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The map label for this gene is pqqL [C]

Identifier: 225852019

GI number: 225852019

Start: 501928

End: 503220

Strand: Reverse

Name: pqqL [C]

Synonym: BMEA_A0519

Alternate gene names: 225852019

Gene position: 503220-501928 (Counterclockwise)

Preceding gene: 225852020

Following gene: 225852018

Centisome position: 23.67

GC content: 59.09

Gene sequence:

>1293_bases
ATGGGTGTTGAAGTAACGCGTCTTCCCAACGGGTTGACAATAGCCACCGATACCATGCCGCATGTTGAAAGCGTGGCGTT
GGGAATCTGGGTAAAGGCGGGAGCGCGTAACGAAGCCCCCGACCGTCACGGAATTGCGCATCTTCTGGAGCATATGGCTT
TCAAGGGCACGGAAAACCGTACAGCCTGGCAGATCGCATCGGACATTGAAAATGTGGGTGGCGAGATCAACGCCACCACC
AGCGTGGAGACCACCTCCTATTATGCCCGCGTGCTGCGCAACGATATGCCGCTGGCCATCGACATTCTTTCCGATATCCT
GACCGCCTCCAAATTCGACGAGGGCGAGCTGGAACGCGAAAAGCAGGTCATCATGCAGGAGATCGGCGCGGCGCACGATA
CGCCCGACGATATCGTCTTCGACCGTTTCACCGAAACCGCCTATCGCCACCAGCCCATCGGCCGCGCGATCCTGGGCGAG
CCGGAAACGGTGATGTCATTCACATCCGACGACCTGCGCCAATATATGCAGGAGCAATATAGCGCCGACCGCATGGTGGT
GACGGCGGCTGGCGGCATCGACCATGACGAATTCGTGCGCGAGGTTGAAAAGCGGCTCGGCAGTTTCCGTCCGCACAATA
CCGCGCCAACACTCGACCTTGCTCATTATGTCGGCGGCGATTTCCGCGAAAACCGCGAATTGATGGATGCGCAGGTGCTG
ATCGGTTTTGAAGGCCGCGCCTATCATGTGCGCGACTTCTACGCTTCGCAGCTTCTTTCGATGATCCTCGGCGGCGGCAT
GTCCTCGCGGCTTTTCCAGGAAGTGCGCGAAAAGCGCGGGCTTTGCTATTCGGTCTATGCCTTCCATTGGGGCTTTTCCG
ATACGGGGCTGTTTGGCATCCATGCCGCAACGGGGCGCGACGAGCTTGTGGAACTCGTGCCGGTCATTATCGACGAATTG
CACAAGGCAGCCAATTCCATCGGCATCGAGGAAGTGGACCGCGCCCGTGCGCAATATCGCGCAAGCCTCCTCATGTCGCA
GGAAAGCGCGGCAAGCCGTGCGGGCCAGATTGCGCGCCAGTTCCTGCTCTATGGACGCCCGGTGGAAAACAGCGAATTGC
TGGACCGCCTGTCCCTCATCACCCCGGAACGCCTGACCGACCTTGCCGGACGGCTTTTCCTCAACAACAAACCAACCATC
GCAGGCGTCGGTCCCGTTGGCCGCCTCATGAGCTTCGATCGCCTGACCGATGCGCTTTCGACCAATGCGCATACGAGGAA
GATAGCTGTCTAG

Upstream 100 bases:

>100_bases
AGCTGAAAATCGTGGAAGAATATGTGCGCCACCATTCCCGAGCCTGAATAGAGCAGGCACGAAAGGGAACCAGGGTGAGA
ATGCAGGGAGCAATTTGCTA

Downstream 100 bases:

>100_bases
AGCATTTTCGAGCCAAAAGTGCGAAGCGGCTTTGCGTCGGATAATGCGTCAAAACAAAGAGATAGAACAATAGGGCAGTA
AGGGAGTTAGGGCAGTATGT

Product: processing protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MGVEVTRLPNGLTIATDTMPHVESVALGIWVKAGARNEAPDRHGIAHLLEHMAFKGTENRTAWQIASDIENVGGEINATT
SVETTSYYARVLRNDMPLAIDILSDILTASKFDEGELEREKQVIMQEIGAAHDTPDDIVFDRFTETAYRHQPIGRAILGE
PETVMSFTSDDLRQYMQEQYSADRMVVTAAGGIDHDEFVREVEKRLGSFRPHNTAPTLDLAHYVGGDFRENRELMDAQVL
IGFEGRAYHVRDFYASQLLSMILGGGMSSRLFQEVREKRGLCYSVYAFHWGFSDTGLFGIHAATGRDELVELVPVIIDEL
HKAANSIGIEEVDRARAQYRASLLMSQESAASRAGQIARQFLLYGRPVENSELLDRLSLITPERLTDLAGRLFLNNKPTI
AGVGPVGRLMSFDRLTDALSTNAHTRKIAV

Sequences:

>Translated_430_residues
MGVEVTRLPNGLTIATDTMPHVESVALGIWVKAGARNEAPDRHGIAHLLEHMAFKGTENRTAWQIASDIENVGGEINATT
SVETTSYYARVLRNDMPLAIDILSDILTASKFDEGELEREKQVIMQEIGAAHDTPDDIVFDRFTETAYRHQPIGRAILGE
PETVMSFTSDDLRQYMQEQYSADRMVVTAAGGIDHDEFVREVEKRLGSFRPHNTAPTLDLAHYVGGDFRENRELMDAQVL
IGFEGRAYHVRDFYASQLLSMILGGGMSSRLFQEVREKRGLCYSVYAFHWGFSDTGLFGIHAATGRDELVELVPVIIDEL
HKAANSIGIEEVDRARAQYRASLLMSQESAASRAGQIARQFLLYGRPVENSELLDRLSLITPERLTDLAGRLFLNNKPTI
AGVGPVGRLMSFDRLTDALSTNAHTRKIAV
>Mature_429_residues
GVEVTRLPNGLTIATDTMPHVESVALGIWVKAGARNEAPDRHGIAHLLEHMAFKGTENRTAWQIASDIENVGGEINATTS
VETTSYYARVLRNDMPLAIDILSDILTASKFDEGELEREKQVIMQEIGAAHDTPDDIVFDRFTETAYRHQPIGRAILGEP
ETVMSFTSDDLRQYMQEQYSADRMVVTAAGGIDHDEFVREVEKRLGSFRPHNTAPTLDLAHYVGGDFRENRELMDAQVLI
GFEGRAYHVRDFYASQLLSMILGGGMSSRLFQEVREKRGLCYSVYAFHWGFSDTGLFGIHAATGRDELVELVPVIIDELH
KAANSIGIEEVDRARAQYRASLLMSQESAASRAGQIARQFLLYGRPVENSELLDRLSLITPERLTDLAGRLFLNNKPTIA
GVGPVGRLMSFDRLTDALSTNAHTRKIAV

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=423, Percent_Identity=32.387706855792, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI46593007, Length=429, Percent_Identity=27.972027972028, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI24308013, Length=449, Percent_Identity=26.0579064587973, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI50592988, Length=429, Percent_Identity=24.9417249417249, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1787770, Length=219, Percent_Identity=26.4840182648402, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999683, Length=414, Percent_Identity=31.1594202898551, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17553678, Length=416, Percent_Identity=24.5192307692308, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17510601, Length=455, Percent_Identity=24.6153846153846, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17570205, Length=415, Percent_Identity=20.9638554216867, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566323, Length=415, Percent_Identity=20.9638554216867, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17569737, Length=364, Percent_Identity=21.4285714285714, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=418, Percent_Identity=34.688995215311, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6321813, Length=416, Percent_Identity=28.6057692307692, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319426, Length=438, Percent_Identity=22.1461187214612, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357875, Length=425, Percent_Identity=30.3529411764706, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24646943, Length=425, Percent_Identity=30.3529411764706, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI19921772, Length=455, Percent_Identity=25.7142857142857, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24665395, Length=429, Percent_Identity=24.7086247086247, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47825; Mature: 47693

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVEVTRLPNGLTIATDTMPHVESVALGIWVKAGARNEAPDRHGIAHLLEHMAFKGTENR
CCCEEEECCCCCEEEECCCCHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
TAWQIASDIENVGGEINATTSVETTSYYARVLRNDMPLAIDILSDILTASKFDEGELERE
HHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHH
KQVIMQEIGAAHDTPDDIVFDRFTETAYRHQPIGRAILGEPETVMSFTSDDLRQYMQEQY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHCCHHHHHHHHHHHH
SADRMVVTAAGGIDHDEFVREVEKRLGSFRPHNTAPTLDLAHYVGGDFRENRELMDAQVL
CCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHCHHHHCEEEE
IGFEGRAYHVRDFYASQLLSMILGGGMSSRLFQEVREKRGLCYSVYAFHWGFSDTGLFGI
EECCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEE
HAATGRDELVELVPVIIDELHKAANSIGIEEVDRARAQYRASLLMSQESAASRAGQIARQ
EECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLYGRPVENSELLDRLSLITPERLTDLAGRLFLNNKPTIAGVGPVGRLMSFDRLTDALS
HHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHEECCCCCEEECCCHHHHHHHHHHHHHHH
TNAHTRKIAV
CCCCCEEECC
>Mature Secondary Structure 
GVEVTRLPNGLTIATDTMPHVESVALGIWVKAGARNEAPDRHGIAHLLEHMAFKGTENR
CCEEEECCCCCEEEECCCCHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
TAWQIASDIENVGGEINATTSVETTSYYARVLRNDMPLAIDILSDILTASKFDEGELERE
HHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHH
KQVIMQEIGAAHDTPDDIVFDRFTETAYRHQPIGRAILGEPETVMSFTSDDLRQYMQEQY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHCCHHHHHHHHHHHH
SADRMVVTAAGGIDHDEFVREVEKRLGSFRPHNTAPTLDLAHYVGGDFRENRELMDAQVL
CCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHCHHHHCEEEE
IGFEGRAYHVRDFYASQLLSMILGGGMSSRLFQEVREKRGLCYSVYAFHWGFSDTGLFGI
EECCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEE
HAATGRDELVELVPVIIDELHKAANSIGIEEVDRARAQYRASLLMSQESAASRAGQIARQ
EECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLYGRPVENSELLDRLSLITPERLTDLAGRLFLNNKPTIAGVGPVGRLMSFDRLTDALS
HHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHEECCCCCEEECCCHHHHHHHHHHHHHHH
TNAHTRKIAV
CCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA