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The map label for this gene is strD [H]

Identifier: 222525377

GI number: 222525377

Start: 2697004

End: 2698071

Strand: Direct

Name: strD [H]

Synonym: Chy400_2122

Alternate gene names: 222525377

Gene position: 2697004-2698071 (Clockwise)

Preceding gene: 222525373

Following gene: 222525381

Centisome position: 51.19

GC content: 54.12

Gene sequence:

>1068_bases
ATGAAAGGTCTTGTGCTCAGTGGCGGTAAAGGAACTCGACTGCGACCGATTACCTACACCAGTGCAAAACAGCTTGTGCC
GGTTGCCAACAAGCCGGTCTTGTTTCGGGTAATCGAAGCGATCCGCGACGCCGGAATTACCGACATCGGGATTGTTATTG
GCGATACCGGTGATGAGATTCGCTCAGCGGTGGGCAATGGTCGGCGCTGGGGCGTGAAAATTTCGTACATCCCGCAAGAA
GCACCCCTGGGACTGGCCCATGCCGTGAAAATCAGTCGTGACTTTCTCGGTGATGACCGGTTTGTGATGTTTTTGGGCGA
TAACTGCATTCAGGGTGGGATCAGTCCGTTAATCGAGCAATTTGGGCGGAGCGATTACAATGCCCAGATTGTGTTGAAAA
AGGTCAGCGATCCGCGCTCGTTTGGTGTCGCCGAACTCGATGATGAGGGTCGGGTCGTGCGTCTGGTTGAGAAGCCGCGT
GAGCCGAAGTCGGATCTGGCGCTGGTCGGTATCTACATGTTCGATCACCATATTTTTGAAGCGGTTGAGGCAATCAGACC
ATCAGCACGCGGTGAACTTGAGATTACCGACGCTATCCAGTGGCTGGTAAGCAACGGCTACAACGTGTATCCCTACGTTC
ACGAGGGCTGGTGGATCGACACCGGGAAGAAGGATGATATGCTGGAAGCCAATCGCCTGGTGCTCGAAGAGCTGGAACCT
TCAGTGCAAGGGTATGTTGACCGCGACTCGCAGTTGATCGGCAAGGTGATCATCGAGCCAGGTGCAGAAATCATCAATAG
CACGATCCGTGGCCCGGCAATTATTGGTGAGCATACCCGGATCGTGAACGCCTATGTCGGCCCGTTCACCTCAATCTATC
ACCACTGCCACATTGAGGAATGTGAGATCGAGCATAGCATTGTGCTTGAATACTGCACGATCCGTGGTCTGCCACACCGC
CTGGAAGATAGCCTGATCGGGCGGAATGTCGAGATCGGGCGTAGTCCATTGCGGCCAAAGGCGTATCGGTTTATGCTCGG
GGATAACAGTTCGGTCGGCGTATTGTGA

Upstream 100 bases:

>100_bases
TGTCCTCCGTTGACTCTACCATAAGTTGCCGTTTCCGCGACATGGTGTAGAATCAAGCAGCAGCAAGCGTGATCAGGTTT
GACCATAGAAAAGGCGGTTT

Downstream 100 bases:

>100_bases
GATCGGTTCTACGCCGTCTCATCGGCGGCGATCTCCAGCCAGATCGCGTAGACGGTATTTTTCGCCACATTCAGATCTTG
CGCAGTCTGCCGAACTGCGG

Product: glucose-1-phosphate thymidyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEAIRDAGITDIGIVIGDTGDEIRSAVGNGRRWGVKISYIPQE
APLGLAHAVKISRDFLGDDRFVMFLGDNCIQGGISPLIEQFGRSDYNAQIVLKKVSDPRSFGVAELDDEGRVVRLVEKPR
EPKSDLALVGIYMFDHHIFEAVEAIRPSARGELEITDAIQWLVSNGYNVYPYVHEGWWIDTGKKDDMLEANRLVLEELEP
SVQGYVDRDSQLIGKVIIEPGAEIINSTIRGPAIIGEHTRIVNAYVGPFTSIYHHCHIEECEIEHSIVLEYCTIRGLPHR
LEDSLIGRNVEIGRSPLRPKAYRFMLGDNSSVGVL

Sequences:

