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The map label for this gene is 226222650

Identifier: 226222650

GI number: 226222650

Start: 13842

End: 14813

Strand: Direct

Name: 226222650

Synonym: Lm4b_00011

Alternate gene names: NA

Gene position: 13842-14813 (Clockwise)

Preceding gene: 226222649

Following gene: 226222651

Centisome position: 0.48

GC content: 40.64

Gene sequence:

>972_bases
ATGAAAGCGACAGCCATCGCACACACGAATGTGGCGCTAATTAAATACTGGGGAAAACGCGATGAACACTTGATTCTACC
TGCAAACAGTAGTTTATCCTTCACGGTAGATAAATTTTATACAAAAACAACGGTAGAATGGGACGGAAATTTAGCCCAAG
ATACATTTATTCTAAATAATGAACACAAAACGGATGCAAAAGTAGCTCGTTTTATAGATAAAATGCGTGAAGAATTCGGT
ATTTCAGCAAAAGCAAAAATCACTTCCGAAAATCACGTTCCAACTGCGGCCGGGCTTGCTTCATCGGCTTCTGCATTTGC
AGCTCTTGCACTTGCTGGATCTAGCGCTGCTGGCAGAAAAGACACAAAAGAATATATTTCCAGACTGGCTCGTTTCGGGT
CTGGTTCTGCTTCTCGTTCCGTTTTCGGAGATTTTGTCATTTGGGAAAAAGGCGAACTCGCGGACGGTAGTGATTCATTT
GCAGTACCTTTCACCAACAAATTATGTGATAAAATGTCTCTTGTAGTCGCAGTCGTTTCGGATAAAGAAAAGAAAGTTTC
TAGTCGGGATGGAATGCGCCTAACTGTTGAAACATCACCGTTTTTCGAAAAATGGGTTTCTGCTGCTGAAACAGACTTGG
AAGAAATGAAACAAGCTATTTTGGATGAAGATTTCATCAAAGTGGGCGAAATCACAGAACGAAACGGAATGAAAATGCAT
GCGACAACGCTTGGTGCCGAGCCTCCATTTACTTATTTTCAACCGAAGTCCCTTGAAATAATGGATGCTGTTAGAGAATT
ACGAGAAAATGGTATACCGGCCTATTTTACAATGGATGCTGGTCCAAATGTTAAAGTTATTTGTGAGCGTGAAAATGAAA
ATATCGTAGCAGATAAGTTGTCAGGTTTGGCTAAAAACGTTCTAATTTGCCACGCTGGTAAGGAAGCGAGTGTTGTATCA
GATGAAAAATAA

Upstream 100 bases:

>100_bases
GCTGTAGCAAAAAATCAAGAAATCGCTGAACAAATAACGAAGGAGCTTCATAATGCTGGAGCTGCACAAGAATGGATTTT
TACGATTGGAGAAGGTAGTT

Downstream 100 bases:

>100_bases
ACTACAGGTTAAAATACCCGGAAAATTATATGTAGCTGGTGAATATGCAGTTGTAGAATCAGGTCATACGGCTATTCTAA
CTGCAGTTAATCGTTATATA

Product: mevalonate diphosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase; GHMP Kinase Domain-Containing Protein; Phosphomevalonate Kinase; Ghmp Kinase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDGNLAQDTFILNNEHKTDAKVARFIDKMREEFG
ISAKAKITSENHVPTAAGLASSASAFAALALAGSSAAGRKDTKEYISRLARFGSGSASRSVFGDFVIWEKGELADGSDSF
AVPFTNKLCDKMSLVVAVVSDKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKQAILDEDFIKVGEITERNGMKMH
ATTLGAEPPFTYFQPKSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVADKLSGLAKNVLICHAGKEASVVS
DEK

Sequences:

>Translated_323_residues
MKATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDGNLAQDTFILNNEHKTDAKVARFIDKMREEFG
ISAKAKITSENHVPTAAGLASSASAFAALALAGSSAAGRKDTKEYISRLARFGSGSASRSVFGDFVIWEKGELADGSDSF
AVPFTNKLCDKMSLVVAVVSDKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKQAILDEDFIKVGEITERNGMKMH
ATTLGAEPPFTYFQPKSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVADKLSGLAKNVLICHAGKEASVVS
DEK
>Mature_323_residues
MKATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDGNLAQDTFILNNEHKTDAKVARFIDKMREEFG
ISAKAKITSENHVPTAAGLASSASAFAALALAGSSAAGRKDTKEYISRLARFGSGSASRSVFGDFVIWEKGELADGSDSF
AVPFTNKLCDKMSLVVAVVSDKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKQAILDEDFIKVGEITERNGMKMH
ATTLGAEPPFTYFQPKSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVADKLSGLAKNVLICHAGKEASVVS
DEK

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=308, Percent_Identity=35.7142857142857, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17537201, Length=315, Percent_Identity=34.2857142857143, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17537203, Length=168, Percent_Identity=35.7142857142857, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324371, Length=313, Percent_Identity=39.6166134185303, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28571205, Length=297, Percent_Identity=36.026936026936, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 35394; Mature: 35394

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDGNLAQDTFILNN
CCCCEEEECCEEEEEECCCCCCEEEEECCCCCEEEEEHEEEEEEEEECCCCCCCEEEECC
EHKTDAKVARFIDKMREEFGISAKAKITSENHVPTAAGLASSASAFAALALAGSSAAGRK
CCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DTKEYISRLARFGSGSASRSVFGDFVIWEKGELADGSDSFAVPFTNKLCDKMSLVVAVVS
HHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCCCCCCCCEECCCHHHHHHHHHEEEEEEC
DKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKQAILDEDFIKVGEITERNGMKMH
CCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCEECCCCCEEE
ATTLGAEPPFTYFQPKSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVADKL
EEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCHHHHH
SGLAKNVLICHAGKEASVVSDEK
HHHHCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDGNLAQDTFILNN
CCCCEEEECCEEEEEECCCCCCEEEEECCCCCEEEEEHEEEEEEEEECCCCCCCEEEECC
EHKTDAKVARFIDKMREEFGISAKAKITSENHVPTAAGLASSASAFAALALAGSSAAGRK
CCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DTKEYISRLARFGSGSASRSVFGDFVIWEKGELADGSDSFAVPFTNKLCDKMSLVVAVVS
HHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCCCCCCCCEECCCHHHHHHHHHEEEEEEC
DKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKQAILDEDFIKVGEITERNGMKMH
CCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCEECCCCCEEE
ATTLGAEPPFTYFQPKSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVADKL
EEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCHHHHH
SGLAKNVLICHAGKEASVVSDEK
HHHHCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA