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The map label for this gene is tlpA [H]

Identifier: 220933071

GI number: 220933071

Start: 2438163

End: 2440190

Strand: Reverse

Name: tlpA [H]

Synonym: Hore_22390

Alternate gene names: 220933071

Gene position: 2440190-2438163 (Counterclockwise)

Preceding gene: 220933072

Following gene: 220933070

Centisome position: 94.65

GC content: 43.39

Gene sequence:

>2028_bases
ATGGACCAGTCGGGTAACAGACGAAATGTAGTTAAAAACTTTTTATCACAGGTTAAGTTCCGTGAAAGTATTGGCATAAG
GGTTATGGTGTTTATTTGTATTATTATTTTAATGGCGGGTTTACTAATGTATTACAGGATAAATACCACTGTAAAACAGG
AGATAACCGGGTTAGTGAGGGATAGAAACCTGGGTATTGCTATGGCCCTGGAGGGAAGGTTAAGGGGCCAGTTTGACGAG
GTTGAGGATATTATAACTTTAACTTCCCACCAGGAAGCTGTTAAAAATAGAGATATAGAGAGGATCAAAGTATTTTTAAA
AGAAGTTACCGAAGATTCTCCTTTAATATCCCGGGTGTATTTTGCTGGCCAGAATGGGGAATTTATTACATACCCTGATT
CTAAATTGTCTAATTTTGACCCTGTTGAAACCGGTTGGTATAATAAAGCTCTGGATAAAAAAGGGGTTACCTGGCTCGGG
GCTAGGGAGAGTAAAATATCAGGTAACCGGGTTATAACAGTTGTTACTCCTGTATACCACCCGGAACAGGGGCTTATAGG
TGTCATAGGTGGTGATGTTTCCCTGGAGGTTTTAAACCAGCTTGTGAAAGCGACCCCGGTTGGGGAAAATGGCTATACTT
TTATTATAGATGATCAGGGAAGGATAATTGCCCATCCAGAGGAAAACATGGTAGAGGAAAGTTATGATTTTGGCCAGGAA
GTTAACCTGGAAAGGGTCCTCAGCGGAGAAAGTGATTCTACTGAATATACCTACAATGGAGTAACCAAACTTGCTTCTTA
TACCCCCACTCCGAAGATAAAAGGGGCAATTGTAGCCCAGATACCTGTCAAAGAGGCCTATCAGGCTCAGTCCCGGGTTA
ACAGACAACTATTTATAATTTCAGGTATAGTGCTACTGGTTCTGGTTGTCGGGGTCTATTTAATTATTAATTTGTTGTTG
CTTAAACCTGTTATCCGGATATCACAGGCCATGCAGGAAGTAGCCAGTGGGAATTTAAAGGTTTCTGTACCTGCTAAACG
CCGGCATGAAATCGGGGTTATGGGACAGATATTTAACAGAATGGTTTCAGAACTCAAGACCCTTATAACCAGTATTGATT
CCGATTCGGGTCAGGTTAAAGAACTATCCCGGGAACTTGAAGAGGCTTCTGACCAGGTGGGAGAAGTGTCGGAACAGGTC
TCAGCTTCCATCCAGGAGGTAGCAACCGGTGCTGATGATCAGGCCCACAATATTGAGAAAATAGATGAAAGGATTCAAAA
CCTGGCCGGGGTTCTGGATGAGCTTGAAAATACAAATGGTATGGTGGAGAACATGGCCGGGGAAATGAATCAGGCCTCAG
AAAATGGGCAGGAAGAAATAGAAGAGGTAAGGGAGCAGATGAACAGTATTAAATCAGCCATCAAGGAAGTGGCCCGGGAT
ATTAATAATTTAAAGACCATTTCAGAGGAAATAGATAGTATCCTGGAGATAATTAATAATATAGCAAATCAAACCAATCT
GCTGGCTTTAAATGCTGCCATAGAGGCGGCCAGGGCCGGGGAAGCCGGTCAGGGTTTCAGTGTTGTTGCTGATGAGATTC
GCCAGCTGGCTGAGGAATCTGCCGCTTCAGCTGATAAAATAAGAAAATTAATTGAAGAGATCAAAAACGAGACAGCCCGG
GCCGGTGAAAGAATGGCCAGAGGGACAGAAGAAGTAGAAAATGGTCAGGAAGTTGTTCTTTCAGCCGCAAGGGCATTTAA
AAATATTGATCAGGCTGTTCAGAGGGTAACTGAGGGTATTTCCAAAGCCAGTGAGGCTGTTAAGAATGCCAGTGATAGCA
GTCAGGACATTGTGGAGAGAATTCAAAACATTGCCAGTATCTCTGAGGAAACCTCGGCCAGTGCTGAGGAAGTGGCTGCA
GCCAGTGAAGAGCAAAGTGCTTCTGTAGAAGAAATAGCTGCCATGGCTGACAGGCTTGCCGAAATGTCAGCCAGGCTTGA
TAAACTCGTCGAAAATTTTGAGGTTTAA

Upstream 100 bases:

>100_bases
AACGTTGATTTCAAAGTACATATTTTTTACATTTCTTGTTTAAAAACATTTAGATTTGATAGTGGAGCCAACCTATTACT
ATAAAGGGAGGGACCTGGAT

Downstream 100 bases:

>100_bases
TTCGTAACTGTTTGCAGGATAGATATATTAATTACAAGATAGACATATTAATTATTTTATAATAAATGAGGTAGGGTTGT
TTTAATTAACCTTACCTCAT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MDQSGNRRNVVKNFLSQVKFRESIGIRVMVFICIIILMAGLLMYYRINTTVKQEITGLVRDRNLGIAMALEGRLRGQFDE
VEDIITLTSHQEAVKNRDIERIKVFLKEVTEDSPLISRVYFAGQNGEFITYPDSKLSNFDPVETGWYNKALDKKGVTWLG
ARESKISGNRVITVVTPVYHPEQGLIGVIGGDVSLEVLNQLVKATPVGENGYTFIIDDQGRIIAHPEENMVEESYDFGQE
VNLERVLSGESDSTEYTYNGVTKLASYTPTPKIKGAIVAQIPVKEAYQAQSRVNRQLFIISGIVLLVLVVGVYLIINLLL
LKPVIRISQAMQEVASGNLKVSVPAKRRHEIGVMGQIFNRMVSELKTLITSIDSDSGQVKELSRELEEASDQVGEVSEQV
SASIQEVATGADDQAHNIEKIDERIQNLAGVLDELENTNGMVENMAGEMNQASENGQEEIEEVREQMNSIKSAIKEVARD
INNLKTISEEIDSILEIINNIANQTNLLALNAAIEAARAGEAGQGFSVVADEIRQLAEESAASADKIRKLIEEIKNETAR
AGERMARGTEEVENGQEVVLSAARAFKNIDQAVQRVTEGISKASEAVKNASDSSQDIVERIQNIASISEETSASAEEVAA
ASEEQSASVEEIAAMADRLAEMSARLDKLVENFEV

Sequences:

>Translated_675_residues
MDQSGNRRNVVKNFLSQVKFRESIGIRVMVFICIIILMAGLLMYYRINTTVKQEITGLVRDRNLGIAMALEGRLRGQFDE
VEDIITLTSHQEAVKNRDIERIKVFLKEVTEDSPLISRVYFAGQNGEFITYPDSKLSNFDPVETGWYNKALDKKGVTWLG
ARESKISGNRVITVVTPVYHPEQGLIGVIGGDVSLEVLNQLVKATPVGENGYTFIIDDQGRIIAHPEENMVEESYDFGQE
VNLERVLSGESDSTEYTYNGVTKLASYTPTPKIKGAIVAQIPVKEAYQAQSRVNRQLFIISGIVLLVLVVGVYLIINLLL
LKPVIRISQAMQEVASGNLKVSVPAKRRHEIGVMGQIFNRMVSELKTLITSIDSDSGQVKELSRELEEASDQVGEVSEQV
SASIQEVATGADDQAHNIEKIDERIQNLAGVLDELENTNGMVENMAGEMNQASENGQEEIEEVREQMNSIKSAIKEVARD
INNLKTISEEIDSILEIINNIANQTNLLALNAAIEAARAGEAGQGFSVVADEIRQLAEESAASADKIRKLIEEIKNETAR
AGERMARGTEEVENGQEVVLSAARAFKNIDQAVQRVTEGISKASEAVKNASDSSQDIVERIQNIASISEETSASAEEVAA
ASEEQSASVEEIAAMADRLAEMSARLDKLVENFEV
>Mature_675_residues
MDQSGNRRNVVKNFLSQVKFRESIGIRVMVFICIIILMAGLLMYYRINTTVKQEITGLVRDRNLGIAMALEGRLRGQFDE
VEDIITLTSHQEAVKNRDIERIKVFLKEVTEDSPLISRVYFAGQNGEFITYPDSKLSNFDPVETGWYNKALDKKGVTWLG
ARESKISGNRVITVVTPVYHPEQGLIGVIGGDVSLEVLNQLVKATPVGENGYTFIIDDQGRIIAHPEENMVEESYDFGQE
VNLERVLSGESDSTEYTYNGVTKLASYTPTPKIKGAIVAQIPVKEAYQAQSRVNRQLFIISGIVLLVLVVGVYLIINLLL
LKPVIRISQAMQEVASGNLKVSVPAKRRHEIGVMGQIFNRMVSELKTLITSIDSDSGQVKELSRELEEASDQVGEVSEQV
SASIQEVATGADDQAHNIEKIDERIQNLAGVLDELENTNGMVENMAGEMNQASENGQEEIEEVREQMNSIKSAIKEVARD
INNLKTISEEIDSILEIINNIANQTNLLALNAAIEAARAGEAGQGFSVVADEIRQLAEESAASADKIRKLIEEIKNETAR
AGERMARGTEEVENGQEVVLSAARAFKNIDQAVQRVTEGISKASEAVKNASDSSQDIVERIQNIASISEETSASAEEVAA
ASEEQSASVEEIAAMADRLAEMSARLDKLVENFEV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=381, Percent_Identity=27.5590551181102, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788194, Length=386, Percent_Identity=29.0155440414508, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1788195, Length=283, Percent_Identity=30.7420494699647, Blast_Score=109, Evalue=7e-25,
Organism=Escherichia coli, GI2367378, Length=304, Percent_Identity=28.9473684210526, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1789453, Length=350, Percent_Identity=25.7142857142857, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 74236; Mature: 74236

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2 ; PS00251 TNF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQSGNRRNVVKNFLSQVKFRESIGIRVMVFICIIILMAGLLMYYRINTTVKQEITGLVR
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
DRNLGIAMALEGRLRGQFDEVEDIITLTSHQEAVKNRDIERIKVFLKEVTEDSPLISRVY
CCCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHE
FAGQNGEFITYPDSKLSNFDPVETGWYNKALDKKGVTWLGARESKISGNRVITVVTPVYH
EECCCCCEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEECCCCCCCCCCEEEEEEECCCC
PEQGLIGVIGGDVSLEVLNQLVKATPVGENGYTFIIDDQGRIIAHPEENMVEESYDFGQE
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCCC
VNLERVLSGESDSTEYTYNGVTKLASYTPTPKIKGAIVAQIPVKEAYQAQSRVNRQLFII
CCHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHCCHHHHH
SGIVLLVLVVGVYLIINLLLLKPVIRISQAMQEVASGNLKVSVPAKRRHEIGVMGQIFNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHH
MVSELKTLITSIDSDSGQVKELSRELEEASDQVGEVSEQVSASIQEVATGADDQAHNIEK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IDERIQNLAGVLDELENTNGMVENMAGEMNQASENGQEEIEEVREQMNSIKSAIKEVARD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
INNLKTISEEIDSILEIINNIANQTNLLALNAAIEAARAGEAGQGFSVVADEIRQLAEES
HHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
AASADKIRKLIEEIKNETARAGERMARGTEEVENGQEVVLSAARAFKNIDQAVQRVTEGI
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
SKASEAVKNASDSSQDIVERIQNIASISEETSASAEEVAAASEEQSASVEEIAAMADRLA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHCCHHHHHHHHHHHH
EMSARLDKLVENFEV
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MDQSGNRRNVVKNFLSQVKFRESIGIRVMVFICIIILMAGLLMYYRINTTVKQEITGLVR
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
DRNLGIAMALEGRLRGQFDEVEDIITLTSHQEAVKNRDIERIKVFLKEVTEDSPLISRVY
CCCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHE
FAGQNGEFITYPDSKLSNFDPVETGWYNKALDKKGVTWLGARESKISGNRVITVVTPVYH
EECCCCCEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEECCCCCCCCCCEEEEEEECCCC
PEQGLIGVIGGDVSLEVLNQLVKATPVGENGYTFIIDDQGRIIAHPEENMVEESYDFGQE
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCCC
VNLERVLSGESDSTEYTYNGVTKLASYTPTPKIKGAIVAQIPVKEAYQAQSRVNRQLFII
CCHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHCCHHHHH
SGIVLLVLVVGVYLIINLLLLKPVIRISQAMQEVASGNLKVSVPAKRRHEIGVMGQIFNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHH
MVSELKTLITSIDSDSGQVKELSRELEEASDQVGEVSEQVSASIQEVATGADDQAHNIEK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IDERIQNLAGVLDELENTNGMVENMAGEMNQASENGQEEIEEVREQMNSIKSAIKEVARD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
INNLKTISEEIDSILEIINNIANQTNLLALNAAIEAARAGEAGQGFSVVADEIRQLAEES
HHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
AASADKIRKLIEEIKNETARAGERMARGTEEVENGQEVVLSAARAFKNIDQAVQRVTEGI
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
SKASEAVKNASDSSQDIVERIQNIASISEETSASAEEVAAASEEQSASVEEIAAMADRLA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHCCHHHHHHHHHHHH
EMSARLDKLVENFEV
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]