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The map label for this gene is asd [H]

Identifier: 222523525

GI number: 222523525

Start: 276684

End: 277733

Strand: Reverse

Name: asd [H]

Synonym: Chy400_0231

Alternate gene names: 222523525

Gene position: 277733-276684 (Counterclockwise)

Preceding gene: 222523527

Following gene: 222523524

Centisome position: 5.27

GC content: 56.86

Gene sequence:

>1050_bases
ATGGCAACAATTCCGGTTGCAGTGCTTGGTGCCACCGGTGCAGTGGGCCAGCGCTTTATTCAATTACTCGAAGGACATCC
ATTGTTTCAGGTTGTTGCATTGACCGGTAGCGAGCGCAGTGCAGGGAAGAAATATCACGAAGTGTGCCGATGGGTACTCG
ACACCCCGATGCCGGCAGCCGTCGCCAATCTCACCGTGCTCGATGCCGATGCCGATCTACCGGCTCAGCTCGTCTTTTCT
GCTCTCCCCAGCACGGTCGCCGGCCCGATTGAACAGCGTCTGGCAGCAGCCGGGCATATTGTCTGCTCCAATGCTTCGAA
TCATCGCATGGAGCCGGATGTACCTCTGATTATTCCTGAAGTGAATCCCGATCATCTGGCCCTGATTCCGGTACAGCGCC
GGCGCCGTGGTTGGTCAGGGGCGATTGTGACCAATCCTAACTGTACGTCCACGCCGGCAACGATGGTCTTACGCCCACTG
CTTGATACGTTTGGCGTGCGGCGGATGCTGTTGGTAAGTATGCAGGCTCTCTCTGGTGCAGGCTATCCGGGTGTGCCCAG
CTACGATGTGGTTGACAATGTCATCCCCTATATCGGTGGGGAAGAGCCAAAACTGGAAATTGAACCTCAAAAGATGCTCG
GTCGGTTAGAGGGGGAGACGATTGTGCCGGCTGGGTTCACGACCTCAGCCCATTGCAATCGGGTACCGGTGTTAGAGGGA
CATCTGGTCTGTCTCTCAATTGAGCTGGAGCGCAAAGCTGATCCGGCAGAGATTGCGACGGTGCTAAGTAATTTCCGTGC
TCTACCCCAGGAATTGCGGCTGCCTACCGCACCAGAGCAACCGATTATCGTGCGCCACGAGCCGGATCGGCCACAGCCAC
GCCGTGATCGCGATGCCGGACGTGGTATGGCAACGGTTGTGGGCCGCATCCGTCCATGCTCATTGTTCGATATCAAGCTG
ATTGCACTGAGTCACAATACAATTCGTGGCGCCGCCGGTGCCTCTATTCTCAATGCCGAATTGATGCACGCACAGGGGTG
GCTGGCATGA

Upstream 100 bases:

>100_bases
AACTTTGGTGAGCAAATTACAACAGATTTTGTTGTGTATGCAACTGTTCAGAAGCGGGTATAATGTGGGGTGACAATGTG
CTATCGCCAGGAGGTTACAG

Downstream 100 bases:

>100_bases
GTGCCTGGGCAACGATTGCTGATCTGACCGAAGATCGCGTCATTTATCGCGATTTACAACCTTGCGATGCCAGCTTGCCC
GGCTTGCCGGCACTGCGCAC

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MATIPVAVLGATGAVGQRFIQLLEGHPLFQVVALTGSERSAGKKYHEVCRWVLDTPMPAAVANLTVLDADADLPAQLVFS
ALPSTVAGPIEQRLAAAGHIVCSNASNHRMEPDVPLIIPEVNPDHLALIPVQRRRRGWSGAIVTNPNCTSTPATMVLRPL
LDTFGVRRMLLVSMQALSGAGYPGVPSYDVVDNVIPYIGGEEPKLEIEPQKMLGRLEGETIVPAGFTTSAHCNRVPVLEG
HLVCLSIELERKADPAEIATVLSNFRALPQELRLPTAPEQPIIVRHEPDRPQPRRDRDAGRGMATVVGRIRPCSLFDIKL
IALSHNTIRGAAGASILNAELMHAQGWLA

Sequences:

>Translated_349_residues
MATIPVAVLGATGAVGQRFIQLLEGHPLFQVVALTGSERSAGKKYHEVCRWVLDTPMPAAVANLTVLDADADLPAQLVFS
ALPSTVAGPIEQRLAAAGHIVCSNASNHRMEPDVPLIIPEVNPDHLALIPVQRRRRGWSGAIVTNPNCTSTPATMVLRPL
LDTFGVRRMLLVSMQALSGAGYPGVPSYDVVDNVIPYIGGEEPKLEIEPQKMLGRLEGETIVPAGFTTSAHCNRVPVLEG
HLVCLSIELERKADPAEIATVLSNFRALPQELRLPTAPEQPIIVRHEPDRPQPRRDRDAGRGMATVVGRIRPCSLFDIKL
IALSHNTIRGAAGASILNAELMHAQGWLA
>Mature_348_residues
ATIPVAVLGATGAVGQRFIQLLEGHPLFQVVALTGSERSAGKKYHEVCRWVLDTPMPAAVANLTVLDADADLPAQLVFSA
LPSTVAGPIEQRLAAAGHIVCSNASNHRMEPDVPLIIPEVNPDHLALIPVQRRRRGWSGAIVTNPNCTSTPATMVLRPLL
DTFGVRRMLLVSMQALSGAGYPGVPSYDVVDNVIPYIGGEEPKLEIEPQKMLGRLEGETIVPAGFTTSAHCNRVPVLEGH
LVCLSIELERKADPAEIATVLSNFRALPQELRLPTAPEQPIIVRHEPDRPQPRRDRDAGRGMATVVGRIRPCSLFDIKLI
ALSHNTIRGAAGASILNAELMHAQGWLA

Specific function: This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp [H]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788658, Length=304, Percent_Identity=25, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320362, Length=358, Percent_Identity=41.0614525139665, Blast_Score=263, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR005676
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 37563; Mature: 37432

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIPVAVLGATGAVGQRFIQLLEGHPLFQVVALTGSERSAGKKYHEVCRWVLDTPMPAA
CCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHH
VANLTVLDADADLPAQLVFSALPSTVAGPIEQRLAAAGHIVCSNASNHRMEPDVPLIIPE
HHEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCEEEEC
VNPDHLALIPVQRRRRGWSGAIVTNPNCTSTPATMVLRPLLDTFGVRRMLLVSMQALSGA
CCCCCEEEEEHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYPGVPSYDVVDNVIPYIGGEEPKLEIEPQKMLGRLEGETIVPAGFTTSAHCNRVPVLEG
CCCCCCCHHHHHHHHHHCCCCCCCEEECHHHHHHHCCCCEEECCCCCCCCCCCCCCEECC
HLVCLSIELERKADPAEIATVLSNFRALPQELRLPTAPEQPIIVRHEPDRPQPRRDRDAG
CEEEEEEEECCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHC
RGMATVVGRIRPCSLFDIKLIALSHNTIRGAAGASILNAELMHAQGWLA
CCHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ATIPVAVLGATGAVGQRFIQLLEGHPLFQVVALTGSERSAGKKYHEVCRWVLDTPMPAA
CCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHH
VANLTVLDADADLPAQLVFSALPSTVAGPIEQRLAAAGHIVCSNASNHRMEPDVPLIIPE
HHEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCEEEEC
VNPDHLALIPVQRRRRGWSGAIVTNPNCTSTPATMVLRPLLDTFGVRRMLLVSMQALSGA
CCCCCEEEEEHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYPGVPSYDVVDNVIPYIGGEEPKLEIEPQKMLGRLEGETIVPAGFTTSAHCNRVPVLEG
CCCCCCCHHHHHHHHHHCCCCCCCEEECHHHHHHHCCCCEEECCCCCCCCCCCCCCEECC
HLVCLSIELERKADPAEIATVLSNFRALPQELRLPTAPEQPIIVRHEPDRPQPRRDRDAG
CEEEEEEEECCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHC
RGMATVVGRIRPCSLFDIKLIALSHNTIRGAAGASILNAELMHAQGWLA
CCHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]