Click here to switch to the map view.

The map label for this gene is comEA

Identifier: 226224085

GI number: 226224085

Start: 1501945

End: 1502547

Strand: Reverse

Name: comEA

Synonym: Lm4b_01494

Alternate gene names: 226224085

Gene position: 1502547-1501945 (Counterclockwise)

Preceding gene: 226224086

Following gene: 226224084

Centisome position: 51.59

GC content: 36.48

Gene sequence:

>603_bases
ATGATGGACTTAGTAAAAAAACACAAAAATTATATCTTAATAGGGATTGCTATTCTTTGTGCTGGTTTAGTTTATATTTG
GATACCAGATAGTAAATCTGATGCTGTAACTGCCAATCAAGCAGTAACGAAAGAAGAAAAACCGAAGAAAGAAGAAACAA
AATTATCAAATGAAGTTTATATTGACATTAAAGGAGCAGTAAGGACCCCTGGTGTCTATAAACTGCCAATGGACGCTAGA
GTTCAAGATGTGGTGAAAATTGCAGGAGGGCTCACAGCTGAAGCCGATTGCAGTAAATTGAATTTAGCTGAAAAACTAAA
AGACGAGATGAGTATCTACGTTTATAAAAAGGGAGAAGAAGGTCCCGCAACACAAGGAGCTAACACAGAAGAAGCAAGTA
CCGGTTCTGCGAAAATTAACCTTAACAGTGCAACGAAGGACGATTTACAACAAGTCCCAGGGATTGGAGAATCGAAGGCA
ACAGCGATAATAGAGTACCGAGAAAAAGAAGGCTTATTCCAAACAATAGAAGATTTAAAAAATGTTTCAGGCATCGGCGA
AAAAACAGTAGAGAAATTAAAAGAATATTTGGATGTTAATTAA

Upstream 100 bases:

>100_bases
TTTCATTATTACTTTCTTTTTTTGTGCGATTTTCACCTTAAACTATCAAAAAGGAATTTGTCCTAGCATGGCGAATAGTA
TATTAAGGACGGTGATATGG

Downstream 100 bases:

>100_bases
TAAAAGTGGTTGACGAACTTCCTTCTAAACACCTATACTAATATTTATCAAATCATAAGGGAGTTTTTAATGTGCAGAGA
ATCGCATGGGATCAGTTTTT

Product: integral membrane protein ComEA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MMDLVKKHKNYILIGIAILCAGLVYIWIPDSKSDAVTANQAVTKEEKPKKEETKLSNEVYIDIKGAVRTPGVYKLPMDAR
VQDVVKIAGGLTAEADCSKLNLAEKLKDEMSIYVYKKGEEGPATQGANTEEASTGSAKINLNSATKDDLQQVPGIGESKA
TAIIEYREKEGLFQTIEDLKNVSGIGEKTVEKLKEYLDVN

Sequences:

>Translated_200_residues
MMDLVKKHKNYILIGIAILCAGLVYIWIPDSKSDAVTANQAVTKEEKPKKEETKLSNEVYIDIKGAVRTPGVYKLPMDAR
VQDVVKIAGGLTAEADCSKLNLAEKLKDEMSIYVYKKGEEGPATQGANTEEASTGSAKINLNSATKDDLQQVPGIGESKA
TAIIEYREKEGLFQTIEDLKNVSGIGEKTVEKLKEYLDVN
>Mature_200_residues
MMDLVKKHKNYILIGIAILCAGLVYIWIPDSKSDAVTANQAVTKEEKPKKEETKLSNEVYIDIKGAVRTPGVYKLPMDAR
VQDVVKIAGGLTAEADCSKLNLAEKLKDEMSIYVYKKGEEGPATQGANTEEASTGSAKINLNSATKDDLQQVPGIGESKA
TAIIEYREKEGLFQTIEDLKNVSGIGEKTVEKLKEYLDVN

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 21867; Mature: 21867

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDLVKKHKNYILIGIAILCAGLVYIWIPDSKSDAVTANQAVTKEEKPKKEETKLSNEVY
CCCHHHHCCCEEEEHHHHHHHCEEEEEECCCCCCCEECCHHHCCCCCCCHHHHHCCCEEE
IDIKGAVRTPGVYKLPMDARVQDVVKIAGGLTAEADCSKLNLAEKLKDEMSIYVYKKGEE
EEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCC
GPATQGANTEEASTGSAKINLNSATKDDLQQVPGIGESKATAIIEYREKEGLFQTIEDLK
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCHHEEEEEHHHCCHHHHHHHHH
NVSGIGEKTVEKLKEYLDVN
HHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MMDLVKKHKNYILIGIAILCAGLVYIWIPDSKSDAVTANQAVTKEEKPKKEETKLSNEVY
CCCHHHHCCCEEEEHHHHHHHCEEEEEECCCCCCCEECCHHHCCCCCCCHHHHHCCCEEE
IDIKGAVRTPGVYKLPMDARVQDVVKIAGGLTAEADCSKLNLAEKLKDEMSIYVYKKGEE
EEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCC
GPATQGANTEEASTGSAKINLNSATKDDLQQVPGIGESKATAIIEYREKEGLFQTIEDLK
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCHHEEEEEHHHCCHHHHHHHHH
NVSGIGEKTVEKLKEYLDVN
HHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]