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The map label for this gene is thlA [H]

Identifier: 225686254

GI number: 225686254

Start: 417066

End: 418256

Strand: Reverse

Name: thlA [H]

Synonym: BMEA_B0427

Alternate gene names: 225686254

Gene position: 418256-417066 (Counterclockwise)

Preceding gene: 225686255

Following gene: 225686253

Centisome position: 35.28

GC content: 62.3

Gene sequence:

>1191_bases
ATGTCCAAGAGCGATCCTATTGTCATCGTCGGTGCTTCGCGCACCCCCATGGGCGGTTTTCAGGGTGACTTCACAAATGC
GCAGGCAACCGACCTTGGCGCTTCCGCCATCGGCGGCGCGCTTGCCGGTGCAGGCCTTGCCCCGGAAGCCGTCGAGGAGG
TTATCATGGGCTGTGTCCTGCCTGCTGGTCAGGGTCAGGCGCCTGCGCGTCAGGCCTCGCTCAAGGCCGGGCTGCCGCTT
GGCACCGGTGCCACGACCGTCAACAAGATGTGCGGCTCGGGCATGAAGGCCGCGATGCTTGCCCATGACCTCATCCTTGC
CGGTTCCGCCGATGTCATCGTCGCGGGCGGCATGGAAAGCATGACAAATGCCCCCTATCTTCTGCCCAAGGCGCGCGGGG
GCTATCGCATGGGCCATGGACAGGTGCTCGACCATATGTTCCTCGATGGGCTGGAAGATGCCTATGACAAGGGGCGCCTG
ATGGGCACGTTTGCGGAAGATTGCGCCGAGGCCTACCAGTTCACGCGCGAGGCGCAGGACGCATTTGCGATATCCTCCCT
GACCCGCGCGCAGAACGCGATCAAGGATGGTCTTTTTGCGGCGGAAATCACGCCGGTCAAGGTCAAGTCCGGCCGCGCCG
AGGTGGAAGTTACCATTGACGAGCAGCCAGGCAAGGCAAAGCTGGACAAGATCCCCACGCTGCGCCCCGCCTTCCGCGAA
GGCGGCACGGTAACGGCGGCCAATTCCTCTTCCATTTCCGATGGCGCGGCAGCACTTCTGCTCATGCGCGCATCGGAGGC
AGAAAAACGTGGCCTCACCCCGCGCGCGGTCATCACCGGCCATGCAACCTATGCCGACAAGCCAAATCTCTTCTCCACGG
CCCCCATTGGCGCGATCCGCAAACTGTCTGAAAAGACTGGCTGGGATTTGAAGGATGTCGATCTCTTCGAGATCAATGAA
GCCTTTGCCGTTGTTGCCATGGCCGCCGTGCGCGATCTCGACCTGCCGCACGACAAGGTCAATATTCATGGCGGCGCCTG
TGCACTTGGCCACCCCATCGGCGCATCGGGCGCACGTATTCTCGTAACCCTGCTGGCGGCACTTGAAACACATGGCCTGA
AGCGCGGCATCGCGGGCATCTGCCTTGGCGGCGGCGAGGCAACCGCAATGGGTATCGAAAGGATCATCTGA

Upstream 100 bases:

>100_bases
TCGACGGCGCACTGCGTATGGCCGCCAAGTAAAGGCCGCGAAGTAAAGCCAAGGCAATTTCTGACGAAATTGCGCACAGA
CAAAGCAGCGAGGAACAGTC

Downstream 100 bases:

>100_bases
TGCTTCTGACCGATACGCAGGAACAGATCCGCGAAGCCGCCCGCGACTTCGCACAGGAGCGCCTTGCCCCCGGCGCCGCG
GCGCGTGACCGTGAACATGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSKSDPIVIVGASRTPMGGFQGDFTNAQATDLGASAIGGALAGAGLAPEAVEEVIMGCVLPAGQGQAPARQASLKAGLPL
GTGATTVNKMCGSGMKAAMLAHDLILAGSADVIVAGGMESMTNAPYLLPKARGGYRMGHGQVLDHMFLDGLEDAYDKGRL
MGTFAEDCAEAYQFTREAQDAFAISSLTRAQNAIKDGLFAAEITPVKVKSGRAEVEVTIDEQPGKAKLDKIPTLRPAFRE
GGTVTAANSSSISDGAAALLLMRASEAEKRGLTPRAVITGHATYADKPNLFSTAPIGAIRKLSEKTGWDLKDVDLFEINE
AFAVVAMAAVRDLDLPHDKVNIHGGACALGHPIGASGARILVTLLAALETHGLKRGIAGICLGGGEATAMGIERII

Sequences:

