Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 222523517

GI number: 222523517

Start: 266054

End: 267235

Strand: Direct

Name: hemN [H]

Synonym: Chy400_0223

Alternate gene names: 222523517

Gene position: 266054-267235 (Clockwise)

Preceding gene: 222523516

Following gene: 222523518

Centisome position: 5.05

GC content: 59.31

Gene sequence:

>1182_bases
ATGCGTCACCTGTACCTGCACATTCCCTTCTGTCACCGGCGCTGCTCCTATTGCGATTTTAACACCTACGCCAACATGGA
GCACCGGATTGAAGCGTATGTTGATGCGCTGTGCCAGGAGCTGGCAATGTTGCGCGATCAGCTACCGCCATTGCCGGCAT
CGCCCGAAGCGGCGGCCTTACGCCCCAGCATCTTCTTCGGCGGGGGCACACCCAGCATGCTCTCGCCGGCGCAGATCGAA
CGCATTCTGCAAGCCGCAGCGGAGATCGTGCCACTGACAGGAGCGGAAATCTCGCTCGAAGCCAATCCTGGCACCGTCCT
GGGTCGCGATTACCTGCGCGATCTGCGTAGTCTGGGGATCAATCGCCTCAGTATGGGGGTACAGAGTCTGCATGACCCGA
CGCTACGGATGCTGGGCCGCATTCACACAGCAGCCGAGGCTTATGCCAGTTTCAATGACGCCCGTGCGGTTGGGTTTGAA
TCGATCAACCTGGATTTTATCTTCGGCTTGCCGGGGCAGGATATTGAGCAATGGCGGGCAACCCTCACCGAGATTATCCG
ATGGGAAGTAGACCATATTGCCCTCTACTCGCTCATCCTGGAAGAGAACACACCGCTTTACGCGCAGGTCACCGCCGGAC
GCTTGCAGATTCCCGATGACGACCTGACCGGTGCAATGTACGAACTGGCGATGGAGATGCTTGGCGCTGCCGGCTATCGC
CACTACGAAATCTCAAACTGGGTGCGCCCATCTGTATCCGACCGCCCCGATGCACCACCGGCCCTGGCCTGTCAGCACAA
CCTGGCCTACTGGCTCAACAGCGACTATCTTGCCGCCGGTGCCGGCGCCCATGGCCACGTCTTTCCGCAACGTTACGCGA
ATCTACGCCCTATCGACAGCTACATCACGGCTGTGCAATCTGGTCGGCGACCAATCGCCGAAACCACCCTGCTCACATCC
GCCGATCTGGCAGCAGAGACCATGTTCATGGGGCTGCGTCTCGACATCGGGGTCGGATTTGCCCACTTCGCCGCCCGTGT
CGGACAATCACTGCTGGATTACTACGGCCCAACGCTCGAACAGCTCAGTCAGCAGGGATTGATCGAATGCAGCGCACAGC
GGGTCTATCTCACCCCGCGTGGACGGATGCTCGGCAACCAGGTCTTTGCACATTTTGTGTAA

Upstream 100 bases:

>100_bases
ACGCCTGGGGGCACTTACCATCATTACCGCCATAGCCCGCCAGAGCGCGACTCCACAACAGATCACCTATCCCGAAGAGC
AAATCCTGATCGGATAACCT

Downstream 100 bases:

>100_bases
AAAAGACATCATTTGTACCGCAATCGATCATATCATGCCCCCTGGATTGCGAGAGTATGTCAAGCGGGGTCCACACTCTC
TGCTATAATGATGGTATGAA

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRHLYLHIPFCHRRCSYCDFNTYANMEHRIEAYVDALCQELAMLRDQLPPLPASPEAAALRPSIFFGGGTPSMLSPAQIE
RILQAAAEIVPLTGAEISLEANPGTVLGRDYLRDLRSLGINRLSMGVQSLHDPTLRMLGRIHTAAEAYASFNDARAVGFE
SINLDFIFGLPGQDIEQWRATLTEIIRWEVDHIALYSLILEENTPLYAQVTAGRLQIPDDDLTGAMYELAMEMLGAAGYR
HYEISNWVRPSVSDRPDAPPALACQHNLAYWLNSDYLAAGAGAHGHVFPQRYANLRPIDSYITAVQSGRRPIAETTLLTS
ADLAAETMFMGLRLDIGVGFAHFAARVGQSLLDYYGPTLEQLSQQGLIECSAQRVYLTPRGRMLGNQVFAHFV

Sequences:

>Translated_393_residues
MRHLYLHIPFCHRRCSYCDFNTYANMEHRIEAYVDALCQELAMLRDQLPPLPASPEAAALRPSIFFGGGTPSMLSPAQIE
RILQAAAEIVPLTGAEISLEANPGTVLGRDYLRDLRSLGINRLSMGVQSLHDPTLRMLGRIHTAAEAYASFNDARAVGFE
SINLDFIFGLPGQDIEQWRATLTEIIRWEVDHIALYSLILEENTPLYAQVTAGRLQIPDDDLTGAMYELAMEMLGAAGYR
HYEISNWVRPSVSDRPDAPPALACQHNLAYWLNSDYLAAGAGAHGHVFPQRYANLRPIDSYITAVQSGRRPIAETTLLTS
ADLAAETMFMGLRLDIGVGFAHFAARVGQSLLDYYGPTLEQLSQQGLIECSAQRVYLTPRGRMLGNQVFAHFV
>Mature_393_residues
MRHLYLHIPFCHRRCSYCDFNTYANMEHRIEAYVDALCQELAMLRDQLPPLPASPEAAALRPSIFFGGGTPSMLSPAQIE
RILQAAAEIVPLTGAEISLEANPGTVLGRDYLRDLRSLGINRLSMGVQSLHDPTLRMLGRIHTAAEAYASFNDARAVGFE
SINLDFIFGLPGQDIEQWRATLTEIIRWEVDHIALYSLILEENTPLYAQVTAGRLQIPDDDLTGAMYELAMEMLGAAGYR
HYEISNWVRPSVSDRPDAPPALACQHNLAYWLNSDYLAAGAGAHGHVFPQRYANLRPIDSYITAVQSGRRPIAETTLLTS
ADLAAETMFMGLRLDIGVGFAHFAARVGQSLLDYYGPTLEQLSQQGLIECSAQRVYLTPRGRMLGNQVFAHFV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=379, Percent_Identity=35.3562005277045, Blast_Score=192, Evalue=5e-49,
Organism=Escherichia coli, GI1789325, Length=401, Percent_Identity=32.9177057356608, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87082341, Length=394, Percent_Identity=27.4111675126904, Blast_Score=141, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43612; Mature: 43612

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHLYLHIPFCHRRCSYCDFNTYANMEHRIEAYVDALCQELAMLRDQLPPLPASPEAAAL
CCEEEEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
RPSIFFGGGTPSMLSPAQIERILQAAAEIVPLTGAEISLEANPGTVLGRDYLRDLRSLGI
CCEEEECCCCCCCCCHHHHHHHHHHHHHHEECCCCEEEEECCCCCEECHHHHHHHHHCCC
NRLSMGVQSLHDPTLRMLGRIHTAAEAYASFNDARAVGFESINLDFIFGLPGQDIEQWRA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECEEEEECCCCCHHHHHHH
TLTEIIRWEVDHIALYSLILEENTPLYAQVTAGRLQIPDDDLTGAMYELAMEMLGAAGYR
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHHCCCC
HYEISNWVRPSVSDRPDAPPALACQHNLAYWLNSDYLAAGAGAHGHVFPQRYANLRPIDS
EEECCCCCCCCCCCCCCCCCCHHHCCCEEEEECCCEEEECCCCCCCCCHHHHCCCCCHHH
YITAVQSGRRPIAETTLLTSADLAAETMFMGLRLDIGVGFAHFAARVGQSLLDYYGPTLE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCHHH
QLSQQGLIECSAQRVYLTPRGRMLGNQVFAHFV
HHHHCCCEEECCCEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRHLYLHIPFCHRRCSYCDFNTYANMEHRIEAYVDALCQELAMLRDQLPPLPASPEAAAL
CCEEEEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
RPSIFFGGGTPSMLSPAQIERILQAAAEIVPLTGAEISLEANPGTVLGRDYLRDLRSLGI
CCEEEECCCCCCCCCHHHHHHHHHHHHHHEECCCCEEEEECCCCCEECHHHHHHHHHCCC
NRLSMGVQSLHDPTLRMLGRIHTAAEAYASFNDARAVGFESINLDFIFGLPGQDIEQWRA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECEEEEECCCCCHHHHHHH
TLTEIIRWEVDHIALYSLILEENTPLYAQVTAGRLQIPDDDLTGAMYELAMEMLGAAGYR
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHHCCCC
HYEISNWVRPSVSDRPDAPPALACQHNLAYWLNSDYLAAGAGAHGHVFPQRYANLRPIDS
EEECCCCCCCCCCCCCCCCCCHHHCCCEEEEECCCEEEECCCCCCCCCHHHHCCCCCHHH
YITAVQSGRRPIAETTLLTSADLAAETMFMGLRLDIGVGFAHFAARVGQSLLDYYGPTLE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCHHH
QLSQQGLIECSAQRVYLTPRGRMLGNQVFAHFV
HHHHCCCEEECCCEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]