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The map label for this gene is yisQ [H]

Identifier: 226223234

GI number: 226223234

Start: 647534

End: 648874

Strand: Reverse

Name: yisQ [H]

Synonym: Lm4b_00631

Alternate gene names: 226223234

Gene position: 648874-647534 (Counterclockwise)

Preceding gene: 226223239

Following gene: 226223233

Centisome position: 22.28

GC content: 40.64

Gene sequence:

>1341_bases
GTGAGTTCAGTACATAAAGTCGCCAGCATAAGTCTTTTTACGCTTGCTTGGCCGATTTTTCTAGAGCAATTTTTACGTCT
GATGATTAGTTATATTGATGTCTTTATGTTGGGGCATTATTCAGATGATGCGGTAGCTGCGACAGGGGTAGCAAATCAGA
TTCTTGTTATTTCTATTATTATTTACGGCTTTATCAGTGTTGGCGTACAGATTATCGTTGCCCAAATGATTGGTGCCAAA
AAACATAAAGAAATTGAAAATGTGATTACAAATGGCTTAGTGGTCGCTTTCTTAATTGGAATTGTGATGAGTATTATTTT
CATTTTTATGTCGAAAAACTTCCTGACTTGGATGGGAATTGATCCTCATTTAGTTCAAGTTGGTGCACCGTTTTTAGAAA
TTATCGGTGGAAGCTCGGTTGTTATCGCTATTCATGCTTCGATTTTGCCTATTCTCCGGGCGCATGGTTACGTAAGACAA
TCCATTCTTGTTCCTGTGACGATTAGCATTATCAATGTTGTCGGTAATTACTTATTCCTGTACGGCCCGCTTGCATACTT
AGATTACGGGGTAGCAGGTGTTGGTATTTCCACTGCTGTCGCAAACTTCGTCGGAATGGGTCTAGCCATCTGGATGCTTC
GAAAATATATCGGCTATACTTTCCATTTCAAAAAACTGGAGCAAGTTTCCAAAAAATTACTTTATTCGATTTTACGACTT
GGCCTTCCCTCTGCTGGGGAAAATTTATCGTATGCCGGCTCGCAACTAGTTGTTACCGCAATTATTGCGATTCTTGGTAC
AGAGGCGCTTACCACAAAAGTTTATGCTTCGACGGTTAGCCAGTTTGTCGCACTCTTTGCTATCGCGCTCGGTCAGGCCT
CTCAAATTATTATCGGTCGCGCGGTTGGTGCAAAAGAAATCGATAAAGCTTATAAGCAAGGTCTACGTAGTTGGAAGATT
GGTTTGGTTGTCGCAATTGTGGTCAGCGTTTCGATTTACCTTTTCGCGGAACCAATTATGAGTTTATTTACTACCAATAC
CGAAATCATTGCGATGACGAAAGAATTGTTCTTACTTTCGATTTTCCTAGAACTTGGACGTGCGACGAATATTATCATTA
TTAGCAGTCTTAACTCAACAGGCGATGTTCGTTTTCCATTTATATGCGGACTTATCGTTATGTGGATTGTTAGTTTGCCG
TTCTCCTATGTACTTGGTATCTCTGCTGGTCTTGGGCTTGTAGGTGTTTGGCTCGCCTATATTATTGATGAAGGCGTTCG
AGCTGTTCTAATGTACCGAAGATGGCGCAGTAAAGTTTGGTCCCTAAAATCAGTCATATAA

Upstream 100 bases:

>100_bases
TCAAGCGATATCTTGGAGCGATTTTGAAATTAATCTATACTTTTAACTTTAATTACCTTATAATGGCTTTAATTGTGTTA
ATGCGAAGGGAGGGAAATAA

Downstream 100 bases:

>100_bases
AGAAACGTCTCTTTGATTTTTTCGAAGAGGCGTTTTTGTATATGACAAAACTGTCATCTTCCTCTGTATATCGTCACCTA
ATTCGATGGTTCCATTTCTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSSVHKVASISLFTLAWPIFLEQFLRLMISYIDVFMLGHYSDDAVAATGVANQILVISIIIYGFISVGVQIIVAQMIGAK
KHKEIENVITNGLVVAFLIGIVMSIIFIFMSKNFLTWMGIDPHLVQVGAPFLEIIGGSSVVIAIHASILPILRAHGYVRQ
SILVPVTISIINVVGNYLFLYGPLAYLDYGVAGVGISTAVANFVGMGLAIWMLRKYIGYTFHFKKLEQVSKKLLYSILRL
GLPSAGENLSYAGSQLVVTAIIAILGTEALTTKVYASTVSQFVALFAIALGQASQIIIGRAVGAKEIDKAYKQGLRSWKI
GLVVAIVVSVSIYLFAEPIMSLFTTNTEIIAMTKELFLLSIFLELGRATNIIIISSLNSTGDVRFPFICGLIVMWIVSLP
FSYVLGISAGLGLVGVWLAYIIDEGVRAVLMYRRWRSKVWSLKSVI

Sequences:

>Translated_446_residues
MSSVHKVASISLFTLAWPIFLEQFLRLMISYIDVFMLGHYSDDAVAATGVANQILVISIIIYGFISVGVQIIVAQMIGAK
KHKEIENVITNGLVVAFLIGIVMSIIFIFMSKNFLTWMGIDPHLVQVGAPFLEIIGGSSVVIAIHASILPILRAHGYVRQ
SILVPVTISIINVVGNYLFLYGPLAYLDYGVAGVGISTAVANFVGMGLAIWMLRKYIGYTFHFKKLEQVSKKLLYSILRL
GLPSAGENLSYAGSQLVVTAIIAILGTEALTTKVYASTVSQFVALFAIALGQASQIIIGRAVGAKEIDKAYKQGLRSWKI
GLVVAIVVSVSIYLFAEPIMSLFTTNTEIIAMTKELFLLSIFLELGRATNIIIISSLNSTGDVRFPFICGLIVMWIVSLP
FSYVLGISAGLGLVGVWLAYIIDEGVRAVLMYRRWRSKVWSLKSVI
>Mature_445_residues
SSVHKVASISLFTLAWPIFLEQFLRLMISYIDVFMLGHYSDDAVAATGVANQILVISIIIYGFISVGVQIIVAQMIGAKK
HKEIENVITNGLVVAFLIGIVMSIIFIFMSKNFLTWMGIDPHLVQVGAPFLEIIGGSSVVIAIHASILPILRAHGYVRQS
ILVPVTISIINVVGNYLFLYGPLAYLDYGVAGVGISTAVANFVGMGLAIWMLRKYIGYTFHFKKLEQVSKKLLYSILRLG
LPSAGENLSYAGSQLVVTAIIAILGTEALTTKVYASTVSQFVALFAIALGQASQIIIGRAVGAKEIDKAYKQGLRSWKIG
LVVAIVVSVSIYLFAEPIMSLFTTNTEIIAMTKELFLLSIFLELGRATNIIIISSLNSTGDVRFPFICGLIVMWIVSLPF
SYVLGISAGLGLVGVWLAYIIDEGVRAVLMYRRWRSKVWSLKSVI

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=437, Percent_Identity=23.7986270022883, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI226510954, Length=441, Percent_Identity=24.4897959183673, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI48994890, Length=438, Percent_Identity=19.634703196347, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48673; Mature: 48542

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSVHKVASISLFTLAWPIFLEQFLRLMISYIDVFMLGHYSDDAVAATGVANQILVISII
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
IYGFISVGVQIIVAQMIGAKKHKEIENVITNGLVVAFLIGIVMSIIFIFMSKNFLTWMGI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
DPHLVQVGAPFLEIIGGSSVVIAIHASILPILRAHGYVRQSILVPVTISIINVVGNYLFL
CHHHHHHCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGPLAYLDYGVAGVGISTAVANFVGMGLAIWMLRKYIGYTFHFKKLEQVSKKLLYSILRL
HHHHHHHHHCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
GLPSAGENLSYAGSQLVVTAIIAILGTEALTTKVYASTVSQFVALFAIALGQASQIIIGR
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
AVGAKEIDKAYKQGLRSWKIGLVVAIVVSVSIYLFAEPIMSLFTTNTEIIAMTKELFLLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IFLELGRATNIIIISSLNSTGDVRFPFICGLIVMWIVSLPFSYVLGISAGLGLVGVWLAY
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IIDEGVRAVLMYRRWRSKVWSLKSVI
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]