Click here to switch to the map view.

The map label for this gene is resD

Identifier: 226224553

GI number: 226224553

Start: 2017326

End: 2018042

Strand: Reverse

Name: resD

Synonym: Lm4b_01967

Alternate gene names: 226224553

Gene position: 2018042-2017326 (Counterclockwise)

Preceding gene: 226224554

Following gene: 226224552

Centisome position: 69.28

GC content: 40.31

Gene sequence:

>717_bases
ATGAGTGAACAAGTTAGAGTGCTTGTTGTGGATGATGAGGACCGGATACGACGCCTTCTTAAGATGTATCTTGAAAGAGA
AAACTATCGTATTGAAGAAGCTAGTGATGGTGATCAAGCATTAAGCATGGCGCTGAACAATAATTATGAAGTAATCCTAC
TTGATTTAATGATGCCTGGTAAAGATGGCATCGAAGTTTGTCGTGAACTGAGAGAGTTTAAATCCACACCTGTTGTCATG
TTGACTGCAAAAGGAGAGGAAGCTAACCGAGTACAAGGCTTTGAAGTTGGTGCAGATGATTACATCGTAAAACCATTTAG
CCCAAGAGAAGTTGTGCTTCGCGTGAAAGCTGTTCTTCGTCGCGCCAAACAATCCTCAGAAGAATCAGCAGGAGGAACAC
CGGGAGACATTATTACCTTCCCACATTTGAAAATTGATAACGAAGCTCACCGTGTTATTGTCGACGGAAAAGAAATCGGT
TTGACACCGAAAGAATATGACTTGCTTTATTATTTAGCGAGATCTCCGGATAAAGTATTCGACCGCGAGTCTCTTTTAAA
AGAAGTATGGCGTTATGAATTCTTTGGCGATTTGCGAACAATTGATACACACGTTAAAAGACTTCGCGAAAAATTGCATG
ATGTATCAGAAGACGCTGCTAGAATGATTGTAACAGTTTGGGGTCTTGGATATAAATTTGAAGTTCCAGAAGATTAA

Upstream 100 bases:

>100_bases
AATTGTATGGTTTTTTCGTATGTGGGTACGGAAGATTCCATTTATCTGATTGAATGTAAATGATCGTTTTATGTAAATGA
GAGTTAGGGGATGAGTACTT

Downstream 100 bases:

>100_bases
TAAACCAGACTAAGATAACGGGCAAAGACGTTTAATCGGCAAGTGTTATGCCGCACGTGCTTTGTTCGTTATTTTTTTGC
GAGGACCGAGGTGAGAATAG

Product: two-component response regulator (ResD)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSEQVRVLVVDDEDRIRRLLKMYLERENYRIEEASDGDQALSMALNNNYEVILLDLMMPGKDGIEVCRELREFKSTPVVM
LTAKGEEANRVQGFEVGADDYIVKPFSPREVVLRVKAVLRRAKQSSEESAGGTPGDIITFPHLKIDNEAHRVIVDGKEIG
LTPKEYDLLYYLARSPDKVFDRESLLKEVWRYEFFGDLRTIDTHVKRLREKLHDVSEDAARMIVTVWGLGYKFEVPED

Sequences:

>Translated_238_residues
MSEQVRVLVVDDEDRIRRLLKMYLERENYRIEEASDGDQALSMALNNNYEVILLDLMMPGKDGIEVCRELREFKSTPVVM
LTAKGEEANRVQGFEVGADDYIVKPFSPREVVLRVKAVLRRAKQSSEESAGGTPGDIITFPHLKIDNEAHRVIVDGKEIG
LTPKEYDLLYYLARSPDKVFDRESLLKEVWRYEFFGDLRTIDTHVKRLREKLHDVSEDAARMIVTVWGLGYKFEVPED
>Mature_237_residues
SEQVRVLVVDDEDRIRRLLKMYLERENYRIEEASDGDQALSMALNNNYEVILLDLMMPGKDGIEVCRELREFKSTPVVML
TAKGEEANRVQGFEVGADDYIVKPFSPREVVLRVKAVLRRAKQSSEESAGGTPGDIITFPHLKIDNEAHRVIVDGKEIGL
TPKEYDLLYYLARSPDKVFDRESLLKEVWRYEFFGDLRTIDTHVKRLREKLHDVSEDAARMIVTVWGLGYKFEVPED

Specific function: Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=43.9130434782609, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=41.1255411255411, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI1789809, Length=243, Percent_Identity=38.2716049382716, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI87082012, Length=231, Percent_Identity=36.3636363636364, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=37.280701754386, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=38.4955752212389, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=35.042735042735, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=36.0869565217391, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.5789473684211, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.8777292576419, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=233, Percent_Identity=30.4721030042918, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=31.6017316017316, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790552, Length=235, Percent_Identity=29.7872340425532, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=35.5371900826446, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788191, Length=110, Percent_Identity=32.7272727272727, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788713, Length=108, Percent_Identity=35.1851851851852, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788222, Length=117, Percent_Identity=31.6239316239316, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27482; Mature: 27351

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQVRVLVVDDEDRIRRLLKMYLERENYRIEEASDGDQALSMALNNNYEVILLDLMMPG
CCCCEEEEEECCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCCCCEEEEEEEECCC
KDGIEVCRELREFKSTPVVMLTAKGEEANRVQGFEVGADDYIVKPFSPREVVLRVKAVLR
CHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCEEECCCCHHHHHHHHHHHHH
RAKQSSEESAGGTPGDIITFPHLKIDNEAHRVIVDGKEIGLTPKEYDLLYYLARSPDKVF
HHHHCCCCCCCCCCCCEEEECCEEECCCCCEEEECCHHHCCCCCHHHEEEEEECCCHHHH
DRESLLKEVWRYEFFGDLRTIDTHVKRLREKLHDVSEDAARMIVTVWGLGYKFEVPED
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCC
>Mature Secondary Structure 
SEQVRVLVVDDEDRIRRLLKMYLERENYRIEEASDGDQALSMALNNNYEVILLDLMMPG
CCCEEEEEECCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCCCCEEEEEEEECCC
KDGIEVCRELREFKSTPVVMLTAKGEEANRVQGFEVGADDYIVKPFSPREVVLRVKAVLR
CHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCEEECCCCHHHHHHHHHHHHH
RAKQSSEESAGGTPGDIITFPHLKIDNEAHRVIVDGKEIGLTPKEYDLLYYLARSPDKVF
HHHHCCCCCCCCCCCCEEEECCEEECCCCCEEEECCHHHCCCCCHHHEEEEEECCCHHHH
DRESLLKEVWRYEFFGDLRTIDTHVKRLREKLHDVSEDAARMIVTVWGLGYKFEVPED
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715; 8682783 [H]