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The map label for this gene is dxs [H]

Identifier: 226949179

GI number: 226949179

Start: 2155056

End: 2156924

Strand: Reverse

Name: dxs [H]

Synonym: CLM_2098

Alternate gene names: 226949179

Gene position: 2156924-2155056 (Counterclockwise)

Preceding gene: 226949180

Following gene: 226949178

Centisome position: 51.91

GC content: 30.39

Gene sequence:

>1869_bases
ATGAAAATGAAAAACATATTAGATAAATATCAAGATTTTGATAGTATAAAATCCATGTCTATAAATGAGTTAAACCAATT
CTCTTACGAGATAAGAGAATTTTTAATAGATAATGTATCTAAAACAGGGGGGCATTTGGCCTCTAATTTAGGAGTGGTAG
AACTTACTTTAAGTATTTTTAATGTATTCGATTTAAATAAAGATAAAGTTATTTGGGATGTAGGACATCAAGCCTATGTA
CATAAAATATTAACGGGAAGAAAGGATAAATTTAATACATTAAGACAATATGGAGGATTAAGTGGTTTTCCTAAAATATG
TGAGAGTCCTTACGATGTATTTGAAACAGGACATAGCAGTACCTCTATATCTGCCGCTCTAGGAATGGCAAGAGCAAGGG
ACATAAAAGGAGAAAATAATAAAGTTATAGCTGTAATAGGAGATGGAGCTCTAACTGGTGGAATGGCTTTAGAAGCATTA
AATGATTTGGGGTTTAATAAAACAGACTTAATTATTATATTAAATGATAATCAAATGTCCATAGCTGAGAATGTAGGAGG
AATGTCTAGCTACTTAAGTAAAGTAAGACTTGATCCTACCTATAATAAATTAAAAAAAGAAGTTAATAATACTTTAAACA
AAATACCTAATGTTGGAAAAGGAATGGCCCGTTCTTTGGAAAGAGTAAAAAACGGTATAAAGCAAATGATTGTACCGGGT
ATGCTTTTTGAAAATTTAGGAATAAAATATTTGGGGCCAATAGATGGTCATGATATAAAAGAGTTAAGTAAAGTTATGAA
AATGGCTAAAAATATAAATGGACCAGTTCTAATACATACTATAACTAAAAAAGGAAAAGGCTATGCTTATGCAGAAAAAA
AACCTGATAAATTTCATGGCATAGGTCCTTTTGATTGTGATAGTGGTGAAGTTAATTCAAAAACCTGTTTAACTTATTCA
AAAGTTTTTGGAGAAGAGCTAACTAAAATAGCAAAAGAAGATAAAAAAGTGGTAGCTATAACTGCAGCTATGAAAGATGG
TACTGGTCTTAGAAAATTCGGAGAAACTTTCCCCAAAAAATTTTTTGACGTTGGCATAGCAGAACAGCATGCAGTAACCT
TAGCAGCAGGAATAGCAACAGAAGGATTAAAACCTGTTTTTGCTGTTTATTCAACATTTCTTCAAAGAGCATATGATCAA
ATATTACATGACATATGTATACAAAATTTACCTGTAGTATTAGGTATAGATAGAGCAGGTATAGTAGGAAGTGATGGAGA
AACACACCAAGGAATTTTTGACTTGTCATATTTATCTTCTTTACCTAATATGACAATAATAGCACCTAAATGTTTAGAAG
AAATGGGGATAATGCTAAGGTGGGCATTAAATCAAAATTCACCAGTAGCCATAAGATATCCTAGAGGTGGGGATATAAAA
TCCTTAGAAATGACTCCTATAAAAAATATGAAAAAAGGTAAGTGGGAAGTAATTTGCGAGGAAGGAGATATAGCCATAAT
AGCCACGGGAAAAATGGTGCAGCATGCTATAATAGCACGAGAAAAATTAAAAGAATATGGAATAAAATCTACAATTGTAA
ATGCAAACTTTATAAAACCTATAGATAAGGAATTAATAAAAAACTTTGTAAAAAAAGGATATAAGATAGTAACTGTAGAA
GATAATGTAATAAAAGGTGGATTTGGTTCTCTAGTTCTTCAATACATAAGTGAGCTAAAAGCTAACAATACTGTTTTAAA
TTTAGGTTTTAAAGATAAGTTTGTACCCCATGGTAGTACAGATATATTATATAAAATAGAAGGATTAGATCCAGAGGGTA
TTGTTAAAAATATAATAAAGATTATATAA

Upstream 100 bases:

>100_bases
TATAGGGGGAAAAGCTTTAGGTAAAGGATTTGCTATAACAAATAGTAATGATATATTAGAAAAGGTTACAAGAATAATAT
ATTTTTTTAAAAGAGGATAG

Downstream 100 bases:

>100_bases
TATTATATGAAGGAGTTAGTTATGGCAGAAAAAAAAGAAAGATTAGATTTGCTTTTGGTGGAAAAGGGGATTTTTCAGTC
TAGAGAAAGAGCAAAAGCTA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIFNVFDLNKDKVIWDVGHQAYV
HKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSSTSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEAL
NDLGFNKTDLIIILNDNQMSIAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLERVKNGIKQMIVPG
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHGIGPFDCDSGEVNSKTCLTYS
KVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKKFFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQ
ILHDICIQNLPVVLGIDRAGIVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKPIDKELIKNFVKKGYKIVTVE
DNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGSTDILYKIEGLDPEGIVKNIIKII

Sequences:

>Translated_622_residues
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIFNVFDLNKDKVIWDVGHQAYV
HKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSSTSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEAL
NDLGFNKTDLIIILNDNQMSIAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLERVKNGIKQMIVPG
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHGIGPFDCDSGEVNSKTCLTYS
KVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKKFFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQ
ILHDICIQNLPVVLGIDRAGIVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKPIDKELIKNFVKKGYKIVTVE
DNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGSTDILYKIEGLDPEGIVKNIIKII
>Mature_622_residues
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIFNVFDLNKDKVIWDVGHQAYV
HKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSSTSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEAL
NDLGFNKTDLIIILNDNQMSIAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLERVKNGIKQMIVPG
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHGIGPFDCDSGEVNSKTCLTYS
KVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKKFFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQ
ILHDICIQNLPVVLGIDRAGIVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKPIDKELIKNFVKKGYKIVTVE
DNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGSTDILYKIEGLDPEGIVKNIIKII

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=414, Percent_Identity=24.6376811594203, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507521, Length=414, Percent_Identity=24.6376811594203, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637463, Length=261, Percent_Identity=26.4367816091954, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI225637461, Length=261, Percent_Identity=26.4367816091954, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI225637459, Length=261, Percent_Identity=26.4367816091954, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI133778974, Length=370, Percent_Identity=23.2432432432432, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=44.8051948051948, Blast_Score=534, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17539652, Length=407, Percent_Identity=23.5872235872236, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319698, Length=247, Percent_Identity=27.1255060728745, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24666278, Length=593, Percent_Identity=24.7892074198988, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45551847, Length=673, Percent_Identity=22.2882615156018, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550715, Length=673, Percent_Identity=22.2882615156018, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645119, Length=626, Percent_Identity=22.8434504792332, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21358145, Length=277, Percent_Identity=24.5487364620939, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650940, Length=277, Percent_Identity=24.5487364620939, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68642; Mature: 68642

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIF
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHH
NVFDLNKDKVIWDVGHQAYVHKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSS
HHHCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCC
TSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEALNDLGFNKTDLIIILNDNQMS
CHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCH
IAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLERVKNGIKQMIVPG
HHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHG
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCCCCCCCC
IGPFDCDSGEVNSKTCLTYSKVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHH
FFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQILHDICIQNLPVVLGIDRAG
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
CCCCCCCCCCCEEEHHHHHHCCCCEEECHHHHHHCCCEEEEEECCCCCEEEECCCCCCCC
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKP
EEECCCCCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCHHEEECCHHCCH
IDKELIKNFVKKGYKIVTVEDNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGST
HHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCC
DILYKIEGLDPEGIVKNIIKII
EEEEEEECCCHHHHHHHHHHHC
>Mature Secondary Structure
MKMKNILDKYQDFDSIKSMSINELNQFSYEIREFLIDNVSKTGGHLASNLGVVELTLSIF
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHH
NVFDLNKDKVIWDVGHQAYVHKILTGRKDKFNTLRQYGGLSGFPKICESPYDVFETGHSS
HHHCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCC
TSISAALGMARARDIKGENNKVIAVIGDGALTGGMALEALNDLGFNKTDLIIILNDNQMS
CHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCH
IAENVGGMSSYLSKVRLDPTYNKLKKEVNNTLNKIPNVGKGMARSLERVKNGIKQMIVPG
HHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
MLFENLGIKYLGPIDGHDIKELSKVMKMAKNINGPVLIHTITKKGKGYAYAEKKPDKFHG
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCCCCCCCC
IGPFDCDSGEVNSKTCLTYSKVFGEELTKIAKEDKKVVAITAAMKDGTGLRKFGETFPKK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHH
FFDVGIAEQHAVTLAAGIATEGLKPVFAVYSTFLQRAYDQILHDICIQNLPVVLGIDRAG
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IVGSDGETHQGIFDLSYLSSLPNMTIIAPKCLEEMGIMLRWALNQNSPVAIRYPRGGDIK
CCCCCCCCCCCEEEHHHHHHCCCCEEECHHHHHHCCCEEEEEECCCCCEEEECCCCCCCC
SLEMTPIKNMKKGKWEVICEEGDIAIIATGKMVQHAIIAREKLKEYGIKSTIVNANFIKP
EEECCCCCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCHHEEECCHHCCH
IDKELIKNFVKKGYKIVTVEDNVIKGGFGSLVLQYISELKANNTVLNLGFKDKFVPHGST
HHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCC
DILYKIEGLDPEGIVKNIIKII
EEEEEEECCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA