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The map label for this gene is thrC [H]

Identifier: 225852020

GI number: 225852020

Start: 503274

End: 504665

Strand: Reverse

Name: thrC [H]

Synonym: BMEA_A0520

Alternate gene names: 225852020

Gene position: 504665-503274 (Counterclockwise)

Preceding gene: 225852024

Following gene: 225852019

Centisome position: 23.74

GC content: 58.76

Gene sequence:

>1392_bases
ATGAAATATGTAAGTACGCGTGGGGAAGCACCGGTTCTGGGATTCAGCGATGCATTGCTCGCAGGCCTCGCCCGTGATGG
CGGTCTTTATCTGCCGCAGGAATATCCGCAATTCACAGCCGAACAGATCCGCGCCCTGCGTGGAAAATCCTATGTCGAAG
TCGCGCTGGCCGTCCTCACGCCCTTTACCGGCGGTGAAATTCCGGCAGCCGATTTCGAGCGCATGGTCCGCGAAGCTTAC
GGAACCTTCCGTCACGATGCCGTCTGCCCGTTGGTGCAGACCGACGCGAACGAATTCGTGCTGGAGCTTTTCCATGGCCC
CACCCTTGCCTTCAAGGATGTCGCCATGCAGCTTCTGGCCCGCATGATGGATTATGTTCTGGCACAGCGCGGCGAGCGCG
CAACGATCGTCGGCGCTACATCCGGCGATACGGGCGGCGCAGCCATCGAAGCCTTTGGCGGGCGCGACAACACAGACATT
TTCATCCTGTTCCCCAATGGGCGGGTCTCGCCGGTACAGCAACGCCAGATGACGTCTTCCGGCTTTTCCAATGTCCATGC
GCTTTCCATCGAGGGCAATTTCGACGATTGCCAGAACCTCGTAAAAGGCATGTTCAATGATCTGGAATTCTGTGACGCCC
TGTCGCTTTCCGGCGTGAACTCGATCAACTGGGCGCGCATCATGCCGCAGGTTGTCTATTATTTCACGGCAGCACTCAGC
CTCGGCGCACCGGACCGCGCCGTGTCCTTCACGGTGCCCACCGGCAATTTCGGCGATATTTTCGCAGGCTACGTCGCCAA
GCGCATGGGCCTGCCCATCGAGCAACTCATCATCGCCACCAACGACAACGATATTCTTTCGCGCACGCTGGAAAGCGGGG
CCTATGAGATGCGCGGCGTAGCGCAGACCACTTCGCCCTCAATGGATATCCAGATTTCCTCCAATTTCGAGCGGCTTCTG
TTCGAGGCACACGGGCGCGATGCGGCGGCCGTGCGCGGGCTGATGCAGGGCCTGAAGCAATCTGGCGGATTTACGATTTC
CGAAAAGCCGCTTTCGGCCATCCGCAGCGAATTTTCGGCTGGCCGCTCCACCGTCGATGAGACGGCGGCGACTATCGAAT
CGGTTCTTTCCAAAGACGGCTATCTGCTTGATCCGCATTCGGCGATCGGTGTGAAGGTCGCGCGTGAAAAAGCATCCGGC
ACCGCCCCGATGGTGGTTCTGGCGACCGCCCATCCGGCCAAATTCCCGGATGCGGTGAAGGCTGCATGTGGGGTCGAGCC
GCAATTGCCGGCATGGCTTTGCGACCTGATGCAACGAAAAGAAAGCTTCACAGTTCTTCACAACGAGCTGAAAATCGTGG
AAGAATATGTGCGCCACCATTCCCGAGCCTGA

Upstream 100 bases:

>100_bases
CATTGGGGATGTTTTAAATAGTTGCGGCTTTTTTGGGGACGCCCTATTGCATTTACACAGCTTTGAATGGGCAGCCGCTC
TGGAATGAAGGCCTGACGAA

Downstream 100 bases:

>100_bases
ATAGAGCAGGCACGAAAGGGAACCAGGGTGAGAATGCAGGGAGCAATTTGCTAATGGGTGTTGAAGTAACGCGTCTTCCC
AACGGGTTGACAATAGCCAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKYVSTRGEAPVLGFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLTPFTGGEIPAADFERMVREAY
GTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLARMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDI
FILFPNGRVSPVQQRQMTSSGFSNVHALSIEGNFDDCQNLVKGMFNDLEFCDALSLSGVNSINWARIMPQVVYYFTAALS
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGVAQTTSPSMDIQISSNFERLL
FEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSAGRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASG
TAPMVVLATAHPAKFPDAVKAACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA

Sequences:

>Translated_463_residues
MKYVSTRGEAPVLGFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLTPFTGGEIPAADFERMVREAY
GTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLARMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDI
FILFPNGRVSPVQQRQMTSSGFSNVHALSIEGNFDDCQNLVKGMFNDLEFCDALSLSGVNSINWARIMPQVVYYFTAALS
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGVAQTTSPSMDIQISSNFERLL
FEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSAGRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASG
TAPMVVLATAHPAKFPDAVKAACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA
>Mature_463_residues
MKYVSTRGEAPVLGFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLTPFTGGEIPAADFERMVREAY
GTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLARMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDI
FILFPNGRVSPVQQRQMTSSGFSNVHALSIEGNFDDCQNLVKGMFNDLEFCDALSLSGVNSINWARIMPQVVYYFTAALS
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGVAQTTSPSMDIQISSNFERLL
FEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSAGRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASG
TAPMVVLATAHPAKFPDAVKAACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=468, Percent_Identity=36.3247863247863, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI153792148, Length=436, Percent_Identity=36.697247706422, Blast_Score=276, Evalue=4e-74,
Organism=Escherichia coli, GI1786185, Length=451, Percent_Identity=34.1463414634146, Blast_Score=239, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=44.2982456140351, Blast_Score=364, Evalue=1e-101,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50140; Mature: 50140

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVSTRGEAPVLGFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLT
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHC
PFTGGEIPAADFERMVREAYGTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
RMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDIFILFPNGRVSPVQQRQMTSS
HHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHC
GFSNVHALSIEGNFDDCQNLVKGMFNDLEFCDALSLSGVNSINWARIMPQVVYYFTAALS
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCHHHCCC
AQTTSPSMDIQISSNFERLLFEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSA
CCCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHC
GRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASGTAPMVVLATAHPAKFPDAVK
CCHHHHHHHHHHHHHHCCCCEEECCCCHHHHEEEHHCCCCCCCEEEEEECCCCCCCHHHH
AACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKYVSTRGEAPVLGFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLT
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHC
PFTGGEIPAADFERMVREAYGTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
RMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDIFILFPNGRVSPVQQRQMTSS
HHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHC
GFSNVHALSIEGNFDDCQNLVKGMFNDLEFCDALSLSGVNSINWARIMPQVVYYFTAALS
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCHHHCCC
AQTTSPSMDIQISSNFERLLFEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSA
CCCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHC
GRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASGTAPMVVLATAHPAKFPDAVK
CCHHHHHHHHHHHHHHCCCCEEECCCCHHHHEEEHHCCCCCCCEEEEEECCCCCCCHHHH
AACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]