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The map label for this gene is hemE

Identifier: 222526049

GI number: 222526049

Start: 3457521

End: 3458588

Strand: Direct

Name: hemE

Synonym: Chy400_2806

Alternate gene names: 222526049

Gene position: 3457521-3458588 (Clockwise)

Preceding gene: 222526048

Following gene: 222526050

Centisome position: 65.62

GC content: 57.4

Gene sequence:

>1068_bases
ATGCGAGATCGTTTTCTGCGCGCCTGTCGTCGTCAGCCGGTTGATCGCACACCGATCTGGTTAATGCGCCAGGCTGGACG
TTACATGCCGGAATACCGGGCCATCCGCGAGCGCTATGGCTTTTTGCAGATGGTTAAAACCCCAGAAGTTGCCGCCGAGG
TGACCCTTCAGCCTGTGCAGGCATTTGGCGTTGATGCGGCAATTATCTTTGCCGATATTTTGCCCCCACTCGAAGGGCTA
GGGTTACAGCTCACGTATGAAAAAGGGGAAGGGCCGGTCATCCACAACCCGATCCGCAGCCCGCATGATGTCAGTGTATT
ACGCTCGTGCGATCCGCGCGAGACGGTTGCCTATACCCTGGCGGCACTGCAACTTGTCAAGCGGGAGCTGAACGGTTTAC
CGCTCATCGGGTTCAGCGGTGCGCCATTTACGCTCGCCAGTTATGCCATTGAAGGTGGTGGATCGCGCGAATATCGGCTT
ACCAAGCGCTTTATGTACGAGCAACCGGCAGCGTGGCACGATCTGATGGAACGTCTCAGCCGGTTAGTTGCCGACTATCT
AATCGCTCAGATCGAAGCCGGTGCCGACGCGGTCCAGATTTTTGATAGCTGGGCCGGTGCTCTCTCGCCTGCCGACTACC
GGGCGTATGTGCTACGCCATACCCAGGCGCTCGTGCAAACAATCCGCGCCCGTTTAGGCGACGTAACACCACCAATTATT
TATTTTGGTACCGATATGGCCGGTCTGGCCGGCGAAGTGCGCCAGATCGGAGCCGATGTGCTCGGTGTTGATTGGCGGAT
TGATCTTGATGTGGCCTGGGCGCAGTACGGGTTCAATCATGCGGTTCAGGGCAATCTCGATCCGATGACCCTCTTTGCAC
CGCCGTCGATCATTGCCGCTCGTGCCCGTGACATTCTGGAACGGGCCGGTGGGCGTCCGGGACACATCTTTAATCTCGGT
CACGGCATTCTCACCGAAACACCGGTTGATCACGTGCGCTATCTGGTCGAGTTTGTCCAATCGTATCCGCTCCCAGCTAC
CGCTCCCGTCCTTCAGGAGGTTGTGTAA

Upstream 100 bases:

>100_bases
CACCGAGGCACAGCAGACACAGAGATAACAAAAAAACCTCTGTGCCCTCTGTGTCTTTGTGGTAACCCAACCCGCCATTG
TAAAGATTGAGAGGAGTGCA

Downstream 100 bases:

>100_bases
TGAGTGTTGTAACCGAACGCTACAGCCGTTCGCAGGCCGATTATGCTGCTGCTCGGGAAGTGATTCCCGGTGGTGTAAAT
TCGCCGGTGCGGGCTTTTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MRDRFLRACRRQPVDRTPIWLMRQAGRYMPEYRAIRERYGFLQMVKTPEVAAEVTLQPVQAFGVDAAIIFADILPPLEGL
GLQLTYEKGEGPVIHNPIRSPHDVSVLRSCDPRETVAYTLAALQLVKRELNGLPLIGFSGAPFTLASYAIEGGGSREYRL
TKRFMYEQPAAWHDLMERLSRLVADYLIAQIEAGADAVQIFDSWAGALSPADYRAYVLRHTQALVQTIRARLGDVTPPII
YFGTDMAGLAGEVRQIGADVLGVDWRIDLDVAWAQYGFNHAVQGNLDPMTLFAPPSIIAARARDILERAGGRPGHIFNLG
HGILTETPVDHVRYLVEFVQSYPLPATAPVLQEVV

Sequences:

>Translated_355_residues
MRDRFLRACRRQPVDRTPIWLMRQAGRYMPEYRAIRERYGFLQMVKTPEVAAEVTLQPVQAFGVDAAIIFADILPPLEGL
GLQLTYEKGEGPVIHNPIRSPHDVSVLRSCDPRETVAYTLAALQLVKRELNGLPLIGFSGAPFTLASYAIEGGGSREYRL
TKRFMYEQPAAWHDLMERLSRLVADYLIAQIEAGADAVQIFDSWAGALSPADYRAYVLRHTQALVQTIRARLGDVTPPII
YFGTDMAGLAGEVRQIGADVLGVDWRIDLDVAWAQYGFNHAVQGNLDPMTLFAPPSIIAARARDILERAGGRPGHIFNLG
HGILTETPVDHVRYLVEFVQSYPLPATAPVLQEVV
>Mature_355_residues
MRDRFLRACRRQPVDRTPIWLMRQAGRYMPEYRAIRERYGFLQMVKTPEVAAEVTLQPVQAFGVDAAIIFADILPPLEGL
GLQLTYEKGEGPVIHNPIRSPHDVSVLRSCDPRETVAYTLAALQLVKRELNGLPLIGFSGAPFTLASYAIEGGGSREYRL
TKRFMYEQPAAWHDLMERLSRLVADYLIAQIEAGADAVQIFDSWAGALSPADYRAYVLRHTQALVQTIRARLGDVTPPII
YFGTDMAGLAGEVRQIGADVLGVDWRIDLDVAWAQYGFNHAVQGNLDPMTLFAPPSIIAARARDILERAGGRPGHIFNLG
HGILTETPVDHVRYLVEFVQSYPLPATAPVLQEVV

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=38.2183908045977, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI2367337, Length=341, Percent_Identity=43.4017595307918, Blast_Score=287, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6320252, Length=346, Percent_Identity=32.0809248554913, Blast_Score=209, Evalue=6e-55,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=36.3372093023256, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=36.3372093023256, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_CHLAA (A9WIS6)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001636192.1
- ProteinModelPortal:   A9WIS6
- SMR:   A9WIS6
- GeneID:   5827066
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_2597
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   CLSK973756
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39489; Mature: 39489

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 72-72 BINDING 148-148 BINDING 203-203 BINDING 321-321

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDRFLRACRRQPVDRTPIWLMRQAGRYMPEYRAIRERYGFLQMVKTPEVAAEVTLQPVQ
CCHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AFGVDAAIIFADILPPLEGLGLQLTYEKGEGPVIHNPIRSPHDVSVLRSCDPRETVAYTL
HHCCCHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCCCHHHHHHCCCCHHHHHHHH
AALQLVKRELNGLPLIGFSGAPFTLASYAIEGGGSREYRLTKRFMYEQPAAWHDLMERLS
HHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
RLVADYLIAQIEAGADAVQIFDSWAGALSPADYRAYVLRHTQALVQTIRARLGDVTPPII
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
YFGTDMAGLAGEVRQIGADVLGVDWRIDLDVAWAQYGFNHAVQGNLDPMTLFAPPSIIAA
EECCCHHHHHHHHHHHCCHHCCCCEEEEEEEHHHHHCCCCCCCCCCCCEEEECCHHHHHH
RARDILERAGGRPGHIFNLGHGILTETPVDHVRYLVEFVQSYPLPATAPVLQEVV
HHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure
MRDRFLRACRRQPVDRTPIWLMRQAGRYMPEYRAIRERYGFLQMVKTPEVAAEVTLQPVQ
CCHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AFGVDAAIIFADILPPLEGLGLQLTYEKGEGPVIHNPIRSPHDVSVLRSCDPRETVAYTL
HHCCCHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCCCHHHHHHCCCCHHHHHHHH
AALQLVKRELNGLPLIGFSGAPFTLASYAIEGGGSREYRLTKRFMYEQPAAWHDLMERLS
HHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
RLVADYLIAQIEAGADAVQIFDSWAGALSPADYRAYVLRHTQALVQTIRARLGDVTPPII
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
YFGTDMAGLAGEVRQIGADVLGVDWRIDLDVAWAQYGFNHAVQGNLDPMTLFAPPSIIAA
EECCCHHHHHHHHHHHCCHHCCCCEEEEEEEHHHHHCCCCCCCCCCCCEEEECCHHHHHH
RARDILERAGGRPGHIFNLGHGILTETPVDHVRYLVEFVQSYPLPATAPVLQEVV
HHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA