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The map label for this gene is hisI [H]

Identifier: 226948904

GI number: 226948904

Start: 1845227

End: 1845559

Strand: Direct

Name: hisI [H]

Synonym: CLM_1814

Alternate gene names: 226948904

Gene position: 1845227-1845559 (Clockwise)

Preceding gene: 226948903

Following gene: 226948905

Centisome position: 44.41

GC content: 29.73

Gene sequence:

>333_bases
ATGAATTTACAGGAAATATTAAAGGAAATAGATTTTAAAAAAGGATCAGATCTTATACCTACTATTATTCAGGATTTTTA
CTCAGGGGAAGTTTTAATGTTAGCATATATGAATAAAGAGTCTCTAGAAAAAACTATTGAAACTAATACTACTTGGTTTT
GGAGTAGATCTAGAGAAGAACTTTGGAATAAGGGAGCAACCTCAGGTCATTTTCAATATGTTAAAAGTATTCATATAGAT
TGTGATGGAGATACTTTATTAATTAAAGTAGAGCAACTTGGACCGGCATGTCATACTGGTCATAGAAGTTGCTTTTATAC
ACCATTAATATAA

Upstream 100 bases:

>100_bases
GATTATAAATGATTACAAATATATATTGTAACTCTCATCTGCATATTTTTAAATAAAGGATGTTAGATTATATGGTTATA
GATTAAGATGGAGGATAAAA

Downstream 100 bases:

>100_bases
ATGTATTATTTATATTAATAGAAAAAATCACATATAGGAATTGATGTTATAAAATGGATAGGGGGAAGGATGTGAGTATT
TGGTGGTTTGATGTAATTTA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MNLQEILKEIDFKKGSDLIPTIIQDFYSGEVLMLAYMNKESLEKTIETNTTWFWSRSREELWNKGATSGHFQYVKSIHID
CDGDTLLIKVEQLGPACHTGHRSCFYTPLI

Sequences:

>Translated_110_residues
MNLQEILKEIDFKKGSDLIPTIIQDFYSGEVLMLAYMNKESLEKTIETNTTWFWSRSREELWNKGATSGHFQYVKSIHID
CDGDTLLIKVEQLGPACHTGHRSCFYTPLI
>Mature_110_residues
MNLQEILKEIDFKKGSDLIPTIIQDFYSGEVLMLAYMNKESLEKTIETNTTWFWSRSREELWNKGATSGHFQYVKSIHID
CDGDTLLIKVEQLGPACHTGHRSCFYTPLI

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=52.0408163265306, Blast_Score=113, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319819, Length=106, Percent_Identity=38.6792452830189, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 12717; Mature: 12717

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQEILKEIDFKKGSDLIPTIIQDFYSGEVLMLAYMNKESLEKTIETNTTWFWSRSREE
CCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEEECCHHH
LWNKGATSGHFQYVKSIHIDCDGDTLLIKVEQLGPACHTGHRSCFYTPLI
HHHCCCCCCCEEEEEEEEEECCCCEEEEEEHHCCCCCCCCCCCEEECCCC
>Mature Secondary Structure
MNLQEILKEIDFKKGSDLIPTIIQDFYSGEVLMLAYMNKESLEKTIETNTTWFWSRSREE
CCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEEECCHHH
LWNKGATSGHFQYVKSIHIDCDGDTLLIKVEQLGPACHTGHRSCFYTPLI
HHHCCCCCCCEEEEEEEEEECCCCEEEEEEHHCCCCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA