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The map label for this gene is mngB [H]

Identifier: 226223031

GI number: 226223031

Start: 428403

End: 431036

Strand: Direct

Name: mngB [H]

Synonym: Lm4b_00425

Alternate gene names: 226223031

Gene position: 428403-431036 (Clockwise)

Preceding gene: 226223030

Following gene: 226223032

Centisome position: 14.71

GC content: 39.83

Gene sequence:

>2634_bases
ATGAAAATGGCTAAAACGAAAGTACACGTAATTCCGCATTCGCACTGGGATAGAGAATGGTATTTCACTTCAAGCCGTTC
AACAATCTATTTAGTGAAGCATTTAAAAGAAGTAATTGAAACATTGGAAGCGAAAGACGATTACCATTTTTACTTAATGG
ATGCCCAAAGCTCTTTAATAGAAGATTATTTGCGCTACTGCCCGGAAGATAAAACAAGATTAGAAAAACTGATTGCTGAA
AAACGGCTTATTACCGGGCCATGGTATACACAAACGGACCAATTAGTCATTTCACAAGAGTCGATTGTTAGAAACTTGTT
ATATGGTACGAGAATTGCACGCGAAATGGGACATAGCATGGCTGTCGGTTATGTCCCGGATGCATTCGGACAAGGCGGGA
ACATGCCACAAATTTATAAAGAATTTGGGATTTCAAAGTTTCTGTTTTGGCGCGGAGTTGCCGATAATCGCTTAAAACAA
ACCGAATTTATCTGGCGCGGTGATGATGGGACGGAAATGCTAGCAGAGCAAATTCCGTTTGGCTATTACTACGGCGCGAA
CATTCCGGAAAACGAAGCCGAACTTAAAACCTATTTGGATGATCAAATTGGTGCTCTGGAAGAGAAGGCCTCAACGCGAA
ATGTCTATTTCCCAAATGGCTTAGACCAAGCGCCAGTTAGGAAAAATTTGCCAGAATTAGTTGCGAAATTCAATGAATTA
GATAGCACGCGGGAATACCAAATCGCATCACCAGAAACATTTTTCGCGGACTTAGAAAAAGATGTGACCAATTTGCCAGT
CATTGCTGGTGAACTAACAGAAGGAAAACATAGTCGGCTGCACAAATCGATTTTCTCTACTCGAGCTGATTTAAAACAAG
CAAACAATGAAATCGAAAACTTTTTAAGTAATGTATTAGAGCCGGTTCTTTCCATCAGCTACTCTCTTGGAAATCGCTAT
CCGCACAATGAACTCGCAGAAATTTGGAAGTTAATGTTTGAAAATGCTGCACATGATAGCATTGGCGGCTGTAATAGTGA
TACAACCAACCGCGACGTCAAACATCGTTACAAATTGGCTTCGGATTTAGCGACCAATTTACTCGATTTAAACATGCGCC
TAATCAGCGAAAAAATCGAACAAAAACAACCGTTCCAATTTACCGTTTTCAACCCACTACCATACGAAAAAAGCGGTGTG
ATTAAAATGACCGCGTATATCCCAGAAGATAATTTCGAGATAGAAGATACGCAAGGAAACACGCTTGAATACACGATTTT
AGAAAAAACAGACCTAACTGATTACGTCTTAAATCAACATATCGACCTAAATCCTAGCAAATCCATTTATTTGCCAGAAA
AAGTCTTTTTAGCAACAATGCTAGTAAACGTAAATAGTCTTCCGGCGCTAGGCTACGACACCATCTACTTTAATTTAGAA
AAAGAAACAGCGGAGCAAGAACCAACACAATCCACCATGACAAAAATCGAAAACGAATTTTATGAAATCCAGCTAGCTGC
CAACAATTCACTCACGATTCATGATAAAAAAGCGGGCAGAACCTATACAGATCAAATGCTTTTTGTGGAAAATGGCGATG
ATGGCGATTCGTATAACTATTCGCCACCACGTAAAGACCTTGTAATCTCATCGGAAGAAGCGGTAGTGGAAAGCCTAGAG
TCTAGTATATCAAGCGTCAACCAAACATTAACTATTTCCTTCAAGTTAAATGTACCGTATAATTTAGAAGAACGTGCAAA
TGGTGAAAAAAATAACGAAATGACTATCAAAACAGTAATTTCTTTACGTAAAAATGAAGAACTCATTCGCTTTGATGTAC
AAGTTGCTAATCAAGTATTGAGTCATCGTTTATGTGTTACATTCGCCACCGAAATTGCTAGCAAATTCTCAACAGCTGAT
CAATTATTCGCACCAATCCAGCGTCCGGTTCGTCTTCCAGAAATGGATGTATGGGAAGCAGAAGAATGGCAAGAAGCGCC
AATTTCGATTGAAGCTATGCAAAGTTTTGTCAGCTTACACGATGAAGCTCATGGGGTTGCTGTAATGACAGAGGGCGTAC
GCGAATATGAAATCATTGGCGAAAATTATGATACGATCTCGCTAACCCTGTTCCGCACATTTAGCCATATGGGTAAAACT
GATTTACTATATCGTCCTGGTCGCGCTTCCGGTGAGTCAATCGTTGCGACACCAGACGCACAACTGCTTGGCGAAATAAA
TGCCACATTTGCGCTAACTTTATTCGAAAGCTCTTTTGACGAAGCGGATATCGCGAAAAAAGCAAAAGAATATCTATCGA
ACCCGCCAGTTTACCAAATGTCTGATTTCCTAAATGGCCGTTTGATTTATGTTTACCGCGATGAAGAAAAAACGCTAGAT
GCCACATATAGCCTGGCACTTCCGACAATAGATGGAGCGATTATTAGTGCAGTAAAAAAAGCCGAAGACGCCGATGCCTT
CATTACACGCTTTTTCAATCCATATTTACAAAAAGAAATTACCATCCCAGAAGTTTTCCAAGGCAAGGAACGCCACTTGG
ATGAAAGCGAATCAAACGAGAAACAAACGAGATTAAAACATGCAAAAGTACAAAGCTATTTATTTGAAAAATAA

Upstream 100 bases:

>100_bases
CAATTTCACAGAAGAAGAAACAGCTGCTGCAGACGATGCTGTGGATGATATCGATATTAGTTTTGATGAAATAGAGATTA
AATAATAGTTGGAGGATTTA

Downstream 100 bases:

>100_bases
CGCTTAACTACCTAAAAAAGGAGCTGCTAATAATGGGATATTTCGCTTATAAACGTTTGGAAACACTATATGGCATGCTC
CTTGATGCGGGTAGCCACTT

Product: alpha-mannosidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 877; Mature: 877

Protein sequence:

>877_residues
MKMAKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKDDYHFYLMDAQSSLIEDYLRYCPEDKTRLEKLIAE
KRLITGPWYTQTDQLVISQESIVRNLLYGTRIAREMGHSMAVGYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQ
TEFIWRGDDGTEMLAEQIPFGYYYGANIPENEAELKTYLDDQIGALEEKASTRNVYFPNGLDQAPVRKNLPELVAKFNEL
DSTREYQIASPETFFADLEKDVTNLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIENFLSNVLEPVLSISYSLGNRY
PHNELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLASDLATNLLDLNMRLISEKIEQKQPFQFTVFNPLPYEKSGV
IKMTAYIPEDNFEIEDTQGNTLEYTILEKTDLTDYVLNQHIDLNPSKSIYLPEKVFLATMLVNVNSLPALGYDTIYFNLE
KETAEQEPTQSTMTKIENEFYEIQLAANNSLTIHDKKAGRTYTDQMLFVENGDDGDSYNYSPPRKDLVISSEEAVVESLE
SSISSVNQTLTISFKLNVPYNLEERANGEKNNEMTIKTVISLRKNEELIRFDVQVANQVLSHRLCVTFATEIASKFSTAD
QLFAPIQRPVRLPEMDVWEAEEWQEAPISIEAMQSFVSLHDEAHGVAVMTEGVREYEIIGENYDTISLTLFRTFSHMGKT
DLLYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEADIAKKAKEYLSNPPVYQMSDFLNGRLIYVYRDEEKTLD
ATYSLALPTIDGAIISAVKKAEDADAFITRFFNPYLQKEITIPEVFQGKERHLDESESNEKQTRLKHAKVQSYLFEK

Sequences:

>Translated_877_residues
MKMAKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKDDYHFYLMDAQSSLIEDYLRYCPEDKTRLEKLIAE
KRLITGPWYTQTDQLVISQESIVRNLLYGTRIAREMGHSMAVGYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQ
TEFIWRGDDGTEMLAEQIPFGYYYGANIPENEAELKTYLDDQIGALEEKASTRNVYFPNGLDQAPVRKNLPELVAKFNEL
DSTREYQIASPETFFADLEKDVTNLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIENFLSNVLEPVLSISYSLGNRY
PHNELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLASDLATNLLDLNMRLISEKIEQKQPFQFTVFNPLPYEKSGV
IKMTAYIPEDNFEIEDTQGNTLEYTILEKTDLTDYVLNQHIDLNPSKSIYLPEKVFLATMLVNVNSLPALGYDTIYFNLE
KETAEQEPTQSTMTKIENEFYEIQLAANNSLTIHDKKAGRTYTDQMLFVENGDDGDSYNYSPPRKDLVISSEEAVVESLE
SSISSVNQTLTISFKLNVPYNLEERANGEKNNEMTIKTVISLRKNEELIRFDVQVANQVLSHRLCVTFATEIASKFSTAD
QLFAPIQRPVRLPEMDVWEAEEWQEAPISIEAMQSFVSLHDEAHGVAVMTEGVREYEIIGENYDTISLTLFRTFSHMGKT
DLLYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEADIAKKAKEYLSNPPVYQMSDFLNGRLIYVYRDEEKTLD
ATYSLALPTIDGAIISAVKKAEDADAFITRFFNPYLQKEITIPEVFQGKERHLDESESNEKQTRLKHAKVQSYLFEK
>Mature_877_residues
MKMAKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKDDYHFYLMDAQSSLIEDYLRYCPEDKTRLEKLIAE
KRLITGPWYTQTDQLVISQESIVRNLLYGTRIAREMGHSMAVGYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQ
TEFIWRGDDGTEMLAEQIPFGYYYGANIPENEAELKTYLDDQIGALEEKASTRNVYFPNGLDQAPVRKNLPELVAKFNEL
DSTREYQIASPETFFADLEKDVTNLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIENFLSNVLEPVLSISYSLGNRY
PHNELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLASDLATNLLDLNMRLISEKIEQKQPFQFTVFNPLPYEKSGV
IKMTAYIPEDNFEIEDTQGNTLEYTILEKTDLTDYVLNQHIDLNPSKSIYLPEKVFLATMLVNVNSLPALGYDTIYFNLE
KETAEQEPTQSTMTKIENEFYEIQLAANNSLTIHDKKAGRTYTDQMLFVENGDDGDSYNYSPPRKDLVISSEEAVVESLE
SSISSVNQTLTISFKLNVPYNLEERANGEKNNEMTIKTVISLRKNEELIRFDVQVANQVLSHRLCVTFATEIASKFSTAD
QLFAPIQRPVRLPEMDVWEAEEWQEAPISIEAMQSFVSLHDEAHGVAVMTEGVREYEIIGENYDTISLTLFRTFSHMGKT
DLLYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEADIAKKAKEYLSNPPVYQMSDFLNGRLIYVYRDEEKTLD
ATYSLALPTIDGAIISAVKKAEDADAFITRFFNPYLQKEITIPEVFQGKERHLDESESNEKQTRLKHAKVQSYLFEK

Specific function: May hydrolyze mannosyl-D-glycerate to mannose-6- phosphate and glycerate [H]

COG id: COG0383

COG function: function code G; Alpha-mannosidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 38 family [H]

Homologues:

Organism=Homo sapiens, GI46852164, Length=343, Percent_Identity=25.3644314868805, Blast_Score=85, Evalue=3e-16,
Organism=Escherichia coli, GI1786952, Length=834, Percent_Identity=34.8920863309352, Blast_Score=555, Evalue=1e-159,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011013
- InterPro:   IPR011330
- InterPro:   IPR011682
- InterPro:   IPR015341
- InterPro:   IPR000602 [H]

Pfam domain/function: PF09261 Alpha-mann_mid; PF01074 Glyco_hydro_38; PF07748 Glyco_hydro_38C [H]

