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The map label for this gene is pcp2

Identifier: 221232775

GI number: 221232775

Start: 2019266

End: 2019910

Strand: Reverse

Name: pcp2

Synonym: SPN23F_20830

Alternate gene names: 221232775

Gene position: 2019910-2019266 (Counterclockwise)

Preceding gene: 221232776

Following gene: 221232773

Centisome position: 90.93

GC content: 44.34

Gene sequence:

>645_bases
ATGAAAGTATTAGTGACAGGTTTTGAGCCCTTTGGAGGGGAAAAGGGCAATCCAGCTTTGGAGGCCATTAAAGGTTTACC
AGCTGAAATCCATGGTGCTGAGGTCCGTTGGCTAGAGGTGCCGACAGTTTTTCACAAATCTGCTCAAGTATTGGAAGAAG
AGATGAATCGTTATCAACCTGACTTTGTCCTTTGTATTGGGCAAGCTGGTGGAAGAACTAGTTTGACACCTGAACGAGTG
ACCATTAATCAAGACGATGCATGCATTTCTGATAACGAAGATAATCAACCGATTGACCGTCCCATTCGCCCAGATGGTGC
TTCGGCCTACTTTAGTAGTTTGCCGATTAAAGCGATGGTTCAAGCTATAAAAAAAGAGGGCTTACCGGCCTCTGTTTCCA
ATACGGCAGGGACTTTTGTCTGCAGCCATTTGATGTATCAGGCTCTCTATTTGGTAGAAAAGAAATCTCCATATGTTAAG
GCAGGTTTTATGCATATTCCTTATATGATGGAACAGGTGGTGAACAGACCGACTACTCCAGCTATGAGTTTAGTGGATAT
TCGGCGAGGGATAGAAGCAGCAATCGGCGCTATAATAGAACATGGAGATCAGGAACTCAAGTTGGTAGGCGGAGAAACTC
ATTGA

Upstream 100 bases:

>100_bases
ATTCTAATCTCGCTAATCCTTTTTAATCCAGAATAAGGGAAATATGTTATACTTGTTTTTAAGAAAAAAGTCTCATTGAA
TTGGTTTTGAGGAGTTAGAA

Downstream 100 bases:

>100_bases
TAGAAAAAAGCTTGAGGGGAAAAACCTTCAAGCTTTTGGACGTTTTCGGGCCAATACTGCTCGGTAAAACATAATTTTAG
TGCATTGGATATAAGGTAGG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase 2; Pyroglutamyl-peptidase I 2; PGP-I 2; Pyrase 2

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKVLVTGFEPFGGEKGNPALEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQPDFVLCIGQAGGRTSLTPERV
TINQDDACISDNEDNQPIDRPIRPDGASAYFSSLPIKAMVQAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKSPYVK
AGFMHIPYMMEQVVNRPTTPAMSLVDIRRGIEAAIGAIIEHGDQELKLVGGETH

Sequences:

>Translated_214_residues
MKVLVTGFEPFGGEKGNPALEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQPDFVLCIGQAGGRTSLTPERV
TINQDDACISDNEDNQPIDRPIRPDGASAYFSSLPIKAMVQAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKSPYVK
AGFMHIPYMMEQVVNRPTTPAMSLVDIRRGIEAAIGAIIEHGDQELKLVGGETH
>Mature_214_residues
MKVLVTGFEPFGGEKGNPALEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQPDFVLCIGQAGGRTSLTPERV
TINQDDACISDNEDNQPIDRPIRPDGASAYFSSLPIKAMVQAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKSPYVK
AGFMHIPYMMEQVVNRPTTPAMSLVDIRRGIEAAIGAIIEHGDQELKLVGGETH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP2_STRPN (Q97NG9)

Other databases:

- EMBL:   AE005672
- PIR:   C95241
- RefSeq:   NP_346484.1
- ProteinModelPortal:   Q97NG9
- SMR:   Q97NG9
- MEROPS:   C15.001
- EnsemblBacteria:   EBSTRT00000025246
- GeneID:   931978
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_2060
- TIGR:   SP_2060
- GeneTree:   EBGT00050000029708
- HOGENOM:   HBG360405
- OMA:   LERCATN
- ProtClustDB:   PRK13197
- BioCyc:   SPNE170187-1:SP_2060-MONOMER
- BRENDA:   3.4.19.3
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23406; Mature: 23406

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 78-78 ACT_SITE 141-141 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVTGFEPFGGEKGNPALEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQP
CEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCC
DFVLCIGQAGGRTSLTPERVTINQDDACISDNEDNQPIDRPIRPDGASAYFSSLPIKAMV
CEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHH
QAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKSPYVKAGFMHIPYMMEQVVNRPTTP
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHCCCCCC
AMSLVDIRRGIEAAIGAIIEHGDQELKLVGGETH
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure
MKVLVTGFEPFGGEKGNPALEAIKGLPAEIHGAEVRWLEVPTVFHKSAQVLEEEMNRYQP
CEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCC
DFVLCIGQAGGRTSLTPERVTINQDDACISDNEDNQPIDRPIRPDGASAYFSSLPIKAMV
CEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHH
QAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKSPYVKAGFMHIPYMMEQVVNRPTTP
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHCCCCCC
AMSLVDIRRGIEAAIGAIIEHGDQELKLVGGETH
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916