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The map label for this gene is hssR [H]

Identifier: 226948175

GI number: 226948175

Start: 1100006

End: 1100677

Strand: Direct

Name: hssR [H]

Synonym: CLM_1049

Alternate gene names: 226948175

Gene position: 1100006-1100677 (Clockwise)

Preceding gene: 226948173

Following gene: 226948176

Centisome position: 26.47

GC content: 29.91

Gene sequence:

>672_bases
ATGTTTAAAGTATTAGTAGTAGAAGATGACCCAGCTTTGCGTAAACTTTTTTGTACAGTACTTAATAAAAATGGATATAA
ATCCATTGAAGCTAAAGATGGAGACAGTGCATTAGATATATTATATAGAGAGTACATAGACTTAATTATTTCAGATATAA
TGATGCCGAATATGGATGGCTATACCCTCACAAAATTAATAAGAGAGTCAAATAATAATGTGCCTATATTAATGATTACT
GCAAAAGAAACATTTTCCGATAAACAAGAAGGTTTTAGAGTAGGTACGGACGATTATATGGTGAAACCTATTGATGTGAA
TGAAATGATTTTACGTGTAGGTGCTTTGCTTAGACGATCCCAAATAATCAATGAACGAAGAATTGTAATAGGTGAAACAA
CATTCTTATATGACTTTCTAAGTGTTAAATATAATAATAAGGAATTAGTATTACCCCAAAAAGAGTTTTATTTAATTTAT
AAACTTGTATCCACACCTAATAAGATTTTCACACGACAGCAATTAATGGATGAAATATGGGGCATAGAATCTGAAACAGA
TCCAAGAACAGTTGATGTTCATATAAATAGATTACGGGATCGGTTTAAAGATAATAAAGACTTCAATATTATTACAATTA
GAGGATTAGGTTATAAGGTGGTTAAACAGTGA

Upstream 100 bases:

>100_bases
AACTGGTGAGTTTATATTCAGTTTATATTTATTTGATAAATTTTTTAATAAGAATAAAAATGTGTTATAATTTAAAACCT
ATTAAAAGGAGGTCTAGATA

Downstream 100 bases:

>100_bases
TGAATAATAAAATATCCGTTAAAGTGGTAGTTGCTTTTTCTTTAATAGTTTTTTTTATTGTTACTTCGGCCGTTGTTATT
AGTGGCTTAGTGGTGGTATT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MFKVLVVEDDPALRKLFCTVLNKNGYKSIEAKDGDSALDILYREYIDLIISDIMMPNMDGYTLTKLIRESNNNVPILMIT
AKETFSDKQEGFRVGTDDYMVKPIDVNEMILRVGALLRRSQIINERRIVIGETTFLYDFLSVKYNNKELVLPQKEFYLIY
KLVSTPNKIFTRQQLMDEIWGIESETDPRTVDVHINRLRDRFKDNKDFNIITIRGLGYKVVKQ

Sequences:

>Translated_223_residues
MFKVLVVEDDPALRKLFCTVLNKNGYKSIEAKDGDSALDILYREYIDLIISDIMMPNMDGYTLTKLIRESNNNVPILMIT
AKETFSDKQEGFRVGTDDYMVKPIDVNEMILRVGALLRRSQIINERRIVIGETTFLYDFLSVKYNNKELVLPQKEFYLIY
KLVSTPNKIFTRQQLMDEIWGIESETDPRTVDVHINRLRDRFKDNKDFNIITIRGLGYKVVKQ
>Mature_223_residues
MFKVLVVEDDPALRKLFCTVLNKNGYKSIEAKDGDSALDILYREYIDLIISDIMMPNMDGYTLTKLIRESNNNVPILMIT
AKETFSDKQEGFRVGTDDYMVKPIDVNEMILRVGALLRRSQIINERRIVIGETTFLYDFLSVKYNNKELVLPQKEFYLIY
KLVSTPNKIFTRQQLMDEIWGIESETDPRTVDVHINRLRDRFKDNKDFNIITIRGLGYKVVKQ

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=34.841628959276, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=34.0807174887892, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=31.8181818181818, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=32.579185520362, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=30.7692307692308, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=31.6017316017316, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=29.4117647058824, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=31.7391304347826, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=29.4117647058824, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=30.316742081448, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=32.034632034632, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=26.9058295964126, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=27.1111111111111, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=38.4615384615385, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1787487, Length=108, Percent_Identity=35.1851851851852, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=126, Percent_Identity=32.5396825396825, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=143, Percent_Identity=27.972027972028, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790437, Length=177, Percent_Identity=25.4237288135593, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788905, Length=124, Percent_Identity=31.4516129032258, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=36.1904761904762, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=114, Percent_Identity=34.2105263157895, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26090; Mature: 26090

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKVLVVEDDPALRKLFCTVLNKNGYKSIEAKDGDSALDILYREYIDLIISDIMMPNMDG
CEEEEEECCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YTLTKLIRESNNNVPILMITAKETFSDKQEGFRVGTDDYMVKPIDVNEMILRVGALLRRS
HHHHHHHHHCCCCCEEEEEECCCHHCCHHCCCEECCCCEEEECCCHHHHHHHHHHHHHHH
QIINERRIVIGETTFLYDFLSVKYNNKELVLPQKEFYLIYKLVSTPNKIFTRQQLMDEIW
HHHCCCEEEEECHHHHHHHHHEEECCCEEECCCHHHEEEEHHHCCCHHHHHHHHHHHHHC
GIESETDPRTVDVHINRLRDRFKDNKDFNIITIRGLGYKVVKQ
CCCCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCEEECCC
>Mature Secondary Structure
MFKVLVVEDDPALRKLFCTVLNKNGYKSIEAKDGDSALDILYREYIDLIISDIMMPNMDG
CEEEEEECCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YTLTKLIRESNNNVPILMITAKETFSDKQEGFRVGTDDYMVKPIDVNEMILRVGALLRRS
HHHHHHHHHCCCCCEEEEEECCCHHCCHHCCCEECCCCEEEECCCHHHHHHHHHHHHHHH
QIINERRIVIGETTFLYDFLSVKYNNKELVLPQKEFYLIYKLVSTPNKIFTRQQLMDEIW
HHHCCCEEEEECHHHHHHHHHEEECCCEEECCCHHHEEEEHHHCCCHHHHHHHHHHHHHC
GIESETDPRTVDVHINRLRDRFKDNKDFNIITIRGLGYKVVKQ
CCCCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA