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The map label for this gene is ffh

Identifier: 226224404

GI number: 226224404

Start: 1860017

End: 1861369

Strand: Reverse

Name: ffh

Synonym: Lm4b_01817

Alternate gene names: 226224404

Gene position: 1861369-1860017 (Counterclockwise)

Preceding gene: 226224405

Following gene: 226224403

Centisome position: 63.91

GC content: 40.87

Gene sequence:

>1353_bases
ATGGCATTTGAAGGACTAGCTGGAAGACTCCAAGAAACAATGAACAAAATTCGCGGCAAAGGGAAAGTAAACGAAGCTGA
CGTAAAAGAAATGATGCGTGAAGTTCGTCTTGCTCTACTTGAAGCCGATGTTAACTTTAAAGTCGTTAAACAATTTATTA
AAACAGTAAGCGAACGTGCTGTCGGCGCGGACGTTATGAAAAGCCTAACACCCGGCCAACAAGTTATCAAAATCGTTCAA
GAAGAACTAACAAGCTTAATGGGCGGAGAAGAAAGCAAAATCGGAACAGCGGACCGCCCACCAACCGTGATTATGATGGT
AGGTTTACAAGGGGCTGGTAAAACAACGACTTCCGGCAAACTTGCTAATTTATTACGCAAAAAATATAACCGTAAACCAT
TACTTGTCGCAGCAGATATTTACCGACCTGCCGCAATCAAACAATTAGAAACACTTGGCAAGCAATTAGATATGCCGGTA
TTTTCTCTAGGAGACCAAGTAAGCCCGGTAGAAATCGCCAAACAAGCTATTGCTAAAGCAAAAGAAGAACATTTAGATTA
TGTTATTATCGATACAGCGGGTCGTCTTCATATTGACGAAACGCTAATGGATGAGTTAAAACAAGTGAAAGAAATTGCAA
CGCCAACCGAAATCCTGCTTGTTGTCGATTCCATGACTGGGCAAGATGCTGTCAACGTGGCGCAAAGCTTCAACGAACAA
TTAGAAATTACAGGTGTCGTGCTAACCAAATTAGACGGTGATACACGTGGTGGTGCAGCGCTTTCGATTCGTTCCGTCAC
TGGCAAACCAATTAAATTTATCGCGACTGGTGAAAAAATGGAAGCTCTAGAAACTTTCCATCCAGATCGTATGGCTTCCA
GAATTCTCGGCATGGGCGATGTGCTTTCCCTGATTGAAAAAGCGCAAACCGATGTAGATACAGAAAAAATGAAAGCTATG
GAACAAAAAATGAAAGACAACAGCATGACGCTAGATGACTTCTTAGAACAGTTACAACAAGTAAAACAAATGGGACCACT
AGATGAACTACTTAAAATGATGCCAGGGGCAAACAAAATGAAAGGCCTCGACAACATGAACGTCGATGATAAACAACTAG
GTCATATTGAAGCAATTATCAAGTCAATGACCAAAAATGAAAAAGACAATCCAGATATCATCAATGCAAGTAGAAGAAAA
CGGATTGCACGTGGTAGCGGACGTCCGGTTCAAGAAATTAACCGTCTCCTAAAACAATTTGGTGAAATGAAAAAAATGAT
GAAGCAAATGACTGGTGGCGGCAAAGGCAAAAAAGGCAAAAATCCATTCGGCAATTTCAAAATGCCATTTTAA

Upstream 100 bases:

>100_bases
TAGTCAATTAGAAGCACAATTAACCAAGAAGAATTTTCTGGACGAGCAAGTGAAAGATACGCTCGAACAGCTTAAAAATA
TCGATTAGGAGGCCAGAATC

Downstream 100 bases:

>100_bases
TTCTAAAAGTCAAAACCCATTCCGGGTTTTGGCTTTTTTTCATACCTTAACATCCCTAAAATCATTTCTTTACAAACCCT
TCATTCAACCAACAAATTGC

Product: signal recognition particle protein Ffh

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MAFEGLAGRLQETMNKIRGKGKVNEADVKEMMREVRLALLEADVNFKVVKQFIKTVSERAVGADVMKSLTPGQQVIKIVQ
EELTSLMGGEESKIGTADRPPTVIMMVGLQGAGKTTTSGKLANLLRKKYNRKPLLVAADIYRPAAIKQLETLGKQLDMPV
FSLGDQVSPVEIAKQAIAKAKEEHLDYVIIDTAGRLHIDETLMDELKQVKEIATPTEILLVVDSMTGQDAVNVAQSFNEQ
LEITGVVLTKLDGDTRGGAALSIRSVTGKPIKFIATGEKMEALETFHPDRMASRILGMGDVLSLIEKAQTDVDTEKMKAM
EQKMKDNSMTLDDFLEQLQQVKQMGPLDELLKMMPGANKMKGLDNMNVDDKQLGHIEAIIKSMTKNEKDNPDIINASRRK
RIARGSGRPVQEINRLLKQFGEMKKMMKQMTGGGKGKKGKNPFGNFKMPF

Sequences:

>Translated_450_residues
MAFEGLAGRLQETMNKIRGKGKVNEADVKEMMREVRLALLEADVNFKVVKQFIKTVSERAVGADVMKSLTPGQQVIKIVQ
EELTSLMGGEESKIGTADRPPTVIMMVGLQGAGKTTTSGKLANLLRKKYNRKPLLVAADIYRPAAIKQLETLGKQLDMPV
FSLGDQVSPVEIAKQAIAKAKEEHLDYVIIDTAGRLHIDETLMDELKQVKEIATPTEILLVVDSMTGQDAVNVAQSFNEQ
LEITGVVLTKLDGDTRGGAALSIRSVTGKPIKFIATGEKMEALETFHPDRMASRILGMGDVLSLIEKAQTDVDTEKMKAM
EQKMKDNSMTLDDFLEQLQQVKQMGPLDELLKMMPGANKMKGLDNMNVDDKQLGHIEAIIKSMTKNEKDNPDIINASRRK
RIARGSGRPVQEINRLLKQFGEMKKMMKQMTGGGKGKKGKNPFGNFKMPF
>Mature_449_residues
AFEGLAGRLQETMNKIRGKGKVNEADVKEMMREVRLALLEADVNFKVVKQFIKTVSERAVGADVMKSLTPGQQVIKIVQE
ELTSLMGGEESKIGTADRPPTVIMMVGLQGAGKTTTSGKLANLLRKKYNRKPLLVAADIYRPAAIKQLETLGKQLDMPVF
SLGDQVSPVEIAKQAIAKAKEEHLDYVIIDTAGRLHIDETLMDELKQVKEIATPTEILLVVDSMTGQDAVNVAQSFNEQL
EITGVVLTKLDGDTRGGAALSIRSVTGKPIKFIATGEKMEALETFHPDRMASRILGMGDVLSLIEKAQTDVDTEKMKAME
QKMKDNSMTLDDFLEQLQQVKQMGPLDELLKMMPGANKMKGLDNMNVDDKQLGHIEAIIKSMTKNEKDNPDIINASRRKR
IARGSGRPVQEINRLLKQFGEMKKMMKQMTGGGKGKKGKNPFGNFKMPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=451, Percent_Identity=33.7028824833703, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI226371618, Length=345, Percent_Identity=35.9420289855072, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI89061728, Length=142, Percent_Identity=38.0281690140845, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI23308697, Length=318, Percent_Identity=27.0440251572327, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI295424842, Length=318, Percent_Identity=27.0440251572327, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=54.0094339622642, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.2075471698113, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=454, Percent_Identity=30.8370044052863, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI193206261, Length=261, Percent_Identity=31.8007662835249, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=433, Percent_Identity=32.7944572748268, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=318, Percent_Identity=28.3018867924528, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17647949, Length=446, Percent_Identity=31.390134529148, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24641198, Length=336, Percent_Identity=25.5952380952381, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49701; Mature: 49570

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLAGRLQETMNKIRGKGKVNEADVKEMMREVRLALLEADVNFKVVKQFIKTVSERA
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGADVMKSLTPGQQVIKIVQEELTSLMGGEESKIGTADRPPTVIMMVGLQGAGKTTTSGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHH
LANLLRKKYNRKPLLVAADIYRPAAIKQLETLGKQLDMPVFSLGDQVSPVEIAKQAIAKA
HHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KEEHLDYVIIDTAGRLHIDETLMDELKQVKEIATPTEILLVVDSMTGQDAVNVAQSFNEQ
HHHCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCC
LEITGVVLTKLDGDTRGGAALSIRSVTGKPIKFIATGEKMEALETFHPDRMASRILGMGD
EEEEEEEEEEECCCCCCCCEEEEECCCCCCEEEEECCHHHHHHHHCCHHHHHHHHHCHHH
VLSLIEKAQTDVDTEKMKAMEQKMKDNSMTLDDFLEQLQQVKQMGPLDELLKMMPGANKM
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHH
KGLDNMNVDDKQLGHIEAIIKSMTKNEKDNPDIINASRRKRIARGSGRPVQEINRLLKQF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
GEMKKMMKQMTGGGKGKKGKNPFGNFKMPF
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AFEGLAGRLQETMNKIRGKGKVNEADVKEMMREVRLALLEADVNFKVVKQFIKTVSERA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGADVMKSLTPGQQVIKIVQEELTSLMGGEESKIGTADRPPTVIMMVGLQGAGKTTTSGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHH
LANLLRKKYNRKPLLVAADIYRPAAIKQLETLGKQLDMPVFSLGDQVSPVEIAKQAIAKA
HHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KEEHLDYVIIDTAGRLHIDETLMDELKQVKEIATPTEILLVVDSMTGQDAVNVAQSFNEQ
HHHCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCC
LEITGVVLTKLDGDTRGGAALSIRSVTGKPIKFIATGEKMEALETFHPDRMASRILGMGD
EEEEEEEEEEECCCCCCCCEEEEECCCCCCEEEEECCHHHHHHHHCCHHHHHHHHHCHHH
VLSLIEKAQTDVDTEKMKAMEQKMKDNSMTLDDFLEQLQQVKQMGPLDELLKMMPGANKM
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHH
KGLDNMNVDDKQLGHIEAIIKSMTKNEKDNPDIINASRRKRIARGSGRPVQEINRLLKQF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
GEMKKMMKQMTGGGKGKKGKNPFGNFKMPF
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]