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The map label for this gene is hsp90 [H]

Identifier: 226949283

GI number: 226949283

Start: 2265800

End: 2267680

Strand: Reverse

Name: hsp90 [H]

Synonym: CLM_2202

Alternate gene names: 226949283

Gene position: 2267680-2265800 (Counterclockwise)

Preceding gene: 226949288

Following gene: 226949282

Centisome position: 54.57

GC content: 28.55

Gene sequence:

>1881_bases
ATGGAAACTAAACAATTCAAGGCCGAATCTAAGAGACTTTTAGATCTTATGATTAACTCAATTTATACTCATAAGGAGAT
TTTTTTAAGGGAACTTATCTCCAATTCTAGTGATGCTATTGATAAAATTTATTACAAAACTTTAACAGATGATTCCTTAA
AATTCGAGAGAGATGATTACTATATTAGAGTGGTTTCTGATAAGGAAAATAGGATATTAAAAATTGCTGATACTGGTATT
GGCATGACAAAGGAAGAGCTTGAAAATAACCTTGGAGTTATAGCTAAGAGCGGATCATTACAGTTTAAAAAAGAAAATGA
AGTAAAAGAAGGTTATGACATAATAGGCCAATTTGGTGTAGGATTTTATTCAGCCTTTTTAGTATCTGATGATGTTACAG
TTATAAGTAAAGCCTTTGGAAGTAATGAGGCTTACAAATGGAATTCAAAGGGAGCAGAAGGGTACACTATAGAACCTTGT
GAAAAGGAAGCTTATGGTACAGAGATTATACTTAAAATTAAAGATAATACAGAGGAAGAAAACTATGATGAGTTTTTAGA
GGAATACACATTAAAATCTATAATCAAAAAATACTCTGATTTTATTAGATACCCAATAAAAATGGATTTAACAAAGACCA
AACCTAAAGAGGACAATAAAGAAGAGTTTGAAGAATATAAAGAAGAAGAAACTATAAATAGTATGGTTCCTATCTGGAGA
AAAAATAAGAATGAGCTAAAATCAGAGGATTATGAGAACTTTTATGCTGAAAAGCACTATGGATTTGATAAACCAATAAA
ATATATTCATACTAGTGTTGATGGTGTAGTAAGTTACAATGCTATTTTATTTATTCCAGAAACAACACCTTATGATTTCT
ATACAAAAGAATATGAAAAAGGTCTAGAGTTATATTCAAGTGGCGTTTTAATTATGAATAAGTGCGGAGATTTATTACCA
GACTATTTTGGATTTGTTAAAGGTATAGTAGACTCTGAGGATTTATCTCTTAACATATCTAGAGAGATACTACAACATGA
TAGACAATTAAAGCTTATTGCTAAAAACATAAAAACTAAAATTAAAAATGAGTTAGAAAGCTTATTAAAAAAGGAAAGGG
ATAAATATGAAAAATTCTATGAATCCTTTGGAAGACAATTAAAATATGGTGTTTATAGTGATTTTGGAAGTAACAAAGAC
ATACTACAGGATTTATTAATGTTTTATTCTTCTAAAGAGAAAAAGATGGTTACTTTAGCTGAATATGTTTCTAGAATGCC
AGAGGATCAAAAATATATTTATTATGCTGTAGGGGAATCTAATGAAAGAATTGAAAAACTTCCACAAATAGAAGGAGTAC
TAGATAAGGGATATGAAGTACTATACTTTACAGATGATATAGATGAGTTTGCTATTAAAATGCTTATGAATTACAAAGAG
AAAGAATTTAAATCTGTATCAAGTGGTGATTTGGGTATAGAAGGTGAGGAAAAAGAAAATACATCTAATTCTGATGACAA
AGAAAACAAAGAGTTGTTTGAATCTATGAAAGATATTTTATCAGGAAAAGTTAAAGATGTTAGAGCCTCAAAAAGGTTAA
AAAATCATCCAGTATGCTTAGCAAATGAGGGTGAGCTTTCAATTGAAATGGAGAAAGTACTAAATGCTATGCCTAACAAT
CAAAACATAAAAGCAGATAAAGTTTTAGAAATAAATATGAATCACGACGTATTTAAGTCACTAAAAGAAGCTTATGAAGG
AGATAAGGAAAAACTTAAATTATATACAGATTTATTATACAACCAAGCTTTACTTATAGAAGGATTAGCAATAAATGATC
CAGTAGAATTTACAAATAACATTTGTAAAATAATGAAATAG

Upstream 100 bases:

>100_bases
GCACTCACTAGCTTAAAGTGCTAACAATTAAATTATATTATATTTAGAGTAAATACATAAAAATGTATTTGTAGTTTTTA
ATCTGAAGGGAGAGACTAAT

Downstream 100 bases:

>100_bases
GTGTAAAAGTTTTATAATAATATGAACTTAAAAATTTGCAATACAAATAGCATGTAAAAATTAAAATAGTTTATTATGTT
TAATTTAATTTTGATATAAA

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDDYYIRVVSDKENRILKIADTGI
GMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGVGFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPC
EKEAYGTEIILKIKDNTEEENYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
KNKNELKSEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEKGLELYSSGVLIMNKCGDLLP
DYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTKIKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKD
ILQDLLMFYSSKEKKMVTLAEYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMNYKE
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDILSGKVKDVRASKRLKNHPVCLANEGELSIEMEKVLNAMPNN
QNIKADKVLEINMNHDVFKSLKEAYEGDKEKLKLYTDLLYNQALLIEGLAINDPVEFTNNICKIMK

Sequences:

>Translated_626_residues
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDDYYIRVVSDKENRILKIADTGI
GMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGVGFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPC
EKEAYGTEIILKIKDNTEEENYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
KNKNELKSEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEKGLELYSSGVLIMNKCGDLLP
DYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTKIKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKD
ILQDLLMFYSSKEKKMVTLAEYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMNYKE
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDILSGKVKDVRASKRLKNHPVCLANEGELSIEMEKVLNAMPNN
QNIKADKVLEINMNHDVFKSLKEAYEGDKEKLKLYTDLLYNQALLIEGLAINDPVEFTNNICKIMK
>Mature_626_residues
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDDYYIRVVSDKENRILKIADTGI
GMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGVGFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPC
EKEAYGTEIILKIKDNTEEENYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
KNKNELKSEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEKGLELYSSGVLIMNKCGDLLP
DYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTKIKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKD
ILQDLLMFYSSKEKKMVTLAEYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMNYKE
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDILSGKVKDVRASKRLKNHPVCLANEGELSIEMEKVLNAMPNN
QNIKADKVLEINMNHDVFKSLKEAYEGDKEKLKLYTDLLYNQALLIEGLAINDPVEFTNNICKIMK

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI20149594, Length=680, Percent_Identity=37.2058823529412, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI4507677, Length=681, Percent_Identity=35.9765051395007, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI155722983, Length=641, Percent_Identity=30.2652106084243, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI154146191, Length=412, Percent_Identity=34.7087378640777, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI153792590, Length=412, Percent_Identity=34.7087378640777, Blast_Score=233, Evalue=4e-61,
Organism=Escherichia coli, GI1786679, Length=635, Percent_Identity=36.6929133858268, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17559162, Length=666, Percent_Identity=37.987987987988, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17542208, Length=672, Percent_Identity=35.5654761904762, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI115535205, Length=657, Percent_Identity=32.7245053272451, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI115535167, Length=441, Percent_Identity=36.281179138322, Blast_Score=243, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6325016, Length=680, Percent_Identity=35.8823529411765, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6323840, Length=676, Percent_Identity=35.7988165680473, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI17647529, Length=681, Percent_Identity=37.0044052863436, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI21357739, Length=678, Percent_Identity=34.9557522123894, Blast_Score=335, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24586016, Length=647, Percent_Identity=33.0757341576507, Blast_Score=308, Evalue=8e-84,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 72867; Mature: 72867

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDDY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCCE
YIRVVSDKENRILKIADTGIGMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGV
EEEEEECCCCCEEEEECCCCCCCHHHHHCCCCEEEECCCEEECCCCCHHHHHHHHHHHHH
GFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPCEKEAYGTEIILKIKDNTEEE
HHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
NYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
CHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHC
KNKNELKSEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEK
CCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCEEEEEECCCCCCHHHHHHHH
GLELYSSGVLIMNKCGDLLPDYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTK
HHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHH
IKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKDILQDLLMFYSSKEKKMVTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
EYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMNYKE
HHHHHCCCCCCEEEEEECCCCHHHHHCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHH
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDILSGKVKDVRASKRLKNHPVCL
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEE
ANEGELSIEMEKVLNAMPNNQNIKADKVLEINMNHDVFKSLKEAYEGDKEKLKLYTDLLY
ECCCCCEEEHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHH
NQALLIEGLAINDPVEFTNNICKIMK
CCHHHEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDDY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCCE
YIRVVSDKENRILKIADTGIGMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGV
EEEEEECCCCCEEEEECCCCCCCHHHHHCCCCEEEECCCEEECCCCCHHHHHHHHHHHHH
GFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPCEKEAYGTEIILKIKDNTEEE
HHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
NYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
CHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHC
KNKNELKSEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEK
CCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCEEEEEECCCCCCHHHHHHHH
GLELYSSGVLIMNKCGDLLPDYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTK
HHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHH
IKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKDILQDLLMFYSSKEKKMVTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
EYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMNYKE
HHHHHCCCCCCEEEEEECCCCHHHHHCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHH
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDILSGKVKDVRASKRLKNHPVCL
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEE
ANEGELSIEMEKVLNAMPNNQNIKADKVLEINMNHDVFKSLKEAYEGDKEKLKLYTDLLY
ECCCCCEEEHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHH
NQALLIEGLAINDPVEFTNNICKIMK
CCHHHEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA