTTTTAAACCTCAACGATAACCCACTCGGTGCTGCCATCTTGGCCGGTTTGTTCTTGATCTCGGTGGTG
TTTGGTATTCACCAAGGTTTTGTGCCGGTTTATTTCGCACTGATGGAAGCGCAAGGCTTTAACTCACTGTTCCCGATCCT
TGCCATGGCAGGCGCTGGGCAAGTCGGTGCTTCACTGGCGCTGTACGCGAGAGCCAAAAAAGAGACCACGATTCGCACCC
AAATTAAAGGGGCGATCATCCCGGGTATTCTCGGCATTGGTGAGCCACTGATTTATGGCGTGACGCTACCGCGGGTGAAA
CCTTTTGTCACCGCCTGTATTGGCGGTGCGGCGGGTGGCTTCTTTATCGGTCTCATCTCTTATTTGGGTTTGCCCGTTGG
CCTCAATACGGTGTTTGGCCCATCCGGTGTGGTGGCGATTCCCCTGATGACTTCAGCCGACGGTATTTTTGCGGGTATGG
CGGTATTTGTCGGTGGTTTGCTCATCTCTTATACCGTTGGCTTTGCGGCTACCTACTTCTTCGGTTGTAAAGACGTCGAT
CTGAGCTAA

Upstream 100 bases:

>100_bases
GGGGCTTTAGTGCAGAGCAAGCCGCACAAAAACTGGCGCAGCACCAAGGCTTTATCCGCGCAGCGCTCAACCAAGAATAA
ACAGCAGAGAGAAGGAGCCG

Downstream 100 bases:

>100_bases
GTTGGTTCCCTGTAGGTTATCCCCTTAACGGACGGGGGGATAGTAAAAGCGCCCAATCTAGGGCGCTTTCTTTTCAACGA
TTGAAGTTTTTCAACGATTC

Product: PTS system N-acetylmuramic acid transporter subunits EIIBC

Products: NA

Alternate protein names: EIIBC-MurNAc; N-acetylmuramic acid-specific phosphotransferase enzyme IIB component; PTS system N-acetylmuramic acid-specific EIIB component; N-acetylmuramic acid permease IIC component; PTS system N-acetylmuramic acid-specific EIIC component [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MMAKITQTMMAQVLSLVGGSGNVAKCGNCMTRLRLTLNNSALADHAALKKISGVMGVVESDAQLQIILGPGKAQTAADMM
NALIESGDNVAPAVSEADLSTIAAQQKKQMKSKQTSAVQRFLSKFATIFTPLIPGFIAAGLLLGIATLLEQIYVVGQTPS
EFMLDLVTYLKVFGKGLFAFLSILIGYNAQQAFGGSGVNGAILASLFVLGYDPEATKGIYSGMSEFFGFAIDPRGNIIGV
LLAAILGAQVERKVREYMPDDLDMILTSVVTLLIMGAVTFLIIMPIGGELFKGMSWLFLNLNDNPLGAAILAGLFLISVV
FGIHQGFVPVYFALMEAQGFNSLFPILAMAGAGQVGASLALYARAKKETTIRTQIKGAIIPGILGIGEPLIYGVTLPRVK
PFVTACIGGAAGGFFIGLISYLGLPVGLNTVFGPSGVVAIPLMTSADGIFAGMAVFVGGLLISYTVGFAATYFFGCKDVD
LS

Sequences:

