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The map label for this gene is relA [H]

Identifier: 226950488

GI number: 226950488

Start: 3485021

End: 3487192

Strand: Reverse

Name: relA [H]

Synonym: CLM_3464

Alternate gene names: 226950488

Gene position: 3487192-3485021 (Counterclockwise)

Preceding gene: 226950489

Following gene: 226950487

Centisome position: 83.92

GC content: 30.66

Gene sequence:

>2172_bases
ATGCTAGAAGATTTAATGATAAAAATAAAATATAGTTTCACTGAAAAAGAAATAGAGTTTATCAAAAAAGCATATAATTT
TGCTTGCAATGCCCACAAGGAACAAAAGAGAATATCTGGTGAACCTTATATAACCCATCCAGAAGAGGTGGCTATAATAT
TATTTGAAATGGGTATGGATGTTAACACCATGATAGCAGGGCTTATGCATGATGTTGTTGAAGATACTCAATATACATAT
GAAGATGTAGCTAAAGAATTTGGAAATGAAGTAGCAGATTTAGTAAATGGAGTTACTAAATTAGGTAAAATTGAATACAA
AACAAAAGAAGAACAACAAGCTGATAATGTAAGAAAAATGTTATTAGCAATGACAAAGGATATAAGAGTTATACTTATAA
AGTTAGCGGATAGATTACATAATATGAGAACATTAAGATTTATGCCTGTAGAAAAACAAAAGGAGAAAGCCCAGGAAACT
TTAGACATCTATGCTCCATTAGCTCATAGATTAGGAATATCTAAAATAAAATGGGAGCTAGAAGACTTATCTTTTAGATA
TATAAATCCCAATGAATACTATTTTTTGGTACGTAAAATTGCAGAGAAAAGAGCAGAGAGAGAAGAACATATAAAAGAAA
TAATTTCAAATTTACAACAAAACCTAAAAAGATCAGGTATTGAATCAGAAATAGATGGAAGGCCAAAACATTTCTATAGT
ATATATAAAAAAATGCATAACAAAAATAAAAATTTAGATCAAATATTTGATTTGACAGCAGTTAGAATATTAGTAGATAC
AGTTAAGGATTGTTATGCGGCCTTAGGTATAGCGCATACTGTATATAAGCCTATACCAGGGAGATTTAAAGATTATATAG
CAATGCCTAAACCTAATATGTATCAATCATTACATTCCACAGTAATGGGAGTGGGTGGTAGACCTTTTGAAATCCAAATA
AGAACCTATGAAATGCATAAAACTGCAGAATATGGTATAGCAGCTCACTGGAAATATAAAGAAGGCGTAGAGAATTCTAA
CAATATAGATTTAAAATTAACATGGCTTAGGGAAATGTTAGATTGGCAAAAGGAAACTACAGACCCAGAAGAGTTTATGC
AAGGATTTAAAATAGATTTATTTTCTGATGAAGTTTTTGTATTTACTCCAAAGGGAAAAGTTATAAGCTTGCCTAACAAA
GCTACACCAGTAGATTTTGCATATAAAATACATACAGATATAGGCCACAGGTGCATAGGTGCCAAGGTGAATGGTAAAAT
GGTGCCTTTAGATTATGAACTTAAAACTGGAGAGATAATAGAAGTTTTAACTTCTACTACACCTAAAGGACCAAATTTAG
ATTGGCTTAGTATGGTAAAAAGCAATCAAGCTAAAAGCAAAATAAGAGCCTGGTTTAAGAAAGAAGATAAAGAAGAAAAT
ATAACTAAAGGTAAAGATATATTAGAAAAAGAAACTAAAAAACAAGGCTATAACTTTGGGGAACTTGCAAAGGGTGAAGT
TTTGGAAACTGTATTAAAAAGATACAATATGAGCAGTATAGAAGATATGTTTGCTGCTGTTGGTATAGGGGCTTTAGCTG
CTTCAGCGGTAGTATTAAGATTTAGAGAACAGTATTTAAAAAAGAATAAACCAGAGCTTAATTGGAATGAAGTTAGGGAC
CAAATAAATAAATCAAATAAACAAAAGAAAAAGAAGAGTAGTTCACCAGGAATTATAGTAAAAGGTGAGGATAATTTATT
GGTTAGGTTTGCCAAATGTTGTAATCCTGTGCCTGGAGATAATATAATAGGGTATATAACAAAGGGGAGAGGAATATCCA
TACATAGAACTGATTGCGAAAATATGGAACAATTGGTAGAAGAAGATCCAACAAAAATAGTAGAGGTTAGTTGGGGAAAA
CCCAAGGGCGGAGAGTATATTTCAGAATTAGAAGTTATAGCTGAAAATACAGATGGTCTATTAGCAGATATTATGCTGAC
TATAAATGGGAGTAAGACAAATCTTTATGCTGTAAATGCAAAACCTATTAGAAATGACTCAGTAGTTGTAAATATAAAAT
TAAAAATAAGTAATATAGAAGATTTAAAATCAGTAATGAAAGATATAAGAAAACTAAAGGGTGTATTAGAAGTATATAGG
ACTAAAAAATAA

Upstream 100 bases:

>100_bases
CTTAAAAGTTTGAAACTTTAAAAAAAATATAATATAATAGAAATAAAAAATATTGGCTGGTTTTATAAACCAGCCTTTGA
TTTTGAGGAGTAATTAGGGT

Downstream 100 bases:

>100_bases
ATACTATAAATATAAAAGATTACAAATAAAGGTGGGATATGTTTGAGAGCGGTAGTTCAGAGAGTTATATCTTCTAAAGT
AGAAGTGGATGGAAAGGTTA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 723; Mature: 723

Protein sequence:

>723_residues
MLEDLMIKIKYSFTEKEIEFIKKAYNFACNAHKEQKRISGEPYITHPEEVAIILFEMGMDVNTMIAGLMHDVVEDTQYTY
EDVAKEFGNEVADLVNGVTKLGKIEYKTKEEQQADNVRKMLLAMTKDIRVILIKLADRLHNMRTLRFMPVEKQKEKAQET
LDIYAPLAHRLGISKIKWELEDLSFRYINPNEYYFLVRKIAEKRAEREEHIKEIISNLQQNLKRSGIESEIDGRPKHFYS
IYKKMHNKNKNLDQIFDLTAVRILVDTVKDCYAALGIAHTVYKPIPGRFKDYIAMPKPNMYQSLHSTVMGVGGRPFEIQI
RTYEMHKTAEYGIAAHWKYKEGVENSNNIDLKLTWLREMLDWQKETTDPEEFMQGFKIDLFSDEVFVFTPKGKVISLPNK
ATPVDFAYKIHTDIGHRCIGAKVNGKMVPLDYELKTGEIIEVLTSTTPKGPNLDWLSMVKSNQAKSKIRAWFKKEDKEEN
ITKGKDILEKETKKQGYNFGELAKGEVLETVLKRYNMSSIEDMFAAVGIGALAASAVVLRFREQYLKKNKPELNWNEVRD
QINKSNKQKKKKSSSPGIIVKGEDNLLVRFAKCCNPVPGDNIIGYITKGRGISIHRTDCENMEQLVEEDPTKIVEVSWGK
PKGGEYISELEVIAENTDGLLADIMLTINGSKTNLYAVNAKPIRNDSVVVNIKLKISNIEDLKSVMKDIRKLKGVLEVYR
TKK

Sequences:

>Translated_723_residues
MLEDLMIKIKYSFTEKEIEFIKKAYNFACNAHKEQKRISGEPYITHPEEVAIILFEMGMDVNTMIAGLMHDVVEDTQYTY
EDVAKEFGNEVADLVNGVTKLGKIEYKTKEEQQADNVRKMLLAMTKDIRVILIKLADRLHNMRTLRFMPVEKQKEKAQET
LDIYAPLAHRLGISKIKWELEDLSFRYINPNEYYFLVRKIAEKRAEREEHIKEIISNLQQNLKRSGIESEIDGRPKHFYS
IYKKMHNKNKNLDQIFDLTAVRILVDTVKDCYAALGIAHTVYKPIPGRFKDYIAMPKPNMYQSLHSTVMGVGGRPFEIQI
RTYEMHKTAEYGIAAHWKYKEGVENSNNIDLKLTWLREMLDWQKETTDPEEFMQGFKIDLFSDEVFVFTPKGKVISLPNK
ATPVDFAYKIHTDIGHRCIGAKVNGKMVPLDYELKTGEIIEVLTSTTPKGPNLDWLSMVKSNQAKSKIRAWFKKEDKEEN
ITKGKDILEKETKKQGYNFGELAKGEVLETVLKRYNMSSIEDMFAAVGIGALAASAVVLRFREQYLKKNKPELNWNEVRD
QINKSNKQKKKKSSSPGIIVKGEDNLLVRFAKCCNPVPGDNIIGYITKGRGISIHRTDCENMEQLVEEDPTKIVEVSWGK
PKGGEYISELEVIAENTDGLLADIMLTINGSKTNLYAVNAKPIRNDSVVVNIKLKISNIEDLKSVMKDIRKLKGVLEVYR
TKK
>Mature_723_residues
MLEDLMIKIKYSFTEKEIEFIKKAYNFACNAHKEQKRISGEPYITHPEEVAIILFEMGMDVNTMIAGLMHDVVEDTQYTY
EDVAKEFGNEVADLVNGVTKLGKIEYKTKEEQQADNVRKMLLAMTKDIRVILIKLADRLHNMRTLRFMPVEKQKEKAQET
LDIYAPLAHRLGISKIKWELEDLSFRYINPNEYYFLVRKIAEKRAEREEHIKEIISNLQQNLKRSGIESEIDGRPKHFYS
IYKKMHNKNKNLDQIFDLTAVRILVDTVKDCYAALGIAHTVYKPIPGRFKDYIAMPKPNMYQSLHSTVMGVGGRPFEIQI
RTYEMHKTAEYGIAAHWKYKEGVENSNNIDLKLTWLREMLDWQKETTDPEEFMQGFKIDLFSDEVFVFTPKGKVISLPNK
ATPVDFAYKIHTDIGHRCIGAKVNGKMVPLDYELKTGEIIEVLTSTTPKGPNLDWLSMVKSNQAKSKIRAWFKKEDKEEN
ITKGKDILEKETKKQGYNFGELAKGEVLETVLKRYNMSSIEDMFAAVGIGALAASAVVLRFREQYLKKNKPELNWNEVRD
QINKSNKQKKKKSSSPGIIVKGEDNLLVRFAKCCNPVPGDNIIGYITKGRGISIHRTDCENMEQLVEEDPTKIVEVSWGK
PKGGEYISELEVIAENTDGLLADIMLTINGSKTNLYAVNAKPIRNDSVVVNIKLKISNIEDLKSVMKDIRKLKGVLEVYR
TKK

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=130, Percent_Identity=39.2307692307692, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790082, Length=723, Percent_Identity=40.1106500691563, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1789147, Length=688, Percent_Identity=39.5348837209302, Blast_Score=558, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI25143118, Length=165, Percent_Identity=33.9393939393939, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650996, Length=128, Percent_Identity=35.9375, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83065; Mature: 83065

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEDLMIKIKYSFTEKEIEFIKKAYNFACNAHKEQKRISGEPYITHPEEVAIILFEMGMD
CCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEECCHHEEEEEEECCCC
VNTMIAGLMHDVVEDTQYTYEDVAKEFGNEVADLVNGVTKLGKIEYKTKEEQQADNVRKM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHH
LLAMTKDIRVILIKLADRLHNMRTLRFMPVEKQKEKAQETLDIYAPLAHRLGISKIKWEL
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHEEEE
EDLSFRYINPNEYYFLVRKIAEKRAEREEHIKEIISNLQQNLKRSGIESEIDGRPKHFYS
ECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IYKKMHNKNKNLDQIFDLTAVRILVDTVKDCYAALGIAHTVYKPIPGRFKDYIAMPKPNM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHH
YQSLHSTVMGVGGRPFEIQIRTYEMHKTAEYGIAAHWKYKEGVENSNNIDLKLTWLREML
HHHHHHHHHCCCCCCEEEEEEEEEEHHHHCCCCEEEEEHHHCCCCCCCEEEEHHHHHHHH
DWQKETTDPEEFMQGFKIDLFSDEVFVFTPKGKVISLPNKATPVDFAYKIHTDIGHRCIG
HHHHCCCCHHHHHCCCEEEEECCCEEEECCCCCEEECCCCCCCCEEEEEEECCCCCEEEC
AKVNGKMVPLDYELKTGEIIEVLTSTTPKGPNLDWLSMVKSNQAKSKIRAWFKKEDKEEN
CEECCEEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCH
ITKGKDILEKETKKQGYNFGELAKGEVLETVLKRYNMSSIEDMFAAVGIGALAASAVVLR
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
FREQYLKKNKPELNWNEVRDQINKSNKQKKKKSSSPGIIVKGEDNLLVRFAKCCNPVPGD
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCC
NIIGYITKGRGISIHRTDCENMEQLVEEDPTKIVEVSWGKPKGGEYISELEVIAENTDGL
CEEEEEECCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCE
LADIMLTINGSKTNLYAVNAKPIRNDSVVVNIKLKISNIEDLKSVMKDIRKLKGVLEVYR
EEEEEEEEECCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
TKK
CCC
>Mature Secondary Structure
MLEDLMIKIKYSFTEKEIEFIKKAYNFACNAHKEQKRISGEPYITHPEEVAIILFEMGMD
CCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEECCHHEEEEEEECCCC
VNTMIAGLMHDVVEDTQYTYEDVAKEFGNEVADLVNGVTKLGKIEYKTKEEQQADNVRKM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHH
LLAMTKDIRVILIKLADRLHNMRTLRFMPVEKQKEKAQETLDIYAPLAHRLGISKIKWEL
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHEEEE
EDLSFRYINPNEYYFLVRKIAEKRAEREEHIKEIISNLQQNLKRSGIESEIDGRPKHFYS
ECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IYKKMHNKNKNLDQIFDLTAVRILVDTVKDCYAALGIAHTVYKPIPGRFKDYIAMPKPNM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHH
YQSLHSTVMGVGGRPFEIQIRTYEMHKTAEYGIAAHWKYKEGVENSNNIDLKLTWLREML
HHHHHHHHHCCCCCCEEEEEEEEEEHHHHCCCCEEEEEHHHCCCCCCCEEEEHHHHHHHH
DWQKETTDPEEFMQGFKIDLFSDEVFVFTPKGKVISLPNKATPVDFAYKIHTDIGHRCIG
HHHHCCCCHHHHHCCCEEEEECCCEEEECCCCCEEECCCCCCCCEEEEEEECCCCCEEEC
AKVNGKMVPLDYELKTGEIIEVLTSTTPKGPNLDWLSMVKSNQAKSKIRAWFKKEDKEEN
CEECCEEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCH
ITKGKDILEKETKKQGYNFGELAKGEVLETVLKRYNMSSIEDMFAAVGIGALAASAVVLR
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
FREQYLKKNKPELNWNEVRDQINKSNKQKKKKSSSPGIIVKGEDNLLVRFAKCCNPVPGD
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCC
NIIGYITKGRGISIHRTDCENMEQLVEEDPTKIVEVSWGKPKGGEYISELEVIAENTDGL
CEEEEEECCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCE
LADIMLTINGSKTNLYAVNAKPIRNDSVVVNIKLKISNIEDLKSVMKDIRKLKGVLEVYR
EEEEEEEEECCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
TKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]