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The map label for this gene is cobC [H]

Identifier: 226223750

GI number: 226223750

Start: 1161505

End: 1162080

Strand: Direct

Name: cobC [H]

Synonym: Lm4b_01154

Alternate gene names: 226223750

Gene position: 1161505-1162080 (Clockwise)

Preceding gene: 226223749

Following gene: 226223752

Centisome position: 39.88

GC content: 38.72

Gene sequence:

>576_bases
GTGCAACTTATTTTTGTGCGACACGGAGAAACGGACTGGAATGTAGCGAAAAAATATTGTGGTCAGTTAGATGTCGCGTT
AAATGAAAATGGTATTCGACAAATGGAGCAACTCCGCGAAAAGCTGGAGAATTACTCGATCGATTTAGTTGTTACGAGTG
ATCTTATGCGCGTGAAGCAGTCGGCAAATATTTTAAGTAACGCAAAGACGCTTCGGTTTCCGGCTTTGAATGAAATGAAT
TTCGGTGACTTTGAAGGTTATACATATCAGGAAATTAGCACTAAGTTTCCAAAGGCGTGGAATGAATACTGTAATAACTG
GCAAACGGCACTATTTCCAAATGGGGAAAGTTTTCCGATATTTTATGAGCGAGTAGTTGCGATATTAGAAGAAGAAATGG
AAAAATGGCAGCAACTTGATACGGTGTTGCTCGTGGGTCATCTCGGTGTTTTACGAGTCATTGCGCTTTTTTTACAAAAA
CAAACTATAGCACAATATTGGGATATCGATTTTAAGCAAGGATGTTATTCGCTCTGGGACAACAAATCTCAACATTTTCT
TATTTCTAATCAATAG

Upstream 100 bases:

>100_bases
ACGGATTGGTGGTATGAATGGGGATACGCTTGGTGCGGGTGGACAAATGGGACAACTTATTTGTTTATTTTGTTTAGTGC
TGCTTTGGGGGTTGATTTAA

Downstream 100 bases:

>100_bases
TAGATTTTTGTTGTTTCAGATGAAAACGCTTTTTTTATAAATACTTTGTGGTAAGATGTAGGTAGTTAAATAGGTCTTAT
GTTGGTGGAATGTATGTACA

Product: alpha-ribazole-5'-phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MQLIFVRHGETDWNVAKKYCGQLDVALNENGIRQMEQLREKLENYSIDLVVTSDLMRVKQSANILSNAKTLRFPALNEMN
FGDFEGYTYQEISTKFPKAWNEYCNNWQTALFPNGESFPIFYERVVAILEEEMEKWQQLDTVLLVGHLGVLRVIALFLQK
QTIAQYWDIDFKQGCYSLWDNKSQHFLISNQ

Sequences:

>Translated_191_residues
MQLIFVRHGETDWNVAKKYCGQLDVALNENGIRQMEQLREKLENYSIDLVVTSDLMRVKQSANILSNAKTLRFPALNEMN
FGDFEGYTYQEISTKFPKAWNEYCNNWQTALFPNGESFPIFYERVVAILEEEMEKWQQLDTVLLVGHLGVLRVIALFLQK
QTIAQYWDIDFKQGCYSLWDNKSQHFLISNQ
>Mature_191_residues
MQLIFVRHGETDWNVAKKYCGQLDVALNENGIRQMEQLREKLENYSIDLVVTSDLMRVKQSANILSNAKTLRFPALNEMN
FGDFEGYTYQEISTKFPKAWNEYCNNWQTALFPNGESFPIFYERVVAILEEEMEKWQQLDTVLLVGHLGVLRVIALFLQK
QTIAQYWDIDFKQGCYSLWDNKSQHFLISNQ

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=183, Percent_Identity=32.7868852459016, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790856, Length=157, Percent_Identity=29.9363057324841, Blast_Score=66, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510917, Length=159, Percent_Identity=32.7044025157233, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993390, Length=159, Percent_Identity=32.7044025157233, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322306, Length=155, Percent_Identity=34.1935483870968, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 22448; Mature: 22448

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLIFVRHGETDWNVAKKYCGQLDVALNENGIRQMEQLREKLENYSIDLVVTSDLMRVKQ
CEEEEEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
SANILSNAKTLRFPALNEMNFGDFEGYTYQEISTKFPKAWNEYCNNWQTALFPNGESFPI
HHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCEEECCCCCCCHH
FYERVVAILEEEMEKWQQLDTVLLVGHLGVLRVIALFLQKQTIAQYWDIDFKQGCYSLWD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
NKSQHFLISNQ
CCCCEEEEECC
>Mature Secondary Structure
MQLIFVRHGETDWNVAKKYCGQLDVALNENGIRQMEQLREKLENYSIDLVVTSDLMRVKQ
CEEEEEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
SANILSNAKTLRFPALNEMNFGDFEGYTYQEISTKFPKAWNEYCNNWQTALFPNGESFPI
HHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCEEECCCCCCCHH
FYERVVAILEEEMEKWQQLDTVLLVGHLGVLRVIALFLQKQTIAQYWDIDFKQGCYSLWD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
NKSQHFLISNQ
CCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]