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The map label for this gene is hemF [H]

Identifier: 222526051

GI number: 222526051

Start: 3459931

End: 3460839

Strand: Direct

Name: hemF [H]

Synonym: Chy400_2808

Alternate gene names: 222526051

Gene position: 3459931-3460839 (Clockwise)

Preceding gene: 222526050

Following gene: 222526056

Centisome position: 65.67

GC content: 57.54

Gene sequence:

>909_bases
ATGACAATCACCGATACCCGTACCATCGTACACGATCTGATGCGGAGTGGCCAGCAGCGGTTATGCGCCGCCTTTGAAGA
GATCGATCAGCACGCTCAGTTTGTCGCCGAGAGTTGGGAGCGCCCAGGTGGTGGTGGTGGCACCGCACGGGTAATGACTG
AAGGGGCTGTCTTCGAGCGGGCCGGTGTCAATGTCTCGGCGGTCTATGGTGTCGAAGTACCACCCAGCATCTGGCAACAT
CGCCCCTCAACCCGTGGTCAGCCCTACTTCGCAACCGGCATCTCGATGGTGCTGCACCCGCGCAACCCCTACGTACCGGC
GTTTCACGCCAATTTTCGCTACTTTGAAGCCGGCGATGACTGGTGGTTTGGCGGGGGGATGGATCTCACCCCCAGCTACG
GTTTCGCTGAAGATGCCCGCCATTTTCACGTAACATTACGCGACTATTGTGCCCGTCACCCAATTGCCGACTATCGTGAA
ATGAAGGCGACCTGCGATAACTACTTCTTCCTCAAGCATCGCAACGAAATGCGAGGGATTGGTGGCATCTTTTTCGATGA
TCTGCATCCCGCCGGCGACGATGGCTTCGAGCGCGCCTTCGCCTTCGTGAGTGATGGCATTACCACCATCCTCGACGCCT
ACCTGCCCATCGTGCGTCGTCGTATGCACACCCCATACGGTGAACGCGAACGCATGTGGCAACTCTACCGTCGTGGACGC
TACGTCGAATTCAATCTGATTTACGACCGTGGCACCCTCTTTGGGCTGCAAACCGGGGGCAACATCGAAGCGATTTTAAT
GTCATTACCACCGCTGGCGCGCTGGCAATTCAAATACCAGCCCGAACCCGGTTCACCGGAAGCAGCGATGGCCGAATTTC
TCAAGCCACGTGACTGGGCGGAGGAGTAG

Upstream 100 bases:

>100_bases
TCAGCACTGCGCACTCCGATGCCGACATCGATGAAACCCTGGCGGCGGCAGAAGTGGCGTTTGCTGGACTGGTATCGTCG
GCGGAATGAGGAGATTACAT

Downstream 100 bases:

>100_bases
CTGCGTGTCCATACCACGCTGCATATCTGACAGCATACTGGTAGATTGCCCAGACCGCTCCCAATTCGTCGGCCCACAAT
CCATACTCGTTACCTACACG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTITDTRTIVHDLMRSGQQRLCAAFEEIDQHAQFVAESWERPGGGGGTARVMTEGAVFERAGVNVSAVYGVEVPPSIWQH
RPSTRGQPYFATGISMVLHPRNPYVPAFHANFRYFEAGDDWWFGGGMDLTPSYGFAEDARHFHVTLRDYCARHPIADYRE
MKATCDNYFFLKHRNEMRGIGGIFFDDLHPAGDDGFERAFAFVSDGITTILDAYLPIVRRRMHTPYGERERMWQLYRRGR
YVEFNLIYDRGTLFGLQTGGNIEAILMSLPPLARWQFKYQPEPGSPEAAMAEFLKPRDWAEE

Sequences:

>Translated_302_residues
MTITDTRTIVHDLMRSGQQRLCAAFEEIDQHAQFVAESWERPGGGGGTARVMTEGAVFERAGVNVSAVYGVEVPPSIWQH
RPSTRGQPYFATGISMVLHPRNPYVPAFHANFRYFEAGDDWWFGGGMDLTPSYGFAEDARHFHVTLRDYCARHPIADYRE
MKATCDNYFFLKHRNEMRGIGGIFFDDLHPAGDDGFERAFAFVSDGITTILDAYLPIVRRRMHTPYGERERMWQLYRRGR
YVEFNLIYDRGTLFGLQTGGNIEAILMSLPPLARWQFKYQPEPGSPEAAMAEFLKPRDWAEE
>Mature_301_residues
TITDTRTIVHDLMRSGQQRLCAAFEEIDQHAQFVAESWERPGGGGGTARVMTEGAVFERAGVNVSAVYGVEVPPSIWQHR
PSTRGQPYFATGISMVLHPRNPYVPAFHANFRYFEAGDDWWFGGGMDLTPSYGFAEDARHFHVTLRDYCARHPIADYREM
KATCDNYFFLKHRNEMRGIGGIFFDDLHPAGDDGFERAFAFVSDGITTILDAYLPIVRRRMHTPYGERERMWQLYRRGRY
VEFNLIYDRGTLFGLQTGGNIEAILMSLPPLARWQFKYQPEPGSPEAAMAEFLKPRDWAEE

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=311, Percent_Identity=45.016077170418, Blast_Score=269, Evalue=2e-72,
Organism=Escherichia coli, GI1788777, Length=296, Percent_Identity=56.0810810810811, Blast_Score=323, Evalue=8e-90,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=44.375, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI17864388, Length=324, Percent_Identity=46.9135802469136, Blast_Score=281, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34609; Mature: 34478

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITDTRTIVHDLMRSGQQRLCAAFEEIDQHAQFVAESWERPGGGGGTARVMTEGAVFER
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHH
AGVNVSAVYGVEVPPSIWQHRPSTRGQPYFATGISMVLHPRNPYVPAFHANFRYFEAGDD
CCCCEEEEECCCCCHHHHCCCCCCCCCCEEECCEEEEECCCCCCCCEEECCEEEEECCCC
WWFGGGMDLTPSYGFAEDARHFHVTLRDYCARHPIADYREMKATCDNYFFLKHRNEMRGI
EEECCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCHHHHHHHHHHHCCEEEEEECCCCCCC
GGIFFDDLHPAGDDGFERAFAFVSDGITTILDAYLPIVRRRMHTPYGERERMWQLYRRGR
CCEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
YVEFNLIYDRGTLFGLQTGGNIEAILMSLPPLARWQFKYQPEPGSPEAAMAEFLKPRDWA
EEEEEEEEECCEEEEEECCCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCC
EE
CC
>Mature Secondary Structure 
TITDTRTIVHDLMRSGQQRLCAAFEEIDQHAQFVAESWERPGGGGGTARVMTEGAVFER
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHH
AGVNVSAVYGVEVPPSIWQHRPSTRGQPYFATGISMVLHPRNPYVPAFHANFRYFEAGDD
CCCCEEEEECCCCCHHHHCCCCCCCCCCEEECCEEEEECCCCCCCCEEECCEEEEECCCC
WWFGGGMDLTPSYGFAEDARHFHVTLRDYCARHPIADYREMKATCDNYFFLKHRNEMRGI
EEECCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCHHHHHHHHHHHCCEEEEEECCCCCCC
GGIFFDDLHPAGDDGFERAFAFVSDGITTILDAYLPIVRRRMHTPYGERERMWQLYRRGR
CCEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
YVEFNLIYDRGTLFGLQTGGNIEAILMSLPPLARWQFKYQPEPGSPEAAMAEFLKPRDWA
EEEEEEEEECCEEEEEECCCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCC
EE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA