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The map label for this gene is pdhA [H]

Identifier: 222525382

GI number: 222525382

Start: 2701953

End: 2703026

Strand: Direct

Name: pdhA [H]

Synonym: Chy400_2127

Alternate gene names: 222525382

Gene position: 2701953-2703026 (Clockwise)

Preceding gene: 222525381

Following gene: 222525383

Centisome position: 51.28

GC content: 56.33

Gene sequence:

>1074_bases
ATGGCCGAAGTAGCCGAGACGGCTCAGCCCCTACTTGAACGCGCCACCGCCGACGAACTTAAGCATTATTACTATCAAAT
GCTATTGTTGCGTCGGTTTGAAGAGCGCGCCGGCGAGATGTATGTAAAAGCTAAAATTGGCGGATACTGCCACCTCAATC
TCGGTGAAGAGGCAACCATCGTTGGTCTGATGGCTGCCCTGACTCCAGACGACTACATCTTCACTAATTATCGCGAGCAC
GGTTACATTATTGCGCGCGGTGTTCCCCCTGGCCCGGTGATGGCCGAATTGTTCGGTAAGGAAACGGGTGTCTCTGGTGG
TCGTGGCGGTTCGATGCATCTGTTCGACCGCAAGACCAATTTTATGGGTGGCTATGCCATCGTTGGTGGTCAGGTACCGC
TGGCAGTCGGTGCAGCCTATGCACTGCGTTACCAGAACAAGCCCGGTGTGGTTGTTGCCCAGATGGGTGACGGTACGACG
AACATCGGGGCATTTTACGAGTCGCTGAACCTGGCGAAACTCTGGAAGTGTCCGGTGCTCTTCTTCATCGTTAATAACGG
CTACGGTATGGGCACCTCGGTCGAGGCCGGTTCATCAGAGCCGGATTTGTGGAAGAAAGGTGCTTCCTTCCGCATCCACG
GCGAGCGCGTTGATGGTACCGATGTCCTGGCTGTGCGCGATGTCGTTCGCCGCTTGCGGGCACGCGCCGAAGCCGAAGGC
GAGCCGGCGATTATCGATGCCGTGAGCTTCCGCTTCCGTGGCCATTCGGTGATCGACTCGGATCGCTACCGTGACCCGGA
GGCTGTGCGGCGGGGACGCGAGTTGTACGACCCGATTCGGAAGTTTGCTACCCTCCTGCTTGACCATGGGGTCGTTGACG
ATGCCTGGTTGAAGGGCATCGCCGAACAAGTTGAGCGTGAAGTGCAAGAGGCCATCGATTTCGCGAACAATAGCCCTGAT
CCGAAATTCGAGGACCTCTACAAATATATGTACGCCACACCGGTACCCAACACACCAACCGCCGAAGATGCCATTCGGGC
AGTGAAGATCAATCGCGGCGAGTTTGATGTGTAA

Upstream 100 bases:

>100_bases
GCGTGGTACAGGGATCAGACGGCGGACCAAAACGGCTAAAACAACCCAAACCCTCAGCAAGCCGGAGCGGAACGCCCAGC
ATACGAGAGGAGTTCTCACT

Downstream 100 bases:

>100_bases
CGATGTGAGAGTACGTAACGCATGTATCTGATCAATAAGTTCCGCGATAGCCGGCCATACATCCGGCAATTGTTGAATGC
AAAGAGGTTTCTATGCCTGT

Product: pyruvate dehydrogenase E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MAEVAETAQPLLERATADELKHYYYQMLLLRRFEERAGEMYVKAKIGGYCHLNLGEEATIVGLMAALTPDDYIFTNYREH
GYIIARGVPPGPVMAELFGKETGVSGGRGGSMHLFDRKTNFMGGYAIVGGQVPLAVGAAYALRYQNKPGVVVAQMGDGTT
NIGAFYESLNLAKLWKCPVLFFIVNNGYGMGTSVEAGSSEPDLWKKGASFRIHGERVDGTDVLAVRDVVRRLRARAEAEG
EPAIIDAVSFRFRGHSVIDSDRYRDPEAVRRGRELYDPIRKFATLLLDHGVVDDAWLKGIAEQVEREVQEAIDFANNSPD
PKFEDLYKYMYATPVPNTPTAEDAIRAVKINRGEFDV

Sequences:

>Translated_357_residues
MAEVAETAQPLLERATADELKHYYYQMLLLRRFEERAGEMYVKAKIGGYCHLNLGEEATIVGLMAALTPDDYIFTNYREH
GYIIARGVPPGPVMAELFGKETGVSGGRGGSMHLFDRKTNFMGGYAIVGGQVPLAVGAAYALRYQNKPGVVVAQMGDGTT
NIGAFYESLNLAKLWKCPVLFFIVNNGYGMGTSVEAGSSEPDLWKKGASFRIHGERVDGTDVLAVRDVVRRLRARAEAEG
EPAIIDAVSFRFRGHSVIDSDRYRDPEAVRRGRELYDPIRKFATLLLDHGVVDDAWLKGIAEQVEREVQEAIDFANNSPD
PKFEDLYKYMYATPVPNTPTAEDAIRAVKINRGEFDV
>Mature_356_residues
AEVAETAQPLLERATADELKHYYYQMLLLRRFEERAGEMYVKAKIGGYCHLNLGEEATIVGLMAALTPDDYIFTNYREHG
YIIARGVPPGPVMAELFGKETGVSGGRGGSMHLFDRKTNFMGGYAIVGGQVPLAVGAAYALRYQNKPGVVVAQMGDGTTN
IGAFYESLNLAKLWKCPVLFFIVNNGYGMGTSVEAGSSEPDLWKKGASFRIHGERVDGTDVLAVRDVVRRLRARAEAEGE
PAIIDAVSFRFRGHSVIDSDRYRDPEAVRRGRELYDPIRKFATLLLDHGVVDDAWLKGIAEQVEREVQEAIDFANNSPDP
KFEDLYKYMYATPVPNTPTAEDAIRAVKINRGEFDV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=37.0820668693009, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI4505685, Length=332, Percent_Identity=37.6506024096386, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI291084742, Length=332, Percent_Identity=37.9518072289157, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI291084744, Length=339, Percent_Identity=36.8731563421829, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI291084757, Length=332, Percent_Identity=33.7349397590361, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI11386135, Length=314, Percent_Identity=33.1210191082803, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI258645172, Length=314, Percent_Identity=33.4394904458599, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32564172, Length=339, Percent_Identity=37.7581120943953, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17536047, Length=339, Percent_Identity=37.7581120943953, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI86563357, Length=281, Percent_Identity=31.3167259786477, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI86563355, Length=281, Percent_Identity=31.3167259786477, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6321026, Length=331, Percent_Identity=36.8580060422961, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24639744, Length=320, Percent_Identity=39.0625, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28571106, Length=320, Percent_Identity=39.0625, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24639740, Length=321, Percent_Identity=38.9408099688474, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24639746, Length=308, Percent_Identity=38.961038961039, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24639748, Length=313, Percent_Identity=39.6166134185303, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI21355903, Length=330, Percent_Identity=27.5757575757576, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39586; Mature: 39455

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVAETAQPLLERATADELKHYYYQMLLLRRFEERAGEMYVKAKIGGYCHLNLGEEATI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEEEECCCCCHHH
VGLMAALTPDDYIFTNYREHGYIIARGVPPGPVMAELFGKETGVSGGRGGSMHLFDRKTN
HHHHHHCCCCCCEEECCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCC
FMGGYAIVGGQVPLAVGAAYALRYQNKPGVVVAQMGDGTTNIGAFYESLNLAKLWKCPVL
CCCCEEEECCCCHHHHHHHHHEEECCCCCEEEEECCCCCCHHHHHHHHCCHHHHHCCCEE
FFIVNNGYGMGTSVEAGSSEPDLWKKGASFRIHGERVDGTDVLAVRDVVRRLRARAEAEG
EEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
EPAIIDAVSFRFRGHSVIDSDRYRDPEAVRRGRELYDPIRKFATLLLDHGVVDDAWLKGI
CCEEEEEEEHEECCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AEQVEREVQEAIDFANNSPDPKFEDLYKYMYATPVPNTPTAEDAIRAVKINRGEFDV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCCCC
>Mature Secondary Structure 
AEVAETAQPLLERATADELKHYYYQMLLLRRFEERAGEMYVKAKIGGYCHLNLGEEATI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEEEECCCCCHHH
VGLMAALTPDDYIFTNYREHGYIIARGVPPGPVMAELFGKETGVSGGRGGSMHLFDRKTN
HHHHHHCCCCCCEEECCCCCCEEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCC
FMGGYAIVGGQVPLAVGAAYALRYQNKPGVVVAQMGDGTTNIGAFYESLNLAKLWKCPVL
CCCCEEEECCCCHHHHHHHHHEEECCCCCEEEEECCCCCCHHHHHHHHCCHHHHHCCCEE
FFIVNNGYGMGTSVEAGSSEPDLWKKGASFRIHGERVDGTDVLAVRDVVRRLRARAEAEG
EEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
EPAIIDAVSFRFRGHSVIDSDRYRDPEAVRRGRELYDPIRKFATLLLDHGVVDDAWLKGI
CCEEEEEEEHEECCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AEQVEREVQEAIDFANNSPDPKFEDLYKYMYATPVPNTPTAEDAIRAVKINRGEFDV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]