>Translated_355_residues
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEAIRDAGITDIGIVIGDTGDEIRSAVGNGRRWGVKISYIPQE
APLGLAHAVKISRDFLGDDRFVMFLGDNCIQGGISPLIEQFGRSDYNAQIVLKKVSDPRSFGVAELDDEGRVVRLVEKPR
EPKSDLALVGIYMFDHHIFEAVEAIRPSARGELEITDAIQWLVSNGYNVYPYVHEGWWIDTGKKDDMLEANRLVLEELEP
SVQGYVDRDSQLIGKVIIEPGAEIINSTIRGPAIIGEHTRIVNAYVGPFTSIYHHCHIEECEIEHSIVLEYCTIRGLPHR
LEDSLIGRNVEIGRSPLRPKAYRFMLGDNSSVGVL
>Mature_355_residues
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEAIRDAGITDIGIVIGDTGDEIRSAVGNGRRWGVKISYIPQE
APLGLAHAVKISRDFLGDDRFVMFLGDNCIQGGISPLIEQFGRSDYNAQIVLKKVSDPRSFGVAELDDEGRVVRLVEKPR
EPKSDLALVGIYMFDHHIFEAVEAIRPSARGELEITDAIQWLVSNGYNVYPYVHEGWWIDTGKKDDMLEANRLVLEELEP
SVQGYVDRDSQLIGKVIIEPGAEIINSTIRGPAIIGEHTRIVNAYVGPFTSIYHHCHIEECEIEHSIVLEYCTIRGLPHR
LEDSLIGRNVEIGRSPLRPKAYRFMLGDNSSVGVL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=339, Percent_Identity=26.2536873156342, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI11761619, Length=339, Percent_Identity=26.2536873156342, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI31881779, Length=346, Percent_Identity=23.6994219653179, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI45447090, Length=346, Percent_Identity=23.6994219653179, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788351, Length=237, Percent_Identity=37.1308016877637, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1790224, Length=238, Percent_Identity=37.8151260504202, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788355, Length=270, Percent_Identity=27.037037037037, Blast_Score=84, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI133931050, Length=338, Percent_Identity=29.2899408284024, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17509979, Length=341, Percent_Identity=26.3929618768328, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509981, Length=330, Percent_Identity=25.4545454545455, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=345, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21355443, Length=339, Percent_Identity=26.5486725663717, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644084, Length=339, Percent_Identity=26.5486725663717, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 39436; Mature: 39436

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEAIRDAGITDIGIVIGDTGDEI
CCCEEEECCCCCEEEEEEECCCHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
RSAVGNGRRWGVKISYIPQEAPLGLAHAVKISRDFLGDDRFVMFLGDNCIQGGISPLIEQ
HHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHCCHHHHHHH
FGRSDYNAQIVLKKVSDPRSFGVAELDDEGRVVRLVEKPREPKSDLALVGIYMFDHHIFE
HCCCCCCEEEEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHH
AVEAIRPSARGELEITDAIQWLVSNGYNVYPYVHEGWWIDTGKKDDMLEANRLVLEELEP
HHHHHCCCCCCCEEHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCHHHHHHHHHHHHCC
SVQGYVDRDSQLIGKVIIEPGAEIINSTIRGPAIIGEHTRIVNAYVGPFTSIYHHCHIEE
HHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCCEEECCCCEEEEHHHCHHHHHHHHCCCHH
CEIEHSIVLEYCTIRGLPHRLEDSLIGRNVEIGRSPLRPKAYRFMLGDNSSVGVL
HCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEAIRDAGITDIGIVIGDTGDEI
CCCEEEECCCCCEEEEEEECCCHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
RSAVGNGRRWGVKISYIPQEAPLGLAHAVKISRDFLGDDRFVMFLGDNCIQGGISPLIEQ
HHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHCCHHHHHHH
FGRSDYNAQIVLKKVSDPRSFGVAELDDEGRVVRLVEKPREPKSDLALVGIYMFDHHIFE
HCCCCCCEEEEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHH
AVEAIRPSARGELEITDAIQWLVSNGYNVYPYVHEGWWIDTGKKDDMLEANRLVLEELEP
HHHHHCCCCCCCEEHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCHHHHHHHHHHHHCC
SVQGYVDRDSQLIGKVIIEPGAEIINSTIRGPAIIGEHTRIVNAYVGPFTSIYHHCHIEE
HHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCCEEECCCCEEEEHHHCHHHHHHHHCCCHH
CEIEHSIVLEYCTIRGLPHRLEDSLIGRNVEIGRSPLRPKAYRFMLGDNSSVGVL
HCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]