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The map label for this gene is resE

Identifier: 226224552

GI number: 226224552

Start: 2015435

End: 2017225

Strand: Reverse

Name: resE

Synonym: Lm4b_01966

Alternate gene names: 226224552

Gene position: 2017225-2015435 (Counterclockwise)

Preceding gene: 226224553

Following gene: 226224551

Centisome position: 69.26

GC content: 35.51

Gene sequence:

>1791_bases
ATGAAGATTTGGAATAGTATTGTTGGGAAAATTTGGAGTACCATTATTCTCTTACTGATAGGGATTTTAGTTATTTCTGG
ATTTTTAGTTGCAATGATTTATGAAAAAAATAACATTACTCAAATAACAAATGAATTAGAAGACAAAACAGCTAGTATCA
TCACTGTAATGCAAGAAAATAATGAAGTAATCTCTGCTGAAAATAATAATGATTCTGCACTGATACTACTTGATGATACG
ATGGGCGTCATTATCGAACAAAATGGAAAAAGCGTCTATCAATCACAGTCACCAGATACCATTTCTAGTGCATCTGCTAA
TAAATTAATTCAAGATAAGACATTAGATAAAGCTTTAGAAAAAGATAATAGTGTAACGATGAAATATAATTTTAAAACAG
AAAAAAGCTCCTTACCGGTTGAAATTTCTGCACAGAAATTCAAACTAGCGAACGGTGAAACTGGTGTTGTTTACGTTTAT
CAGTCTTACCATGATATTCTAAAAGTGAACGAAAAAACGATGAGTACTTTGATTATTTCGGGTATTATTGCGATAGTCAT
CACGTCTATCTTATCTTTCGTCTTTTCTTCTCGCATGGCTTTCCCGCTTCGTGAAATGAAAAAAATTGCGATTGCTGTTT
CTAAAGGGAACTTTGATAATCGCGTACCAACTTATACGCATGATGAAATTGGTGAACTCGGAGTAGCTTTTAACGATATG
GCAAAGCAATTGAAGTATAATGTTAGCGCCCTTAGGCAAGAAAAGGAACAGCTATCCAATATTTTAGTTGGGATGGCTGA
TGGTGTTATTAAATTTAGTGTGGATAAAACGATCATTCTTAGTAATCCGCCGGCAGAAGAATTTTTACATAATTGGTTCT
TCTCACCTGAAAATACCGAAAAAGTGCTCATTCCAGTGGCTTTAAATGAATTATTGAATGATACGTTAGAAAAGAAAGAA
TCTCAAGTCGGAGAAATTACGTTTGCTGATCATACGTATGTTGCCATTTTAACACTTTTGTATACAGGGGAACATGTGCG
TAGTGTCGTTGCGGTTATTCGCGATATGACCGAAGAGAAACAACTTGAAAAAATGAAAAGCGATTTTGTTAATAATGTTT
CGCATGAACTTAGAACGCCGATTTCGATGTTACAAGGTTATAGTGAAGCGATTATTGACGGGGTTGCTCAGTCGGATGAA
GAAGTGCGGGAGTTTGCACAAATTATTTACGATGAATCCCTTCGTATTGGGCGTTTGGTTAATGATATGCTAGACCTTGC
TAGAATGGAAGCTGGTTTTAATCAAATGGATAATCAAAAATTACCGCTCGCTCCATTGCTGCGAAAAGTTATTTCTAATT
TTGACGTTCTTGCGAAAGAGAATTATGTGGAACTCGGCTTAGAGCTTGAAACTCCCGATTTAGAGTATTCCTATGACCCC
GACCGGATGGAGCAAGTATTAATTAATTTAATTATGAACGCTATTCGTCATACTGGAAAAGAAGGCTATGATGGAAAAGT
AATTTTAAAACAAACCATTGATGAAGCTAGAAGCAATCTTGTAATCACAGTATCTGACAACGGTAGTGGGATTGCGGAAG
AAGACATCCCATATCTGTTTGAGCGTTTTTATAAAGTGGATAAAGCAAGGAAACGCGGAAAAGCAGTTGGAACAGGTATT
GGTCTTGCAATCGTTAAGAATATTGTAGAAGCACATAATGGGAAAATTTCGGTTGAAAGCGAATTAGGTAAAGGATCTGA
TTTTATTATCACTTTGCCTCTCTATAAATAG

Upstream 100 bases:

>100_bases
TAAACCAGACTAAGATAACGGGCAAAGACGTTTAATCGGCAAGTGTTATGCCGCACGTGCTTTGTTCGTTATTTTTTTGC
GAGGACCGAGGTGAGAATAG

Downstream 100 bases:

>100_bases
ATTGGAGCGAAAAACATGGAAAAAAGACAAACAAAATTTTGCAAAGAATCACTAGTAATTAAAACAAGCCGGGTTTTCCC
GTCGGACACGAATAATCATA

Product: two-component sensor histidine kinase (ResE)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MKIWNSIVGKIWSTIILLLIGILVISGFLVAMIYEKNNITQITNELEDKTASIITVMQENNEVISAENNNDSALILLDDT
MGVIIEQNGKSVYQSQSPDTISSASANKLIQDKTLDKALEKDNSVTMKYNFKTEKSSLPVEISAQKFKLANGETGVVYVY
QSYHDILKVNEKTMSTLIISGIIAIVITSILSFVFSSRMAFPLREMKKIAIAVSKGNFDNRVPTYTHDEIGELGVAFNDM
AKQLKYNVSALRQEKEQLSNILVGMADGVIKFSVDKTIILSNPPAEEFLHNWFFSPENTEKVLIPVALNELLNDTLEKKE
SQVGEITFADHTYVAILTLLYTGEHVRSVVAVIRDMTEEKQLEKMKSDFVNNVSHELRTPISMLQGYSEAIIDGVAQSDE
EVREFAQIIYDESLRIGRLVNDMLDLARMEAGFNQMDNQKLPLAPLLRKVISNFDVLAKENYVELGLELETPDLEYSYDP
DRMEQVLINLIMNAIRHTGKEGYDGKVILKQTIDEARSNLVITVSDNGSGIAEEDIPYLFERFYKVDKARKRGKAVGTGI
GLAIVKNIVEAHNGKISVESELGKGSDFIITLPLYK

Sequences:

>Translated_596_residues
MKIWNSIVGKIWSTIILLLIGILVISGFLVAMIYEKNNITQITNELEDKTASIITVMQENNEVISAENNNDSALILLDDT
MGVIIEQNGKSVYQSQSPDTISSASANKLIQDKTLDKALEKDNSVTMKYNFKTEKSSLPVEISAQKFKLANGETGVVYVY
QSYHDILKVNEKTMSTLIISGIIAIVITSILSFVFSSRMAFPLREMKKIAIAVSKGNFDNRVPTYTHDEIGELGVAFNDM
AKQLKYNVSALRQEKEQLSNILVGMADGVIKFSVDKTIILSNPPAEEFLHNWFFSPENTEKVLIPVALNELLNDTLEKKE
SQVGEITFADHTYVAILTLLYTGEHVRSVVAVIRDMTEEKQLEKMKSDFVNNVSHELRTPISMLQGYSEAIIDGVAQSDE
EVREFAQIIYDESLRIGRLVNDMLDLARMEAGFNQMDNQKLPLAPLLRKVISNFDVLAKENYVELGLELETPDLEYSYDP
DRMEQVLINLIMNAIRHTGKEGYDGKVILKQTIDEARSNLVITVSDNGSGIAEEDIPYLFERFYKVDKARKRGKAVGTGI
GLAIVKNIVEAHNGKISVESELGKGSDFIITLPLYK
>Mature_596_residues
MKIWNSIVGKIWSTIILLLIGILVISGFLVAMIYEKNNITQITNELEDKTASIITVMQENNEVISAENNNDSALILLDDT
MGVIIEQNGKSVYQSQSPDTISSASANKLIQDKTLDKALEKDNSVTMKYNFKTEKSSLPVEISAQKFKLANGETGVVYVY
QSYHDILKVNEKTMSTLIISGIIAIVITSILSFVFSSRMAFPLREMKKIAIAVSKGNFDNRVPTYTHDEIGELGVAFNDM
AKQLKYNVSALRQEKEQLSNILVGMADGVIKFSVDKTIILSNPPAEEFLHNWFFSPENTEKVLIPVALNELLNDTLEKKE
SQVGEITFADHTYVAILTLLYTGEHVRSVVAVIRDMTEEKQLEKMKSDFVNNVSHELRTPISMLQGYSEAIIDGVAQSDE
EVREFAQIIYDESLRIGRLVNDMLDLARMEAGFNQMDNQKLPLAPLLRKVISNFDVLAKENYVELGLELETPDLEYSYDP
DRMEQVLINLIMNAIRHTGKEGYDGKVILKQTIDEARSNLVITVSDNGSGIAEEDIPYLFERFYKVDKARKRGKAVGTGI
GLAIVKNIVEAHNGKISVESELGKGSDFIITLPLYK

