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The map label for this gene is hemL

Identifier: 222526050

GI number: 222526050

Start: 3458588

End: 3459919

Strand: Direct

Name: hemL

Synonym: Chy400_2807

Alternate gene names: 222526050

Gene position: 3458588-3459919 (Clockwise)

Preceding gene: 222526049

Following gene: 222526051

Centisome position: 65.64

GC content: 61.04

Gene sequence:

>1332_bases
ATGAGTGTTGTAACCGAACGCTACAGCCGTTCGCAGGCCGATTATGCTGCTGCTCGGGAAGTGATTCCCGGTGGTGTAAA
TTCGCCGGTGCGGGCTTTTCGAGGGGTTGGCGGAATACCTATCTTCTTTGAGCGTGGGCAGGGCGCTTATGTGTGGGATG
TCGATGGCAATCGTTACATCGACTACGTGCTCTCGTGGGGGCCGCTTCTGCTCGGTCACGCCCATCCTGCGGTGGTCGAG
GCGATTACCCTTCAGGCACAACGGGGTACCAGCTTCGGCGCGCCAACCGAGCTGGAGACCGAACTTGCCCGGCTGGTGAT
CGAACTGGTGCCTTCGATTGAACAGATTCGCTTTGTCAACAGCGGTACCGAGGCAACGATGAGCGCATTGCGTCTGGCTC
GTGCCGCTACCGGTCGCCGCCTGATTGTCAAGTTCAACGGTTGCTACCACGGCCATGCCGATATGCTGCTGGTGCAGGCG
GGCAGTGGGGTGGCGACCCTTGGCCTGCCTGATAGTCCCGGCGTCCCGCCATCGGTGGCTGCCGAGACCATCACCATCGA
GTACAACGACCTCGATGCGGCGGCAGCGTTGTTTGCCAACCGTGGTGCCGAGATTGCGGCAGTGATTGTTGAACCTATTG
CCGCCAATATGGGCTTCGTGCTGCCTAAACCTGGCTTCCTGAGTGGGTTGCGTGAACTGACCCAGACCCACGGCGCGATC
TTCATTCTCGACGAAGTGATGACCGGTTTCCGGGTGGCGGCGGGTGGTGCGCAGGCGCTGTGGGGTCTTGATCCCGATCT
GACCTGCCTGGGGAAGGTCATCGGCGGCGGTTTACCGGTAGGTGCCTATGCCGGCAAACGGCAGTTGATGCAACTGGTTG
CGCCTGCCGGGCCGATGTATCAGGCCGGTACCCTGAGTGGTAACCCTCTGGCGATGACCGCCGGTCTGACGACCCTTCGT
ACCGCTTTCGGCGGGGATGCCGGTGCCTTCCAGCAGGCAGTCACCCGCACTGCCCGGCTTGCCGATGGCCTGCGCATGCT
TGGCGAACGCTATCGCATTCCGGTGCAGGTTGGTAATGTCGGCACTATGTTCGGCTGCTACTTTTTGCGTCAAGAGGGGA
GCCAGATCACCAGCTATGCCGAAGCAAAAGCCTACGCCGATTCCCAGCGCTACGCCCGTTTCTTCTGGGCGATGGCCGAT
CAGGGCATCTATCTGGCCCCGTCACAGTTTGAGGCCGGTTTCCTCAGCACTGCGCACTCCGATGCCGACATCGATGAAAC
CCTGGCGGCGGCAGAAGTGGCGTTTGCTGGACTGGTATCGTCGGCGGAATGA

Upstream 100 bases:

>100_bases
TTCTCACCGAAACACCGGTTGATCACGTGCGCTATCTGGTCGAGTTTGTCCAATCGTATCCGCTCCCAGCTACCGCTCCC
GTCCTTCAGGAGGTTGTGTA

Downstream 100 bases:

>100_bases
GGAGATTACATATGACAATCACCGATACCCGTACCATCGTACACGATCTGATGCGGAGTGGCCAGCAGCGGTTATGCGCC
GCCTTTGAAGAGATCGATCA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSVVTERYSRSQADYAAAREVIPGGVNSPVRAFRGVGGIPIFFERGQGAYVWDVDGNRYIDYVLSWGPLLLGHAHPAVVE
AITLQAQRGTSFGAPTELETELARLVIELVPSIEQIRFVNSGTEATMSALRLARAATGRRLIVKFNGCYHGHADMLLVQA
GSGVATLGLPDSPGVPPSVAAETITIEYNDLDAAAALFANRGAEIAAVIVEPIAANMGFVLPKPGFLSGLRELTQTHGAI
FILDEVMTGFRVAAGGAQALWGLDPDLTCLGKVIGGGLPVGAYAGKRQLMQLVAPAGPMYQAGTLSGNPLAMTAGLTTLR
TAFGGDAGAFQQAVTRTARLADGLRMLGERYRIPVQVGNVGTMFGCYFLRQEGSQITSYAEAKAYADSQRYARFFWAMAD
QGIYLAPSQFEAGFLSTAHSDADIDETLAAAEVAFAGLVSSAE

Sequences:

>Translated_443_residues
MSVVTERYSRSQADYAAAREVIPGGVNSPVRAFRGVGGIPIFFERGQGAYVWDVDGNRYIDYVLSWGPLLLGHAHPAVVE
AITLQAQRGTSFGAPTELETELARLVIELVPSIEQIRFVNSGTEATMSALRLARAATGRRLIVKFNGCYHGHADMLLVQA
GSGVATLGLPDSPGVPPSVAAETITIEYNDLDAAAALFANRGAEIAAVIVEPIAANMGFVLPKPGFLSGLRELTQTHGAI
FILDEVMTGFRVAAGGAQALWGLDPDLTCLGKVIGGGLPVGAYAGKRQLMQLVAPAGPMYQAGTLSGNPLAMTAGLTTLR
TAFGGDAGAFQQAVTRTARLADGLRMLGERYRIPVQVGNVGTMFGCYFLRQEGSQITSYAEAKAYADSQRYARFFWAMAD
QGIYLAPSQFEAGFLSTAHSDADIDETLAAAEVAFAGLVSSAE
>Mature_442_residues
SVVTERYSRSQADYAAAREVIPGGVNSPVRAFRGVGGIPIFFERGQGAYVWDVDGNRYIDYVLSWGPLLLGHAHPAVVEA
ITLQAQRGTSFGAPTELETELARLVIELVPSIEQIRFVNSGTEATMSALRLARAATGRRLIVKFNGCYHGHADMLLVQAG
SGVATLGLPDSPGVPPSVAAETITIEYNDLDAAAALFANRGAEIAAVIVEPIAANMGFVLPKPGFLSGLRELTQTHGAIF
ILDEVMTGFRVAAGGAQALWGLDPDLTCLGKVIGGGLPVGAYAGKRQLMQLVAPAGPMYQAGTLSGNPLAMTAGLTTLRT
AFGGDAGAFQQAVTRTARLADGLRMLGERYRIPVQVGNVGTMFGCYFLRQEGSQITSYAEAKAYADSQRYARFFWAMADQ
GIYLAPSQFEAGFLSTAHSDADIDETLAAAEVAFAGLVSSAE

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=288, Percent_Identity=31.9444444444444, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI24119277, Length=396, Percent_Identity=28.2828282828283, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI37574042, Length=299, Percent_Identity=28.7625418060201, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI226442705, Length=297, Percent_Identity=27.9461279461279, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI226442709, Length=268, Percent_Identity=28.7313432835821, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI284507298, Length=207, Percent_Identity=32.8502415458937, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786349, Length=430, Percent_Identity=57.4418604651163, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1789016, Length=331, Percent_Identity=33.8368580060423, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788044, Length=337, Percent_Identity=32.3442136498516, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789759, Length=339, Percent_Identity=29.2035398230088, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1787560, Length=290, Percent_Identity=32.7586206896552, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI145693181, Length=317, Percent_Identity=31.8611987381703, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786991, Length=299, Percent_Identity=28.7625418060201, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=297, Percent_Identity=29.6296296296296, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=364, Percent_Identity=25.8241758241758, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=299, Percent_Identity=25.4180602006689, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144274, Length=138, Percent_Identity=34.0579710144928, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=302, Percent_Identity=28.1456953642384, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=350, Percent_Identity=25.7142857142857, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357415, Length=296, Percent_Identity=29.0540540540541, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356575, Length=362, Percent_Identity=27.9005524861878, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_CHLAA (A9WIS7)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001636193.1
- ProteinModelPortal:   A9WIS7
- SMR:   A9WIS7
- GeneID:   5827067
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_2598
- HOGENOM:   HBG725944
- OMA:   DKVIKFE
- ProtClustDB:   PRK00062
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46747; Mature: 46616

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVTERYSRSQADYAAAREVIPGGVNSPVRAFRGVGGIPIFFERGQGAYVWDVDGNRYI
CCCCHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCEEEEECCCCEEE
DYVLSWGPLLLGHAHPAVVEAITLQAQRGTSFGAPTELETELARLVIELVPSIEQIRFVN
HHHHHCCCEEECCCCHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEEC
SGTEATMSALRLARAATGRRLIVKFNGCYHGHADMLLVQAGSGVATLGLPDSPGVPPSVA
CCHHHHHHHHHHHHHCCCCEEEEEECCEECCCCCEEEEECCCCEEEECCCCCCCCCCCCC
AETITIEYNDLDAAAALFANRGAEIAAVIVEPIAANMGFVLPKPGFLSGLRELTQTHGAI
EEEEEEEECCCHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHCCEE
FILDEVMTGFRVAAGGAQALWGLDPDLTCLGKVIGGGLPVGAYAGKRQLMQLVAPAGPMY
EEHHHHHCCCEEECCCCHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCE
QAGTLSGNPLAMTAGLTTLRTAFGGDAGAFQQAVTRTARLADGLRMLGERYRIPVQVGNV
ECCCCCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECEEEECCC
GTMFGCYFLRQEGSQITSYAEAKAYADSQRYARFFWAMADQGIYLAPSQFEAGFLSTAHS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHCCCCC
DADIDETLAAAEVAFAGLVSSAE
CCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVVTERYSRSQADYAAAREVIPGGVNSPVRAFRGVGGIPIFFERGQGAYVWDVDGNRYI
CCCHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCEEEEECCCCEEE
DYVLSWGPLLLGHAHPAVVEAITLQAQRGTSFGAPTELETELARLVIELVPSIEQIRFVN
HHHHHCCCEEECCCCHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEEC
SGTEATMSALRLARAATGRRLIVKFNGCYHGHADMLLVQAGSGVATLGLPDSPGVPPSVA
CCHHHHHHHHHHHHHCCCCEEEEEECCEECCCCCEEEEECCCCEEEECCCCCCCCCCCCC
AETITIEYNDLDAAAALFANRGAEIAAVIVEPIAANMGFVLPKPGFLSGLRELTQTHGAI
EEEEEEEECCCHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHCCEE
FILDEVMTGFRVAAGGAQALWGLDPDLTCLGKVIGGGLPVGAYAGKRQLMQLVAPAGPMY
EEHHHHHCCCEEECCCCHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCE
QAGTLSGNPLAMTAGLTTLRTAFGGDAGAFQQAVTRTARLADGLRMLGERYRIPVQVGNV
ECCCCCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECEEEECCC
GTMFGCYFLRQEGSQITSYAEAKAYADSQRYARFFWAMADQGIYLAPSQFEAGFLSTAHS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHCCCCC
DADIDETLAAAEVAFAGLVSSAE
CCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA