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The map label for this gene is 226222651

Identifier: 226222651

GI number: 226222651

Start: 14794

End: 15873

Strand: Direct

Name: 226222651

Synonym: Lm4b_00012

Alternate gene names: NA

Gene position: 14794-15873 (Clockwise)

Preceding gene: 226222650

Following gene: 226222653

Centisome position: 0.51

GC content: 39.17

Gene sequence:

>1080_bases
TTGTATCAGATGAAAAATAAACTACAGGTTAAAATACCCGGAAAATTATATGTAGCTGGTGAATATGCAGTTGTAGAATC
AGGTCATACGGCTATTCTAACTGCAGTTAATCGTTATATAACGCTAACTCTTGAAGATAGTGAACGCAATGAATTATGGA
TTCCACATTATGAAAATCCAGTTTCATGGCCAATTGGCGGAGAACTTAAACCAGACGGGGAACATTGGACGTTTACAGCT
GAAGCAATTAATATCGCGACAACTTTCCTGAAATCAGAAGGAATCGAGCTAACGCCTGTGAAAATGGTCATTGAAACAGA
ATTAATCGACCAATCTGGCGCAAAATATGGACTCGGTTCCAGTGCAGCGGCTACAGTTGCTGTAATCAACGCGCTAATGA
CGAAATTTTATCCAGAAATATCAATGCTTAAAAAATTCAAACTTGCTGCACTTTCGCATTTAGTAGTACAAGGAAATGGC
TCTTGTGGCGACATTGCTTCTTGTATGTATGGCGGCTGGATTGCGTATACAACGTTTGATCAAGAATGGGTGAAGCATCG
TTTGGCTTATAAATCACTCGAATGGTTTATGAAAGAGCCGTGGCCAATGCTTCAAATCGAAACATTGGAAGAACCAGTGC
CGACTTTTTCTGTCGGTTGGACGGGCACACCTGTAAGTACCGGAAAACTAGTTTCGCAAATTCATGCTTTTAAACAAGAA
GATAGCAAGAATTACCAACATTTTTTAACTAGAAATAACGAGATTATGAAGCAAATAATTCAAGCTTTCCATACGAAAGA
TGAGGAATTGCTTTATTCATCTATTAAAGAAAATCGTCGCATTCTTCAAGAACTTGGAACAAAAGCTGGCGTAAATATTG
AAACAAGCTTACTAAAAGAACTAGCGGACTCAGCTGAAAACATGGGTGGCGCAGGAAAATCATCTGGCTCTGGTGGAGGA
GACTGCGGAATAGCTTTCTCGAAAACGAAAGAACTAGCCGAAAAACTCGTTAATGAGTGGGAAAAGCTTGGTATTAAGCA
TTTACCTTTCCATACAGGGAGAGTTCAAATTACTGAATAA

Upstream 100 bases:

>100_bases
AAAGTTATTTGTGAGCGTGAAAATGAAAATATCGTAGCAGATAAGTTGTCAGGTTTGGCTAAAAACGTTCTAATTTGCCA
CGCTGGTAAGGAAGCGAGTG

Downstream 100 bases:

>100_bases
TGGGGATATATAATAAAAGCCGAACAACTTTTAAGTAAAAGTTGTTCGGCTTTTGTTTTAATCATTTAAAATAAAGTAAC
AAACTGAATCTTTTATTCAG

Product: mevalonate kinase

Products: ADP; (R)-5-diphosphomevalonate

Alternate protein names: Mevalonate Kinase; LOW QUALITY PROTEIN Phosphomevalonate Kinase; Isopentenyl-Diphosphate Delta-Isomerase

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSERNELWIPHYENPVSWPIGGELKPDGEHWTFTA
EAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLGSSAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGNG
SCGDIASCMYGGWIAYTTFDQEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQE
DSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLKELADSAENMGGAGKSSGSGGG
DCGIAFSKTKELAEKLVNEWEKLGIKHLPFHTGRVQITE

Sequences:

>Translated_359_residues
MYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSERNELWIPHYENPVSWPIGGELKPDGEHWTFTA
EAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLGSSAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGNG
SCGDIASCMYGGWIAYTTFDQEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQE
DSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLKELADSAENMGGAGKSSGSGGG
DCGIAFSKTKELAEKLVNEWEKLGIKHLPFHTGRVQITE
>Mature_359_residues
MYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSERNELWIPHYENPVSWPIGGELKPDGEHWTFTA
EAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLGSSAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGNG
SCGDIASCMYGGWIAYTTFDQEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQE
DSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLKELADSAENMGGAGKSSGSGGG
DCGIAFSKTKELAEKLVNEWEKLGIKHLPFHTGRVQITE

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.4.2

Molecular weight: Translated: 39997; Mature: 39997

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSERNELWIPHYENP
CCCCCCCEEEEECCEEEEECCEEEEECCCCCEEEEECEEEEEEEECCCCCCEECCCCCCC
VSWPIGGELKPDGEHWTFTAEAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLGS
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEHHHHEEEHHHHHCCCCCCCCCC
SAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGNGSCGDIASCMYGGWIAYTTFD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCEEEEECCC
QEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQE
HHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHH
DSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLKE
CCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LADSAENMGGAGKSSGSGGGDCGIAFSKTKELAEKLVNEWEKLGIKHLPFHTGRVQITE
HHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECC
>Mature Secondary Structure
MYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSERNELWIPHYENP
CCCCCCCEEEEECCEEEEECCEEEEECCCCCEEEEECEEEEEEEECCCCCCEECCCCCCC
VSWPIGGELKPDGEHWTFTAEAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLGS
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEHHHHEEEHHHHHCCCCCCCCCC
SAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGNGSCGDIASCMYGGWIAYTTFD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCEEEEECCC
QEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQE
HHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHH
DSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLKE
CCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LADSAENMGGAGKSSGSGGGDCGIAFSKTKELAEKLVNEWEKLGIKHLPFHTGRVQITE
HHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-phosphomevalonate

Specific reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA