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The map label for this gene is adhA [H]

Identifier: 225858134

GI number: 225858134

Start: 303282

End: 304301

Strand: Reverse

Name: adhA [H]

Synonym: SP70585_0344

Alternate gene names: 225858134

Gene position: 304301-303282 (Counterclockwise)

Preceding gene: 225858135

Following gene: 225858133

Centisome position: 13.93

GC content: 45.98

Gene sequence:

>1020_bases
ATGAAAGCTGTTGTTGTAAATCCAGAAAGCACTGGTGTTGCTATTGAAGAAAAAGTACTCCGTCCACTTGAAACTGGGGA
AGCACTTGTAGAAGTTGAATACTGTGGTGTTTGCCACACCGACCTCCACGTTGCTCATGGTGACTTTGGTCAAGTCCCAG
GACGTGTTCTTGGGCACGAAGGTATCGGTATCGTTAAAGAGATTGCTCCAGATGTGAAAAGCCTTAAAGTCGGTGACCGC
GTCAGCGTTGCTTGGTTCTTTGAAGGATGTGGCACTTGCGAATACTGTACAACTGGTCGCGAAACCCTTTGCCGTACAGT
GAAAAATGCTGGCTACTCAGTAGACGGTGGTATGGCTGAACAATGTATCGTAACTGCTGACTATGCTGTCAAAGTTCCTG
ACGGACTTGATCCAGCCCAAGCTTCTTCTATCACATGTGCTGGAGTAACAACCTATAAAGCTATCAAAGAAGCAAAAGTT
GAACCAGGCCAATGGGTTGTTCTTTACGGTGCTGGTGGACTTGGTAACCTCGCTGTTCAATACGCTAAAAAAGTATTCAA
TGCTCATGTTATCGCAGTCGATATCAACAATGACAAACTTGCCCTTGCAAAAGAAGTAGGCGCTGACATTGTGATTAACG
GCCTCGAAGTTGAAGATGTAGCTGGACTCATCAAAGAAAAAACTGATGGAGGAGCTCATTCAGCTGTCGTAACTGCTGTG
TCTAAAGTTGCCTTCAACCAGGCTGTTGACTCCGTTCGTGCTGGTGGTCGCGTCGTCGCTGTTGGTCTTCCTTCTGAAAT
GATGGAACTCAGCATCGTTAAAACAGTCCTCGATGGAATCCAAGTCATCGGTTCTCTTGTCGGAACTCGTAAAGACTTAG
AAGAAGCCTTCCAATTTGGTGCAGAAGGTCTGGTAGTCCCAGTTGTTCAAAAACGTCCAGTAGAAGATGCTGTTGCCATT
TTCGACGAAATGGAAAAAGGCCAAATCCAAGGACGTATGGTACTCGACTTCACCCACTAA

Upstream 100 bases:

>100_bases
ACATATAAATACAAGAGAGCTCGTCACACTCGACTCTGTTGACAAAAAATCAATCCAGTCCCGTTGTCCCTGTTCTCGGT
CAATATCAAGGAGGATAGCT

Downstream 100 bases:

>100_bases
TCTAATAGAAACCTATTTTAAAAGTTGGAAACTTCTTCCAACTTTTTTATATTAAATTTTTAAATAAGAATTCAAGATTA
CTCCTCAAAAACTCAACATA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase I; ADH I [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHVAHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDR
VSVAWFFEGCGTCEYCTTGRETLCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKV
EPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVEDVAGLIKEKTDGGAHSAVVTAV
SKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTVLDGIQVIGSLVGTRKDLEEAFQFGAEGLVVPVVQKRPVEDAVAI
FDEMEKGQIQGRMVLDFTH

Sequences:

>Translated_339_residues
MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHVAHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDR
VSVAWFFEGCGTCEYCTTGRETLCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKV
EPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVEDVAGLIKEKTDGGAHSAVVTAV
SKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTVLDGIQVIGSLVGTRKDLEEAFQFGAEGLVVPVVQKRPVEDAVAI
FDEMEKGQIQGRMVLDFTH
>Mature_339_residues
MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHVAHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDR
VSVAWFFEGCGTCEYCTTGRETLCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKV
EPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVEDVAGLIKEKTDGGAHSAVVTAV
SKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTVLDGIQVIGSLVGTRKDLEEAFQFGAEGLVVPVVQKRPVEDAVAI
FDEMEKGQIQGRMVLDFTH

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=30.1075268817204, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=30.6451612903226, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI71565154, Length=255, Percent_Identity=32.156862745098, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=29.1891891891892, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=25, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71743840, Length=233, Percent_Identity=29.1845493562232, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI262073058, Length=233, Percent_Identity=29.1845493562232, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI156627571, Length=312, Percent_Identity=26.2820512820513, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI156523966, Length=255, Percent_Identity=27.843137254902, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4501939, Length=255, Percent_Identity=27.843137254902, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=68.141592920354, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1790045, Length=351, Percent_Identity=28.7749287749288, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=28.5714285714286, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788073, Length=245, Percent_Identity=31.0204081632653, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786518, Length=319, Percent_Identity=26.6457680250784, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082401, Length=325, Percent_Identity=26.7692307692308, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788075, Length=332, Percent_Identity=28.0120481927711, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI226510992, Length=285, Percent_Identity=29.1228070175439, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082125, Length=347, Percent_Identity=25.6484149855908, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790718, Length=323, Percent_Identity=27.5541795665635, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786825, Length=360, Percent_Identity=26.3888888888889, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786552, Length=215, Percent_Identity=33.0232558139535, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788407, Length=218, Percent_Identity=29.3577981651376, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790485, Length=345, Percent_Identity=25.5072463768116, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=345, Percent_Identity=35.6521739130435, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=36.7952522255193, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17562582, Length=316, Percent_Identity=37.9746835443038, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17562876, Length=267, Percent_Identity=31.0861423220974, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562878, Length=268, Percent_Identity=31.3432835820896, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=25.7372654155496, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=25.6, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=358, Percent_Identity=25.1396648044693, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=315, Percent_Identity=39.6825396825397, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=39.6284829721362, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323729, Length=315, Percent_Identity=39.0476190476191, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323961, Length=315, Percent_Identity=39.0476190476191, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319949, Length=329, Percent_Identity=29.483282674772, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323980, Length=328, Percent_Identity=28.6585365853659, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=352, Percent_Identity=28.125, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322619, Length=326, Percent_Identity=27.9141104294479, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=326, Percent_Identity=27.6073619631902, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=312, Percent_Identity=26.6025641025641, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=290, Percent_Identity=24.1379310344828, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=318, Percent_Identity=23.2704402515723, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137530, Length=224, Percent_Identity=28.125, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17737895, Length=298, Percent_Identity=27.8523489932886, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737897, Length=199, Percent_Identity=29.6482412060301, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35736; Mature: 35736

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHVAHGDFGQVPGRVLGHE
CCEEEECCCCCCCCHHHHHHCHHHCCCEEEEEEECCEECCCEEEECCCCCCCCCCEECCC
GIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRETLCRTVKNAGYSVDGGMAE
CCCHHHHHCCCHHHCCCCCCEEEEEEECCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCC
QCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKVEPGQWVVLYGAGGLGNLAVQ
CEEEEECEEEECCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHH
YAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVEDVAGLIKEKTDGGAHSAVVTAV
HHHHHHCCEEEEEEECCCCEEHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHH
SKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTVLDGIQVIGSLVGTRKDLEEAFQFG
HHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
AEGLVVPVVQKRPVEDAVAIFDEMEKGQIQGRMVLDFTH
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHVAHGDFGQVPGRVLGHE
CCEEEECCCCCCCCHHHHHHCHHHCCCEEEEEEECCEECCCEEEECCCCCCCCCCEECCC
GIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRETLCRTVKNAGYSVDGGMAE
CCCHHHHHCCCHHHCCCCCCEEEEEEECCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCC
QCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKVEPGQWVVLYGAGGLGNLAVQ
CEEEEECEEEECCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHH
YAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVEDVAGLIKEKTDGGAHSAVVTAV
HHHHHHCCEEEEEEECCCCEEHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHH
SKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTVLDGIQVIGSLVGTRKDLEEAFQFG
HHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
AEGLVVPVVQKRPVEDAVAIFDEMEKGQIQGRMVLDFTH
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185223; 8320209; 2935393 [H]