Specific function: Member of the two-component regulatory system resD/resE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates resD [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=265, Percent_Identity=35.8490566037736, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=37.7682403433476, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790436, Length=286, Percent_Identity=29.7202797202797, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI48994928, Length=247, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=34.5833333333333, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=29.4820717131474, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI145693157, Length=357, Percent_Identity=28.2913165266106, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1790346, Length=248, Percent_Identity=29.4354838709677, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=29.6943231441048, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788549, Length=485, Percent_Identity=24.9484536082474, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081816, Length=242, Percent_Identity=30.1652892561983, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=261, Percent_Identity=29.5019157088123, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082128, Length=253, Percent_Identity=28.4584980237154, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790300, Length=362, Percent_Identity=27.6243093922652, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=28.169014084507, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=27.6595744680851, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=29.9145299145299, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1789403, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789808, Length=258, Percent_Identity=26.7441860465116, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=243, Percent_Identity=23.0452674897119, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66704; Mature: 66704

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIWNSIVGKIWSTIILLLIGILVISGFLVAMIYEKNNITQITNELEDKTASIITVMQEN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECC
NEVISAENNNDSALILLDDTMGVIIEQNGKSVYQSQSPDTISSASANKLIQDKTLDKALE
CCEEEECCCCCCEEEEEECCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
KDNSVTMKYNFKTEKSSLPVEISAQKFKLANGETGVVYVYQSYHDILKVNEKTMSTLIIS
CCCCEEEEEEEECCCCCCCEEEECCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
GIIAIVITSILSFVFSSRMAFPLREMKKIAIAVSKGNFDNRVPTYTHDEIGELGVAFNDM
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHCHHHHHH
AKQLKYNVSALRQEKEQLSNILVGMADGVIKFSVDKTIILSNPPAEEFLHNWFFSPENTE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCHHHHHHHCCCCCCCCC
KVLIPVALNELLNDTLEKKESQVGEITFADHTYVAILTLLYTGEHVRSVVAVIRDMTEEK
EEEEHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QLEKMKSDFVNNVSHELRTPISMLQGYSEAIIDGVAQSDEEVREFAQIIYDESLRIGRLV
HHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHH
NDMLDLARMEAGFNQMDNQKLPLAPLLRKVISNFDVLAKENYVELGLELETPDLEYSYDP
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCCCCCCH
DRMEQVLINLIMNAIRHTGKEGYDGKVILKQTIDEARSNLVITVSDNGSGIAEEDIPYLF
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHH
ERFYKVDKARKRGKAVGTGIGLAIVKNIVEAHNGKISVESELGKGSDFIITLPLYK
HHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCC
>Mature Secondary Structure
MKIWNSIVGKIWSTIILLLIGILVISGFLVAMIYEKNNITQITNELEDKTASIITVMQEN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECC
NEVISAENNNDSALILLDDTMGVIIEQNGKSVYQSQSPDTISSASANKLIQDKTLDKALE
CCEEEECCCCCCEEEEEECCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
KDNSVTMKYNFKTEKSSLPVEISAQKFKLANGETGVVYVYQSYHDILKVNEKTMSTLIIS
CCCCEEEEEEEECCCCCCCEEEECCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
GIIAIVITSILSFVFSSRMAFPLREMKKIAIAVSKGNFDNRVPTYTHDEIGELGVAFNDM
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHCHHHHHH
AKQLKYNVSALRQEKEQLSNILVGMADGVIKFSVDKTIILSNPPAEEFLHNWFFSPENTE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCHHHHHHHCCCCCCCCC
KVLIPVALNELLNDTLEKKESQVGEITFADHTYVAILTLLYTGEHVRSVVAVIRDMTEEK
EEEEHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QLEKMKSDFVNNVSHELRTPISMLQGYSEAIIDGVAQSDEEVREFAQIIYDESLRIGRLV
HHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHH
NDMLDLARMEAGFNQMDNQKLPLAPLLRKVISNFDVLAKENYVELGLELETPDLEYSYDP
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCCCCCCH
DRMEQVLINLIMNAIRHTGKEGYDGKVILKQTIDEARSNLVITVSDNGSGIAEEDIPYLF
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHH
ERFYKVDKARKRGKAVGTGIGLAIVKNIVEAHNGKISVESELGKGSDFIITLPLYK
HHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715 [H]