>Translated_396_residues
MSKSDPIVIVGASRTPMGGFQGDFTNAQATDLGASAIGGALAGAGLAPEAVEEVIMGCVLPAGQGQAPARQASLKAGLPL
GTGATTVNKMCGSGMKAAMLAHDLILAGSADVIVAGGMESMTNAPYLLPKARGGYRMGHGQVLDHMFLDGLEDAYDKGRL
MGTFAEDCAEAYQFTREAQDAFAISSLTRAQNAIKDGLFAAEITPVKVKSGRAEVEVTIDEQPGKAKLDKIPTLRPAFRE
GGTVTAANSSSISDGAAALLLMRASEAEKRGLTPRAVITGHATYADKPNLFSTAPIGAIRKLSEKTGWDLKDVDLFEINE
AFAVVAMAAVRDLDLPHDKVNIHGGACALGHPIGASGARILVTLLAALETHGLKRGIAGICLGGGEATAMGIERII
>Mature_395_residues
SKSDPIVIVGASRTPMGGFQGDFTNAQATDLGASAIGGALAGAGLAPEAVEEVIMGCVLPAGQGQAPARQASLKAGLPLG
TGATTVNKMCGSGMKAAMLAHDLILAGSADVIVAGGMESMTNAPYLLPKARGGYRMGHGQVLDHMFLDGLEDAYDKGRLM
GTFAEDCAEAYQFTREAQDAFAISSLTRAQNAIKDGLFAAEITPVKVKSGRAEVEVTIDEQPGKAKLDKIPTLRPAFREG
GTVTAANSSSISDGAAALLLMRASEAEKRGLTPRAVITGHATYADKPNLFSTAPIGAIRKLSEKTGWDLKDVDLFEINEA
FAVVAMAAVRDLDLPHDKVNIHGGACALGHPIGASGARILVTLLAALETHGLKRGIAGICLGGGEATAMGIERII

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=47.7157360406091, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=45.9390862944162, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=35.9897172236504, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=35.75, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4504327, Length=421, Percent_Identity=31.1163895486936, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=28.4263959390863, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI87082165, Length=389, Percent_Identity=43.4447300771208, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI1788554, Length=390, Percent_Identity=49.2307692307692, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1787663, Length=393, Percent_Identity=37.4045801526718, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=37.8109452736318, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1788683, Length=404, Percent_Identity=29.7029702970297, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=44.2455242966752, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=40.5684754521964, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=37.4358974358974, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=32.7365728900256, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=31.4420803782506, Blast_Score=170, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=47.2361809045226, Blast_Score=335, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=46.1538461538462, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=45.8646616541353, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI17648125, Length=395, Percent_Identity=36.2025316455696, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=31.7757009345794, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40733; Mature: 40602

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSDPIVIVGASRTPMGGFQGDFTNAQATDLGASAIGGALAGAGLAPEAVEEVIMGCVL
CCCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCC
PAGQGQAPARQASLKAGLPLGTGATTVNKMCGSGMKAAMLAHDLILAGSADVIVAGGMES
CCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHEECCCCEEEECCHHH
MTNAPYLLPKARGGYRMGHGQVLDHMFLDGLEDAYDKGRLMGTFAEDCAEAYQFTREAQD
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
AFAISSLTRAQNAIKDGLFAAEITPVKVKSGRAEVEVTIDEQPGKAKLDKIPTLRPAFRE
HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCEEEEEEEECCCCCCHHCCCCCCCHHHHC
GGTVTAANSSSISDGAAALLLMRASEAEKRGLTPRAVITGHATYADKPNLFSTAPIGAIR
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCCCCCCCCHHHHH
KLSEKTGWDLKDVDLFEINEAFAVVAMAAVRDLDLPHDKVNIHGGACALGHPIGASGARI
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEECCCCCCCCHHHH
LVTLLAALETHGLKRGIAGICLGGGEATAMGIERII
HHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
SKSDPIVIVGASRTPMGGFQGDFTNAQATDLGASAIGGALAGAGLAPEAVEEVIMGCVL
CCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCC
PAGQGQAPARQASLKAGLPLGTGATTVNKMCGSGMKAAMLAHDLILAGSADVIVAGGMES
CCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHEECCCCEEEECCHHH
MTNAPYLLPKARGGYRMGHGQVLDHMFLDGLEDAYDKGRLMGTFAEDCAEAYQFTREAQD
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
AFAISSLTRAQNAIKDGLFAAEITPVKVKSGRAEVEVTIDEQPGKAKLDKIPTLRPAFRE
HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCEEEEEEEECCCCCCHHCCCCCCCHHHHC
GGTVTAANSSSISDGAAALLLMRASEAEKRGLTPRAVITGHATYADKPNLFSTAPIGAIR
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCCCCCCCCHHHHH
KLSEKTGWDLKDVDLFEINEAFAVVAMAAVRDLDLPHDKVNIHGGACALGHPIGASGARI
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEECCCCCCCCHHHH
LVTLLAALETHGLKRGIAGICLGGGEATAMGIERII
HHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]