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The map label for this gene is apt

Identifier: 226950489

GI number: 226950489

Start: 3487317

End: 3487835

Strand: Reverse

Name: apt

Synonym: CLM_3465

Alternate gene names: 226950489

Gene position: 3487835-3487317 (Counterclockwise)

Preceding gene: 226950490

Following gene: 226950488

Centisome position: 83.94

GC content: 29.87

Gene sequence:

>519_bases
GTGAATTTAAAAGAACACATAAGGGTAATTGAAAATTTCCCAAAAGAAGGTATAAGTTTTAAAGATGTAACTACAATACT
TCAAGATGGAAAAGTGTTAAATTACACTATTGATAAACTAGCAGAAAACTTAAAGGATAAAAAAATAGATAAAATAGTAG
GACCAGAAGCCAGAGGATTTTTATTTGGAACCCCTTTAGCCTATAAATTAGGTGTTGGTTTTGTACCAGTAAGAAAAAAA
GGCAAATTACCATATGAGACTATTAGTTGTAAATATGATTTAGAATATGGTCAAGACGAGCTTCAGATACATAAAGATTC
TATAAAAAAAGGTGACAAGGTAGCCATAGTAGATGATCTTCTTGCTACAGGTGGAACTATTGCTTCAGTAGTAAAATTAG
TAGAGGAATTAGGTGGAGAAGTTGTTAATGTAAGTTTTGTAATAGAACTTACAGATCTAAAGGGAAAAGACAAATTAGAA
GGGTATGATATTAACTCTTTGGTACAATATAATATATAA

Upstream 100 bases:

>100_bases
ATAATTACTTGAATAGAATGGGCTCTTTAATATATAATAATCTGTGTACAAAATTGAAAAATAAAAATAAATTGTTCGTA
TGAATTTAGGGGGAAGAGAA

Downstream 100 bases:

>100_bases
CACAATATATATATTATATTCCTGCTTAAAAGTTTGAAACTTTAAAAAAAATATAATATAATAGAAATAAAAAATATTGG
CTGGTTTTATAAACCAGCCT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MNLKEHIRVIENFPKEGISFKDVTTILQDGKVLNYTIDKLAENLKDKKIDKIVGPEARGFLFGTPLAYKLGVGFVPVRKK
GKLPYETISCKYDLEYGQDELQIHKDSIKKGDKVAIVDDLLATGGTIASVVKLVEELGGEVVNVSFVIELTDLKGKDKLE
GYDINSLVQYNI

Sequences:

>Translated_172_residues
MNLKEHIRVIENFPKEGISFKDVTTILQDGKVLNYTIDKLAENLKDKKIDKIVGPEARGFLFGTPLAYKLGVGFVPVRKK
GKLPYETISCKYDLEYGQDELQIHKDSIKKGDKVAIVDDLLATGGTIASVVKLVEELGGEVVNVSFVIELTDLKGKDKLE
GYDINSLVQYNI
>Mature_172_residues
MNLKEHIRVIENFPKEGISFKDVTTILQDGKVLNYTIDKLAENLKDKKIDKIVGPEARGFLFGTPLAYKLGVGFVPVRKK
GKLPYETISCKYDLEYGQDELQIHKDSIKKGDKVAIVDDLLATGGTIASVVKLVEELGGEVVNVSFVIELTDLKGKDKLE
GYDINSLVQYNI

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=43.6046511627907, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=45.6, Blast_Score=116, Evalue=1e-26,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=59.7560975609756, Blast_Score=194, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=42.1052631578947, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=47.239263803681, Blast_Score=126, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=35.9756097560976, Blast_Score=92, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136334, Length=161, Percent_Identity=44.7204968944099, Blast_Score=136, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_CLOB1 (A7FY09)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385382.1
- ProteinModelPortal:   A7FY09
- SMR:   A7FY09
- STRING:   A7FY09
- GeneID:   5397750
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3089
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   CBOT441770:CLB_3089-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19130; Mature: 19130

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKEHIRVIENFPKEGISFKDVTTILQDGKVLNYTIDKLAENLKDKKIDKIVGPEARGF
CCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCE
LFGTPLAYKLGVGFVPVRKKGKLPYETISCKYDLEYGQDELQIHKDSIKKGDKVAIVDDL
EEECCHHHHHCCCEEEECCCCCCCCEEEEEEEECCCCCHHHEEEHHHHCCCCEEEEHHHH
LATGGTIASVVKLVEELGGEVVNVSFVIELTDLKGKDKLEGYDINSLVQYNI
HHCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MNLKEHIRVIENFPKEGISFKDVTTILQDGKVLNYTIDKLAENLKDKKIDKIVGPEARGF
CCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCE
LFGTPLAYKLGVGFVPVRKKGKLPYETISCKYDLEYGQDELQIHKDSIKKGDKVAIVDDL
EEECCHHHHHCCCEEEECCCCCCCCEEEEEEEECCCCCHHHEEEHHHHCCCCEEEEHHHH
LATGGTIASVVKLVEELGGEVVNVSFVIELTDLKGKDKLEGYDINSLVQYNI
HHCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA