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The map label for this gene is pheA [H]

Identifier: 222523473

GI number: 222523473

Start: 207027

End: 207881

Strand: Direct

Name: pheA [H]

Synonym: Chy400_0179

Alternate gene names: 222523473

Gene position: 207027-207881 (Clockwise)

Preceding gene: 222523472

Following gene: 222523474

Centisome position: 3.93

GC content: 58.71

Gene sequence:

>855_bases
ATGCAAACCATTGCCTACCTCGGCCCACCGGGAACCTTCAGCGAAGAAGCAGCGCTTGCCTATGCCGCAGGGCGCGAGGC
ACGACTGCTGCCGCTGGCCAGTATTCCGGCTGTGGTCACAGCCATTGAAACGGAAGCGGCAACCGTTGGGGTGTTGCCGA
TTGAAAACCTGTTGGAAGGTAGCGTCAGCTATACGCTTGATCTGCTGATCCACGAGACGAATTTGCAAATCGCCGGCGAG
ATTGTTGTGCCAATTCGCCAGTATCTCCTGGCCCGACCCGGTTTACAACTGAGCGATATTAAAGTGCTGTACGCGCATCC
GCAATCACTGGCCCAGTGTCGGCGCTTTGTTGAGCGCTGCCTGCCCGGCGTGGCTACCGTCGCTTCGCTGAGCAATTCGG
CTGCCCCCGCCGAGGCGATGGCTGATGAACGTCCGGCGGCGGCAATTGGCACACTGCGCGCAGCCGAACTGGTCGGTGCA
ACGATCCTGGCCCGTGAGATTGCCGATAGCCCTCACAATGTGACGCGCTTCATTGTGCTGGCCCGCGAAGATGCCCCGCC
CACCGGTGATGACAAAACCAGTTTCTGTTTTGGGTTCACCCGCGAGGATCGACCCGGCAGTCTGGTGAGCGCCCTCCAGG
AGCTGGCCGTCGAAAATATTAATATGACGAAGCTCGAATCGCGCCCAACCCGTGCGATTCTTGGTCAATACATCTTTCTG
GTTGACATCAATGGACACCGCCGCGAACCACACGTTGCCCGTGCCCTCGAACGCATTCGCCTGCATACGGGCATGCTGAA
AATCTTTGGTAGCTATCCGCGCTGGCGTGGCGCTAATGGTAATCATGCGTCGTAG

Upstream 100 bases:

>100_bases
GGAAGCATATACTTCCCGCCAGGATCGGTTAACCACGACACCGGGATGCCACAAGCGTAACCTGGCATCTCATCTGCAAC
ACACCTGCGTCAGTACACGT

Downstream 100 bases:

>100_bases
GTTGCGGCAAGGAGGAGAGCAAAGATGAACAAACCGCGCACCCTGTTTGAGAAAGTCTGGGAAGCACATCTGGTACGACC
AGAAACCGCTGAAACGCCTG

Product: Prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MQTIAYLGPPGTFSEEAALAYAAGREARLLPLASIPAVVTAIETEAATVGVLPIENLLEGSVSYTLDLLIHETNLQIAGE
IVVPIRQYLLARPGLQLSDIKVLYAHPQSLAQCRRFVERCLPGVATVASLSNSAAPAEAMADERPAAAIGTLRAAELVGA
TILAREIADSPHNVTRFIVLAREDAPPTGDDKTSFCFGFTREDRPGSLVSALQELAVENINMTKLESRPTRAILGQYIFL
VDINGHRREPHVARALERIRLHTGMLKIFGSYPRWRGANGNHAS

Sequences:

>Translated_284_residues
MQTIAYLGPPGTFSEEAALAYAAGREARLLPLASIPAVVTAIETEAATVGVLPIENLLEGSVSYTLDLLIHETNLQIAGE
IVVPIRQYLLARPGLQLSDIKVLYAHPQSLAQCRRFVERCLPGVATVASLSNSAAPAEAMADERPAAAIGTLRAAELVGA
TILAREIADSPHNVTRFIVLAREDAPPTGDDKTSFCFGFTREDRPGSLVSALQELAVENINMTKLESRPTRAILGQYIFL
VDINGHRREPHVARALERIRLHTGMLKIFGSYPRWRGANGNHAS
>Mature_284_residues
MQTIAYLGPPGTFSEEAALAYAAGREARLLPLASIPAVVTAIETEAATVGVLPIENLLEGSVSYTLDLLIHETNLQIAGE
IVVPIRQYLLARPGLQLSDIKVLYAHPQSLAQCRRFVERCLPGVATVASLSNSAAPAEAMADERPAAAIGTLRAAELVGA
TILAREIADSPHNVTRFIVLAREDAPPTGDDKTSFCFGFTREDRPGSLVSALQELAVENINMTKLESRPTRAILGQYIFL
VDINGHRREPHVARALERIRLHTGMLKIFGSYPRWRGANGNHAS

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=278, Percent_Identity=34.1726618705036, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324013, Length=321, Percent_Identity=27.4143302180685, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 30679; Mature: 30679

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIAYLGPPGTFSEEAALAYAAGREARLLPLASIPAVVTAIETEAATVGVLPIENLLEG
CCEEEEECCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHEECCCEEEEEEEHHHHHCC
SVSYTLDLLIHETNLQIAGEIVVPIRQYLLARPGLQLSDIKVLYAHPQSLAQCRRFVERC
CHHEEEEEEEEECCCEEEEEEHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHH
LPGVATVASLSNSAAPAEAMADERPAAAIGTLRAAELVGATILAREIADSPHNVTRFIVL
CCHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
AREDAPPTGDDKTSFCFGFTREDRPGSLVSALQELAVENINMTKLESRPTRAILGQYIFL
EECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHCCEEEE
VDINGHRREPHVARALERIRLHTGMLKIFGSYPRWRGANGNHAS
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQTIAYLGPPGTFSEEAALAYAAGREARLLPLASIPAVVTAIETEAATVGVLPIENLLEG
CCEEEEECCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHEECCCEEEEEEEHHHHHCC
SVSYTLDLLIHETNLQIAGEIVVPIRQYLLARPGLQLSDIKVLYAHPQSLAQCRRFVERC
CHHEEEEEEEEECCCEEEEEEHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHH
LPGVATVASLSNSAAPAEAMADERPAAAIGTLRAAELVGATILAREIADSPHNVTRFIVL
CCHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
AREDAPPTGDDKTSFCFGFTREDRPGSLVSALQELAVENINMTKLESRPTRAILGQYIFL
EECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHCCEEEE
VDINGHRREPHVARALERIRLHTGMLKIFGSYPRWRGANGNHAS
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]