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The map label for this gene is coaBC [H]

Identifier: 222527157

GI number: 222527157

Start: 4889646

End: 4890884

Strand: Reverse

Name: coaBC [H]

Synonym: Chy400_3939

Alternate gene names: 222527157

Gene position: 4890884-4889646 (Counterclockwise)

Preceding gene: 222527164

Following gene: 222527156

Centisome position: 92.82

GC content: 59.73

Gene sequence:

>1239_bases
ATGGATACGCTGGCTGGTAAGCGAATTGTCCTCGGTGTGTGCGGAAGTATCGCTGCGTACAAGGTGGCCCAACTGGCTCG
CGATCTGACGCTGGCCGGGGCGCTGGTTGATGTGATTCTGACCGAGTCTGCCGAGCGTTTTGTTGGGGCAGCAACCTTCC
AGGCTCTGACCGGACGCCCGGTGCTGACCGATATGTGGAGTCTGCCCGAAGATGGGGTTGTGGGCCATGTGAGCCTGGGG
ATGCACGCCGATATGGTGGTCATTGCTCCGGCAACCGCGAATACGATTGCCCGTCTGGCTGCCGGGTTAGCCGATGATTT
GTTGACGACCACAGTCCTGGCGACGCGAGCACCGCTGCTGATCGCTCCGGCGATGAATCCGGCGATGTATGAACATCCGG
CAACGCAGGCGAATCTGGCGGTGTTGCGTGAGCGCGGAGCGTATGTGCTTGAGCCAGAGGTGGGGCGGATGGCCGAGCCG
GTTGTCGGACGTGGTCGGCTGCCCGAACCGGCCGATTTGCTGGCCGAGATACATGCCCTGTGGGGACGTCGGTACGGCCC
GCTCCGTGGGCGCCGGGTGGTCGTTACTGCCGGTGGCACCCGGGAACCGATTGATCCGGTACGTTATATCGGTAATCGTT
CGTCGGGGCAGATGGGGTATGCGCTGGCTACCCGTGCCCGTGATCTGGGTGCACAGGTCACGTTAATCAGTGGCCCGACT
GCCTTGACCCCACCACGAGCGGTATCCTTTGTCGCGGTCGAGACGGCATTAGAGATGCAGGCTGCGGTGCAGTCGGCCTG
TGCACAGGCCGATATCCTTATCATGAATGCAGCAGTGGCCGATTTTCGCCCGGCTTCTACGGCTGCCGAGAAGATCAAGA
AGCACAATGATGAGGGTATGGTGCTGCATCTGGTACAAAACCCCGATGTTGTGGGTGAGCTGGCCGGGCGGCATGATATA
TTTAAGGTTGGCTTCGCGGCTGAAACCAATGATTTGCTGGTCAACGCCCGGCACAAGCTGCGACGTAAAGGCTTGAACCT
GATTGTCGCCAATGATGCAGTGGCCAGTATTGGTCAACCTGAGATTGCGCTTACCGTGCTGGACGGTGAGCGTGCCGTCG
AGTTGCCACGGCAGCCAAAGGCTGTCGCCGCGGCAGCGTTGTTGGATGTTATTGTAGAGCGTTTTGAATATTGGCTGAGC
ACTCGCCGGCCATCTGGTGAAGAGTTTGAGGATCGATGA

Upstream 100 bases:

>100_bases
GACCGATGCCCATGGTGTCACTCCGCCATCCTGCCACATGTGCTACAATGCGCCCGCGGGAGTATCTGTTCGCTATGACA
GGTCGGTTACCGGGTGATAT

Downstream 100 bases:

>100_bases
CGACAGAACCACAATCAAATCAGTCGCCGCCTGAACCACCACCGGCACCTCGCCCAACCCGTCGTCTGACGGTGCCGACA
TTGCCACGGGCAGCGGCTGC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MDTLAGKRIVLGVCGSIAAYKVAQLARDLTLAGALVDVILTESAERFVGAATFQALTGRPVLTDMWSLPEDGVVGHVSLG
MHADMVVIAPATANTIARLAAGLADDLLTTTVLATRAPLLIAPAMNPAMYEHPATQANLAVLRERGAYVLEPEVGRMAEP
VVGRGRLPEPADLLAEIHALWGRRYGPLRGRRVVVTAGGTREPIDPVRYIGNRSSGQMGYALATRARDLGAQVTLISGPT
ALTPPRAVSFVAVETALEMQAAVQSACAQADILIMNAAVADFRPASTAAEKIKKHNDEGMVLHLVQNPDVVGELAGRHDI
FKVGFAAETNDLLVNARHKLRRKGLNLIVANDAVASIGQPEIALTVLDGERAVELPRQPKAVAAAALLDVIVERFEYWLS
TRRPSGEEFEDR

Sequences:

>Translated_412_residues
MDTLAGKRIVLGVCGSIAAYKVAQLARDLTLAGALVDVILTESAERFVGAATFQALTGRPVLTDMWSLPEDGVVGHVSLG
MHADMVVIAPATANTIARLAAGLADDLLTTTVLATRAPLLIAPAMNPAMYEHPATQANLAVLRERGAYVLEPEVGRMAEP
VVGRGRLPEPADLLAEIHALWGRRYGPLRGRRVVVTAGGTREPIDPVRYIGNRSSGQMGYALATRARDLGAQVTLISGPT
ALTPPRAVSFVAVETALEMQAAVQSACAQADILIMNAAVADFRPASTAAEKIKKHNDEGMVLHLVQNPDVVGELAGRHDI
FKVGFAAETNDLLVNARHKLRRKGLNLIVANDAVASIGQPEIALTVLDGERAVELPRQPKAVAAAALLDVIVERFEYWLS
TRRPSGEEFEDR
>Mature_412_residues
MDTLAGKRIVLGVCGSIAAYKVAQLARDLTLAGALVDVILTESAERFVGAATFQALTGRPVLTDMWSLPEDGVVGHVSLG
MHADMVVIAPATANTIARLAAGLADDLLTTTVLATRAPLLIAPAMNPAMYEHPATQANLAVLRERGAYVLEPEVGRMAEP
VVGRGRLPEPADLLAEIHALWGRRYGPLRGRRVVVTAGGTREPIDPVRYIGNRSSGQMGYALATRARDLGAQVTLISGPT
ALTPPRAVSFVAVETALEMQAAVQSACAQADILIMNAAVADFRPASTAAEKIKKHNDEGMVLHLVQNPDVVGELAGRHDI
FKVGFAAETNDLLVNARHKLRRKGLNLIVANDAVASIGQPEIALTVLDGERAVELPRQPKAVAAAALLDVIVERFEYWLS
TRRPSGEEFEDR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=153, Percent_Identity=35.9477124183007, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI87082301, Length=410, Percent_Identity=44.6341463414634, Blast_Score=286, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24657262, Length=151, Percent_Identity=33.7748344370861, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43876; Mature: 43876

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLAGKRIVLGVCGSIAAYKVAQLARDLTLAGALVDVILTESAERFVGAATFQALTGRP
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VLTDMWSLPEDGVVGHVSLGMHADMVVIAPATANTIARLAAGLADDLLTTTVLATRAPLL
HHHHHHCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
IAPAMNPAMYEHPATQANLAVLRERGAYVLEPEVGRMAEPVVGRGRLPEPADLLAEIHAL
EECCCCCHHHCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
WGRRYGPLRGRRVVVTAGGTREPIDPVRYIGNRSSGQMGYALATRARDLGAQVTLISGPT
HCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCC
ALTPPRAVSFVAVETALEMQAAVQSACAQADILIMNAAVADFRPASTAAEKIKKHNDEGM
CCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHHHHHHHHHHCCCCCE
VLHLVQNPDVVGELAGRHDIFKVGFAAETNDLLVNARHKLRRKGLNLIVANDAVASIGQP
EEEEECCCCHHHHHCCCCCEEEEEECCCCCHHEEHHHHHHHHCCCEEEEECCHHHHCCCC
EIALTVLDGERAVELPRQPKAVAAAALLDVIVERFEYWLSTRRPSGEEFEDR
CEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDTLAGKRIVLGVCGSIAAYKVAQLARDLTLAGALVDVILTESAERFVGAATFQALTGRP
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VLTDMWSLPEDGVVGHVSLGMHADMVVIAPATANTIARLAAGLADDLLTTTVLATRAPLL
HHHHHHCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
IAPAMNPAMYEHPATQANLAVLRERGAYVLEPEVGRMAEPVVGRGRLPEPADLLAEIHAL
EECCCCCHHHCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
WGRRYGPLRGRRVVVTAGGTREPIDPVRYIGNRSSGQMGYALATRARDLGAQVTLISGPT
HCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCC
ALTPPRAVSFVAVETALEMQAAVQSACAQADILIMNAAVADFRPASTAAEKIKKHNDEGM
CCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHHHHHHHHHHCCCCCE
VLHLVQNPDVVGELAGRHDIFKVGFAAETNDLLVNARHKLRRKGLNLIVANDAVASIGQP
EEEEECCCCHHHHHCCCCCEEEEEECCCCCHHEEHHHHHHHHCCCEEEEECCHHHHCCCC
EIALTVLDGERAVELPRQPKAVAAAALLDVIVERFEYWLSTRRPSGEEFEDR
CEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]