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The map label for this gene is hssS [H]

Identifier: 226948176

GI number: 226948176

Start: 1100677

End: 1101705

Strand: Direct

Name: hssS [H]

Synonym: CLM_1050

Alternate gene names: 226948176

Gene position: 1100677-1101705 (Clockwise)

Preceding gene: 226948175

Following gene: 226948177

Centisome position: 26.49

GC content: 30.22

Gene sequence:

>1029_bases
ATGAATAATAAAATATCCGTTAAAGTGGTAGTTGCTTTTTCTTTAATAGTTTTTTTTATTGTTACTTCGGCCGTTGTTAT
TAGTGGCTTAGTGGTGGTATTTCTTTCGCGTTTTAATGTATTTACTCAGCCTAATCCTTTAATTTTATTAGGCTGGTTAG
GTATTATCAGTATAATGGTAAGCACAGCGATTGCTCAAATTATAGGAAAAAAGGTACTATCCCCAATTTCTGATCTTAAC
AAAGCAACTAAAGAAGTTGCTAAGGGAAATTTTAATATTAGACTTTCAGAAAGTAGCTGGACAGATGAAATAAGAGAAAT
GGCACATAGCTTTAATATAATGACTCATGAACTAGGTAATATTGAAACCTTAAGAGATGATTTCATTAGCAATGTTTCTC
ATGAATTTAAGACTCCTATTTCAGCTATTGAAGGCTATGCCACATTGTTACAAGATGATGAATTATCTGATGAAGAACGT
AGGGAATATATTCATAAAATACTTATAAGTACAAAAAGATTATCTTCTCTTTCAGGGAATATTTTGCAAATAACAGAACT
TGAAAATCAAAAGATTTTACCTTTAGAACAAAAATATTATTTAGATGAACAAATCAGACAAACTATTTTATTATTTGAAT
ATCAGTGGACAAAAAAAAATATAACTTTAGATATTAATCTAGACAATATTACTTACATTGGAAGTAAAGAGTTGTTAGCT
CAAGTATGGCAAAATATTTTAGGGAATGCCATTAAATTTTCTCACCAGAATGGAACAATACAGGTAACATTAACACAAAC
AAATGAGGAAGTTTTAATTACAATAAAGGATAATGGTATAGGTATGTCTGAAGAGGTTAAGGACCGAGTGTTTGAAAAGT
TTTATCAGGGAGATAGTTCACATTATTCAGAGGGGAATGGATTAGGTTTAGCACTTGTAAAAAGGATTATAGATATTTGT
GAAGGAACTATAGAAATCTCAAGCCATGAAGGAGTAGGTACAGACTTTATTGTCAAACTTCCTAAGTAG

Upstream 100 bases:

>100_bases
TTGATGTTCATATAAATAGATTACGGGATCGGTTTAAAGATAATAAAGACTTCAATATTATTACAATTAGAGGATTAGGT
TATAAGGTGGTTAAACAGTG

Downstream 100 bases:

>100_bases
AATATTTTATTAAAATAAAAATCATTAATAGCATATATATTGTTAAACTAAATAAAAAAATAATAAACCATTTTCTGTGG
ATTCATAATAAATCAAGAGT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MNNKISVKVVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDLN
KATKEVAKGNFNIRLSESSWTDEIREMAHSFNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEER
REYIHKILISTKRLSSLSGNILQITELENQKILPLEQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKDRVFEKFYQGDSSHYSEGNGLGLALVKRIIDIC
EGTIEISSHEGVGTDFIVKLPK

Sequences:

>Translated_342_residues
MNNKISVKVVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDLN
KATKEVAKGNFNIRLSESSWTDEIREMAHSFNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEER
REYIHKILISTKRLSSLSGNILQITELENQKILPLEQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKDRVFEKFYQGDSSHYSEGNGLGLALVKRIIDIC
EGTIEISSHEGVGTDFIVKLPK
>Mature_342_residues
MNNKISVKVVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMVSTAIAQIIGKKVLSPISDLN
KATKEVAKGNFNIRLSESSWTDEIREMAHSFNIMTHELGNIETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEER
REYIHKILISTKRLSSLSGNILQITELENQKILPLEQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKDRVFEKFYQGDSSHYSEGNGLGLALVKRIIDIC
EGTIEISSHEGVGTDFIVKLPK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=26.9230769230769, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786783, Length=270, Percent_Identity=23.3333333333333, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=28.1746031746032, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=28.4444444444444, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=292, Percent_Identity=26.027397260274, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=27.3913043478261, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=30.4166666666667, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790861, Length=226, Percent_Identity=25.6637168141593, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI48994928, Length=219, Percent_Identity=27.3972602739726, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=25.2747252747253, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=21.3815789473684, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=27.8884462151394, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=26.8518518518519, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789403, Length=287, Percent_Identity=23.3449477351916, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=26.5486725663717, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081816, Length=339, Percent_Identity=21.8289085545723, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790551, Length=299, Percent_Identity=23.7458193979933, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787374, Length=268, Percent_Identity=23.8805970149254, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38553; Mature: 38553

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKISVKVVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMV
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHH
STAIAQIIGKKVLSPISDLNKATKEVAKGNFNIRLSESSWTDEIREMAHSFNIMTHELGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
IETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEERREYIHKILISTKRLSSLSGN
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ILQITELENQKILPLEQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCEEEECCHHHHH
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKDRVFEKFYQGDSS
HHHHHHHCHHEEEECCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
HYSEGNGLGLALVKRIIDICEGTIEISSHEGVGTDFIVKLPK
CCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEECCC
>Mature Secondary Structure
MNNKISVKVVVAFSLIVFFIVTSAVVISGLVVVFLSRFNVFTQPNPLILLGWLGIISIMV
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHH
STAIAQIIGKKVLSPISDLNKATKEVAKGNFNIRLSESSWTDEIREMAHSFNIMTHELGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
IETLRDDFISNVSHEFKTPISAIEGYATLLQDDELSDEERREYIHKILISTKRLSSLSGN
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ILQITELENQKILPLEQKYYLDEQIRQTILLFEYQWTKKNITLDINLDNITYIGSKELLA
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCEEEECCHHHHH
QVWQNILGNAIKFSHQNGTIQVTLTQTNEEVLITIKDNGIGMSEEVKDRVFEKFYQGDSS
HHHHHHHCHHEEEECCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
HYSEGNGLGLALVKRIIDICEGTIEISSHEGVGTDFIVKLPK
CCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA