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The map label for this gene is guaB [H]

Identifier: 222525381

GI number: 222525381

Start: 2700918

End: 2701385

Strand: Direct

Name: guaB [H]

Synonym: Chy400_2126

Alternate gene names: 222525381

Gene position: 2700918-2701385 (Clockwise)

Preceding gene: 222525377

Following gene: 222525382

Centisome position: 51.26

GC content: 55.34

Gene sequence:

>468_bases
ATGAAGGCGCGTGAGATCATGACCAAAAATGTGGTGTGCGTCACTGATGATGCTGCCGTAGAGGATGCCGCCCGCTTGAT
GACACGCAATCGGATCAGTGGTCTACCGGTTGTTAACCCCCAGGGTATGCTGGTAGGCCTCGTCACCGAGCACGACCTGA
TCGCCAAAGAGGGGCGTACTGTTAAAGAAATTATGACCCGAAGTGTAATCAGTGTCAGCCCCGACACCGAAGTTGAGCAG
ATTCAGCATCTGCTTACCAACCAGCGTATTCGGCGGGTACCGGTCGTTGAAAACGGCAAAGTTGTAGGCATTGTCAGCCG
TTCCGATCTCGTGCGCCAGATTGCAATGCGTTGGGTCTGCGGCGTATGTGGCGAGATTGTCCGTGCGCTTGAAGCACCCA
AACACTGCCCGCGTTGTGGAGCCGATACGCATGCCTTTACCCACGAGGTGGTTCCGCCAGGGATGTAA

Upstream 100 bases:

>100_bases
CAATCTCTGCTATACTAAAGAAGAGTTGTTTGAGCAACCATTCTCGTGAATAATGTCACGATTGCAGATAACAGCAGGTT
GAAATGAAAGGTAAAGCGGA

Downstream 100 bases:

>100_bases
TGTCGTTGAGCGTGTACTGGTTTCTGGTGAACCCGATTGTGAGAAGATGCCCGGCATCAATTATCACTCTTCATCGTTGT
GTACGCGCGGTGAGTGATAC

Product: putative signal transduction protein with CBS domains

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MKAREIMTKNVVCVTDDAAVEDAARLMTRNRISGLPVVNPQGMLVGLVTEHDLIAKEGRTVKEIMTRSVISVSPDTEVEQ
IQHLLTNQRIRRVPVVENGKVVGIVSRSDLVRQIAMRWVCGVCGEIVRALEAPKHCPRCGADTHAFTHEVVPPGM

Sequences:

>Translated_155_residues
MKAREIMTKNVVCVTDDAAVEDAARLMTRNRISGLPVVNPQGMLVGLVTEHDLIAKEGRTVKEIMTRSVISVSPDTEVEQ
IQHLLTNQRIRRVPVVENGKVVGIVSRSDLVRQIAMRWVCGVCGEIVRALEAPKHCPRCGADTHAFTHEVVPPGM
>Mature_155_residues
MKAREIMTKNVVCVTDDAAVEDAARLMTRNRISGLPVVNPQGMLVGLVTEHDLIAKEGRTVKEIMTRSVISVSPDTEVEQ
IQHLLTNQRIRRVPVVENGKVVGIVSRSDLVRQIAMRWVCGVCGEIVRALEAPKHCPRCGADTHAFTHEVVPPGM

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0517

COG function: function code R; FOG: CBS domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 17056; Mature: 17056

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAREIMTKNVVCVTDDAAVEDAARLMTRNRISGLPVVNPQGMLVGLVTEHDLIAKEGRT
CCCHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHCCCH
VKEIMTRSVISVSPDTEVEQIQHLLTNQRIRRVPVVENGKVVGIVSRSDLVRQIAMRWVC
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHH
GVCGEIVRALEAPKHCPRCGADTHAFTHEVVPPGM
HHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MKAREIMTKNVVCVTDDAAVEDAARLMTRNRISGLPVVNPQGMLVGLVTEHDLIAKEGRT
CCCHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHCCCH
VKEIMTRSVISVSPDTEVEQIQHLLTNQRIRRVPVVENGKVVGIVSRSDLVRQIAMRWVC
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHH
GVCGEIVRALEAPKHCPRCGADTHAFTHEVVPPGM
HHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]