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The map label for this gene is fruA [H]

Identifier: 226224742

GI number: 226224742

Start: 2220809

End: 2221906

Strand: Reverse

Name: fruA [H]

Synonym: Lm4b_02159

Alternate gene names: 226224742

Gene position: 2221906-2220809 (Counterclockwise)

Preceding gene: 226224743

Following gene: 226224741

Centisome position: 76.28

GC content: 42.26

Gene sequence:

>1098_bases
ATGATGAAAAAACTGCAAATCAAAAAACATGCACTTACAGCGATTTCGTATATGTTACCGTTAGTTGTTGCCTCGGGGTT
ACTTATTGCCATTGGAAATTTAACAAATGGACAAGTTATTGAAAACTACAAAGCACCTTATTCGATTCCAGATGCACTTG
TCTCTCTCGGTGTGCTTGGTATGGGACTGCTTGCTCCAGTTATTGCTGGTGCGATTGCCTATTCGATAGCAGATAGGCCG
GGAATTGCGCCAGGGTTACTTATGGGACTTATCGCCAATTCAATCGGTGCTGGATTTTTAGGCGGAATGCTTGGAGGATA
CTTAGTCGGTTATTTTGTACTTATTCTTGTGAAATATTTAAAAGTGCCAAAATGGGCGCAAGGTTTAATGCCAATGATGA
TTATTCCGCTTATTAGTAGTTTAGTCGTCGGGCTTCTGATGTACTTTGTTGTAGGGGTTCCAATCGTTTGGGCCACGGAG
GCGATGACAAGCTTCTTACAAGGCATGCAAGGCAGTATGCGCTTTGTTTTCGGAGCTGTACTTGGAGCTATGGCAGCATT
TGACTTTGGTGGACCTGTAAATAAAGTGGCCTCCTTATTCGCAGATGGGCTCCTTCTTGAAGGCGTCAAAGAACCAGAAG
CAGTAAAAATTCTTGCTTCGATGGTTCCGCCATTCGGGGTGACCCTTTCATGGGTAGTTTCCAAATTAATTAAAAAGAAA
AAATACACGAAGTCAGAAGAAGACAATATCAAAATTGCTTTCCCGATGGGGATTTGTATGATTACAGAAGGTGTTATTCC
CATTGCAGCGGTTGACCCCATTCGCGTTATTATTTCTTGTACACTTGGTGCGGCAGTCGGCGGAGGTCTTAGTATGACTT
GGGGAATTGGCTCACCAGTTCCATCAGGCGGAATGTTTATCGTCCCAGCAATGAATGAACCACTCTTATTCTGTTTAGCA
TTATTAATTGGTACTTGTGTCACAGCAGCCATGTTACTCATCTTGAAACGAGAACCTACTAAAGAAGAAGAACTCATTGC
TGACCAAGGATTAGAAGAGGAAGATGAAGTTGATCTGTCTGGAATTAAAATTTCATAA

Upstream 100 bases:

>100_bases
AAACGAGTTGTCGAAATTCCAACAGACCTAGCGATTAAAGCACCAAAACAAATTATTAATAAAATAGACAAAGAAATAAA
TAACTAGGGAGTGAACCGGT

Downstream 100 bases:

>100_bases
GGTGAGGAGATTTTGAAATGTATGTGTCCATGAAAGGTATGTTAGAACGTGCGAACAAGGAGCATTATGCAGTAATGGCA
ATTAATTGTTTTAATCTGGA

Product: PTS system, fructose-specific enzyme IIC component

Products: NA

Alternate protein names: EIIBBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MMKKLQIKKHALTAISYMLPLVVASGLLIAIGNLTNGQVIENYKAPYSIPDALVSLGVLGMGLLAPVIAGAIAYSIADRP
GIAPGLLMGLIANSIGAGFLGGMLGGYLVGYFVLILVKYLKVPKWAQGLMPMMIIPLISSLVVGLLMYFVVGVPIVWATE
AMTSFLQGMQGSMRFVFGAVLGAMAAFDFGGPVNKVASLFADGLLLEGVKEPEAVKILASMVPPFGVTLSWVVSKLIKKK
KYTKSEEDNIKIAFPMGICMITEGVIPIAAVDPIRVIISCTLGAAVGGGLSMTWGIGSPVPSGGMFIVPAMNEPLLFCLA
LLIGTCVTAAMLLILKREPTKEEELIADQGLEEEDEVDLSGIKIS

Sequences:

>Translated_365_residues
MMKKLQIKKHALTAISYMLPLVVASGLLIAIGNLTNGQVIENYKAPYSIPDALVSLGVLGMGLLAPVIAGAIAYSIADRP
GIAPGLLMGLIANSIGAGFLGGMLGGYLVGYFVLILVKYLKVPKWAQGLMPMMIIPLISSLVVGLLMYFVVGVPIVWATE
AMTSFLQGMQGSMRFVFGAVLGAMAAFDFGGPVNKVASLFADGLLLEGVKEPEAVKILASMVPPFGVTLSWVVSKLIKKK
KYTKSEEDNIKIAFPMGICMITEGVIPIAAVDPIRVIISCTLGAAVGGGLSMTWGIGSPVPSGGMFIVPAMNEPLLFCLA
LLIGTCVTAAMLLILKREPTKEEELIADQGLEEEDEVDLSGIKIS
>Mature_365_residues
MMKKLQIKKHALTAISYMLPLVVASGLLIAIGNLTNGQVIENYKAPYSIPDALVSLGVLGMGLLAPVIAGAIAYSIADRP
GIAPGLLMGLIANSIGAGFLGGMLGGYLVGYFVLILVKYLKVPKWAQGLMPMMIIPLISSLVVGLLMYFVVGVPIVWATE
AMTSFLQGMQGSMRFVFGAVLGAMAAFDFGGPVNKVASLFADGLLLEGVKEPEAVKILASMVPPFGVTLSWVVSKLIKKK
KYTKSEEDNIKIAFPMGICMITEGVIPIAAVDPIRVIISCTLGAAVGGGLSMTWGIGSPVPSGGMFIVPAMNEPLLFCLA
LLIGTCVTAAMLLILKREPTKEEELIADQGLEEEDEVDLSGIKIS

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=333, Percent_Identity=42.3423423423423, Blast_Score=237, Evalue=9e-64,
Organism=Escherichia coli, GI1786951, Length=357, Percent_Identity=33.8935574229692, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1790386, Length=321, Percent_Identity=34.2679127725857, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87082348, Length=367, Percent_Identity=30.5177111716621, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788729, Length=385, Percent_Identity=22.5974025974026, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 38390; Mature: 38390

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKLQIKKHALTAISYMLPLVVASGLLIAIGNLTNGQVIENYKAPYSIPDALVSLGVLG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHH
MGLLAPVIAGAIAYSIADRPGIAPGLLMGLIANSIGAGFLGGMLGGYLVGYFVLILVKYL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVPKWAQGLMPMMIIPLISSLVVGLLMYFVVGVPIVWATEAMTSFLQGMQGSMRFVFGAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHH
LGAMAAFDFGGPVNKVASLFADGLLLEGVKEPEAVKILASMVPPFGVTLSWVVSKLIKKK
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KYTKSEEDNIKIAFPMGICMITEGVIPIAAVDPIRVIISCTLGAAVGGGLSMTWGIGSPV
HCCCCCCCCEEEEECCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
PSGGMFIVPAMNEPLLFCLALLIGTCVTAAMLLILKREPTKEEELIADQGLEEEDEVDLS
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
GIKIS
CCEEC
>Mature Secondary Structure
MMKKLQIKKHALTAISYMLPLVVASGLLIAIGNLTNGQVIENYKAPYSIPDALVSLGVLG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHH
MGLLAPVIAGAIAYSIADRPGIAPGLLMGLIANSIGAGFLGGMLGGYLVGYFVLILVKYL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVPKWAQGLMPMMIIPLISSLVVGLLMYFVVGVPIVWATEAMTSFLQGMQGSMRFVFGAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHH
LGAMAAFDFGGPVNKVASLFADGLLLEGVKEPEAVKILASMVPPFGVTLSWVVSKLIKKK
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KYTKSEEDNIKIAFPMGICMITEGVIPIAAVDPIRVIISCTLGAAVGGGLSMTWGIGSPV
HCCCCCCCCEEEEECCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
PSGGMFIVPAMNEPLLFCLALLIGTCVTAAMLLILKREPTKEEELIADQGLEEEDEVDLS
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
GIKIS
CCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2254279 [H]