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The map label for this gene is cvrA [H]

Identifier: 226949282

GI number: 226949282

Start: 2263772

End: 2265202

Strand: Reverse

Name: cvrA [H]

Synonym: CLM_2201

Alternate gene names: 226949282

Gene position: 2265202-2263772 (Counterclockwise)

Preceding gene: 226949283

Following gene: 226949278

Centisome position: 54.51

GC content: 31.03

Gene sequence:

>1431_bases
ATGGATATTTTATTAATCTCTGGTGTGATTTTGTTTCTATGTGTAATTTCAAGCAAAGTTTTATATAAGTATGGTGTACC
TACACTCATTATATTTCTTGCAATGGGTATGATAATGGGTTCTGAAGGTTTAGGTGGAATTTATTTTGATAATTCTCAAT
TAGCCGGTAAGTTATGCAATTTTGGACTCTTGTTTATTATGTTTTCTGGTGGATTCGAAACAAATTGGAAGACAGCAAGA
CCTGTGGCCTTTGCATCTACAGTTCTTGCTACTATTGGAGTAGCGCTAACAGCTCTTCTTGTAGGTGTTTTTGCTCATTA
TTTTCTTGGTATGACTTTTCTTGAAGGAATGTTACTTGGTTCAATTATTTCTTCTACAGATGCGGCTTCCGTATTTTCTA
TTTTGCGTTCTAAAAATTTAAATCTGAAAAACAGTTTAGCTCCTATGCTAGAAATGGAAAGTGGTTCAAATGATCCAATG
GCATATATGTTAACTACTATTTTTTTAGGCCTTATAACAGGTAATGAGCAGAATATAGTAATGCTTATTACAACACAAGT
ATTAATAGGAGTTTTGGTTGGTTTCTTAGTAGGGAAAGTATCTTTATGGTTGATTAATAATATAAATCTTGATATTGAAG
GCCTTTATTCTGTTTTGGCTATTAGTGTTGCTTTGTTATCTTATTCTATAGCCAGTGCAATTATGGGAAACGGATTTTTA
GCAGTTTATATTACAGGGTTAGTTATGGGAAATAGTAAACTTGTGCAAAAGGTAAGTTTAGTTCGTTATTTTGATGGTAT
ATCTTGGCTTATGCAAATTCTACTATTCTTTACTTTAGGATTATTAGTTTTCCCGTCTCAATTATTAAAGGTAGCATTAA
GTGGAACTGTAACTGCAGCTTTTATTATATTTATAGCACGTCCAATAGCAGTATTTCTTGTACTAACATTATTTAAAAAA
CCTGTAAAAGATAAGTTACTTGTATCTTGGGTTGGATTCCGTGGTGTAGCATCTATTGTTTTCGCTACTTATCCATTAAT
AGCGGGACTTTCAGTAGCAGATGAAATATTTAATATAGTATTCTTTGTGGCTTTAGTATCTGTTTTAGTTCAAGGAACAC
TTTTTATTCCTATAGCTAAGAAACTTGATTTAGTGGGAGAAGAAGAAACAGTACTTAAAACTTTTAATGATTATGAAGAA
TTTGCAGCAGAATTGTTAGAAGTTAATATTGATAAAAATAGTAAAATGGTAGGTAAAGCTATAGGGGATATGAACATTCC
AAGGGATATTTTAATAATTATGGTTAGAAGAGGGGAAAAAATTATTACTCCTAATGGAGCAACTGTAATTAAAGCAAATG
ATACAATTGTATTTTCAGCAGAAGATAAAAATAAGTTATTAAAGATAAATGAAAGATTAAAGCTTGCATAG

Upstream 100 bases:

>100_bases
GGTAAGGGAAATATTTATTTTAATTGGTATGGATTTTCATTTCGCTCCTTCATTAATGAAAGACATGAAGGCAAATAAAC
ATAAAGCTTGGAGGTAGTGT

Downstream 100 bases:

>100_bases
TAAGCTTTGATTTTTTCATTTAATGCTTTAGATTCCTAATTAACAACAATTTTAAATTAATATTAATTGTTATAAAAGTT
ATATGGAACACTTGAAAGAG

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MDILLISGVILFLCVISSKVLYKYGVPTLIIFLAMGMIMGSEGLGGIYFDNSQLAGKLCNFGLLFIMFSGGFETNWKTAR
PVAFASTVLATIGVALTALLVGVFAHYFLGMTFLEGMLLGSIISSTDAASVFSILRSKNLNLKNSLAPMLEMESGSNDPM
AYMLTTIFLGLITGNEQNIVMLITTQVLIGVLVGFLVGKVSLWLINNINLDIEGLYSVLAISVALLSYSIASAIMGNGFL
AVYITGLVMGNSKLVQKVSLVRYFDGISWLMQILLFFTLGLLVFPSQLLKVALSGTVTAAFIIFIARPIAVFLVLTLFKK
PVKDKLLVSWVGFRGVASIVFATYPLIAGLSVADEIFNIVFFVALVSVLVQGTLFIPIAKKLDLVGEEETVLKTFNDYEE
FAAELLEVNIDKNSKMVGKAIGDMNIPRDILIIMVRRGEKIITPNGATVIKANDTIVFSAEDKNKLLKINERLKLA

Sequences:

>Translated_476_residues
MDILLISGVILFLCVISSKVLYKYGVPTLIIFLAMGMIMGSEGLGGIYFDNSQLAGKLCNFGLLFIMFSGGFETNWKTAR
PVAFASTVLATIGVALTALLVGVFAHYFLGMTFLEGMLLGSIISSTDAASVFSILRSKNLNLKNSLAPMLEMESGSNDPM
AYMLTTIFLGLITGNEQNIVMLITTQVLIGVLVGFLVGKVSLWLINNINLDIEGLYSVLAISVALLSYSIASAIMGNGFL
AVYITGLVMGNSKLVQKVSLVRYFDGISWLMQILLFFTLGLLVFPSQLLKVALSGTVTAAFIIFIARPIAVFLVLTLFKK
PVKDKLLVSWVGFRGVASIVFATYPLIAGLSVADEIFNIVFFVALVSVLVQGTLFIPIAKKLDLVGEEETVLKTFNDYEE
FAAELLEVNIDKNSKMVGKAIGDMNIPRDILIIMVRRGEKIITPNGATVIKANDTIVFSAEDKNKLLKINERLKLA
>Mature_476_residues
MDILLISGVILFLCVISSKVLYKYGVPTLIIFLAMGMIMGSEGLGGIYFDNSQLAGKLCNFGLLFIMFSGGFETNWKTAR
PVAFASTVLATIGVALTALLVGVFAHYFLGMTFLEGMLLGSIISSTDAASVFSILRSKNLNLKNSLAPMLEMESGSNDPM
AYMLTTIFLGLITGNEQNIVMLITTQVLIGVLVGFLVGKVSLWLINNINLDIEGLYSVLAISVALLSYSIASAIMGNGFL
AVYITGLVMGNSKLVQKVSLVRYFDGISWLMQILLFFTLGLLVFPSQLLKVALSGTVTAAFIIFIARPIAVFLVLTLFKK
PVKDKLLVSWVGFRGVASIVFATYPLIAGLSVADEIFNIVFFVALVSVLVQGTLFIPIAKKLDLVGEEETVLKTFNDYEE
FAAELLEVNIDKNSKMVGKAIGDMNIPRDILIIMVRRGEKIITPNGATVIKANDTIVFSAEDKNKLLKINERLKLA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=453, Percent_Identity=37.0860927152318, Blast_Score=278, Evalue=8e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 51676; Mature: 51676

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILLISGVILFLCVISSKVLYKYGVPTLIIFLAMGMIMGSEGLGGIYFDNSQLAGKLCN
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHH
FGLLFIMFSGGFETNWKTARPVAFASTVLATIGVALTALLVGVFAHYFLGMTFLEGMLLG
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIISSTDAASVFSILRSKNLNLKNSLAPMLEMESGSNDPMAYMLTTIFLGLITGNEQNIV
HHHHCCHHHHHHHHHHHCCCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCEE
MLITTQVLIGVLVGFLVGKVSLWLINNINLDIEGLYSVLAISVALLSYSIASAIMGNGFL
EEEHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AVYITGLVMGNSKLVQKVSLVRYFDGISWLMQILLFFTLGLLVFPSQLLKVALSGTVTAA
HHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
FIIFIARPIAVFLVLTLFKKPVKDKLLVSWVGFRGVASIVFATYPLIAGLSVADEIFNIV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFVALVSVLVQGTLFIPIAKKLDLVGEEETVLKTFNDYEEFAAELLEVNIDKNSKMVGKA
HHHHHHHHHHCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IGDMNIPRDILIIMVRRGEKIITPNGATVIKANDTIVFSAEDKNKLLKINERLKLA
HCCCCCCHHHEEEEEECCCEEECCCCCEEEEECCEEEEEECCCCCCEEECCHHCCC
>Mature Secondary Structure
MDILLISGVILFLCVISSKVLYKYGVPTLIIFLAMGMIMGSEGLGGIYFDNSQLAGKLCN
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHH
FGLLFIMFSGGFETNWKTARPVAFASTVLATIGVALTALLVGVFAHYFLGMTFLEGMLLG
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIISSTDAASVFSILRSKNLNLKNSLAPMLEMESGSNDPMAYMLTTIFLGLITGNEQNIV
HHHHCCHHHHHHHHHHHCCCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCEE
MLITTQVLIGVLVGFLVGKVSLWLINNINLDIEGLYSVLAISVALLSYSIASAIMGNGFL
EEEHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AVYITGLVMGNSKLVQKVSLVRYFDGISWLMQILLFFTLGLLVFPSQLLKVALSGTVTAA
HHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
FIIFIARPIAVFLVLTLFKKPVKDKLLVSWVGFRGVASIVFATYPLIAGLSVADEIFNIV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFVALVSVLVQGTLFIPIAKKLDLVGEEETVLKTFNDYEEFAAELLEVNIDKNSKMVGKA
HHHHHHHHHHCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IGDMNIPRDILIIMVRRGEKIITPNGATVIKANDTIVFSAEDKNKLLKINERLKLA
HCCCCCCHHHEEEEEECCCEEECCCCCEEEEECCEEEEEECCCCCCEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]