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The map label for this gene is comEB

Identifier: 226224084

GI number: 226224084

Start: 1501313

End: 1501873

Strand: Reverse

Name: comEB

Synonym: Lm4b_01493

Alternate gene names: 226224084

Gene position: 1501873-1501313 (Counterclockwise)

Preceding gene: 226224085

Following gene: 226224083

Centisome position: 51.56

GC content: 38.32

Gene sequence:

>561_bases
GTGCAGAGAATCGCATGGGATCAGTTTTTTATGGCGCAAAGTCATCTAATATCATCTAGGAGCACGTGTACACGACTAAT
GGTCGGTGCGACAATAGTTCGAGATAAACGTATTATTGCGGGCGGATATAATGGGTCCATCGCTGGTGGCGATCATTGTG
CAGAACACGGCTGTTATGTTGTAGACGGTCACTGCATTCGAACAATACATGCAGAGATGAACGCGATTTTACAATGTGCT
AAATTTGGTGCAACGACAGATAAAGCTGAATTATATGTAACGCATTTCCCTTGTCTTGCTTGTACGAAATCTATTATTCA
AGCAGGTATAAAGAAAGTGTATTTCGCTAAAGACTACAAAAACCATCCGTACGCTTTAGAATTATTTAACATTGCTGGCG
TCGAATTACAAAAAGTAGAATTTGATGAATCTGTTCTTCAAGTAAACAATTGGAATGGAGAAAAAATGCATACTTTAGTA
AAAGAAGCTGCAGTGGAAGTAAATATCGAACCAGAAAAAGCAGAGCAACTTTATCAAAACATCTCAGAGAAATTGAACTA
A

Upstream 100 bases:

>100_bases
AATTAAAAGAATATTTGGATGTTAATTAATAAAAGTGGTTGACGAACTTCCTTCTAAACACCTATACTAATATTTATCAA
ATCATAAGGGAGTTTTTAAT

Downstream 100 bases:

>100_bases
ATAGGGAGGGGACGTTATCGAGCGATATTTAGCTATTATTGTTTTAGCTATTGTTTGTGCGAATTTTACAAGCTCTATCG
TTCCCATATGTATTTGTTTG

Product: ComEB protein

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MQRIAWDQFFMAQSHLISSRSTCTRLMVGATIVRDKRIIAGGYNGSIAGGDHCAEHGCYVVDGHCIRTIHAEMNAILQCA
KFGATTDKAELYVTHFPCLACTKSIIQAGIKKVYFAKDYKNHPYALELFNIAGVELQKVEFDESVLQVNNWNGEKMHTLV
KEAAVEVNIEPEKAEQLYQNISEKLN

Sequences:

>Translated_186_residues
MQRIAWDQFFMAQSHLISSRSTCTRLMVGATIVRDKRIIAGGYNGSIAGGDHCAEHGCYVVDGHCIRTIHAEMNAILQCA
KFGATTDKAELYVTHFPCLACTKSIIQAGIKKVYFAKDYKNHPYALELFNIAGVELQKVEFDESVLQVNNWNGEKMHTLV
KEAAVEVNIEPEKAEQLYQNISEKLN
>Mature_186_residues
MQRIAWDQFFMAQSHLISSRSTCTRLMVGATIVRDKRIIAGGYNGSIAGGDHCAEHGCYVVDGHCIRTIHAEMNAILQCA
KFGATTDKAELYVTHFPCLACTKSIIQAGIKKVYFAKDYKNHPYALELFNIAGVELQKVEFDESVLQVNNWNGEKMHTLV
KEAAVEVNIEPEKAEQLYQNISEKLN

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=147, Percent_Identity=37.4149659863946, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI61742821, Length=147, Percent_Identity=37.4149659863946, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321938, Length=149, Percent_Identity=34.2281879194631, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 20826; Mature: 20826

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRIAWDQFFMAQSHLISSRSTCTRLMVGATIVRDKRIIAGGYNGSIAGGDHCAEHGCYV
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHCCCEE
VDGHCIRTIHAEMNAILQCAKFGATTDKAELYVTHFPCLACTKSIIQAGIKKVYFAKDYK
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHEEEECCCC
NHPYALELFNIAGVELQKVEFDESVLQVNNWNGEKMHTLVKEAAVEVNIEPEKAEQLYQN
CCCEEEEEEEECCCEEEEEECCCHHEEEECCCCHHHHHHHHHHHEEEECCHHHHHHHHHH
ISEKLN
HHHHCC
>Mature Secondary Structure
MQRIAWDQFFMAQSHLISSRSTCTRLMVGATIVRDKRIIAGGYNGSIAGGDHCAEHGCYV
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHCCCEE
VDGHCIRTIHAEMNAILQCAKFGATTDKAELYVTHFPCLACTKSIIQAGIKKVYFAKDYK
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHEEEECCCC
NHPYALELFNIAGVELQKVEFDESVLQVNNWNGEKMHTLVKEAAVEVNIEPEKAEQLYQN
CCCEEEEEEEECCCEEEEEECCCHHEEEECCCCHHHHHHHHHHHEEEECCHHHHHHHHHH
ISEKLN
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]