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The map label for this gene is trx1 [H]

Identifier: 226225380

GI number: 226225380

Start: 2885109

End: 2885429

Strand: Reverse

Name: trx1 [H]

Synonym: Lm4b_02803

Alternate gene names: 226225380

Gene position: 2885429-2885109 (Counterclockwise)

Preceding gene: 226225381

Following gene: 226225378

Centisome position: 99.06

GC content: 37.38

Gene sequence:

>321_bases
ATGGCGATTATTTTTGCAAAAGAAGAGAACTTGGAAGAGATTATTAGTAGCCATCCTAAAATATTACTTAATTTTTGGGC
AGAGTGGTGCGCACCGTGTCGCTGCTTTTGGCCAACACTTGAGCAATTCGCTGAGATGGAAGAAGGTAATGTCCAGGTTG
TGAAAATTAATGTAGATAAACAACGCGCATTAGCTCAGAAATTTGATGTAAAAGGAATACCAAATTCGCTTGTTCTTGTT
GATGGAGAAATTAAAGGCGGGATTGCTGGTATTGTAAGTTGTGATGAACTTAGAAGCAGATTTAAAAGTTTGGCAAAATA
A

Upstream 100 bases:

>100_bases
TGTCAAAAAATGAACAAAAAGCAAGATATATTGCTATTCTAAAACCCTTTGCTTGACCACAATACAACTTTGGAATATTC
TGAATGTGAGGTGGATATGT

Downstream 100 bases:

>100_bases
AAATTCCGCGATACCAGTTAATGGTCGCGGAATTTTTTGTTTCACGTGAAACATTTATTATTTGAAAACGCGGAAACGAT
CAGCGTCATCGATGAATTCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MAIIFAKEENLEEIISSHPKILLNFWAEWCAPCRCFWPTLEQFAEMEEGNVQVVKINVDKQRALAQKFDVKGIPNSLVLV
DGEIKGGIAGIVSCDELRSRFKSLAK

Sequences:

>Translated_106_residues
MAIIFAKEENLEEIISSHPKILLNFWAEWCAPCRCFWPTLEQFAEMEEGNVQVVKINVDKQRALAQKFDVKGIPNSLVLV
DGEIKGGIAGIVSCDELRSRFKSLAK
>Mature_105_residues
AIIFAKEENLEEIISSHPKILLNFWAEWCAPCRCFWPTLEQFAEMEEGNVQVVKINVDKQRALAQKFDVKGIPNSLVLVD
GEIKGGIAGIVSCDELRSRFKSLAK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=27.9569892473118, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87082331, Length=97, Percent_Identity=31.9587628865979, Blast_Score=74, Evalue=2e-15,
Organism=Escherichia coli, GI1788936, Length=90, Percent_Identity=32.2222222222222, Blast_Score=72, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=90, Percent_Identity=32.2222222222222, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573567, Length=87, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11951; Mature: 11820

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIIFAKEENLEEIISSHPKILLNFWAEWCAPCRCFWPTLEQFAEMEEGNVQVVKINVDK
CEEEEECCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECCH
QRALAQKFDVKGIPNSLVLVDGEIKGGIAGIVSCDELRSRFKSLAK
HHHHHHHCCCCCCCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCC
>Mature Secondary Structure 
AIIFAKEENLEEIISSHPKILLNFWAEWCAPCRCFWPTLEQFAEMEEGNVQVVKINVDK
EEEEECCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECCH
QRALAQKFDVKGIPNSLVLVDGEIKGGIAGIVSCDELRSRFKSLAK
HHHHHHHCCCCCCCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]