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The map label for this gene is mltD [C]

Identifier: 226225242

GI number: 226225242

Start: 2737084

End: 2738859

Strand: Direct

Name: mltD [C]

Synonym: Lm4b_02664

Alternate gene names: 226225242

Gene position: 2737084-2738859 (Clockwise)

Preceding gene: 226225240

Following gene: 226225246

Centisome position: 93.97

GC content: 39.98

Gene sequence:

>1776_bases
ATGCAAAAGACGAGAAAAGAACGTATTCTTGAAGCCTTACAAGAAGAAAAGAAAAACAAAAAAAGTAAAAAATTCAAAAC
TGGTGCAACGATTGCTGGGGTTACTGCCATCGCAACCTCTATCACTGTTCCCGGCATCGAAGTAATCGTTAGCGCAGACG
AAACAGCGCCTGCTGACGAAGCATCTAAAAGCGCTGAAGCTAACACAACTAAAGAAACACCAGCAACGGCCACTCCTGAA
AACACAACAGAACCAACCGTTGAAGCTAAGCAAACTGAAACAAAAGAACAAACAAAGACAGCAGAAGAAAATCAAGCTGC
AGCGAAGCAAGTAGAAAAAGCTCCAGCTGAACCCGCAACAGTTAGCAATCCTGACAATGCAACAAGCTCTTCTACACCAG
CTACATACAACCTATTACAAAAATCAGCACTCCGTTCGGGAGCAACTGTTCAAAGCTTTATCCAAACAATCCAAGCCTCT
TCTTCCCAAATTGCAGCAGAAAATGACCTGTACGCATCTGTCATGATCGCCCAAGCCATTTTAGAAAGCGCCTATGGAAC
GAGCGAATTAGGCTCTGCTCCAAACTATAACCTTTTTGGAATCAAAGGAGCTTACAACGGCCAATCTTATACAAAACAAA
CACTAGAAGATGATGGTAAAGGAAACTACTACACAATCACAGCTAAATTTAGAAAATATCCGTCTTATCACCAATCCTTA
GAAGATTACGCACAAGTCATTCGAAATGGCCCAAGCTGGAACCCAAATTACTACTCCAAAGTTTGGAAAAGCAACACTAC
TTCCTACAAAGACGCAACGAAAGCCTTAACTGGAACGTACGCAACAGACACAGCCTATGCAACGAAATTAAATGACTTGA
TTAGCCGATATAATTTAACCCAATATGACAGTGGCAAAACAACTGGCGGAAACTCCGGAAGTACTGGTAACACTGGAAAT
TCTAGCAACACCGGAAACACCTCCAATGCAAAAATTTACACAGTTGTAAAAGGGGACTCACTTTGGAGAATCGCTAATAA
CCATAAAGTAACCGTCGCGAACCTAAAAGCTTGGAATAATCTTAAATCTGATTTCATTTACCCAGGGCAAAAACTTAAAG
TAAGTGCTGGTTCCACTACATCGGATACGAATACATCGAAACCGAGCACAGGAACAAGTACATCCAAACCAAGTACAGGC
ACTAGCACAAACGCTAAAGTATACACAGTTGTAAAAGGTGACTCGCTTTGGAGAATCGCTAACAACCATAAAGTAACTAT
TGCTAACCTAAAATCCTGGAACAATCTGAAATCCGATTTCATTTATCCAGGTCAAAAACTTAAAGTAAGTGCCGGTTCTA
CTTCTAACACAAATACTTCTAAACCGAGCACAAACACGAATACATCCAAACCAAGCACAAATACGAACACGAACGCTAAA
GTTTATACGGTAGCAAAAGGTGACTCACTTTGGAGAATCGCTAACAACCACAAAGTAACTATTGCTAACCTAAAATCCTG
GAACAACTTAAAATCCGATTTCATTTACCCAGGACAAAAACTTAAAGTTAGCGCCGGAACTACTACAAACACAAATACCG
CAAAACCAAGCACAAATAAACCAAGTAATTCCACAGTAAAAACATACACCGTCAAAAAAGGCGACTCTTTATGGGCCATT
TCTAGACAATATAAAACAACTGTAGATAATATTAAAGCTTGGAACAAGTTAACAAGCAACATGATTCATGTTGGACAGAA
ATTGACGATTAAGTGA

Upstream 100 bases:

>100_bases
TTTTTGACAATTTAATTACAATTTGTCGATATCAATCATAAGTAATGTGAAGTATGTAATAATGGATGTAGAATATTTAA
AGAATCGGAAGTGACTTACC

Downstream 100 bases:

>100_bases
ATGTAAAAAGCCTACCTCATGAGCGAGATAGGTCAGAAACTGCGGATAAAGCGAGAAATTGCTTTGTCTGCGGTTTTTTT
ATTAAATTAAACAGATTCTA

Product: autolysin

Products: NA

Alternate protein names: 1,4-beta-N-acetylmuramoylhydrolase; Lysozyme; Peptidoglycan hydrolase; Pg-hydrolase 2 [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MQKTRKERILEALQEEKKNKKSKKFKTGATIAGVTAIATSITVPGIEVIVSADETAPADEASKSAEANTTKETPATATPE
NTTEPTVEAKQTETKEQTKTAEENQAAAKQVEKAPAEPATVSNPDNATSSSTPATYNLLQKSALRSGATVQSFIQTIQAS
SSQIAAENDLYASVMIAQAILESAYGTSELGSAPNYNLFGIKGAYNGQSYTKQTLEDDGKGNYYTITAKFRKYPSYHQSL
EDYAQVIRNGPSWNPNYYSKVWKSNTTSYKDATKALTGTYATDTAYATKLNDLISRYNLTQYDSGKTTGGNSGSTGNTGN
SSNTGNTSNAKIYTVVKGDSLWRIANNHKVTVANLKAWNNLKSDFIYPGQKLKVSAGSTTSDTNTSKPSTGTSTSKPSTG
TSTNAKVYTVVKGDSLWRIANNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGSTSNTNTSKPSTNTNTSKPSTNTNTNAK
VYTVAKGDSLWRIANNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGTTTNTNTAKPSTNKPSNSTVKTYTVKKGDSLWAI
SRQYKTTVDNIKAWNKLTSNMIHVGQKLTIK

Sequences:

>Translated_591_residues
MQKTRKERILEALQEEKKNKKSKKFKTGATIAGVTAIATSITVPGIEVIVSADETAPADEASKSAEANTTKETPATATPE
NTTEPTVEAKQTETKEQTKTAEENQAAAKQVEKAPAEPATVSNPDNATSSSTPATYNLLQKSALRSGATVQSFIQTIQAS
SSQIAAENDLYASVMIAQAILESAYGTSELGSAPNYNLFGIKGAYNGQSYTKQTLEDDGKGNYYTITAKFRKYPSYHQSL
EDYAQVIRNGPSWNPNYYSKVWKSNTTSYKDATKALTGTYATDTAYATKLNDLISRYNLTQYDSGKTTGGNSGSTGNTGN
SSNTGNTSNAKIYTVVKGDSLWRIANNHKVTVANLKAWNNLKSDFIYPGQKLKVSAGSTTSDTNTSKPSTGTSTSKPSTG
TSTNAKVYTVVKGDSLWRIANNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGSTSNTNTSKPSTNTNTSKPSTNTNTNAK
VYTVAKGDSLWRIANNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGTTTNTNTAKPSTNKPSNSTVKTYTVKKGDSLWAI
SRQYKTTVDNIKAWNKLTSNMIHVGQKLTIK
>Mature_591_residues
MQKTRKERILEALQEEKKNKKSKKFKTGATIAGVTAIATSITVPGIEVIVSADETAPADEASKSAEANTTKETPATATPE
NTTEPTVEAKQTETKEQTKTAEENQAAAKQVEKAPAEPATVSNPDNATSSSTPATYNLLQKSALRSGATVQSFIQTIQAS
SSQIAAENDLYASVMIAQAILESAYGTSELGSAPNYNLFGIKGAYNGQSYTKQTLEDDGKGNYYTITAKFRKYPSYHQSL
EDYAQVIRNGPSWNPNYYSKVWKSNTTSYKDATKALTGTYATDTAYATKLNDLISRYNLTQYDSGKTTGGNSGSTGNTGN
SSNTGNTSNAKIYTVVKGDSLWRIANNHKVTVANLKAWNNLKSDFIYPGQKLKVSAGSTTSDTNTSKPSTGTSTSKPSTG
TSTNAKVYTVVKGDSLWRIANNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGSTSNTNTSKPSTNTNTSKPSTNTNTNAK
VYTVAKGDSLWRIANNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGTTTNTNTAKPSTNKPSNSTVKTYTVKKGDSLWAI
SRQYKTTVDNIKAWNKLTSNMIHVGQKLTIK

Specific function: May work in concert with and potentiate the processive hydrolytic action of muramidase-1, which requires binding of the enzyme to non-reducing ends of glycan chains. Hydrolysis in the midst of glycan chains would increase the number of binding sites for m

COG id: COG1705

COG function: function code NU; Muramidase (flagellum-specific)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 LysM repeats [H]

Homologues:

Organism=Escherichia coli, GI1786405, Length=117, Percent_Identity=35.8974358974359, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013338
- InterPro:   IPR002901
- InterPro:   IPR018392
- InterPro:   IPR002482 [H]

Pfam domain/function: PF01832 Glucosaminidase; PF01476 LysM [H]

EC number: =3.2.1.17 [H]

Molecular weight: Translated: 63780; Mature: 63780

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTRKERILEALQEEKKNKKSKKFKTGATIAGVTAIATSITVPGIEVIVSADETAPADE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHH
ASKSAEANTTKETPATATPENTTEPTVEAKQTETKEQTKTAEENQAAAKQVEKAPAEPAT
HHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VSNPDNATSSSTPATYNLLQKSALRSGATVQSFIQTIQASSSQIAAENDLYASVMIAQAI
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LESAYGTSELGSAPNYNLFGIKGAYNGQSYTKQTLEDDGKGNYYTITAKFRKYPSYHQSL
HHHHCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEEHHHCCCHHHHH
EDYAQVIRNGPSWNPNYYSKVWKSNTTSYKDATKALTGTYATDTAYATKLNDLISRYNLT
HHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
QYDSGKTTGGNSGSTGNTGNSSNTGNTSNAKIYTVVKGDSLWRIANNHKVTVANLKAWNN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCEEEEEECHHHCC
LKSDFIYPGQKLKVSAGSTTSDTNTSKPSTGTSTSKPSTGTSTNAKVYTVVKGDSLWRIA
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEE
NNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGSTSNTNTSKPSTNTNTSKPSTNTNTNAK
CCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VYTVAKGDSLWRIANNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGTTTNTNTAKPSTNK
EEEEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
PSNSTVKTYTVKKGDSLWAISRQYKTTVDNIKAWNKLTSNMIHVGQKLTIK
CCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MQKTRKERILEALQEEKKNKKSKKFKTGATIAGVTAIATSITVPGIEVIVSADETAPADE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHH
ASKSAEANTTKETPATATPENTTEPTVEAKQTETKEQTKTAEENQAAAKQVEKAPAEPAT
HHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VSNPDNATSSSTPATYNLLQKSALRSGATVQSFIQTIQASSSQIAAENDLYASVMIAQAI
CCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LESAYGTSELGSAPNYNLFGIKGAYNGQSYTKQTLEDDGKGNYYTITAKFRKYPSYHQSL
HHHHCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEEHHHCCCHHHHH
EDYAQVIRNGPSWNPNYYSKVWKSNTTSYKDATKALTGTYATDTAYATKLNDLISRYNLT
HHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
QYDSGKTTGGNSGSTGNTGNSSNTGNTSNAKIYTVVKGDSLWRIANNHKVTVANLKAWNN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCEEEEEECHHHCC
LKSDFIYPGQKLKVSAGSTTSDTNTSKPSTGTSTSKPSTGTSTNAKVYTVVKGDSLWRIA
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEE
NNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGSTSNTNTSKPSTNTNTSKPSTNTNTNAK
CCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VYTVAKGDSLWRIANNHKVTIANLKSWNNLKSDFIYPGQKLKVSAGTTTNTNTAKPSTNK
EEEEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
PSNSTVKTYTVKKGDSLWAISRQYKTTVDNIKAWNKLTSNMIHVGQKLTIK
CCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1347040; 2753858 [H]