EC number: NA

Molecular weight: Translated: 100349; Mature: 100349

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMAKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKDDYHFYLMDAQSSLI
CCCCCCEEEEECCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
EDYLRYCPEDKTRLEKLIAEKRLITGPWYTQTDQLVISQESIVRNLLYGTRIAREMGHSM
HHHHHHCCCHHHHHHHHHHHHHEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCE
AVGYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQTEFIWRGDDGTEMLAEQIPF
EEECCCHHCCCCCCCHHHHHHHCCHHEEHHCCCCCCCCCCCEEEEECCCHHHHHHHHCCC
GYYYGANIPENEAELKTYLDDQIGALEEKASTRNVYFPNGLDQAPVRKNLPELVAKFNEL
CEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHCCHHHHHHHHHHC
DSTREYQIASPETFFADLEKDVTNLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIEN
CCCCCEEECCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLSNVLEPVLSISYSLGNRYPHNELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
SDLATNLLDLNMRLISEKIEQKQPFQFTVFNPLPYEKSGVIKMTAYIPEDNFEIEDTQGN
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEECCCCC
TLEYTILEKTDLTDYVLNQHIDLNPSKSIYLPEKVFLATMLVNVNSLPALGYDTIYFNLE
EEEEEEEECCCCHHHHHHCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCEEEEEEEE
KETAEQEPTQSTMTKIENEFYEIQLAANNSLTIHDKKAGRTYTDQMLFVENGDDGDSYNY
HHHCCCCCHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCEECCEEEEEECCCCCCCCCC
SPPRKDLVISSEEAVVESLESSISSVNQTLTISFKLNVPYNLEERANGEKNNEMTIKTVI
CCCCCCEEECCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCCCCCCCEEHHHHH
SLRKNEELIRFDVQVANQVLSHRLCVTFATEIASKFSTADQLFAPIQRPVRLPEMDVWEA
HHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EEWQEAPISIEAMQSFVSLHDEAHGVAVMTEGVREYEIIGENYDTISLTLFRTFSHMGKT
HHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCEEEEHHHHHHHHCCCC
DLLYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEADIAKKAKEYLSNPPVYQM
CEEECCCCCCCCEEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHH
SDFLNGRLIYVYRDEEKTLDATYSLALPTIDGAIISAVKKAEDADAFITRFFNPYLQKEI
HHHCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHCHHHHCCC
TIPEVFQGKERHLDESESNEKQTRLKHAKVQSYLFEK
CCHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKMAKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKDDYHFYLMDAQSSLI
CCCCCCEEEEECCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
EDYLRYCPEDKTRLEKLIAEKRLITGPWYTQTDQLVISQESIVRNLLYGTRIAREMGHSM
HHHHHHCCCHHHHHHHHHHHHHEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCE
AVGYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQTEFIWRGDDGTEMLAEQIPF
EEECCCHHCCCCCCCHHHHHHHCCHHEEHHCCCCCCCCCCCEEEEECCCHHHHHHHHCCC
GYYYGANIPENEAELKTYLDDQIGALEEKASTRNVYFPNGLDQAPVRKNLPELVAKFNEL
CEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHCCHHHHHHHHHHC
DSTREYQIASPETFFADLEKDVTNLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIEN
CCCCCEEECCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLSNVLEPVLSISYSLGNRYPHNELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
SDLATNLLDLNMRLISEKIEQKQPFQFTVFNPLPYEKSGVIKMTAYIPEDNFEIEDTQGN
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEECCCCC
TLEYTILEKTDLTDYVLNQHIDLNPSKSIYLPEKVFLATMLVNVNSLPALGYDTIYFNLE
EEEEEEEECCCCHHHHHHCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCEEEEEEEE
KETAEQEPTQSTMTKIENEFYEIQLAANNSLTIHDKKAGRTYTDQMLFVENGDDGDSYNY
HHHCCCCCHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCEECCEEEEEECCCCCCCCCC
SPPRKDLVISSEEAVVESLESSISSVNQTLTISFKLNVPYNLEERANGEKNNEMTIKTVI
CCCCCCEEECCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCCCCCCCEEHHHHH
SLRKNEELIRFDVQVANQVLSHRLCVTFATEIASKFSTADQLFAPIQRPVRLPEMDVWEA
HHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EEWQEAPISIEAMQSFVSLHDEAHGVAVMTEGVREYEIIGENYDTISLTLFRTFSHMGKT
HHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCEEEEHHHHHHHHCCCC
DLLYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEADIAKKAKEYLSNPPVYQM
CEEECCCCCCCCEEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHH
SDFLNGRLIYVYRDEEKTLDATYSLALPTIDGAIISAVKKAEDADAFITRFFNPYLQKEI
HHHCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHCHHHHCCC
TIPEVFQGKERHLDESESNEKQTRLKHAKVQSYLFEK
CCHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 9063979 [H]