>Translated_482_residues
MMAKITQTMMAQVLSLVGGSGNVAKCGNCMTRLRLTLNNSALADHAALKKISGVMGVVESDAQLQIILGPGKAQTAADMM
NALIESGDNVAPAVSEADLSTIAAQQKKQMKSKQTSAVQRFLSKFATIFTPLIPGFIAAGLLLGIATLLEQIYVVGQTPS
EFMLDLVTYLKVFGKGLFAFLSILIGYNAQQAFGGSGVNGAILASLFVLGYDPEATKGIYSGMSEFFGFAIDPRGNIIGV
LLAAILGAQVERKVREYMPDDLDMILTSVVTLLIMGAVTFLIIMPIGGELFKGMSWLFLNLNDNPLGAAILAGLFLISVV
FGIHQGFVPVYFALMEAQGFNSLFPILAMAGAGQVGASLALYARAKKETTIRTQIKGAIIPGILGIGEPLIYGVTLPRVK
PFVTACIGGAAGGFFIGLISYLGLPVGLNTVFGPSGVVAIPLMTSADGIFAGMAVFVGGLLISYTVGFAATYFFGCKDVD
LS
>Mature_482_residues
MMAKITQTMMAQVLSLVGGSGNVAKCGNCMTRLRLTLNNSALADHAALKKISGVMGVVESDAQLQIILGPGKAQTAADMM
NALIESGDNVAPAVSEADLSTIAAQQKKQMKSKQTSAVQRFLSKFATIFTPLIPGFIAAGLLLGIATLLEQIYVVGQTPS
EFMLDLVTYLKVFGKGLFAFLSILIGYNAQQAFGGSGVNGAILASLFVLGYDPEATKGIYSGMSEFFGFAIDPRGNIIGV
LLAAILGAQVERKVREYMPDDLDMILTSVVTLLIMGAVTFLIIMPIGGELFKGMSWLFLNLNDNPLGAAILAGLFLISVV
FGIHQGFVPVYFALMEAQGFNSLFPILAMAGAGQVGASLALYARAKKETTIRTQIKGAIIPGILGIGEPLIYGVTLPRVK
PFVTACIGGAAGGFFIGLISYLGLPVGLNTVFGPSGVVAIPLMTSADGIFAGMAVFVGGLLISYTVGFAATYFFGCKDVD
LS

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788769, Length=482, Percent_Identity=61.6182572614108, Blast_Score=594, Evalue=1e-171,
Organism=Escherichia coli, GI1790159, Length=436, Percent_Identity=29.1284403669725, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI2367362, Length=433, Percent_Identity=26.3279445727483, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI48994906, Length=431, Percent_Identity=26.4501160092807, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018113
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013 [H]

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 50425; Mature: 50425

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAKITQTMMAQVLSLVGGSGNVAKCGNCMTRLRLTLNNSALADHAALKKISGVMGVVES
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCC
DAQLQIILGPGKAQTAADMMNALIESGDNVAPAVSEADLSTIAAQQKKQMKSKQTSAVQR
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLSKFATIFTPLIPGFIAAGLLLGIATLLEQIYVVGQTPSEFMLDLVTYLKVFGKGLFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LSILIGYNAQQAFGGSGVNGAILASLFVLGYDPEATKGIYSGMSEFFGFAIDPRGNIIGV
HHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCCCHHHH
LLAAILGAQVERKVREYMPDDLDMILTSVVTLLIMGAVTFLIIMPIGGELFKGMSWLFLN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEE
LNDNPLGAAILAGLFLISVVFGIHQGFVPVYFALMEAQGFNSLFPILAMAGAGQVGASLA
CCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHH
LYARAKKETTIRTQIKGAIIPGILGIGEPLIYGVTLPRVKPFVTACIGGAAGGFFIGLIS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCHHHHHHHHHHCCHHHHHHHHHH
YLGLPVGLNTVFGPSGVVAIPLMTSADGIFAGMAVFVGGLLISYTVGFAATYFFGCKDVD
HHCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LS
CC
>Mature Secondary Structure
MMAKITQTMMAQVLSLVGGSGNVAKCGNCMTRLRLTLNNSALADHAALKKISGVMGVVES
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCC
DAQLQIILGPGKAQTAADMMNALIESGDNVAPAVSEADLSTIAAQQKKQMKSKQTSAVQR
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLSKFATIFTPLIPGFIAAGLLLGIATLLEQIYVVGQTPSEFMLDLVTYLKVFGKGLFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LSILIGYNAQQAFGGSGVNGAILASLFVLGYDPEATKGIYSGMSEFFGFAIDPRGNIIGV
HHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCCCHHHH
LLAAILGAQVERKVREYMPDDLDMILTSVVTLLIMGAVTFLIIMPIGGELFKGMSWLFLN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEE
LNDNPLGAAILAGLFLISVVFGIHQGFVPVYFALMEAQGFNSLFPILAMAGAGQVGASLA
CCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHH
LYARAKKETTIRTQIKGAIIPGILGIGEPLIYGVTLPRVKPFVTACIGGAAGGFFIGLIS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCHHHHHHHHHHCCHHHHHHHHHH
YLGLPVGLNTVFGPSGVVAIPLMTSADGIFAGMAVFVGGLLISYTVGFAATYFFGCKDVD
HHCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]